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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy

Author(s): Zongrui Xing, Xiangyan Jiang, Yuxia Wu and Zeyuan Yu*

Volume 24, Issue 9, 2024

Published on: 24 January, 2024

Page: [890 - 909] Pages: 20

DOI: 10.2174/0115680096273730231206054104

Abstract

Tumors of the digestive system are currently one of the leading causes of cancer-related death worldwide. Despite considerable progress in tumor immunotherapy, the prognosis for most patients remains poor. In the tumor microenvironment (TME), tumor cells attain immune escape through immune editing and acquire immune tolerance. The mevalonate pathway and autophagy play important roles in cancer biology, antitumor immunity, and regulation of the TME. In addition, there is metabolic crosstalk between the two pathways. However, their role in promoting immune tolerance in digestive system tumors has not previously been summarized. Therefore, this review focuses on the cancer biology of the mevalonate pathway and autophagy, the regulation of the TME, metabolic crosstalk between the pathways, and the evaluation of their efficacy as targeted inhibitors in clinical tumor immunotherapy.

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