Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses

Title:Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses

Volume: 20

Author(s): Carlos Polanco*, Vladimir N. Uversky, Alberto Huberman, Claudia Pimentel-Hernández, Martha Rios Castro, Enrique Hernandez-Lemus, Thomas Buhse, Gilberto Vargas Alarcon, Francisco J. Roldan Gomez, Mireya Martínez-Garcia, Gabriela Calvo-Leroux Corona, Brayans Becerra-Luna, Cynthia Karen Gutierrez Juárez, Juan Luciano Díaz González, Raul Martinez-Memije and Pedro L Flores Ch

Affiliation:

• Department of Electromechanical Instrumentation, Instituto Nacional de Cardiologia 'Ignacio Chavez', Mexico City, 14080, Mexico
• Department of Mathematics, Faculty of Sciences, Universidad Nacional Autonoma de Mexico, Mexico City, 04510, Mexico

Abstract: Background: Rodents and many wild and domestic animals, including cattle, donkeys, goats, hares, ostriches, and sheep, spread the Crimean-Congo Hemorrhagic Fever Virus (CCHFV), acting as hosts for infected ticks primarily of the Hyalomma genus, which serve as vectors and reservoirs of the virus. CCHF is a severe, potentially lethal, and widespread disease, making it a serious public health issue. Environmental changes impacting rodent populations affect their global distribution and, therefore, play a role in the spread of CCHFV.

Objective: This study aims togain a deeper understanding of the envelope glycoproteins expressed by the CCHFV.

Methods: Multiple computational algorithms determined the Intrinsic Disorder Predisposition (PIDP), Polarity Index, and genomic profiles of each sequence of the glycoproteins.

Results: When examining the Polarity Index Method Profile, 3.0v profile, and the PIDP profile, the envelope glycoproteins of the CCHFV showed different patterns. With these patterns, it was possible to identify structural and morphological similarities.

Conclusion: With the PIM 3.0v profile, our computer programs were able to identify isolated CCHFV envelope glycoproteins. We believe that this research provides a deeper understanding of this virus.

Cite this article as:

Polanco Carlos*, Uversky N. Vladimir, Huberman Alberto, Pimentel-Hernández Claudia, Rios Castro Martha, Hernandez-Lemus Enrique, Buhse Thomas, Alarcon Vargas Gilberto, Roldan Gomez J. Francisco, Martínez-Garcia Mireya, Corona Calvo-Leroux Gabriela, Becerra-Luna Brayans, Gutierrez Juárez Karen Cynthia, Díaz González Luciano Juan, Martinez-Memije Raul and Flores Ch L Pedro, Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses, Current Analytical Chemistry 2024; 20 () . https://dx.doi.org/10.2174/0115734110298088240515063827