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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Glia as a New Target for Therapeutic Actions of Electroconvulsive Therapy

In Press, (this is not the final "Version of Record"). Available online 12 July, 2024
Author(s): Sadayuki Hashioka*
Published on: 12 July, 2024

DOI: 10.2174/0118715273319405240707164638

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Abstract

Although electroconvulsive therapy (ECT) has immediate and profound effects on severe psychiatric disorders compared to pharmacotherapy, the mechanisms underlying its therapeutic effects remain elusive. Increasing evidence indicates that glial activation is a common pathogenetic factor in both major depression and schizophrenia, raising the question of whether ECT can inhibit glial activation. This article summarizes the findings from both clinical and experimental studies addressing this key question. Based on the findings, it is proposed that the suppression of glial activation associated with neuroinflammation is the mechanism by which ECT restores brain homeostasis and exerts its therapeutic effects.

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