Antioxidant Properties of Resveratrol in the Brain Tissues of Rats after
Radiotherapy

Gholamreza      Ghavipanjeh; Abolfazl      Ardjmand; Mohammad Amin      Farzin; Behrang      Alani; Akbar      Aliasgharzadeh; Nejat      Kheiripour; Bagher      Farhood; Shahram      Taeb; Masoud      Najafi

doi:10.2174/0115748855281034240328074850

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Abstract

Background: In recent years, there has been growing interest in the use of herbal products as complementary or alternative therapies for cancer patients. RVT has been extensively studied for its potential role in managing oxidative stress in cancer patients undergoing treatment.

Method: In this study, the radioprotective effects of Resveratrol (RVT) (200 mg/kg) were evaluated in the brain tissues of rats after Radiation Therapy (RT). 20 male adult Wistar rats weighing 180–200 g were used. The animals were exposed to single-fraction Irradiation (IR) (15 Gy) using a linear accelerator unit (Siemens Primus) at a dosage rate of 200 cGy/min at a distance of 100 cm from the source to the axis.

Results: The results of the study showed that compared to the IR group, administration of RVT decreased the levels of MDA and NOx, and increased the levels of CAT and SOD significantly (p<0.05).

Conclusion: Finally, our finding suggests that RVT could have radioprotective effects on the brain by enhancing antioxidant defense mechanisms.

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DOI https://dx.doi.org/10.2174/0115748855281034240328074850	Print ISSN 1574-8855
Publisher Name Bentham Science Publisher	Online ISSN 2212-3903

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Antioxidant Properties of Resveratrol in the Brain Tissues of Rats after Radiotherapy

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