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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Ischemic Stroke and Autophagy: The Roles of Long Non-Coding RNAs

In Press, (this is not the final "Version of Record"). Available online 04 July, 2024
Author(s): Longqiang Ouyang, Wenyan Xia*, Ameen Abdulhasan Al-Alwany, Reena Gupta, Ibrokhim Sapaev, Sami G. Almalki, Saud Almawash*, Rand Ali Ziyad, Ahmed Hussien Alawadi and Ali Alsalamy
Published on: 04 July, 2024

DOI: 10.2174/1570159X22666240704123701

Price: $95

Abstract

Ischemic stroke is a significant cause of morbidity and mortality worldwide. Autophagy, a process of intracellular degradation, has been shown to play a crucial role in the pathogenesis of ischemic stroke. Long non-coding RNAs (lncRNAs) have emerged as essential regulators of autophagy in various diseases, including ischemic stroke. Recent studies have identified several lncRNAs that modulate autophagy in ischemic stroke, including MALAT1, MIAT, SNHG12, H19, AC136007. 2, C2dat2, MEG3, KCNQ1OT1, SNHG3, and RMRP. These lncRNAs regulate autophagy by interacting with key proteins involved in the autophagic process, such as Beclin-1, ATG7, and LC3. Understanding the role of lncRNAs in regulating autophagy in ischemic stroke may provide new insights into the pathogenesis of this disease and identify potential therapeutic targets for its treatment.

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