Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment

Title:Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment

Volume: 24

Author(s): Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohamad Rahmati, Mostafa Golshekan, Mahmoud Abedinzadeh, Elham Ahmadi, Singh Neha and masoud najafi*

Affiliation:

• Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract: In recent years, mesenchymal stem cells (MSCs) have emerged as promising anti-- cancer mediators with the potential to treat several cancers. MSCs have been modified to produce anti-proliferative, pro-apoptotic, and anti-angiogenic molecules that could be effective against a variety of malignancies. Additionally, customizing MSCs with cytokines that stimulate pro-tumorigenic immunity or using them as vehicles for traditional chemical molecules with anti-cancer characteristics. Even though the specific function of MSCs in tumors is still challenged, promising outcomes from preclinical investigations of MSC-based gene therapy for a variety of cancers inspire the beginning of clinical trials. In addition, the tumor microenvironment (TME) could have a substantial influence on normal tissue stem cells, which can affect the treatment outcomes. To overcome the complications of TME in cancer development, MSCs could provide some signs of hope for converting TME into unequivocal therapeutic tools. Hence, this review focuses on engineered MSCs (En-MSCs) as a promising approach to overcoming the complications of TME.

Cite this article as:

Taeb Shahram, Rostamzadeh Davoud, Amini Seyed Mohammad, Rahmati Mohamad, Golshekan Mostafa, Abedinzadeh Mahmoud, Ahmadi Elham, Neha Singh and najafi masoud*, Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment, Current Topics in Medicinal Chemistry 2024; 24 () . https://dx.doi.org/10.2174/0115680266299112240514103048