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Current Drug Targets

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ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

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Review Article

Quercetin in Oncology: A Phytochemical with Immense Therapeutic Potential

In Press, (this is not the final "Version of Record"). Available online 10 July, 2024
Author(s): Raj Kamal, Priyanka Paul, Shubham Thakur, Sachin Kumar Singh and Ankit Awasthi*
Published on: 10 July, 2024

DOI: 10.2174/0113894501292466240627050638

Price: $95

Abstract

Quercetin is a natural flavonoid with various pharmacological actions such as anti-inflammatory, antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, cardioprotective, neuroprotective, and antiviral activities. Looking at these enormous potentials, researchers have explored how they can be used to manage numerous cancers. It's been studied for cancer management due to its anti-angiogenesis, anti-metastatic, and antiproliferative mechanisms. Despite having these proven pharmacological activities, the clinical use of quercetin is limited due to its first-- pass metabolism, poor solubility, and bioavailability. To address these shortcomings, researchers have fabricated various nanocarriers-based formulations to fight cancer. The present review overshadows the pharmacological potential, mechanisms, and application of nanoformulations against different cancers.

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