An In vitro Study on the Antibacterial Effect of a Combined Photodynamic and Sonodynamic Therapy Using IR780 Iodide-loaded Mesoporous Silica Nanoparticles Against P. aeruginosa and Multi-Drug Resistant P. aeruginosa

Heba   Z.   Alagha; Murat      Gülsoy

doi:10.2174/0127724344309438240529064221

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Abstract

Background: The aim of this study was to investigate the antimicrobial photodynamic, sonodynamic, and combined photodynamic and sonodynamic potentials of IR780 iodideloaded mesoporous silica nanoparticles against gram-negative Pseudomonas aeruginosa (P. aeruginosa) and multi drug resistant Pseudomonas aeruginosa (MDR P. aeruginosa).

Method: The results revealed that for P. aeruginosa, the combined photodynamic therapy (PDT) and sonodynamic therapy (SDT) showed a 44% reduction in bacterial cell viability as compared to 18% and 31% when exposed to SDT alone and PDT alone, respectively. For MDR. P. aeruginosa, the combined treatment resulted in a 45% reduction in bacterial cell viability, as compared to 14% and 30% when exposed to SDT alone and PDT alone, respectively.

Result: The results of this study demonstrated that IR780 iodide-loaded mesoporous silica nanoparticles have the potential to be utilized as photo/sono therapeutic agents for the inactivation of drug-resistant bacteria.

Conclusion: The killing effect was mainly due to the photodynamic and sonodynamic effects of the nanoparticles, mainly caused by singlet oxygen. No photothermal effect was involved in the killing.

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DOI https://dx.doi.org/10.2174/0127724344309438240529064221	Print ISSN 2772-4344
Publisher Name Bentham Science Publisher	Online ISSN 2772-4352

Recent Advances in Anti-Infective Drug Discovery

An In vitro Study on the Antibacterial Effect of a Combined Photodynamic and Sonodynamic Therapy Using IR780 Iodide-loaded Mesoporous Silica Nanoparticles Against P. aeruginosa and Multi-Drug Resistant P. aeruginosa

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