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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Research Article

Nanofabrication of Losartan Potassium Sustained Release Floating Microspheres Using Different Grades of Ethyl Cellulose and its Insight on Release Profiles

Author(s): Tanavirsing Rajput, Popat Mohite, Santosh Ghule, Kuldeep Vinchurkar and Sudarshan Singh*

Volume 30, Issue 28, 2024

Published on: 20 June, 2024

Page: [2257 - 2265] Pages: 9

DOI: 10.2174/0113816128309675240530060752

Price: $65

Abstract

Introduction: A sustained release system for losartan potassium designed to delay its residence time in the stomach through the preparation of solvent evaporation technique-based floating microspheres. The influence of the different grades of Ethocel™ such as 4 cps, 10 cps, and 22 cps as well as the drug: polymer ratio on various properties of microspheres were tested.

Methods: Thermal and functional analysis revealed no interaction between the encapsulated drug and polymer. The results indicated that the mean diameter of microspheres increased with a change in grades of ethyl cellulose relating to viscosity. However, the drug incorporation efficiency within ethyl cellulose microspheres decreased with increasing viscosity of ethyl cellulose.

Results: The bulk density of the formulations was proportionally dependent on concentration and the viscosity of the polymer, which resulted in a decrease in floating capacity from 90.02% to 73.58%. Moreover, the drug release was indirectly proportional to the viscosity of ethyl cellulose tested. The in vitro release profile exhibited a burst effect with a biphasic release pattern following Fickian diffusion, indicating a diffusioncontrolled release mechanism.

Conclusion: The results demonstrated that the viscosity of ethyl cellulose significantly affects the floating capacity and drug release pattern from microspheres.

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