Low Expression MCEMP1 Promoting Lung Adenocarcinoma Progression by and its Clinical Value

Title:Low Expression MCEMP1 Promoting Lung Adenocarcinoma Progression by and its Clinical Value

Volume: 24

Author(s): Liqun Ling, Tianqi Hu, Chenkang Zhou, Shuhui Chen, Lunan Chou, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang*Junjun Wang*

Affiliation:

• Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University; Wenzhou, 325000, China
• Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou, 325015, China

• Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University; Wenzhou, 325000, China

Abstract: Background: Lung cancer is a highly prevalent tumor with a lack of biological markers that reflect its progression. Mast cell surface membrane protein 1 (MCEMP1, also known as C19ORF59) has not been reported in lung adenocarcinoma (LUAD).

Objective: We aimed to investigate the role of MCEMP1 in LUAD.

Methods: MCEMP1 expression in LUAD was analyzed using The Cancer Genome Atlas (TCGA) data, and conducted univariate and multivariate Cox regression analyses to evaluate the prognostic significance of MCEMP1 expression in TCGA. Tumor Immune Estimation Resource (TIMER) was used for examining the correlation between MCEMP1 expression and immune cell infiltration in LUAD. Furthermore, proliferation, migration, invasion, and colony-forming ability were investigated using LUAD cell lines.

Results: MCEMP1 had low expression in LUAD patient tissues and was correlated with lymph node metastasis, differentiation level, and tumor status. The Area under Curve (AUC) value of MCEMP1 for the Receiver Operating Characteristic (ROC) curve analysis was 0.984. The immune infiltration analysis revealed a correlation between MCEMP1 expression and the extent of macrophages and neutrophil infiltration in LUAD. Additionally, MCEMP1 has low expression in clinical samples, MCEMP1 overexpressed in LUAD cells substantially reduced cell growth, migration, and invasion of malignant cells.

Conclusion: Low expression MCEMP1 promotes LUAD progression, which provides new insights and a potential biological target for future LUAD therapies.

Cite this article as:

Ling Liqun, Hu Tianqi, Zhou Chenkang, Chen Shuhui, Chou Lunan, Chen Yuxin, Hu Zhaoting, Huang Kate, Chen Jie, Wang Yumin*, Wang Junjun*, Low Expression MCEMP1 Promoting Lung Adenocarcinoma Progression by and its Clinical Value, Current Cancer Drug Targets 2024; 24 () . https://dx.doi.org/10.2174/0115680096292054240409070618

DOI https://dx.doi.org/10.2174/0115680096292054240409070618	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576