Computational Insights on Migraine and Anxiety in Association with BDNF

Goadsby, P.J.; Lipton, R.B.; Ferrari, M.D. Migraine--current understanding and treatment. N. Engl. J. Med., 2002, 346(4), 257-270.
[http://dx.doi.org/10.1056/NEJMra010917] [PMID: 11807151]

Vos, T.; Barber, R.M.; Bell, B.; Bertozzi-Villa, A.; Biryukov, S.; Bolliger, I.; Charlson, F.; Davis, A.; Degenhardt, L.; Dicker, D.; Duan, L.; Erskine, H.; Feigin, V.L.; Ferrari, A.J.; Fitzmaurice, C.; Fleming, T.; Graetz, N.; Guinovart, C.; Haagsma, J.; Hansen, G.M.; Hanson, S.W.; Heuton, K.R.; Higashi, H.; Kassebaum, N.; Kyu, H.; Laurie, E.; Liang, X.; Lofgren, K.; Lozano, R.; MacIntyre, M.F.; Moradi-Lakeh, M.; Naghavi, M.; Nguyen, G.; Odell, S.; Ortblad, K.; Roberts, D.A.; Roth, G.A.; Sandar, L.; Serina, P.T.; Stanaway, J.D.; Steiner, C.; Thomas, B.; Vollset, S.E.; Whiteford, H.; Wolock, T.M.; Ye, P.; Zhou, M.; Ãvila, M.A.; Aasvang, G.M.; Abbafati, C.; Ozgoren, A.A.; Abd-Allah, F.; Aziz, M.I.A.; Abera, S.F.; Aboyans, V.; Abraham, J.P.; Abraham, B.; Abubakar, I.; Abu-Raddad, L.J.; Abu-Rmeileh, N.M.E.; Aburto, T.C.; Achoki, T.; Ackerman, I.N.; Adelekan, A.; Ademi, Z.; Adou, A.K.; Adsuar, J.C.; Arnlov, J.; Agardh, E.E.; Al Khabouri, M.J.; Alam, S.S.; Alasfoor, D.; Albittar, M.I.; Alegretti, M.A.; Aleman, A.V.; Alemu, Z.A.; Alfonso-Cristancho, R.; Alhabib, S.; Ali, R.; Alla, F.; Allebeck, P.; Allen, P.J.; AlMazroa, M.A.A.; Alsharif, U.; Alvarez, E.; Alvis-Guzman, N.; Ameli, O.; Amini, H.; Ammar, W.; Anderson, B.O.; Anderson, H.R.; Antonio, C.A.T.; Anwari, P.; Apfel, H.; Arsenijevic, V.S.A.; Artaman, A.; Asghar, R.J.; Assadi, R.; Atkins, L.S.; Atkinson, C.; Badawi, A.; Bahit, M.C.; Bakfalouni, T.; Balakrishnan, K.; Balalla, S.; Banerjee, A.; Barker-Collo, S.L.; Barquera, S.; Barregard, L.; Barrero, L.H.; Basu, S.; Basu, A.; Baxter, A.; Beardsley, J.; Bedi, N.; Beghi, E.; Bekele, T.; Bell, M.L.; Benjet, C.; Bennett, D.A.; Bensenor, I.M.; Benzian, H.; Bernabe, E.; Beyene, T.J.; Bhala, N.; Bhalla, A.; Bhutta, Z.; Bienhoff, K.; Bikbov, B.; Abdulhak, A.B.; Blore, J.D.; Blyth, F.M.; Bohensky, M.A.; Basara, B.B.; Borges, G.; Bornstein, N.M.; Bose, D.; Boufous, S.; Bourne, R.R.; Boyers, L.N.; Brainin, M.; Brauer, M.; Brayne, C.E.G.; Brazinova, A.; Breitborde, N.J.K.; Brenner, H.; Briggs, A.D.M.; Brooks, P.M.; Brown, J.; Brugha, T.S.; Buchbinder, R.; Buckle, G.C.; Bukhman, G.; Bulloch, A.G.; Burch, M.; Burnett, R.; Cardenas, R.; Cabral, N.L.; Nonato, I.R.C.; Campuzano, J.C.; Carapetis, J.R.; Carpenter, D.O.; Caso, V.; Castaneda-Orjuela, C.A.; Catala-Lopez, F.; Chadha, V.K.; Chang, J-C.; Chen, H.; Chen, W.; Chiang, P.P.; Chimed-Ochir, O.; Chowdhury, R.; Christensen, H.; Christophi, C.A.; Chugh, S.S.; Cirillo, M.; Coggeshall, M.; Cohen, A.; Colistro, V.; Colquhoun, S.M.; Contreras, A.G.; Cooper, L.T.; Cooper, C.; Cooperrider, K.; Coresh, J.; Cortinovis, M.; Criqui, M.H.; Crump, J.A.; Cuevas-Nasu, L.; Dandona, R.; Dandona, L.; Dansereau, E.; Dantes, H.G.; Dargan, P.I.; Davey, G.; Davitoiu, D.V.; Dayama, A.; De la Cruz-Gongora, V.; de la Vega, S.F.; De Leo, D.; del Pozo-Cruz, B.; Dellavalle, R.P.; Deribe, K.; Derrett, S.; Des Jarlais, D.C.; Dessalegn, M.; deVeber, G.A.; Dharmaratne, S.D.; Diaz-Torne, C.; Ding, E.L.; Dokova, K.; Dorsey, E.R.; Driscoll, T.R.; Duber, H.; Durrani, A.M.; Edmond, K.M.; Ellenbogen, R.G.; Endres, M.; Ermakov, S.P.; Eshrati, B.; Esteghamati, A.; Estep, K.; Fahimi, S.; Farzadfar, F.; Fay, D.F.J.; Felson, D.T.; Fereshtehnejad, S-M.; Fernandes, J.G.; Ferri, C.P.; Flaxman, A.; Foigt, N.; Foreman, K.J.; Fowkes, F.G.R.; Franklin, R.C.; Furst, T.; Futran, N.D.; Gabbe, B.J.; Gankpe, F.G.; Garcia-Guerra, F.A.; Geleijnse, J.M.; Gessner, B.D.; Gibney, K.B.; Gillum, R.F.; Ginawi, I.A.; Giroud, M.; Giussani, G.; Goenka, S.; Goginashvili, K.; Gona, P.; de Cosio, T.G.; Gosselin, R.A.; Gotay, C.C.; Goto, A.; Gouda, H.N.; Guerrant, R.; Gugnani, H.C.; Gunnell, D.; Gupta, R.; Gupta, R.; Gutierrez, R.A.; Hafezi-Nejad, N.; Hagan, H.; Halasa, Y.; Hamadeh, R.R.; Hamavid, H.; Hammami, M.; Hankey, G.J.; Hao, Y.; Harb, H.L.; Haro, J.M.; Havmoeller, R.; Hay, R.J.; Hay, S.; Hedayati, M.T.; Pi, I.B.H.; Heydarpour, P.; Hijar, M.; Hoek, H.W.; Hoffman, H.J.; Hornberger, J.C.; Hosgood, H.D.; Hossain, M.; Hotez, P.J.; Hoy, D.G.; Hsairi, M.; Hu, H.; Hu, G.; Huang, J.J.; Huang, C.; Huiart, L.; Husseini, A.; Iannarone, M.; Iburg, K.M.; Innos, K.; Inoue, M.; Jacobsen, K.H.; Jassal, S.K.; Jeemon, P.; Jensen, P.N.; Jha, V.; Jiang, G.; Jiang, Y.; Jonas, J.B.; Joseph, J.; Juel, K.; Kan, H.; Karch, A.; Karimkhani, C.; Karthikeyan, G.; Katz, R.; Kaul, A.; Kawakami, N.; Kazi, D.S.; Kemp, A.H.; Kengne, A.P.; Khader, Y.S.; Khalifa, S.E.A.H.; Khan, E.A.; Khan, G.; Khang, Y-H.; Khonelidze, I.; Kieling, C.; Kim, D.; Kim, S.; Kimokoti, R.W.; Kinfu, Y.; Kinge, J.M.; Kissela, B.M.; Kivipelto, M.; Knibbs, L.; Knudsen, A.K.; Kokubo, Y.; Kosen, S.; Kramer, A.; Kravchenko, M.; Krishnamurthi, R.V.; Krishnaswami, S.; Defo, B.K.; Bicer, B.K.; Kuipers, E.J.; Kulkarni, V.S.; Kumar, K.; Kumar, G.A.; Kwan, G.F.; Lai, T.; Lalloo, R.; Lam, H.; Lan, Q.; Lansingh, V.C.; Larson, H.; Larsson, A.; Lawrynowicz, A.E.B.; Leasher, J.L.; Lee, J-T.; Leigh, J.; Leung, R.; Levi, M.; Li, B.; Li, Y.; Li, Y. liang, J.; Lim, S.; Lin, H-H.; Lind, M.; Lindsay, M.P.; Lipshultz, S.E.; Liu, S.; Lloyd, B.K.; Ohno, S.L.; Logroscino, G.; Looker, K.J.; Lopez, A.D.; Lopez-Olmedo, N.; Lortet-Tieulent, J.; Lotufo, P.A.; Low, N.; Lucas, R.M.; Lunevicius, R.; Lyons, R.A.; Ma, J.; Ma, S.; Mackay, M.T.; Majdan, M.; Malekzadeh, R.; Mapoma, C.C.; Marcenes, W.; March, L.M.; Margono, C.; Marks, G.B.; Marzan, M.B.; Masci, J.R.; Mason-Jones, A.J.; Matzopoulos, R.G.; Mayosi, B.M.; Mazorodze, T.T.; McGill, N.W.; McGrath, J.J.; McKee, M.; McLain, A.; McMahon, B.J.; Meaney, P.A.; Mehndiratta, M.M.; Mejia-Rodriguez, F.; Mekonnen, W.; Melaku, Y.A.; Meltzer, M.; Memish, Z.A.; Mensah, G.; Meretoja, A.; Mhimbira, F.A.; Micha, R.; Miller, T.R.; Mills, E.J.; Mitchell, P.B.; Mock, C.N.; Moffitt, T.E.; Ibrahim, N.M.; Mohammad, K.A.; Mokdad, A.H.; Mola, G.L.; Monasta, L.; Montico, M.; Montine, T.J.; Moore, A.R.; Moran, A.E.; Morawska, L.; Mori, R.; Moschandreas, J.; Moturi, W.N.; Moyer, M.; Mozaffarian, D.; Mueller, U.O.; Mukaigawara, M.; Murdoch, M.E.; Murray, J.; Murthy, K.S.; Naghavi, P.; Nahas, Z.; Naheed, A.; Naidoo, K.S.; Naldi, L.; Nand, D.; Nangia, V.; Narayan, K.M.V.; Nash, D.; Nejjari, C.; Neupane, S.P.; Newman, L.M.; Newton, C.R.; Ng, M.; Ngalesoni, F.N.; Nhung, N.T.; Nisar, M.I.; Nolte, S.; Norheim, O.F.; Norman, R.E.; Norrving, B.; Nyakarahuka, L.; Oh, I.H.; Ohkubo, T.; Omer, S.B.; Opio, J.N.; Ortiz, A.; Pandian, J.D.; Panelo, C.I.A.; Papachristou, C.; Park, E-K.; Parry, C.D.; Caicedo, A.J.P.; Patten, S.B.; Paul, V.K.; Pavlin, B.I.; Pearce, N.; Pedraza, L.S.; Pellegrini, C.A.; Pereira, D.M.; Perez-Ruiz, F.P.; Perico, N.; Pervaiz, A.; Pesudovs, K.; Peterson, C.B.; Petzold, M.; Phillips, M.R.; Phillips, D.; Phillips, B.; Piel, F.B.; Plass, D.; Poenaru, D.; Polanczyk, G.V.; Polinder, S.; Pope, C.A.; Popova, S.; Poulton, R.G.; Pourmalek, F.; Prabhakaran, D.; Prasad, N.M.; Qato, D.; Quistberg, D.A.; Rafay, A.; Rahimi, K.; Rahimi-Movaghar, V.; Rahman, S.; Raju, M.; Rakovac, I.; Rana, S.M.; Razavi, H.; Refaat, A.; Rehm, J.; Remuzzi, G.; Resnikoff, S.; Ribeiro, A.L.; Riccio, P.M.; Richardson, L.; Richardus, J.H.; Riederer, A.M.; Robinson, M.; Roca, A.; Rodriguez, A.; Rojas-Rueda, D.; Ronfani, L.; Rothenbacher, D.; Roy, N.; Ruhago, G.M.; Sabin, N.; Sacco, R.L.; Ksoreide, K.; Saha, S.; Sahathevan, R.; Sahraian, M.A.; Sampson, U.; Sanabria, J.R.; Sanchez-Riera, L.; Santos, I.S.; Satpathy, M.; Saunders, J.E.; Sawhney, M.; Saylan, M.I.; Scarborough, P.; Schoettker, B.; Schneider, I.J.C.; Schwebel, D.C.; Scott, J.G.; Seedat, S.; Sepanlou, S.G.; Serdar, B.; Servan-Mori, E.E.; Shackelford, K.; Shaheen, A.; Shahraz, S.; Levy, T.S.; Shangguan, S.; She, J.; Sheikhbahaei, S.; Shepard, D.S.; Shi, P.; Shibuya, K.; Shinohara, Y.; Shiri, R.; Shishani, K.; Shiue, I.; Shrime, M.G.; Sigfusdottir, I.D.; Silberberg, D.H.; Simard, E.P.; Sindi, S.; Singh, J.A.; Singh, L.; Skirbekk, V.; Sliwa, K.; Soljak, M.; Soneji, S.; Soshnikov, S.S.; Speyer, P.; Sposato, L.A.; Sreeramareddy, C.T.; Stoeckl, H.; Stathopoulou, V.K.; Steckling, N.; Stein, M.B.; Stein, D.J.; Steiner, T.J.; Stewart, A.; Stork, E.; Stovner, L.J.; Stroumpoulis, K.; Sturua, L.; Sunguya, B.F.; Swaroop, M.; Sykes, B.L.; Tabb, K.M.; Takahashi, K.; Tan, F.; Tandon, N.; Tanne, D.; Tanner, M.; Tavakkoli, M.; Taylor, H.R.; Te Ao, B.J.; Temesgen, A.M.; Have, M.T.; Tenkorang, E.Y.; Terkawi, A.S.; Theadom, A.M.; Thomas, E.; Thorne-Lyman, A.L.; Thrift, A.G.; Tleyjeh, I.M.; Tonelli, M.; Topouzis, F.; Towbin, J.A.; Toyoshima, H.; Traebert, J.; Tran, B.X.; Trasande, L.; Trillini, M.; Truelsen, T.; Trujillo, U.; Tsilimbaris, M.; Tuzcu, E.M.; Ukwaja, K.N.; Undurraga, E.A.; Uzun, S.B.; van Brakel, W.H.; van de Vijver, S.; Dingenen, R.V.; van Gool, C.H.; Varakin, Y.Y.; Vasankari, T.J.; Vavilala, M.S.; Veerman, L.J.; Velasquez-Melendez, G.; Venketasubramanian, N.; Vijayakumar, L.; Villalpando, S.; Violante, F.S.; Vlassov, V.V.; Waller, S.; Wallin, M.T.; Wan, X.; Wang, L.; Wang, J.L.; Wang, Y.; Warouw, T.S.; Weichenthal, S.; Weiderpass, E.; Weintraub, R.G.; Werdecker, A.; Wessells, K.R.R.; Westerman, R.; Wilkinson, J.D.; Williams, H.C.; Williams, T.N.; Woldeyohannes, S.M.; Wolfe, C.D.A.; Wong, J.Q.; Wong, H.; Woolf, A.D.; Wright, J.L.; Wurtz, B.; Xu, G.; Yang, G.; Yano, Y.; Yenesew, M.A.; Yentur, G.K.; Yip, P.; Yonemoto, N.; Yoon, S-J.; Younis, M.; Yu, C.; Kim, K.Y.; Zaki, M.E.S.; Zhang, Y.; Zhao, Z.; Zhao, Y.; Zhu, J.; Zonies, D.; Zunt, J.R.; Salomon, J.A.; Murray, C.J.L. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 2015, 386(9995), 743-800.
[http://dx.doi.org/10.1016/S0140-6736(15)60692-4] [PMID: 26063472]

Buse, D.C.; Manack, A.; Serrano, D.; Turkel, C.; Lipton, R.B. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J. Neurol. Neurosurg. Psychiatry, 2010, 81(4), 428-432.
[http://dx.doi.org/10.1136/jnnp.2009.192492] [PMID: 20164501]

Amiri, P.; Kazeminasab, S.; Nejadghaderi, S.A.; Mohammadinasab, R.; Pourfathi, H.; Araj-Khodaei, M.; Sullman, M.J.M.; Kolahi, A-A.; Safiri, S. Migraine: A review on its history, global epidemiology, risk factors, and comorbidities. Front. Neurol., 2022, 12, 800605.
[http://dx.doi.org/10.3389/fneur.2021.800605]

Giffin, N.J.; Ruggiero, L.; Lipton, R.B.; Silberstein, S.D.; Tvedskov, J.F.; Olesen, J.; Altman, J.; Goadsby, P.J.; Macrae, A. Premonitory symptoms in migraine: An electronic diary study. Neurology, 2003, 60(6), 935-940.
[http://dx.doi.org/10.1212/01.WNL.0000052998.58526.A9] [PMID: 12654956]

Giffin, N.J.; Lipton, R.B.; Silberstein, S.D.; Olesen, J.; Goadsby, P.J. The migraine postdrome. Neurology, 2016, 87(3), 309-313.
[http://dx.doi.org/10.1212/WNL.0000000000002789] [PMID: 27335112]

Kelman, L. The postdrome of the acute migraine attack. Cephalalgia, 2006, 26(2), 214-220.
[http://dx.doi.org/10.1111/j.1468-2982.2005.01026.x] [PMID: 16426278]

Rasmussen, B.K.; Olesen, J. Migraine with aura and migraine without aura: An epidemiological study. Cephalalgia, 1992, 12(4), 221-228.
[http://dx.doi.org/10.1046/j.1468-2982.1992.1204221.x] [PMID: 1525797]

Markowitz, S.; Saito, K.; Moskowitz, M.A. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J. Neurosci., 1987, 7(12), 4129-4136.
[http://dx.doi.org/10.1523/JNEUROSCI.07-12-04129.1987] [PMID: 3694267]

Radat, F.; Swendsen, J. Psychiatric comorbidity in migraine: A review. Cephalalgia, 2005, 25(3), 165-178.
[http://dx.doi.org/10.1111/j.1468-2982.2004.00839.x] [PMID: 15689191]

Antonaci, F.; Nappi, G.; Galli, F.; Manzoni, G.C.; Calabresi, P.; Costa, A. Migraine and psychiatric comorbidity: A review of clinical findings. J. Headache Pain, 2011, 12(2), 115-125.
[http://dx.doi.org/10.1007/s10194-010-0282-4] [PMID: 21210177]

Dresler, T.; Caratozzolo, S.; Guldolf, K.; Huhn, J.I.; Loiacono, C.; Niiberg-Pikksööt, T.; Puma, M.; Sforza, G.; Tobia, A.; Ornello, R.; Serafini, G. Understanding the nature of psychiatric comorbidity in migraine: A systematic review focused on interactions and treatment implications. J. Headache Pain, 2019, 20(1), 51.
[http://dx.doi.org/10.1186/s10194-019-0988-x] [PMID: 31072313]

Lampl, C.; Thomas, H.; Tassorelli, C.; Katsarava, Z.; Laínez, J.M.; Lantéri-Minet, M.; Rastenyte, D.; de la Torre, R.E.; Stovner, L.J.; Andrée, C.; Steiner, T.J. Headache, depression and anxiety: Associations in the Eurolight project. J. Headache Pain, 2016, 17(1), 59.
[http://dx.doi.org/10.1186/s10194-016-0649-2] [PMID: 27245683]

Karimi, L.; Crewther, S.G.; Wijeratne, T.; Evans, A.E.; Afshari, L.; Khalil, H. The prevalence of migraine with anxiety among genders. Front. Neurol., 2020, 11, 1252.
[http://dx.doi.org/10.3389/fneur.2020.569405]

Blumenfeld, A.M.; Varon, S.F.; Wilcox, T.K.; Buse, D.C.; Kawata, A.K.; Manack, A.; Goadsby, P.J.; Lipton, R.B. Disability, HRQoL and resource use among chronic and episodic migraineurs: Results from the International Burden of Migraine Study (IBMS). Cephalalgia, 2011, 31(3), 301-315.
[http://dx.doi.org/10.1177/0333102410381145] [PMID: 20813784]

Zwart, J.A.; Dyb, G.; Hagen, K.; Ødegård, K.J.; Dahl, A.A.; Bovim, G.; Stovner, L.J. Depression and anxiety disorders associated with headache frequency. The Nord‐Trøndelag Health Study. Eur. J. Neurol., 2003, 10(2), 147-152.
[http://dx.doi.org/10.1046/j.1468-1331.2003.00551.x] [PMID: 12603289]

Zebenholzer, K.; Lechner, A.; Broessner, G.; Lampl, C.; Luthringshausen, G.; Wuschitz, A.; Obmann, S.M.; Berek, K.; Wöber, C. Impact of depression and anxiety on burden and management of episodic and chronic headaches – a cross-sectional multicentre study in eight Austrian headache centres. J. Headache Pain, 2016, 17(1), 15.
[http://dx.doi.org/10.1186/s10194-016-0603-3] [PMID: 26920681]

Pesa, J.; Lage, M.J. The medical costs of migraine and comorbid anxiety and depression. Headache, 2004, 44(6), 562-570.
[http://dx.doi.org/10.1111/j.1526-4610.2004.446004.x] [PMID: 15186300]

Alonso, J.; Liu, Z.; Evans-Lacko, S.; Sadikova, E.; Sampson, N.; Chatterji, S.; Abdulmalik, J.; Aguilar-Gaxiola, S.; Al-Hamzawi, A.; Andrade, L.H.; Bruffaerts, R.; Cardoso, G.; Cia, A.; Florescu, S.; de Girolamo, G.; Gureje, O.; Haro, J.M.; He, Y.; de Jonge, P.; Karam, E.G.; Kawakami, N.; Kovess-Masfety, V.; Lee, S.; Levinson, D.; Medina-Mora, M.E.; Navarro-Mateu, F.; Pennell, B.E.; Piazza, M.; Posada-Villa, J.; ten Have, M.; Zarkov, Z.; Kessler, R.C.; Thornicroft, G. Treatment gap for anxiety disorders is global: Results of the world mental health surveys in 21 countries. Depress. Anxiety, 2018, 35(3), 195-208.
[http://dx.doi.org/10.1002/da.22711] [PMID: 29356216]

Santomauro, D.F.; Mantilla Herrera, A.M.; Shadid, J.; Zheng, P.; Ashbaugh, C.; Pigott, D.M.; Abbafati, C.; Adolph, C.; Amlag, J.O.; Aravkin, A.Y.; Bang-Jensen, B.L.; Bertolacci, G.J.; Bloom, S.S.; Castellano, R.; Castro, E.; Chakrabarti, S.; Chattopadhyay, J.; Cogen, R.M.; Collins, J.K.; Dai, X.; Dangel, W.J.; Dapper, C.; Deen, A.; Erickson, M.; Ewald, S.B.; Flaxman, A.D.; Frostad, J.J.; Fullman, N.; Giles, J.R.; Giref, A.Z.; Guo, G.; He, J.; Helak, M.; Hulland, E.N.; Idrisov, B.; Lindstrom, A.; Linebarger, E.; Lotufo, P.A.; Lozano, R.; Magistro, B.; Malta, D.C.; Månsson, J.C.; Marinho, F.; Mokdad, A.H.; Monasta, L.; Naik, P.; Nomura, S.; O’Halloran, J.K.; Ostroff, S.M.; Pasovic, M.; Penberthy, L.; Reiner, R.C., Jr; Reinke, G.; Ribeiro, A.L.P.; Sholokhov, A.; Sorensen, R.J.D.; Varavikova, E.; Vo, A.T.; Walcott, R.; Watson, S.; Wiysonge, C.S.; Zigler, B.; Hay, S.I.; Vos, T.; Murray, C.J.L.; Whiteford, H.A.; Ferrari, A.J. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet, 2021, 398(10312), 1700-1712.
[http://dx.doi.org/10.1016/S0140-6736(21)02143-7] [PMID: 34634250]

Nutt, D.; Argyropoulos, S.; Hood, S.; Potokar, J. Generalized anxiety disorder: A comorbid disease. Eur Neuropsychopharmacol, 2006, 16(S2), S109-S118.16.
[http://dx.doi.org/10.1016/j.euroneuro.2006.04.003 ]

Buoli, M.; Caldiroli, A.; Caletti, E.; Paoli, R.A.; Altamura, A.C. New approaches to the pharmacological management of generalized anxiety disorder. Expert Opin. Pharmacother., 2013, 14(2), 175-184.
[http://dx.doi.org/10.1517/14656566.2013.759559] [PMID: 23282069]

Bandelow, B.; Zohar, J.; Hollander, E.; Kasper, S.; Möller, H.J.; Bandelow, B.; Zohar, J.; Hollander, E.; Kasper, S.; Möller, H-J.; Allgulander, C.; Ayuso-Gutierrez, J.; Baldwin, D.S.; Buenvicius, R.; Cassano, G.; Fineberg, N.; Gabriels, L.; Hindmarch, I.; Kaiya, H.; Klein, D.F.; Lader, M.; Lecrubier, Y.; Lépine, J.P.; Liebowitz, M.R.; Lopez-Ibor, J.J.; Marazziti, D.; Miguel, E.C.; Oh, K.S.; Preter, M.; Rupprecht, R.; Sato, M.; Starcevic, V.; Stein, D.J.; van Ameringen, M.; Vega, J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. World J. Biol. Psychiatry, 2008, 9(4), 248-312.
[http://dx.doi.org/10.1080/15622970802465807] [PMID: 18949648]

Möhler, H. GABAA receptor diversity and pharmacology. Cell Tissue Res., 2006, 326(2), 505-516.
[http://dx.doi.org/10.1007/s00441-006-0284-3] [PMID: 16937111]

Uusi-Oukari, M.; Korpi, E.R. Regulation of GABA(A) receptor subunit expression by pharmacological agents. Pharmacol. Rev., 2010, 62(1), 97-135.
[http://dx.doi.org/10.1124/pr.109.002063] [PMID: 20123953]

Menif, L.; Oueslati, B.; Maamri, A.; Melki, W.; Zalila, H. Correlates of benzodiazepine dependence in patients with depression followed up in a psychiatric outpatient unit in Tunisia. J. Ethn. Subst. Abuse, 2021, 20(1), 104-116.
[http://dx.doi.org/10.1080/15332640.2019.1589611] [PMID: 30983538]

Bao, X.; Ye, T.; Wang, X.; Han, L.; Wang, T.; Qi, D.; Wang, X.; Cheng, X-R. The molecular mechanisms of suanzaoren prescription for anti-anxiety were investigated based on network pharmacology. Research Square, 2021.
[http://dx.doi.org/10.21203/rs.3.rs-719079/v1]

Dolati, S.; Rikhtegar, R.; Mehdizadeh, A.; Yousefi, M. The role of magnesium in pathophysiology and migraine treatment. Biol. Trace Elem. Res., 2020, 196(2), 375-383.
[http://dx.doi.org/10.1007/s12011-019-01931-z] [PMID: 31691193]

Levi-Montalcini, R.; Hamburger, V. Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J. Exp. Zool., 1951, 116(2), 321-361.
[http://dx.doi.org/10.1002/jez.1401160206] [PMID: 14824426]

Barde, Y.A.; Edgar, D.; Thoenen, H. Purification of a new neurotrophic factor from mammalian brain. EMBO J., 1982, 1(5), 549-553.
[http://dx.doi.org/10.1002/j.1460-2075.1982.tb01207.x] [PMID: 7188352]

Maisonpierre, P.C.; Belluscio, L.; Squinto, S.; Ip, N.Y.; Furth, M.E.; Lindsay, R.M.; Yancopoulos, G.D. Neurotrophin-3: A neurotrophic factor related to NGF and BDNF. Science, 1990, 247(4949), 1446-1451.
[http://dx.doi.org/10.1126/science.2321006] [PMID: 2321006]

Hallböök, F.; Ibáñez, C.F.; Persson, H. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary. Neuron, 1991, 6(5), 845-858.
[http://dx.doi.org/10.1016/0896-6273(91)90180-8] [PMID: 2025430]

Ip, N.Y.; Ibáñez, C.F.; Nye, S.H.; McClain, J.; Jones, P.F.; Gies, D.R.; Belluscio, L.; Le Beau, M.M.; Espinosa, R., III; Squinto, S.P. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA, 1992, 89(7), 3060-3064.
[http://dx.doi.org/10.1073/pnas.89.7.3060] [PMID: 1313578]

Binder, D.K.; Scharfman, H.E. Brain-derived neurotrophic factor. Growth Factors, 2004, 22(3), 123-131.
[http://dx.doi.org/10.1080/08977190410001723308] [PMID: 15518235]

Levi-Montalcini, R. The nerve growth factor: Its mode of action on sensory and sympathetic nerve cells. Harvey Lect., 1966, 60, 217-259.

Hohn, A.; Leibrock, J.; Bailey, K.; Barde, Y.A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature, 1990, 344(6264), 339-341.
[http://dx.doi.org/10.1038/344339a0] [PMID: 2314473]

Metsis, M.; Timmusk, T.; Arenas, E.; Persson, H. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc. Natl. Acad. Sci., 1993, 90(19), 8802-8806.
[http://dx.doi.org/10.1073/pnas.90.19.8802] [PMID: 8415610]

Timmusk, T.; Palm, K.; Metsis, M.; Reintam, T.; Paalme, V.; Saarma, M.; Persson, H. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron, 1993, 10(3), 475-489.
[http://dx.doi.org/10.1016/0896-6273(93)90335-O] [PMID: 8461137]

Tanaka, J.; Horiike, Y.; Matsuzaki, M.; Miyazaki, T.; Ellis-Davies, G.C.R.; Kasai, H. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science, 2008, 319(5870), 1683-1687.
[http://dx.doi.org/10.1126/science.1152864] [PMID: 18309046]

Horch, H.W.; Katz, L.C. BDNF release from single cells elicits local dendritic growth in nearby neurons. Nat. Neurosci., 2002, 5(11), 1177-1184.
[http://dx.doi.org/10.1038/nn927] [PMID: 12368805]

Figurov, A.; Pozzo-Miller, L.D.; Olafsson, P.; Wang, T.; Lu, B. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature, 1996, 381(6584), 706-709.
[http://dx.doi.org/10.1038/381706a0] [PMID: 8649517]

Kang, H.; Schuman, E.M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science, 1995, 267(5204), 1658-1662.
[http://dx.doi.org/10.1126/science.7886457] [PMID: 7886457]

Yamada, K.; Mizuno, M.; Nabeshima, T. Role for brain-derived neurotrophic factor in learning and memory. Life Sci., 2002, 70(7), 735-744.
[http://dx.doi.org/10.1016/S0024-3205(01)01461-8] [PMID: 11833737]

Egan, M.F.; Kojima, M.; Callicott, J.H.; Goldberg, T.E.; Kolachana, B.S.; Bertolino, A.; Zaitsev, E.; Gold, B.; Goldman, D.; Dean, M.; Lu, B.; Weinberger, D.R. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 2003, 112(2), 257-269.
[http://dx.doi.org/10.1016/S0092-8674(03)00035-7] [PMID: 12553913]

Cathomas, F.; Vogler, C.; Euler-Sigmund, J.C.; de Quervain, D.J.F.; Papassotiropoulos, A. Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory. Int. J. Neuropsychopharmacol., 2010, 13(8), 975-980.
[http://dx.doi.org/10.1017/S1461145710000519] [PMID: 20482942]

Xu, B.; Goulding, E.H.; Zang, K.; Cepoi, D.; Cone, R.D.; Jones, K.R.; Tecott, L.H.; Reichardt, L.F. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci., 2003, 6(7), 736-742.
[http://dx.doi.org/10.1038/nn1073] [PMID: 12796784]

Cao, L.; Lin, E.J.D.; Cahill, M.C.; Wang, C.; Liu, X.; During, M.J. Molecular therapy of obesity and diabetes by a physiological autoregulatory approach. Nat. Med., 2009, 15(4), 447-454.
[http://dx.doi.org/10.1038/nm.1933] [PMID: 19270710]

Nagahara, A.H.; Tuszynski, M.H. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat. Rev. Drug Discov., 2011, 10(3), 209-219.
[http://dx.doi.org/10.1038/nrd3366] [PMID: 21358740]

Ernfors, P.; Wetmore, C.; Olson, L.; Persson, H. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron, 1990, 5(4), 511-526.
[http://dx.doi.org/10.1016/0896-6273(90)90090-3] [PMID: 2206535]

Hofer, M.; Pagliusi, S.R.; Hohn, A.; Leibrock, J.; Barde, Y.A. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J., 1990, 9(8), 2459-2464.
[http://dx.doi.org/10.1002/j.1460-2075.1990.tb07423.x] [PMID: 2369898]

Conner, J.M.; Lauterborn, J.C.; Yan, Q.; Gall, C.M.; Varon, S. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: Evidence for anterograde axonal transport. J. Neurosci., 1997, 17(7), 2295-2313.
[http://dx.doi.org/10.1523/JNEUROSCI.17-07-02295.1997] [PMID: 9065491]

Yan, Q.; Rosenfeld, R.D.; Matheson, C.R.; Hawkins, N.; Lopez, O.T.; Bennett, L.; Welcher, A.A. Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience, 1997, 78(2), 431-448.
[http://dx.doi.org/10.1016/S0306-4522(96)00613-6] [PMID: 9145800]

Katoh-Semba, R.; Takeuchi, I.K.; Semba, R.; Kato, K. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. J. Neurochem., 1997, 69(1), 34-42.
[http://dx.doi.org/10.1046/j.1471-4159.1997.69010034.x] [PMID: 9202291]

Gorba, T.; Klostermann, O.; Wahle, P. Development of neuronal activity and activity-dependent expression of brain-derived neurotrophic factor mRNA in organotypic cultures of rat visual cortex. Cereb. Cortex, 1999, 9(8), 864-877.
[http://dx.doi.org/10.1093/cercor/9.8.864] [PMID: 10601005]

Patz, S.; Wahle, P. Developmental changes of neurotrophin mRNA expression in the layers of rat visual cortex. Eur. J. Neurosci., 2006, 24(9), 2453-2460.
[http://dx.doi.org/10.1111/j.1460-9568.2006.05126.x] [PMID: 17100834]

Adachi, N.; Numakawa, T.; Richards, M.; Nakajima, S.; Kunugi, H. New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases. World J. Biol. Chem., 2014, 5(4), 409-428.
[http://dx.doi.org/10.4331/wjbc.v5.i4.409] [PMID: 25426265]

Aid, T.; Kazantseva, A.; Piirsoo, M.; Palm, K.; Timmusk, T. Mouse and rat BDNF gene structure and expression revisited. J. Neurosci. Res., 2007, 85(3), 525-535.
[http://dx.doi.org/10.1002/jnr.21139] [PMID: 17149751]

Pruunsild, P.; Kazantseva, A.; Aid, T.; Palm, K.; Timmusk, T. Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters. Genomics, 2007, 90(3), 397-406.
[http://dx.doi.org/10.1016/j.ygeno.2007.05.004] [PMID: 17629449]

Barker, P.A. Whither proBDNF? Nat. Neurosci., 2009, 12(2), 105-106.
[http://dx.doi.org/10.1038/nn0209-105] [PMID: 19172162]

Azimova, J.; Kondratieva, N.; Cepгeeв, A.B. The role of BDNF gene polymorphism in formation of clinical characteristics of migraine. J. Neurol. Stroke, 2016, 4(2)
[http://dx.doi.org/10.15406/jnsk.2016.04.00123]

Fischer, M.; Wille, G.; Klien, S.; Shanib, H.; Holle, D.; Gaul, C.; Broessner, G. Brain-derived neurotrophic factor in primary headaches. J. Headache Pain, 2012, 13(6), 469-475.
[http://dx.doi.org/10.1007/s10194-012-0454-5] [PMID: 22584531]

Cai, X.; Shi, X.; Zhang, X.; Zhang, A.; Zheng, M.; Fang, Y. The association between brain-derived neurotrophic factor gene polymorphism and migraine: A meta-analysis. J. Headache Pain, 2017, 18(1), 13.
[http://dx.doi.org/10.1186/s10194-017-0725-2] [PMID: 28150221]

Lu, B.; Pang, P.T.; Woo, N.H. The yin and yang of neurotrophin action. Nat. Rev. Neurosci., 2005, 6(8), 603-614.
[http://dx.doi.org/10.1038/nrn1726] [PMID: 16062169]

Minichiello, L.; Trk, B. TrkB signalling pathways in LTP and learning. Nat. Rev. Neurosci., 2009, 10(12), 850-860.
[http://dx.doi.org/10.1038/nrn2738] [PMID: 19927149]

Matsumoto, T.; Rauskolb, S.; Polack, M.; Klose, J.; Kolbeck, R.; Korte, M.; Barde, Y.A. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat. Neurosci., 2008, 11(2), 131-133.
[http://dx.doi.org/10.1038/nn2038] [PMID: 18204444]

Dieni, S.; Matsumoto, T.; Dekkers, M.; Rauskolb, S.; Ionescu, M.S.; Deogracias, R.; Gundelfinger, E.D.; Kojima, M.; Nestel, S.; Frotscher, M.; Barde, Y.A. BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. J. Cell Biol., 2012, 196(6), 775-788.
[http://dx.doi.org/10.1083/jcb.201201038] [PMID: 22412021]

Edelmann, E.; Leßmann, V.; Brigadski, T. Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity. Neuropharmacology, 2014, 76(Pt C), 610-627.
[http://dx.doi.org/10.1016/j.neuropharm.2013.05.043]

Ernfors, P.; Lee, K.F.; Jaenisch, R. Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature, 1994, 368(6467), 147-150.
[http://dx.doi.org/10.1038/368147a0] [PMID: 8139657]

Lommatzsch, M.; Braun, A.; Mannsfeldt, A.; Botchkarev, V.A.; Botchkareva, N.V.; Paus, R.; Fischer, A.; Lewin, G.R.; Renz, H. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Am. J. Pathol., 1999, 155(4), 1183-1193.
[http://dx.doi.org/10.1016/S0002-9440(10)65221-2] [PMID: 10514401]

Fujimura, H.; Chen, R.; Nakamura, T.; Nakahashi, T.; Kambayashi, J.; Sun, B.; Altar, C.; Tandon, N. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb. Haemost., 2002, 87(4), 728-734.
[http://dx.doi.org/10.1055/s-0037-1613072] [PMID: 12008958]

Jiang, H.; Chen, S.; Li, C.; Lu, N.; Yue, Y.; Yin, Y.; Zhang, Y.; Zhi, X.; Zhang, D.; Yuan, Y. The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment. Transl. Psychiatry, 2017, 7(4), e1079-e1079.
[http://dx.doi.org/10.1038/tp.2017.43] [PMID: 28375203]

Borba, E.M.; Duarte, J.A.; Bristot, G.; Scotton, E.; Camozzato, A.L.; Chaves, M.L.F. Brain-derived neurotrophic factor serum levels and hippocampal volume in mild cognitive impairment and dementia due to alzheimer disease. Dement. Geriatr. Cogn. Disord. Extra, 2016, 6(3), 559-567.
[http://dx.doi.org/10.1159/000450601] [PMID: 28101102]

Galvez-Contreras, A.Y.; Campos-Ordonez, T.; Lopez-Virgen, V.; Gomez-Plascencia, J.; Ramos-Zuniga, R.; Gonzalez-Perez, O. Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders. Cytokine Growth Factor Rev., 2016, 32, 85-96.
[http://dx.doi.org/10.1016/j.cytogfr.2016.08.004] [PMID: 27618303]

Autry, A.E.; Monteggia, L.M. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol. Rev., 2012, 64(2), 238-258.
[http://dx.doi.org/10.1124/pr.111.005108] [PMID: 22407616]

Karege, F.; Schwald, M.; Cisse, M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett., 2002, 328(3), 261-264.
[http://dx.doi.org/10.1016/S0304-3940(02)00529-3] [PMID: 12147321]

Sartorius, A.; Hellweg, R.; Litzke, J.; Vogt, M.; Dormann, C.; Vollmayr, B.; Danker-Hopfe, H.; Gass, P. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry, 2009, 42(6), 270-276.
[http://dx.doi.org/10.1055/s-0029-1224162] [PMID: 19924587]

Buse, D.C.; Reed, M.L.; Fanning, K.M.; Bostic, R.; Dodick, D.W.; Schwedt, T.J.; Munjal, S.; Singh, P.; Lipton, R.B. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: Results of the migraine in America symptoms and treatment (MAST) study. J. Headache Pain, 2020, 21(1), 23.
[http://dx.doi.org/10.1186/s10194-020-1084-y] [PMID: 32122324]

Holmuratova, B.; Rashidova, N.; Khalimova, K.; Matmurodov, R.; Rakhmatullaeva, G. The role of BDNF in the clinical course of primary headaches. Cephalalgia Rep., 2023, 6, 25158163231190292.
[http://dx.doi.org/10.1177/25158163231190292]

Duan, S.; Ren, Z.; Xia, H.; Wang, Z.; Zheng, T.; Li, G.; Liu, L.; Liu, Z. Associations between anxiety, depression with migraine, and migraine-related burdens. Front. Neurol., 2023, 14, 1090878.
[http://dx.doi.org/10.3389/fneur.2023.1090878] [PMID: 37181566]

Gorka, S.M.; Teppen, T.; Radoman, M.; Phan, K.L.; Pandey, S.C. Human plasma BDNF is associated with amygdala-prefrontal cortex functional connectivity and problem drinking behaviors. Int. J. Neuropsychopharmacol., 2020, 23(1), 1-11.
[http://dx.doi.org/10.1093/ijnp/pyz057] [PMID: 31722379]

Klein, A.B.; Williamson, R.; Santini, M.A.; Clemmensen, C.; Ettrup, A.; Rios, M.; Knudsen, G.M.; Aznar, S. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int. J. Neuropsychopharmacol., 2011, 14(3), 347-353.
[http://dx.doi.org/10.1017/S1461145710000738] [PMID: 20604989]

Altamura, C.; Corbelli, I.; de Tommaso, M.; Di Lorenzo, C.; Di Lorenzo, G.; Di Renzo, A.; Filippi, M.; Jannini, T.B.; Messina, R.; Parisi, P.; Parisi, V.; Pierelli, F.; Rainero, I.; Raucci, U.; Rubino, E.; Sarchielli, P.; Li, L.; Vernieri, F.; Vollono, C.; Coppola, G. Pathophysiological bases of comorbidity in migraine. Front. Hum. Neurosci., 2021, 15, 640574.
[http://dx.doi.org/10.3389/fnhum.2021.640574] [PMID: 33958992]

Sudershan, A.; Mahajan, K.; Singh, K.; Dhar, M.K.; Kumar, P. The complexities of migraine: A debate among migraine researchers: A review. Clin. Neurol. Neurosurg., 2022, 214, 107136.
[http://dx.doi.org/10.1016/j.clineuro.2022.107136] [PMID: 35101780]

Zhao, Z.; Jin, H.; Yin, Y.; Hou, Y.; Wang, J.; Tang, C.; Fu, J. Association of migraine with its comorbidities and food specific immunoglobulin g antibodies and inflammatory cytokines: Cross-sectional clinical research. J. Pain Res., 2021, 14, 2359-2368.
[http://dx.doi.org/10.2147/JPR.S316619] [PMID: 34385841]

Zarneshan, S.N.; Fakhri, S.; Khan, H. Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach. Pharmacol. Res., 2022, 177, 106099.
[http://dx.doi.org/10.1016/j.phrs.2022.106099] [PMID: 35092819]

Lima Giacobbo, B.; Doorduin, J.; Klein, H.C.; Dierckx, R.A.J.O.; Bromberg, E.; de Vries, E.F.J. Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation. Mol. Neurobiol., 2019, 56(5), 3295-3312.
[http://dx.doi.org/10.1007/s12035-018-1283-6] [PMID: 30117106]

Szklarczyk, D.; Gable, A.L.; Lyon, D.; Junge, A.; Wyder, S.; Huerta-Cepas, J.; Simonovic, M.; Doncheva, N.T.; Morris, J.H.; Bork, P.; Jensen, L.J.; Mering, C. STRING v11: Protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res., 2019, 47(D1), D607-D613.
[http://dx.doi.org/10.1093/nar/gky1131] [PMID: 30476243]

Amin, F.M.; Aristeidou, S.; Baraldi, C.; Czapinska-Ciepiela, E.K.; Ariadni, D.D.; Di Lenola, D.; Fenech, C.; Kampouris, K.; Karagiorgis, G.; Braschinsky, M.; Linde, M. The association between migraine and physical exercise. J. Headache Pain, 2018, 19(1), 83.
[http://dx.doi.org/10.1186/s10194-018-0902-y] [PMID: 30203180]

Neri, L.C.L.; Ferraris, C.; Catalano, G.; Guglielmetti, M.; Pasca, L.; Pezzotti, E.; Carpani, A.; Tagliabue, A. Ketosis and migraine: A systematic review of the literature and meta-analysis. Front. Nutr., 2023, 10, 1204700.
[http://dx.doi.org/10.3389/fnut.2023.1204700] [PMID: 37377485]

Nourollahimoghadam, E.; Gorji, S.; Gorji, A.; Khaleghi Ghadiri, M. Therapeutic role of yoga in neuropsychological disorders. World J. Psychiatry, 2021, 11(10), 754-773.
[http://dx.doi.org/10.5498/wjp.v11.i10.754] [PMID: 34733640]

Zhou, C.; Zhong, J.; Zou, B.; Fang, L.; Chen, J.; Deng, X.; Zhang, L.; Zhao, X.; Qu, Z.; Lei, Y.; Lei, T. Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression. PLoS One, 2017, 12(2), e0172270.
[http://dx.doi.org/10.1371/journal.pone.0172270] [PMID: 28241064]

Kang, M.J.Y.; Hawken, E.; Vazquez, G.H. The mechanisms behind rapid antidepressant effects of ketamine: A systematic review with a focus on molecular neuroplasticity. Front. Psychiatry, 2022, 13, 860882.
[http://dx.doi.org/10.3389/fpsyt.2022.860882] [PMID: 35546951]

Wei, H.L.; Wei, C.; Feng, Y.; Yan, W.; Yu, Y.S.; Chen, Y.C.; Yin, X.; Li, J.; Zhang, H. Predicting the efficacy of non-steroidal anti-inflammatory drugs in migraine using deep learning and three-dimensional T1-weighted images. iScience, 2023, 26(11), 108107.
[http://dx.doi.org/10.1016/j.isci.2023.108107] [PMID: 37867961]

Kinreich, S.; McCutcheon, V.V.; Aliev, F.; Meyers, J.L.; Kamarajan, C.; Pandey, A.K.; Chorlian, D.B.; Zhang, J.; Kuang, W.; Pandey, G.; Viteri, S.S.S.; Francis, M.W.; Chan, G.; Bourdon, J.L.; Dick, D.M.; Anokhin, A.P.; Bauer, L.; Hesselbrock, V.; Schuckit, M.A.; Nurnberger, J.I., Jr; Foroud, T.M.; Salvatore, J.E.; Bucholz, K.K.; Porjesz, B. Predicting alcohol use disorder remission: A longitudinal multimodal multi-featured machine learning approach. Transl. Psychiatry, 2021, 11(1), 166.
[http://dx.doi.org/10.1038/s41398-021-01281-2] [PMID: 33723218]

Peele, K.A.; Potla Durthi, C.; Srihansa, T.; Krupanidhi, S.; Ayyagari, V.S.; Babu, D.J.; Indira, M.; Reddy, A.R.; Venkateswarulu, T.C. Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study. Informatics in Medicine Unlocked, 2020, 19, 100345.
[http://dx.doi.org/10.1016/j.imu.2020.100345] [PMID: 32395606]

Friesner, R.A.; Banks, J.L.; Murphy, R.B.; Halgren, T.A.; Klicic, J.J.; Mainz, D.T.; Repasky, M.P.; Knoll, E.H.; Shelley, M.; Perry, J.K.; Shaw, D.E.; Francis, P.; Shenkin, P.S. Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J. Med. Chem., 2004, 47(7), 1739-1749.
[http://dx.doi.org/10.1021/jm0306430] [PMID: 15027865]

Loganathan, L.; Muthusamy, K.; Jayaraj, J.M.; Kajamaideen, A.; Balthasar, J.J. In silico insights on tankyrase protein: A potential target for colorectal cancer. J. Biomol. Struct. Dyn., 2019, 37(14), 3637-3648.
[http://dx.doi.org/10.1080/07391102.2018.1521748] [PMID: 30204055]

Muthusamy, K.; Krishnasamy, G. A computational study on role of 6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol in the regulation of blood glucose level. J. Biomol. Struct. Dyn., 2016, (12), 1-20.
[http://dx.doi.org/10.1080/07391102.2015.1124289]

Loganathan, L.; Natarajan, K.; Muthusamy, K. Computational study on cross-talking cancer signalling mechanism of ring finger protein 146, AXIN and Tankyrase protein complex. J. Biomol. Struct. Dyn., 2020, 38(17), 5173-5185.
[http://dx.doi.org/10.1080/07391102.2019.1696707] [PMID: 31760854]

Loganathan, L.; Kuriakose, B.B.; Mushfiq, S.; Muthusamy, K. Mechanistic insights on nsSNPs on binding site of renin and cytochrome P450 proteins: A computational perceptual study for pharmacogenomics evaluation. J. Cell. Biochem., 2021, 122(10), 1460-1474.
[http://dx.doi.org/10.1002/jcb.30069] [PMID: 34161641]

Jayaraj, J.M.; Kuriakose, B.B.; Alhazmi, A.H.; Muthusamy, K. Structural and functional insights on vitamin D receptor and CYP24A1 deleterious single nucleotide polymorphisms: A computational and pharmacogenomics perpetual approach. Cell Biochem. Funct., 2021, 39(7), 874-885.
[http://dx.doi.org/10.1002/cbf.3658] [PMID: 34231237]

Gupta, N.; Choudhary, S.K.; Bhagat, N.; Karthikeyan, M.; Chaturvedi, A. In silico prediction, molecular docking and dynamics studies of steroidal alkaloids of holarrhena pubescens wall. ex G. Don to guanylyl cyclase C: Implications in designing of novel antidiarrheal therapeutic strategies. Molecules, 2021, 26(14), 4147.
[http://dx.doi.org/10.3390/molecules26144147] [PMID: 34299422]

Loganathan, L.; Briget, K.B.; Sampayan, L.E.; Muthusamy, K. Targeting renin receptor for the inhibition of renin angiotensin aldosterone system: An alternative approach through in silico drug discovery. Comput. Theor. Chem., 2022, 1208, 113541-113541.
[http://dx.doi.org/10.1016/j.comptc.2021.113541]

Jayaraj, J.M.; Reteti, E.; Kesavan, C.; Muthusamy, K. Structural insights on vitamin D receptor and screening of new potent agonist molecules: Structure and ligand-based approach. J. Biomol. Struct. Dyn., 2021, 39(11), 4148-4159.
[http://dx.doi.org/10.1080/07391102.2020.1775122] [PMID: 32462983]

John Marshal, J.; Kuriakose, B.B.; Alhazmi, A.H.; Muthusamy, K. Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson’s disease. J. Cell. Biochem., 2023, 124(3), 434-445.
[http://dx.doi.org/10.1002/jcb.30379] [PMID: 36780350]

Kandasamy, S.; Selvaraj, M.; Muthusamy, K.; Varadaraju, N.; Kannupal, S.; Sekar, A.K.; Vilwanathan, R. Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes. J. Biomol. Struct. Dyn., 2022, 1-14.
[http://dx.doi.org/10.1080/07391102.2021.2024254] [PMID: 34994284]

Chinnasamy, S.; Nagamani, S.; Muthusamy, K. Zn 2+ ion of the snake venom metalloproteinase (SVMP) plays a critical role in ligand binding: A molecular dynamics simulation study. RSC Advances, 2015, 5(86), 70566-70576.
[http://dx.doi.org/10.1039/C5RA14693C]

Ramakrishnan, P. Pandiselvi Pandi; Muralidharan Jothimani; Sakthi Sasikala Sundaravel; Karthikeyan Muthusamy; Narayanan, U.; Mehboobali Pannipara; Al-Sehemi, A.G.; Jayaraman, A. Computational Approach on Moringa Oleifera as an Inhibitor against SARS-CoV-2 Structural Proteins. Indian Journal of Biochemistry and Biophysics (IJBB)., 2023, 60(12), 941-957.
[http://dx.doi.org/10.56042/ijbb.v60i12.6278]