Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry

Title: Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry

Volume: 5 Issue: 2

Author(s): Willy Morelle

Affiliation:

Keywords: Mass spectrometry, Proteomics, Glycomics, Glycosylation, Phosphorylation, Glycoproteomics, Structural analysis

Abstract: The determination of post-translational modifications is one of the main challenges in proteomics research. Mass spectrometry is a powerful tool for the structural characterization of proteins and different mass spectrometric techniques for the analysis of post-translational modifications of individual proteins or protein populations have been developed. This review describes the most recent advances in mass spectrometry-based approaches for the detection and determination of post-translational modifications, with an emphasis on glycosylation and phosphorylation.

Cite this article as:

Morelle Willy, Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry, Current Analytical Chemistry 2009; 5 (2) . https://dx.doi.org/10.2174/157341109787846153