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Recent Advances in Inflammation & Allergy Drug Discovery

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ISSN (Print): 2772-2708
ISSN (Online): 2772-2716

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Research Article

Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study

In Press, (this is not the final "Version of Record"). Available online 31 January, 2024
Author(s): Payman Bagheri, Majid Nouri, Hesam Eskandarzadeh and Mohammad Darvishi*
Published on: 31 January, 2024

DOI: 10.2174/0127722708281623240116100806

Price: $95

Abstract

Background: Chronic rhinosinusitis is known as a common problem with inflammatory and allergic causes. Several factors are associated with developing chronic rhinosinusitis, including immunoglobulin E (IgE) production and vitamin D deficiency.

Objective: In this study, we investigated the role of IgE and Vitamin D deficiency and differences between patients with chronic, allergic sinusitis and controls.

Methods: A total of 90 subjects were included in 3 groups (n=30) in this cross-sectional, correlational descriptive study. The subjects were divided into three groups, including control (healthy subjects), chronic sinusitis patients, and allergy patients. A checklist was used to collect the necessary data, including age, gender, and body mass index (BMI). To evaluate serum levels of vitamin D3 and IgE, ELISA kits were used.

Results: The mean vitamin D was 22 g/ml. Fifty-four participants (60%) out of all included people had insufficient vitamin D, 13% had a deficiency, and the high deficiency and insufficiency were in the group of allergic sinusitis. Our results indicated that gender (female) was significantly associated with vitamin D deficiency (p =0.01). Thirty-nine participants (43.3%) out of all studied subjects had high IgE, and the highest level of abnormality of IgE was in the allergic sinusitis group. Furthermore, it was found that gender and IgE were not significantly related. However, IgE was significantly associated with vitamin D deficiency in the allergic sinusitis group.

Conclusion: Our findings highlighted that most of the patients with chronic and allergic sinusitis had insufficient vitamin D. A possible association was also found between low vitamin D and IgE levels and the prevalence of allergic sinusitis. This study showed that patients with allergic sinusitis may be more vulnerable to lower serum levels of vitamin D. Therefore, vitamin D supplementation as an adjunctive therapy may be considered in these patients.

[1]
Bachert C, Mannent L, Naclerio RM, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: A randomized clinical trial. JAMA 2016; 315(5): 469-79.
[http://dx.doi.org/10.1001/jama.2015.19330] [PMID: 26836729]
[2]
Delemarre T, Holtappels G, De Ruyck N, Zhang N, Nauwynck H, Bachert C. Type 2 inflammation in chronic rhinosinusitis without nasal polyps: Another relevant endotype. J Allergy Clin Immunol 2020; 146(2): 337-43.e6.
[3]
Bellussi LM, Chen L, Chen D, Passali FM, Passali D. The role of High Mobility Group Box 1 chromosomal protein in the pathogenesis of chronic sinusitis and nasal polyposis. Acta Otorhinolaryngol Ital 2012; 32(6): 386-92.
[PMID: 23349558]
[4]
Bhattacharyya N. Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis. Am J Rhinol Allergy 2012; 26(2): 120-2.
[http://dx.doi.org/10.2500/ajra.2012.26.3752] [PMID: 22487288]
[5]
Collins JG. Prevalence of selected chronic conditions: United States, 1990-1992. Vital Health Stat 10 1997; 194: 1-89.
[6]
Hastan D, Fokkens WJ, Bachert C, et al. Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study. Allergy 2011; 66(9): 1216-23.
[http://dx.doi.org/10.1111/j.1398-9995.2011.02646.x] [PMID: 21605125]
[7]
Shi JB, Fu QL, Zhang H, et al. Epidemiology of chronic rhinosinusitis: Results from a cross‐sectional survey in seven C hinese cities. Allergy 2015; 70(5): 533-9.
[http://dx.doi.org/10.1111/all.12577] [PMID: 25631304]
[8]
Cho YS, Choi SH, Park KH, et al. Prevalence of otolaryngologic diseases in South Korea: Data from the Korea national health and nutrition examination survey 2008. Clin Exp Otorhinolaryngol 2010; 3(4): 183-93.
[http://dx.doi.org/10.3342/ceo.2010.3.4.183] [PMID: 21217958]
[9]
Liu X, Liu H, Li C. The role of bacterial infection in the pathogenesis of chronic sinusitis. Lin Chuang er bi yan hou tou Jing wai ke za zhi= J Clin. Otorhinolaryngol Head Neck Surg 2021; 35(2): 189-92.
[10]
Sonone J, Solanke P, Nagpure PS, Garg D, Puttewar M. Effect of anatomical variations of osteomeatal complex on chronic rhinosinusitis: A propective study. Indian J Otolaryngol Head Neck Surg 2019; 71(S3): 2199-202.
[http://dx.doi.org/10.1007/s12070-019-01653-7] [PMID: 31763320]
[11]
Dejima K, Randell SH, Stutts MJ, Senior BA, Boucher RC. Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis. Arch Otolaryngol Head Neck Surg 2006; 132(12): 1352-62.
[http://dx.doi.org/10.1001/archotol.132.12.1352] [PMID: 17178948]
[12]
Kennedy JL, Borish L. Chronic sinusitis pathophysiology: The role of allergy. Am J Rhinol Allergy 2013; 27(5): 367-71.
[http://dx.doi.org/10.2500/ajra.2013.27.3906] [PMID: 23601202]
[13]
Brustad N, Kim M, Skov F, et al. 25‐hydroxyvitamin D and risk of atopic diseases and infections in early childhood. Allergy 2023; 78(10): 2770-3.
[http://dx.doi.org/10.1111/all.15759] [PMID: 37129456]
[14]
Emanuel IA, Shah SB. Chronic rhinosinusitis: Allergy and sinus computed tomography relationships. Otolaryngol Head Neck Surg 2000; 123(6): 687-91.
[http://dx.doi.org/10.1067/mhn.2000.110961] [PMID: 11112958]
[15]
Gutman M, Torres A, Keen KJ, Houser SM. Prevalence of allergy in patients with chronic rhinosinusitis. Otolaryngol Head Neck Surg 2004; 130(5): 545-52.
[http://dx.doi.org/10.1016/j.otohns.2004.02.007] [PMID: 15138418]
[16]
Halderman AA, Tully LJ. The role of allergy in chronic rhinosinusitis. Otolaryngol Clin North Am 2017; 50(6): 1077-90.
[http://dx.doi.org/10.1016/j.otc.2017.08.003] [PMID: 28964531]
[17]
Fawzan AE, Assiri SA, Althaqafi RMM, Alsufyani A, Alghamdi ASA. Association of allergic rhinitis with hypothyroidism, asthma, and chronic sinusitis: Clinical and radiological features. World J Otorhinolaryngol Head Neck Surg 2022; 8(3): 262-8.
[http://dx.doi.org/10.1016/j.wjorl.2020.12.001] [PMID: 36159906]
[18]
Zhang C, Zhang H, Tang Q, et al. Allergic rhinitis as an independent risk factor for postoperative recurrence of children chronic sinusitis. Children 2023; 10(7): 1207.
[http://dx.doi.org/10.3390/children10071207] [PMID: 37508704]
[19]
Wise SK, Ahn CN, Schlosser RJ. Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis. Curr Opin Otolaryngol Head Neck Surg 2009; 17(3): 216-22.
[http://dx.doi.org/10.1097/MOO.0b013e32832ad23d] [PMID: 19417663]
[20]
Bayar Muluk N, Bafaqeeh SA, Cingi C. Anti-IgE treatment in allergic rhinitis. Int J Pediatr Otorhinolaryngol 2019; 127: 109674.
[http://dx.doi.org/10.1016/j.ijporl.2019.109674] [PMID: 31526939]
[21]
Pinto JM, Mehta N, DiTineo M, Wang J, Baroody FM, Naclerio RM. A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis. Rhinology 2010; 48(3): 318-24.
[http://dx.doi.org/10.4193/Rhino09.144] [PMID: 21038023]
[22]
Alswailmi FK, Sikandar MZ, Shah SIA. Biological roles of vitamin D and immunoglobulin E: Implications in allergic disorders. Pak J Med Health Sci 2020; 14(3): 495-8.
[23]
Matheu V, Bäck O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D–induced alteration of TH1/TH2 cytokine expression Enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 2003; 112(3): 585-92.
[http://dx.doi.org/10.1016/S0091-6749(03)01855-4] [PMID: 13679819]
[24]
Stokes PJ, Rimmer J. The relationship between serum vitamin D and chronic rhinosinusitis: A systematic review. Am J Rhinol Allergy 2016; 30(1): 23-8.
[http://dx.doi.org/10.2500/ajra.2016.30.4267] [PMID: 26867526]
[25]
Ringe JD, Kipshoven C. Vitamin D-insufficiency. Dermatoendocrinol 2012; 4(1): 72-80.
[http://dx.doi.org/10.4161/derm.19829] [PMID: 22870356]
[26]
Schlosser RJ, Soler ZM, Schmedes GW, Storck K, Mulligan JK. Impact of vitamin D deficiency upon clinical presentation in nasal polyposis. Int Forum Allergy Rhinol 2014; 4(3): 196-9.
[http://dx.doi.org/10.1002/alr.21274]
[27]
Mulligan JK, Bleier BS, O’Connell B, Mulligan RM, Wagner C, Schlosser RJ. Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol 2011; 164(3): 312-20.
[http://dx.doi.org/10.1111/j.1365-2249.2011.04325.x] [PMID: 21401575]
[28]
Pinto JM, Schneider J, Perez R, DeTineo M, Baroody FM, Naclerio RM. Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis. J Allergy Clin Immunol 2008; 122(2): 415-7.
[http://dx.doi.org/10.1016/j.jaci.2008.05.038] [PMID: 18585770]
[29]
Wang LF, Lee CH, Chien CY, Chen JYF, Chiang FY, Tai CF. Serum 25-hydroxyvitamin D levels are lower in chronic rhinosinusitis with nasal polyposis and are correlated with disease severity in Taiwanese patients. Am J Rhinol Allergy 2013; 27(6): e162-5.
[http://dx.doi.org/10.2500/ajra.2013.27.3948] [PMID: 24274207]
[30]
Verdoia M, Schaffer A, Barbieri L, et al. Impact of gender difference on vitamin D status and its relationship with the extent of coronary artery disease. Nutr Metab Cardiovasc Dis 2015; 25(5): 464-70.
[http://dx.doi.org/10.1016/j.numecd.2015.01.009] [PMID: 25791862]
[31]
Azizieh F, Alyahya K, Raghupathy R. Association between levels of vitamin D and inflammatory markers in healthy women. J Inflamm Res 2016; 9: 51-7.
[http://dx.doi.org/10.2147/JIR.S103298] [PMID: 27175089]
[32]
Faghih Habibi A, Gerami H, Banan R, et al. Serum 25-hydroxy vitamin D in chronic rhinosinusitis with and without nasal polyposis: A case-control study. Iran J Otorhinolaryngol 2019; 31(102): 19-24.
[PMID: 30783595]
[33]
Latek M, Lacwik P, Molińska K, et al. The role of innate lymphoid cells in chronic rhinosinusitis severity in children: A cross-sectional study. Alergologia Polska 2023; 10(2): 100-6.
[http://dx.doi.org/10.5114/pja.2023.129090]
[34]
Qiu C, Zhong L, Huang C, et al. Cell-bound IgE and plasma IgE as a combined clinical diagnostic indicator for allergic patients. Sci Rep 2020; 10(1): 4700.
[http://dx.doi.org/10.1038/s41598-020-61455-8] [PMID: 32170187]
[35]
Brook CD, Agarwal P. Updates to the current understanding of the relationship between allergy and chronic sinusitis. Curr Otorhinolaryngol Rep 2020; 8(2): 191-7.
[http://dx.doi.org/10.1007/s40136-020-00287-6]
[36]
Rouyar A, Classe M, Gorski R, et al. Type 2/Th2‐driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model. Allergy 2019; 74(3): 549-59.
[http://dx.doi.org/10.1111/all.13559] [PMID: 29987849]
[37]
Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: How important is it? Clin Exp Allergy 2015; 45(1): 114-25.
[http://dx.doi.org/10.1111/cea.12430] [PMID: 25307157]
[38]
Mohammadzadeh I, Darvish S, Qujeq D, Hajiahmadi M, Vaghari-Tabari M, Eds. Association of serum 25-OH vitamin D3 with serum IgE and the Pediatric Asthma Severity Score in patients with pediatric asthma Allergy Asthma Proceedings. OceanSide Publications, Inc. 2020.

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