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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Letter Article

N-Alkylation of Amines Utilizing Magnetic Nano Chitosan Functionalized with EDTA/Co(II)

In Press, (this is not the final "Version of Record"). Available online 09 July, 2024
Author(s): Farzaneh Ebrahimzadeh*
Published on: 09 July, 2024

DOI: 10.2174/0115701786308650240705072830

Price: $95

Abstract

This research work has explored the application of a magnetic catalyst composed of coreshell nanoparticles [Fe3O4@SiO2@CS@EDTA/Co(II)], known as NCM@EDTA/Co(II), in the conversion of various alcohols containing electron-donating or electron-withdrawing groups into their respective secondary or primary amine derivatives. The investigation has focused on optimizing reaction conditions by considering factors, such as the inclusion of a base, duration of reaction time, reaction temperature, catalyst quantity, and choice of transition metal, in order to determine the optimal parameters. The most favorable outcomes have been achieved by using 0.2 mmol of catalyst per 1 mmol of substrate under reflux conditions for a duration ranging from 3 to 24 hours. The reaction has demonstrated high efficiency, with the catalyst's easy separation via an external magnetic field, stability, and recyclability, highlighting its potential applications in chemistry and industrial environments.


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