Login Register Cart 0
Generic placeholder image

Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Edible Vaccines: A Patent-Driven Exploration of Immunization Technologies

In Press, (this is not the final "Version of Record"). Available online 25 January, 2024
Author(s): Sahil Kashyap, Rohit Kamboj, Shikha Kamboj, Kumar Guarve and Sweta Kamboj*
Published on: 25 January, 2024

DOI: 10.2174/0118722083275041231219060829

Price: $95

Abstract

Vaccines are biological preparations that improve immunity to particular diseases. Particularly for poor developing nations, edible vaccines show significant potential as a financially advantageous, simple to administer, straightforward to store, fail-safe, and socially and culturally acceptable vaccine delivery system. A vaccine incorporates the gene-encoding bacterial or viral disease-causing agent in plants without losing its immunogenic property. Potatoes, tomatoes, rice, soybeans, and bananas are the primary plants for edible vaccines. It activates the systemic and mucosal immunity responses against a foreign disease-causing organism. It offers exciting possibilities to reduce diseases like hepatitis B, rabies, HIV/AIDS (human immunodeficiency virus infection and acquired immune deficiency syndrome), etc. These vaccines provide many benefits, like being convenient to administer, efficiently storing, and readily acceptable drug delivery systems for patients of different age groups. So, an edible vaccine may be the most convenient vaccine to improve immunity. However, there are a lot of technical and regulatory challenges to overcome in the way of edible vaccine technology. Though all seem surmountable, various technical obstacles and regulatory and non-scientific challenges need to be overcome. Moreover, edible vaccine patents represent a cutting-edge area of biotechnology, where the integration of genetic material into edible substances holds great promise for revolutionizing vaccination methods. These patents aim to harness the potential of plants and other edibles to stimulate immune responses, offering a potential alternative to traditional injectable vaccines. This review states the technologies, host plants, current status, recent patents, the future of this new preventive modality, and different regulatory issues concerning edible vaccines.

[1]
Marsian J, Lomonossoff GP. Molecular pharming — VLPs made in plants. Curr Opin Biotechnol 2016; 37: 201-6.
[http://dx.doi.org/10.1016/j.copbio.2015.12.007] [PMID: 26773389]
[2]
Walmsley AM, Arntzen CJ. Plant cell factories and mucosal vaccines. Curr Opin Biotechnol 2003; 14(2): 145-50.
[http://dx.doi.org/10.1016/S0958-1669(03)00026-0] [PMID: 12732315]
[3]
Meloen RH, Hamilton WDO, Casal JI, Dalsgaard K, Langeveld JPM. Edible vaccines. Vet Q 2011; 92-5.
[PMID: 9689737]
[4]
Guillermo M, Genelsa E, Guiam-An L, et al. The promising potential of plant-based edible vaccines: A review. Int J Res Pub Rev 2022; 3: 39-49.
[5]
Razzak KSB, Jain D, Hossain MN, Bushra A. Plant edible vaccines: A natural way of vaccination. Vigyan Varta 2020; 1: 21-4.
[6]
Khalid F, Tahir R, Ellahi M, et al. Emerging trends of edible vaccine therapy for combating human diseases especially COVID‐19: Pros, cons, and future challenges. Phytother Res 2022; 36(7): 2746-66.
[http://dx.doi.org/10.1002/ptr.7475] [PMID: 35499291]
[7]
Daniell H, Singh ND, Mason H, Streatfield SJ. Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Sci 2009; 14(12): 669-79.
[http://dx.doi.org/10.1016/j.tplants.2009.09.009] [PMID: 19836291]
[8]
Aggani SL. Edible vaccines: A new approach for immunization in plant biotechnology. Sch Acad J Pharm 2013; 2: 227-32.
[9]
Koprowski H. Vaccines and sera through plant biotechnology. Vaccine 2005; 23(15): 1757-63.
[http://dx.doi.org/10.1016/j.vaccine.2004.11.001] [PMID: 15734037]
[10]
Chen K, Cerutti A. Vaccination strategies to promote mucosal antibody responses. Immunity 2010; 33(4): 479-91.
[http://dx.doi.org/10.1016/j.immuni.2010.09.013] [PMID: 21029959]
[11]
Mason HS, Tacket CO, Richter LJ, Arntzen CJ. Subunit vaccines produced and delivered in transgenic plants as “edible vaccines”. Res Immunol 1998; 149(1): 71-4.
[http://dx.doi.org/10.1016/S0923-2494(98)80050-3]
[12]
Patel P, Patel R, Patel S, Patel Y, Patel M, Trivedi R. Edible vaccines: A nutritional substitute for traditional immunization. Pharmacogn Rev 2022; 16(32): 62-9.
[http://dx.doi.org/10.5530/phrev.2022.16.9]
[13]
Mason HS, Arntzen CJ. Transgenic plants as vaccine production systems. Trends Biotechnol 1995; 13(9): 388-92.
[http://dx.doi.org/10.1016/S0167-7799(00)88986-6] [PMID: 7546570]
[14]
Munshi A, Sharma V. Omics and edible vaccines. Omics Technol Bio-Eng 2018; 2: 129-41.
[http://dx.doi.org/10.1016/B978-0-12-815870-8.00008-5]
[15]
Ricroch AE, Martin-Laffon J, Rault B, Pallares VC, Kuntz M. Next biotechnological plants for addressing global challenges: The contribution of transgenesis and new breeding techniques. N Biotechnol 2022; 66: 25-35.
[http://dx.doi.org/10.1016/j.nbt.2021.09.001] [PMID: 34537403]
[16]
Bhatia S, Dahiya R. Edible Vaccines. Plant Biotech Pharma Sci 2015; pp. 333-43.
[17]
Sharma AK, Sharma MK. Plants as bioreactors: Recent developments and emerging opportunities. Biotechnol Adv 2009; 27(6): 811-32.
[http://dx.doi.org/10.1016/j.biotechadv.2009.06.004] [PMID: 19576278]
[18]
Tajpara MM, Savsani HH, Shah NM, Padodara RJ, Javia BB, Kathiriya JB. Transgenic plant based edible vaccine -A review. Int J Animal Veter Sci 2019; 6: 68-74.
[19]
Sahoo A, Mandal AK, Dwivedi K, Kumar V. A cross talk between the immunization and edible vaccine: Current challenges and future prospects. Life Sci 2020; 261: 118343.
[http://dx.doi.org/10.1016/j.lfs.2020.118343] [PMID: 32858038]
[20]
Bhairy SR, Hirlekar RS. Edible vaccines: An advancement in oral immunization. Asian J Pharm Clin Res 2017; 10(2): 71.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15825]
[21]
Gunn KS, Singh N, Giambrone J, Wu H. Using transgenic plants as bioreactors to produce edible vaccines. J Biotechnol Res 2012; pp. 92-9.
[22]
Saxena J, Rawat S. Edible vaccines. Adv Biotechnol 2013; pp. 207-26.
[23]
Rajangam J, Gosula S, Satya TH, Anitha M. An overview on edible vaccines: A novel approach to oral immunization. Int J Res Inno App Sci 2018; pp. 8-14.
[24]
Edulakanti A, Tejaswani SG. Edible vaccines: A new approach for oral immunization. J Pharmacogn Phytochem 2022; 11(1): 139-41.
[http://dx.doi.org/10.22271/phyto.2022.v11.i1b.14333]
[25]
Esmael H, Hirpa E. Review on edible vaccine. Aca J Nut 2015; 4: 40-9.
[26]
Jain IR, Ansari NM, Shingi RS, Walode SG, Chatur VM. Plant based edible vaccines: A review. World J Pharm Res 2021; 10: 378-92.
[27]
Waghulkar V. Fruit derived edible vaccines: Natural way for the vaccination. Int J Pharm Tech Res 2010; 2: 2124-7.
[28]
Jan N, Shafi F, Hameed OB, et al. An overview on edible vaccines and immunization. Austin J Nutr Food Sci 2016; 1-5.
[29]
Sharma DK. Edible Vaccines: A new approach in immunization. Indian J Sci 2017; 6: 113-6.
[30]
Doshi V, Rawal H, Mukherjee S. Edible vaccines from GM crops: Current status and future scope. J Pharmaceut Sci Innov 2013; 2(3): 1-6.
[http://dx.doi.org/10.7897/2277-4572.02321]
[31]
Athulya M, Vethamoni PI. Vegetables as a factory of bio pharmaceuticals: Edible vaccines. Int J Chem Stud 2018; 6: 846-50.
[32]
Ghosh S, Ghosh S, Karim E, Roy B. A review on edible vaccines: Plant as a platform for biopharmaceutical’s production. Int J Res Cul Soc 2019; 3(2): 31-6.
[33]
Ahire SN, Panchave RT, Patil AB. An overview on edible vaccines: Need of future. Int J Creat Res Thoughts 2020; 8(5): 3158-69.
[34]
Khajuria P, Singh G, Dash SK, Mahajan C, Sharma R. Current status and future prospects of edible vaccines: A review. Pharm Inn J 2022; 3: 110-3.
[35]
Hagio T. Optimizing the Particle Bombardment Method for efficient Genetic transformation. Jpn Agric Res Q 1998; 32: 239-47.
[36]
Mason HS, Thuenemann E, Klyono H, Kessans S, Matoba N, Mor T. Mucosal vaccines from plant biotechnology. Mucosal Immunol 2015; 1271-85.
[37]
Parvathy ST. Engineering plants as platforms for production of vaccines. Am J Plant Sci 2020; 11(5): 707-35.
[http://dx.doi.org/10.4236/ajps.2020.115052]
[38]
Kurup VM, Thomas J. Edible vaccines: Promises and challenges. Mol Biotechnol 2020; 62(2): 79-90.
[http://dx.doi.org/10.1007/s12033-019-00222-1] [PMID: 31758488]
[39]
Su H, van Eerde A, Rimstad E, et al. Plant-made vaccines against viral diseases in humans and farm animals. Front Plant Sci 2023; 14: 1170815.
[http://dx.doi.org/10.3389/fpls.2023.1170815]
[40]
Bhatia V, Malik S, Mishra DK, Paul D. The Labelling of genetically modified foods in India: Consumer’s risk perception, trust, and knowledge. Int J Eng Res Technol 2020; 13(11): 3359-66.
[http://dx.doi.org/10.37624/IJERT/13.11.2020.3359-3366]
[41]
Shah VV, Prajapati RA, Shah SP, Patel SR, Patel HP. A comprehensive review on edible vaccine. J Drug Deliv Ther 2022; 12(2): 192-201.
[42]
Esmael H. Review on edible vaccine. Acad J Nutr 2015; 4(1): 40-9.
[43]
Sasagwa T, Tohda H, Hama Y. Edible vaccine U.S. Patent 20090017063A1, 2005.
[44]
Sasagwa T, Tohda H, Hama Y. Edible vaccines canadian Patent 2579882 C, 2012.
[45]
Sohrab SS, Ashar EIA, Elkafrawy SAA, Abdelhad ATA, Rybicki EP, Margolin EA. Development of an edible vaccine U.S. Patent 0025628 A1, 2022.
[46]
Piller KJ, Bost KL. Edible vaccines expressed in soybeans U.S. Patent 10, 030,250 B2, 2005.
[47]
LAM Y. Oral vaccines produced and administered using edible microorganisms including lactic acid bacterial strains. U.S. Patent 0004547 A1, 2010.
[48]
Salmela H, Freitak D. Edible vaccination against microbial pathogens. U.S. Patent 0275658 A1, 2021.
[49]
Daniell H. Expression of protective antigens in transgenic chloroplasts and the production of improved vaccines. U.S. Patent 0294895 A1, 2002.
[50]
Flaishman M, Pearl A, Golobowicz S. Transgenic ficus, method for producing same and use thereof U.S. Patent 8,148,603 B2, 2005.
[51]
Arakawa T, Langridge WHR. Methods and substances for preventing and treating autoimmune disease A.U. Patent 750623 B2, 2002.
[52]
Lam DMK, Lam OYY, Lei H. Edible vaccines expressed in yeast for preventing and treating infectious diseases, including hepatitis B, in humans U.S. Patent 10,793,866 B2, 2017.
[53]
Cardineau G, Mason H, VanEck J, Kirk D, Walmsley A. Vectors and cells for preparing immunoprotective compositions derived from transgenic plants. U.S. Patent 0048074 A1, 2004.
[54]
Yuki Y. Rice plant having vaccine gene transferred thereinto. U.S. Patent 0192906 A1, 2005.
[55]
Shaaltiel Y, Almon E. Mucosal or enteral administration of biologically active macromolecules. European Patent 2441840 B1, 2008.
[56]
Florack DEA, Bosch HJ. Chimeric carrier molecules for the production of mucosal vaccines. U.S. Patent 0286297 A1, 2003.
[57]
Takaiwa F, Takagi H. Method of accumulating allergen-specific cell antigen determinant in plant and plant having the antigen determinant accumulated therein. U.S. Patent 0136896 A1, 2003.
[58]
Lam DMK, Xu Y. Immunoprotection by oral administration of recombinant lactococcus lactis minicapsules. U.S. Patent 0276167 A1, 2010.
[59]
Deniell H. Chloroplasts engineered to express pharmaceutical proteins in edible plants. W.O. Patent 2141981 B1, 2008.
[60]
Chye M, Li H, Ramalingam S, Poon L, Peiris J. Genetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS. U.S. Patent 0053516 A1, 2006.
[61]
Sorokin A, Malcuit I, Jakubiec A, Cayla T. Protein production in plant cells. European Patent 3260542 A1, 2016.
[62]
Rose RC, Williamson AL, Rybicki EP. Oral immunization with papillomavirus virus-like particles U.S. Patent OO61532O1 A,
[63]
Mason HS, Arntzen CJ. Orally immunogenic bacterial enterotoxins expressed in transgenic plants. Canadian Patent 2359586 A1, 1999.
[64]
Koprowski H, Hooper DC, Hammond J, Mcgarvey PB, Michaels FH. Vaccines synthesized by transgenic plants. PCT Patent 40229 A1, 1996.
[65]
Lam DMK, Arntzen CJ, Mason HS. Vaccines expressed in plants. PCT Patent 20135 A1, 1993.
[66]
Ito A, Gotanda T, Kobayashi S, Kume K, Matsumura T. Oral anti-protozoiasis vaccines based on transgenic plants. Canadian Patent 2567952 C, 2005.
[67]
Daniell H. Orally administerable vaccine for yersinia pestis. PCT Patent 033275 A2, 2009.
[68]
Sin YM, Teh HC, Lim SY. Oral vaccine, method for its preparation and use thereof. PCT Patent 053736 A1, 2003.
[69]
Yang HL, Yu JCC, Lin JHY. Oral vaccines U.S. Patent 6,872,386 B2, 2005.
[70]
Yanshi RA. Edible Vaccines New Technology to Combat Disease. Int J Curr Adv Res 2019; 18303-5.
[71]
Lal P, Ramachandran VG, Goyal R, Sharma R. Edible vaccines: Current status and future. Indian J Med Microbiol 2007; 25(2): 93-102.
[http://dx.doi.org/10.1016/S0255-0857(21)02165-4] [PMID: 17582177]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy