Evaluation of the Anticarcinogenic and Cytotoxicity Effects of Small Gold
Nanorods Against Gliomablast Cell Lines in an In vitro Model

S.      Özer; K.      Kelleci; S.      Canim-Ates; C.      Canbek

doi:10.2174/0115734110304016240530075916

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Abstract

Objectives: The study aimed to evaluate the cytotoxicity and anticancer potential of gold nanorods (GNRs) synthesized using hexadecyltrimethylammonium bromide capped seed (CTAB) on L929 fibroblast cells and glioma cells.

Methods: Gold nanorods were synthesized through the CTAB method, and their characterization was conducted using UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and scanning electron microscopy (SEM). The MTT cell viability assay was employed to assess the cytotoxic and anticancer effects of the synthesized gold nanorods on L929 fibroblast cells and glioma cells.

Results: Analysis results revealed that the synthesized gold nanorods had an average size of 6.4 nm and rod-like morphology, with an absorbance peak of 836 nm. The quantity of synthesized GNRs was calculated to be 3.63 μM. Cytotoxicity analysis showed an IC50 value of 1.29 μM for L929 fibroblast cells and 1.26 μM for C6 glioma cells, indicating significant cytotoxic effects. Treatment with GNRs induced apoptosis in glioma cells and inhibited their proliferation, suggesting potential anticancer activity.

Conclusion: The findings suggest that GNRs hold promise as effective agents for cancer therapy. Further research is warranted to elucidate the precise mechanisms underlying their anticancer effects and to explore their potential clinical applications in cancer treatment.

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DOI https://dx.doi.org/10.2174/0115734110304016240530075916	Print ISSN 1573-4110
Publisher Name Bentham Science Publisher	Online ISSN 1875-6727

Current Analytical Chemistry

Evaluation of the Anticarcinogenic and Cytotoxicity Effects of Small Gold Nanorods Against Gliomablast Cell Lines in an In vitro Model

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