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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

The Phyllanthus Emblica Fruits: A Review on Phytochemistry Traditional Uses, Bioactive Composition and Pharmacological Activities

In Press, (this is not the final "Version of Record"). Available online 25 July, 2024
Author(s): Shilpi Pathak*, Abhishek Pratap, Richa Sharma and Manas Kumar Jha
Published on: 25 July, 2024

DOI: 10.2174/0115680266321320240708060327

Price: $95

Abstract

Phyllanthus emblica, popularly mentioned as amla or Indian gooseberry, has attracted a lot of interest lately because of its varied phytochemical makeup and related pharmacological properties. The phytochemistry, historical applications, bioactive makeup, and pharmacological properties of Phyllanthus emblica fruits are all summarised in this paper. This review emphasises the rich phytochemical profile of Phyllanthus emblica, which contains flavonoids, tannins, alkaloids, and polyphenolic chemicals, through a thorough assessment of the literature. Furthermore, the historical value of Phyllanthus emblica as a therapeutic agent for a variety of health issues is shown by its traditional applications in numerous indigenous medical systems. The bioactive makeup of Phyllanthus emblica fruits, especially its high polyphenol and vitamin C content, is responsible for its hepatoprotective, antioxidant, and anti-inflammatory qualities. Moreover, new pharmacological research has clarified its potential for the cure of neurological illnesses, tumor, diabetes, and cardiovascular diseases. In order to shed light on the pharmacological properties of Phyllanthus emblica fruits and suggest future avenues for study, this review compiles the body of scientific data that is already accessible. All things considered, Phyllanthus Emblica shows great promise as a natural resource with significant applications in complementary and alternative medicine and pharmacological research.

[1]
D’souza, J.J.; D’souza, P.P.; Fazal, F.; Kumar, A.; Bhat, H.P.; Baliga, M.S. Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action. Food Funct., 2014, 5(4), 635-644.
[http://dx.doi.org/10.1039/c3fo60366k] [PMID: 24577384]
[2]
Husain, I.; Zameer, S.; Madaan, T.; Minhaj, A.; Ahmad, W.; Iqubaal, A.; Ali, A.; Najmi, A.K. Exploring the multifaceted neuroprotective actions of Emblica officinalis (Amla): A review. Metab. Brain Dis., 2019, 34(4), 957-965.
[http://dx.doi.org/10.1007/s11011-019-00400-9] [PMID: 30848470]
[3]
Mirunalini, S.; Krishnaveni, M. Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. J. Basic Clin. Physiol. Pharmacol., 2010, 21(1), 93-105.
[http://dx.doi.org/10.1515/JBCPP.2010.21.1.93] [PMID: 20506691]
[4]
Yadav, S.S.; Singh, M.K.; Singh, P.K.; Kumar, V. Traditional knowledge to clinical trials: A review on therapeutic actions of Emblica officinalis. Biomed. Pharmacother., 2017, 93, 1292-1302.
[http://dx.doi.org/10.1016/j.biopha.2017.07.065] [PMID: 28747010]
[5]
Hassan, S.M.; Mughal, S.S.; Aslam, A.; Mushtaq, M.; Munir, M.; Pervez, S.; Shabbir, N.; Ayub, A.R.; Farman, M. Emblica Officinalis (Amla): A prospective review on distinctive properties and therapeutic applications of amla syeda. Biomed. Nurs., 2020, 6, 22-30.
[6]
Saini, R.; Sharma, N.; Oladeji, O.S.; Sourirajan, A.; Dev, K.; Zengin, G.; El-Shazly, M.; Kumar, V. Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review. J. Ethnopharmacol., 2022, 282, 114570.
[http://dx.doi.org/10.1016/j.jep.2021.114570] [PMID: 34480995]
[7]
Hazra, B.; Sarkar, R.; Biswas, S.; Mandal, N. Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of terminalia chebula, terminalia belerica, and emblica officinalis. Recent Adv. Plant-Based, Tradit. Nat. Med., 2014, 181-214.
[8]
Jose, J.K.; Kuttan, G.; Kuttan, R. Antitumour activity of Emblica officinalis. J. Ethnopharmacol., 2001, 75(2-3), 65-69.
[http://dx.doi.org/10.1016/S0378-8741(00)00378-0] [PMID: 11297836]
[9]
Sinha, R.; Jindal, R.; Faggio, C. Nephroprotective effect of Emblica officinalis fruit extract against malachite green toxicity in piscine model: Ultrastructure and oxidative stress study. Microsc. Res. Tech., 2021, 84(8), 1911-1919.
[http://dx.doi.org/10.1002/jemt.23747] [PMID: 33751719]
[10]
Adil, M.D.; Kaiser, P.; Satti, N.K.; Zargar, A.M.; Vishwakarma, R.A.; Tasduq, S.A. Effect of Emblica officinalis (fruit) against UVB-induced photo-aging in human skin fibroblasts. J. Ethnopharmacol., 2010, 132(1), 109-114.
[http://dx.doi.org/10.1016/j.jep.2010.07.047] [PMID: 20688142]
[11]
Fujii, T.; Wakaizumi, M.; Ikami, T.; Saito, M. Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. J. Ethnopharmacol., 2008, 119(1), 53-57.
[http://dx.doi.org/10.1016/j.jep.2008.05.039] [PMID: 18588964]
[12]
Alam, M.I.; Gomes, A. Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts. J. Ethnopharmacol., 2003, 86(1), 75-80.
[http://dx.doi.org/10.1016/S0378-8741(03)00049-7] [PMID: 12686445]
[13]
Aruna, R.; Geetha, A.; Suguna, P.; Suganya, V. Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration. J. Complement. Integr. Med., 2014, 11(1), 9-18.
[http://dx.doi.org/10.1515/jcim-2013-0023] [PMID: 24516008]
[14]
Asmawi, M.Z.; Kankaanranta, H.; Moilanen, E.; Vapaatalo, H. Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts. J. Pharm. Pharmacol., 2011, 45(6), 581-584.
[http://dx.doi.org/10.1111/j.2042-7158.1993.tb05605.x] [PMID: 7689650]
[15]
Golechha, M.; Sarangal, V.; Ojha, S.; Bhatia, J.; Arya, D.S. Anti-inflammatory effect of emblica officinalis in rodent models of acute and chronic inflammation: involvement of possible mechanisms. In: Int. J. Inflam; , 2014; 2014, p. 178408.
[16]
Singh, M.K.; Yadav, S.S.; Yadav, R.S.; Chauhan, A.; Katiyar, D.; Khattri, S. Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice. Springerplus, 2015, 4(1), 438.
[http://dx.doi.org/10.1186/s40064-015-1227-9] [PMID: 26312203]
[17]
Singh, M.K.; Yadav, S.S.; Gupta, V.; Khattri, S. Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice. BMC Complement. Altern. Med., 2013, 13(1), 193.
[http://dx.doi.org/10.1186/1472-6882-13-193] [PMID: 23889914]
[18]
Li, W.; Zhu, H.; Chen, Y.; Xiao, H.; Ge, Y.; Hu, H.; Li, X.; Cao, Y. Bioactivity‐guided isolation of anti‐inflammatory components from Phyllanthus emblica. Food Sci. Nutr., 2020, 8(6), 2670-2679.
[http://dx.doi.org/10.1002/fsn3.1553] [PMID: 32566184]
[19]
Muthuraman, A.; Sood, S.; Singla, S.K. The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in rat. Inflammopharmacology, 2011, 19(6), 327-334.
[http://dx.doi.org/10.1007/s10787-010-0041-9] [PMID: 20596897]
[20]
Bhatia, J.; Tabassum, F.; Sharma, A.K.; Bharti, S.; Golechha, M.; Joshi, S.; Sayeed Akhatar, M.; Srivastava, A.K.; Arya, D.S. Emblica officinalis exerts antihypertensive effect in a rat model of DOCA-salt-induced hypertension: role of (p) eNOS, NO and oxidative stress. Cardiovasc. Toxicol., 2011, 11(3), 272-279.
[http://dx.doi.org/10.1007/s12012-011-9122-2] [PMID: 21748534]
[21]
Bhattacharya, S.K.; Bhattacharya, D.; Sairam, K.; Ghosal, S. Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart. Phytomedicine, 2002, 9(2), 171-174.
[http://dx.doi.org/10.1078/0944-7113-00090] [PMID: 11995952]
[22]
Shukla, V.; Vashistha, M.; Singh, S.N. Evaluation of antioxidant profile and activity of amalaki (Emblica officinalis), spirulina and wheat grass. Indian J. Clin. Biochem., 2009, 24(1), 70-75.
[http://dx.doi.org/10.1007/s12291-009-0012-3] [PMID: 23105810]
[23]
Shivananjappa, M.M.; Joshi, M.K. Influence of Emblica officinalis aqueous extract on growth and antioxidant defense system of human hepatoma cell line (HepG2). Pharm. Biol., 2012, 50(4), 497-505.
[http://dx.doi.org/10.3109/13880209.2011.618501] [PMID: 22133060]
[24]
Pozharitskaya, O.N.; Ivanova, S.A.; Shikov, A.N.; Makarov, V.G. Separation and evaluation of free radical‐scavenging activity of phenol components of Emblica officinalis extract by using an HPTLC–DPPH • method. J. Sep. Sci., 2007, 30(9), 1250-1254.
[http://dx.doi.org/10.1002/jssc.200600532] [PMID: 17623464]
[25]
Yokozawa, T.; Kim, H.Y.; Kim, H.J.; Tanaka, T.; Sugino, H.; Okubo, T.; Chu, D.C.; Juneja, L.R. Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress. J. Agric. Food Chem., 2007, 55(19), 7744-7752.
[http://dx.doi.org/10.1021/jf072105s] [PMID: 17715896]
[26]
Sharma, A.; Sharma, M.K.; Kumar, M. Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice. Chem. Biol. Interact., 2009, 180(1), 20-30.
[http://dx.doi.org/10.1016/j.cbi.2009.01.012] [PMID: 19428342]
[27]
Rao, T.P.; Sakaguchi, N.; Juneja, L.R.; Wada, E.; Yokozawa, T. Amla (Emblica officinalis Gaertn.) extracts reduce oxidative stress in streptozotocin-induced diabetic rats. J. Med. Food, 2005, 8(3), 362-368.
[http://dx.doi.org/10.1089/jmf.2005.8.362] [PMID: 16176148]
[28]
Gunti, L.; Dass, R.S.; Kalagatur, N.K. Phytofabrication of selenium nanoparticles from Emblica officinalis fruit extract and exploring its biopotential applications: antioxidant, antimicrobial, and biocompatibility. Front. Microbiol., 2019, 10, 931.
[http://dx.doi.org/10.3389/fmicb.2019.00931] [PMID: 31114564]
[29]
Nath, A.; Raghunatha, P.; Joshi, S.R. Diversity and biological activities of endophytic fungi of Emblica officinalis, an ethnomedicinal plant of India. Mycobiology, 2012, 40(1), 8-13.
[http://dx.doi.org/10.5941/MYCO.2012.40.1.008] [PMID: 22783128]
[30]
Chahal, A.K.; Chandan, G.; Kumar, R.; Chhillar, A.K.; Saini, A.K.; Saini, R.V. Bioactive constituents of Emblica officinalis overcome oxidative stress in mammalian cells by inhibiting hyperoxidation of peroxiredoxins. J. Food Biochem., 2020, 44(2), e13115.
[http://dx.doi.org/10.1111/jfbc.13115] [PMID: 31821595]
[31]
Golechha, M.; Bhatia, J.; Ojha, S.; Arya, D.S. Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: Evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention. Pharm. Biol., 2011, 49(11), 1128-1136.
[http://dx.doi.org/10.3109/13880209.2011.571264] [PMID: 21749189]
[32]
Nosál’ová, G.; Mokrý, J.; Hassan, K.M.T. Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae). Phytomedicine, 2003, 10(6-7), 583-589.
[http://dx.doi.org/10.1078/094471103322331872] [PMID: 13678247]
[33]
Ojha, S.; Golechha, M.; Kumari, S.; Arya, D.S. Protective effect of Emblica officinalis (amla) on isoproterenol-induced cardiotoxicity in rats. Toxicol. Ind. Health, 2012, 28(5), 399-411.
[http://dx.doi.org/10.1177/0748233711413798] [PMID: 22033422]
[34]
Penolazzi, L.; Lampronti, I.; Borgatti, M.; Khan, M.T.H.; Zennaro, M.; Piva, R.; Gambari, R. Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis. BMC Complement. Altern. Med., 2008, 8(1), 59.
[http://dx.doi.org/10.1186/1472-6882-8-59] [PMID: 18973662]
[35]
Perianayagam, J.B.; Sharma, S.K.; Joseph, A.; Christina, A.J.M. Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn. J. Ethnopharmacol., 2004, 95(1), 83-85.
[http://dx.doi.org/10.1016/j.jep.2004.06.020] [PMID: 15374611]
[36]
Ramanujam, K.; Sundrarajan, M. Antibacterial effects of biosynthesized MgO nanoparticles using ethanolic fruit extract of Emblica officinalis. J. Photochem. Photobiol. B, 2014, 141, 296-300.
[http://dx.doi.org/10.1016/j.jphotobiol.2014.09.011] [PMID: 25463681]
[37]
Ramesh, P.S.; Kokila, T.; Geetha, D. Plant mediated green synthesis and antibacterial activity of silver nanoparticles using Emblica officinalis fruit extract. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2015, 142, 339-343.
[http://dx.doi.org/10.1016/j.saa.2015.01.062] [PMID: 25710891]
[38]
Purena, R.; Seth, R.; Bhatt, R. Protective role of Emblica officinalis hydro-ethanolic leaf extract in cisplatin induced nephrotoxicity in Rats. Toxicol. Rep., 2018, 5, 270-277.
[http://dx.doi.org/10.1016/j.toxrep.2018.01.008] [PMID: 29487802]
[39]
Justin Thenmozhi, A.; Dhivyabharathi, M.; Manivasagam, T.; Essa, M.M. Tannoid principles of Emblica officinalis attenuated aluminum chloride induced apoptosis by suppressing oxidative stress and tau pathology via Akt/GSK-3βsignaling pathway. J. Ethnopharmacol., 2016, 194, 20-29.
[http://dx.doi.org/10.1016/j.jep.2016.08.047] [PMID: 27566203]
[40]
Chen, T.S.; Liou, S.Y.; Wu, H.C.; Tsai, F.J.; Tsai, C.H.; Huang, C.Y.; Chang, Y.L. Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients. J. Med. Food, 2011, 14(7-8), 718-723.
[http://dx.doi.org/10.1089/jmf.2010.1195] [PMID: 21631363]
[41]
Fatima, N.; Hafizur, R.M.; Hameed, A.; Ahmed, S.; Nisar, M.; Kabir, N. Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on β-cells of pancreas. Eur. J. Nutr., 2017, 56(2), 591-601.
[http://dx.doi.org/10.1007/s00394-015-1103-y] [PMID: 26593435]
[42]
Variya, B.C.; Bakrania, A.K.; Patel, S.S. Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-γ and Akt signaling. Phytomedicine, 2020, 73, 152906.
[http://dx.doi.org/10.1016/j.phymed.2019.152906] [PMID: 31064680]
[43]
Vasudevan, M.; Parle, M. Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): An Ayurvedic preparation. Physiol. Behav., 2007, 91(1), 46-54.
[http://dx.doi.org/10.1016/j.physbeh.2007.01.016] [PMID: 17343883]
[44]
Majeed, M.; Majeed, S.; Mundkur, L.; Nagabhushanam, K.; Arumugam, S.; Beede, K.; Ali, F. Standardized Emblica officinalis fruit extract inhibited the activities of α ‐amylase, α ‐glucosidase, and dipeptidyl peptidase‐4 and displayed antioxidant potential. J. Sci. Food Agric., 2020, 100(2), 509-516.
[http://dx.doi.org/10.1002/jsfa.10020] [PMID: 31487036]
[45]
Damodara Reddy, V.; Padmavathi, P.; Gopi, S.; Paramahamsa, M.; Varadacharyulu, N.C. Protective effect of emblica officinalis against alcohol-induced hepatic injury by ameliorating oxidative stress in rats. Indian J. Clin. Biochem., 2010, 25(4), 419-424.
[http://dx.doi.org/10.1007/s12291-010-0058-2] [PMID: 21966117]
[46]
Sultana, S.; Ahmed, S.; Sharma, S.; Jahangir, T. Emblica officinalis reverses thioacetamide-induced oxidative stress and early promotional events of primary hepatocarcinogenesis. J. Pharm. Pharmacol., 2010, 56(12), 1573-1579.
[http://dx.doi.org/10.1211/0022357044931] [PMID: 15586980]
[47]
Reddy, V.D.; Padmavathi, P.; Varadacharyulu, N.C. Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats. J. Med. Food, 2009, 12(2), 327-333.
[http://dx.doi.org/10.1089/jmf.2007.0694] [PMID: 19459733]
[48]
Reddy, V.D.; Padmavathi, P.; Hymavathi, R.; Maturu, P.; Varadacharyulu, N.C. Alcohol-induced oxidative stress in rat liver microsomes: Protective effect of Emblica officinalis. Pathophysiology, 2014, 21(2), 153-159.
[http://dx.doi.org/10.1016/j.pathophys.2013.12.001] [PMID: 24393670]
[49]
Sarkar, R.; Hazra, B.; Mandal, N. Amelioration of iron overload-induced liver toxicity by a potent antioxidant and iron chelator, Emblica officinalis Gaertn. Toxicol. Ind. Health, 2015, 31(7), 656-669.
[http://dx.doi.org/10.1177/0748233713483195] [PMID: 23524878]
[50]
Nazish, I.; Ansari, S.H. Emblica officinalis: Anti-obesity activity. J. Complement. Integr. Med., 2018, 15(2), 20160051.
[http://dx.doi.org/10.1515/jcim-2016-0051]
[51]
Kaleem, Q.M.; Akhtar, M.; Awais, M.M.; Saleem, M.; Zafar, M.; Iqbal, Z.; Muhammad, F.; Anwar, M.I. Studies on Emblica officinalis derived tannins for their immunostimulatory and protective activities against coccidiosis in industrial broiler chickens. Scient.Wor.J., 2014, 2014, 1-10.
[http://dx.doi.org/10.1155/2014/378473] [PMID: 24578631]
[52]
Sumitra, M.; Manikandan, P.; Gayathri, V.S.; Mahendran, P.; Suguna, L. Emblica officinalis exerts wound healing action through up‐regulation of collagen and extracellular signal‐regulated kinases (ERK1/2). Wound Repair Regen., 2009, 17(1), 99-107.
[http://dx.doi.org/10.1111/j.1524-475X.2008.00446.x] [PMID: 19152656]
[53]
Chaudhary, N.; Sabikhi, L.; Hussain, S.A. Emblicanin rich Emblica officinalis extract encapsulated double emulsion: controlled release of bioactive during phagocytosis and in vitro digestion. J. Food Sci. Technol., 2020, 57(4), 1371-1381.
[http://dx.doi.org/10.1007/s13197-019-04171-0] [PMID: 32180633]
[54]
Yokozawa, T.; Young Kim, H.; Ju Kim, H.; Okubo, T.; Chu, D.C.; Raj Juneja, L. Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process. Br. J. Nutr., 2007, 97(6), 1187-1195.
[http://dx.doi.org/10.1017/S0007114507691971] [PMID: 17506915]
[55]
Sharma, N.; Trikha, P.; Athar, M.; Raisuddin, S. Inhibitory effect of Emblica officinals on the in vivo clastogenicity of benzo alpyrene and acyclophosphamide in mice. Hum. Exp. Toxicol., 2000, 19(6), 377-384.
[http://dx.doi.org/10.1191/096032700678815945] [PMID: 10962512]
[56]
Hari KUMAR, K.B.; Sabu, M.C.; Lima, P.S.; Kuttan, R. Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against γ-radiation induced damages in mice. J. Radiat. Res., 2004, 45(4), 549-555.
[http://dx.doi.org/10.1269/jrr.45.549] [PMID: 15635265]
[57]
Rawal, S.; Singh, P.; Gupta, A.; Mohanty, S. Dietary intake of curcuma longa and emblica officinalis increases life span in drosophila melanogaster. Biomed Res. Int., 2014, 2014, 910290.
[58]
Jose, J.K.; Kuttan, R. Hepatoprotective activity of Emblica officinalis and Chyavanaprash. J. Ethnopharmacol., 2000, 72(1-2), 135-140.
[http://dx.doi.org/10.1016/S0378-8741(00)00219-1] [PMID: 10967464]
[59]
Sai Ram, M.; Neetu, D.; Deepti, P.; Vandana, M.; Ilavazhagan, G.; Kumar, D.; Selvamurthy, W. Cytoprotective activity of Amla (Emblica officinalis) against chromium (VI) induced oxidative injury in murine macrophages. Phytother. Res., 2003, 17(4), 430-433.
[http://dx.doi.org/10.1002/ptr.1157] [PMID: 12722158]

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