Advancements in Iron Oxide Nanoparticles for Multimodal Imaging and Tumor Theranostics

Title:Advancements in Iron Oxide Nanoparticles for Multimodal Imaging and Tumor Theranostics

Volume: 31

Author(s): He Liu, Zhiming Zhen, Fengxi Chen, Jiafei Chen*Wei Chen*

Affiliation:

• Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China
• 7T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China

• Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China
• 7T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China

Abstract: The emergence of nanomedicine offers renewed promise in the diagnosis and treatment of diseases. Due to their unique physical and chemical properties, iron oxide nanoparticles (IONPs) exhibit widespread application in the diagnosis and treatment of various ailments, particularly tumors. IONPs have magnetic resonance (MR) T1/T2 imaging capabilities due to their different sizes. In addition, IONPs also have biocatalytic activity (nanozymes) and magnetocaloric effects. They are widely used in chemodynamic therapy (CDT), magnetic hyperthermia treatment (MHT), photodynamic therapy (PDT), and drug delivery. This review outlines the synthesis, modification, and biomedical applications of IONPs, emphasizing their role in enhancing diagnostic imaging (including single-mode and multimodal imaging) and their potential in cancer therapies (including chemotherapy, radiotherapy, CDT, and PDT). Furthermore, we briefly explore the challenges in the clinical application of IONPs, such as surface modification and protein adsorption, and put forward opinions on the clinical transformation of IONPs.

Cite this article as:

Liu He, Zhen Zhiming, Chen Fengxi, Chen Jiafei*, Chen Wei*, Advancements in Iron Oxide Nanoparticles for Multimodal Imaging and Tumor Theranostics, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0109298673301359240705063544