Hidradenoma Papilliferum of Vulva Simulating Vulval Carcinoma: A
Case Report

Naina      Kumar; Immanuel      Pradeep; Mishu      Mangla; Subhrajyoti      Roy

doi:10.2174/0115733947268827231122034503

Note! Please note that this article is currently in the "Article in Press" stage and is not the final "Version of record". While it has been accepted, copy-edited, and formatted, however, it is still undergoing proofreading and corrections by the authors. Therefore, the text may still change before the final publication. Although "Articles in Press" may not have all bibliographic details available, the DOI and the year of online publication can still be used to cite them. The article title, DOI, publication year, and author(s) should all be included in the citation format. Once the final "Version of record" becomes available the "Article in Press" will be replaced by that.

Abstract

Purpose: Vulval Hidradenoma papilliferum is a rare benign tumor originating from apocrine sweat glands. They present as a solid solitary nodule of 1-2 cm on the inner margin of labia majora. Since they are not commonly encountered, their diagnosis is usually difficult and puzzles with other conditions such as benign and malignant lesions of the skin, vulva, and perineum. The present case report highlights one such case of vulval Hidradenoma papilliferum in a postmenopausal woman diagnosed after a histopathological examination of an excised lesion.

Case Presentation: A 55-year-old P2L2 postmenopausal woman presented to the Gynecology outpa- tient department complaining of itching over the vulval region for 3-4 months. There was no associated bleeding or discharge per vaginum. On local examination, a single nodular, hypopigmented, non-tender, ulcerative lesion was seen over the right labia majora of size 1x2 cm. It was solid in consistency. The lesion was excised and sent for histopathological examination, which revealed a well- circumscribed subepithelial tumor composed of delicate, complex branching papillae and glandular elements lined by columnar epithelial secretory cells and myoepithelial cells suggestive of hidrade- noma papilliferum.

Major Findings: The diagnosis of hidradenoma papilliferum is usually made on surgical excision and histopathological evaluation of lesions. Hidradenoma papilliferum is difficult to diagnose clinically as it mimics other benign and malignant gynecological and cutaneous diseases.

Conclusion: Hence, hidradenoma papilliferum should be kept as a differential in diagnosing women with solitary asymptomatic nodules in the anogenital region.

[1]
Birge O, Bakır MS, Karadag C, Eldarova Z, Simsek T. Hidradenoma papilliferum of the hymen: A case report. J Med Case Reports  2021; 15(1): 162.
 [http://dx.doi.org/10.1186/s13256-021-02786-6] [PMID: 33845900]

[2]
El-Khoury J, Renald MH, Plantier F, Avril MF, Moyal-Barracco M. Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors. J Am Acad Dermatol  2016; 75(2): 380-4.
 [http://dx.doi.org/10.1016/j.jaad.2016.01.034] [PMID: 26944596]

[3]
Kuma Y, Yamada Y, Yamamoto H, et al. A novel fusion gene CRTC3-MAML2 in hidradenoma: Histopathological significance. Hum Pathol  2017; 70: 55-61.
 [http://dx.doi.org/10.1016/j.humpath.2017.10.004] [PMID: 29079171]

[4]
Jovic A, Popovic D, Cekic S, et al. Vulvar hidradenoma papilliferum dermoscopically mimicking basal cell carcinoma. Dermatol Pract Concept  2021; 11(4): e2021070.
 [http://dx.doi.org/10.5826/dpc.1104a70] [PMID: 35024216]

[5]
Kambil SM, Bhat RM, D’Souza DC. Hidradenoma papilliferum of the vulva. Indian Dermatol Online J  2014; 5(4): 523-4.
 [http://dx.doi.org/10.4103/2229-5178.142541] [PMID: 25396149]

[6]
Dayal S. Hidradenoma papilliferum of the vulva- is histopathology required? Erciyes Medical Journal  2021; 44(2): 242-3.
 [http://dx.doi.org/10.14744/etd.2021.90337]

[7]
Baker GM, Selim MA, Hoang MP. Vulvar adnexal lesions: A 32-year, single-institution review from massachusetts general hospital. Arch Pathol Lab Med  2013; 137(9): 1237-46.
 [http://dx.doi.org/10.5858/arpa.2012-0434-OA] [PMID: 23991738]

[8]
Cheong JY, Lee CS, Young CJ. Hidradenoma papilliferum: An unusual benign perianal tumour. BMJ Case Rep  2018; 2018: bcr-2017-220354.
 [http://dx.doi.org/10.1136/bcr-2017-220354] [PMID: 30061121]

[9]
McGauran MFG, Manolitsas T, Tawfik B, Joshi D, Lamont JM. Poroid hidradenocarcinoma and atypical hidradenoma papilliferum of the vulva – Two cases. Gynecol Oncol Rep  2021; 38: 100886.
 [http://dx.doi.org/10.1016/j.gore.2021.100886] [PMID: 34926767]

[10]
Sağnıç S, Ay SS, Tuncer HA, Doğan S, Şimşek T. Hidradenoma papilliferum of the perineum; A rare tumour in a rare location. J Obstet Gynaecol  2023; 43(1): 2186781.
 [http://dx.doi.org/10.1080/01443615.2023.2186781] [PMID: 36912189]

[11]
Tosti G, Salvini C, Barisani A, et al. Vulval hidradenoma papilliferum: A clinical and dermoscopic study. Clin Exp Dermatol  2020; 45(8): 1035-9.
 [http://dx.doi.org/10.1111/ced.14254] [PMID: 32356582]

[12]
Lambert WC, Patel S, Behbanani S, Espinal-Mariotte J, Lee P. Hidradenoma papilliferum: Everyone else’s diagnosis. Indian J Dermatol  2020; 65(2): 151-3.
 [http://dx.doi.org/10.4103/ijd.IJD_256_18] [PMID: 32180606]

[13]
Kurashige Y, Kishida K, Kurashige K, Minemura T, Nagatani T. Hidradenoma papilliferum of the vulva in association with an anogenital mammary‐like gland. J Dermatol  2014; 41(5): 411-3.
 [http://dx.doi.org/10.1111/1346-8138.12433] [PMID: 24617304]

[14]
Kim GY, Solanki MH, Guo R. Vulvar apocrine hidradenocarcinoma arising in a hidradenoma papilliferum—A case report. J Cutan Pathol  2021; 48(8): 1085-7.
 [http://dx.doi.org/10.1111/cup.14033] [PMID: 33908057]

[15]
Konstantinova AM, Michal M, Kacerovska D, et al. Hidradenoma papilliferum: A clinicopathologic study of 264 tumors from 261 patients, with emphasis on mammary-type alterations. Am J Dermatopathol  2016; 38(8): 598-607.
 [http://dx.doi.org/10.1097/DAD.0000000000000495] [PMID: 26863059]

[16]
Wondimu B, Chang OH. Hidradenoma papilliferum. Pathology Outlines.com website.  Available From: https://www.pathologyoutlines.com/topic/skintumornonmelanocytichidradenomapap.html Accessed June 21st, 2023

[17]
Lee A, Lim A, Fischer G. Fractional carbon dioxide laser in recalcitrant vulval lichen sclerosus. Australas J Dermatol  2016; 57(1): 39-43.
 [http://dx.doi.org/10.1111/ajd.12305] [PMID: 25755049]

[18]
Handa Y, Yamanaka N, Inagaki H, Tomita Y. Large ulcerated perianal hidradenoma papilliferum in a young female. Dermatol Surg  2003; 29(7): 790-2.
 [http://dx.doi.org/10.1097/00042728-200307000-00025] [PMID: 12828711]

[19]
Offidani A, Campanati A. Papillary hidradenoma: Immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. J Clin Pathol  1999; 52(11): 829-32.
 [http://dx.doi.org/10.1136/jcp.52.11.829] [PMID: 10690173]

[20]
McClain CM, Deavers MT, Sauls CD, Diwan AH. Hidradenoma papilliferum associated with pregnancy: A case report. J Cutan Pathol  2015; 42(12): 983-6.
 [http://dx.doi.org/10.1111/cup.12586] [PMID: 26265265]

[21]
Blind A, Weingertner N, Cribier B. Étude anatomoclinique et immunohistochimique d’une tumeur dérivant des glandes anogénitales de type mammaire: l’hidradénome papillifère [Anatomoclinical and immunohistochemical study of hidradenoma papilliferum, a tumor deriving from anogenital mammary-like glands]. Ann Dermatol Venereol  2019; 146((8-9)): 528-36. French
 [http://dx.doi.org/10.1016/j.annder.2019.03.008]

[22]
Docimo S Jr, Shon W, Elkowitz DE. Bartholin’s abscess arising within hidradenoma papilliferum of the vulva: A case report. Cases J  2008; 1(1): 282.
 [http://dx.doi.org/10.1186/1757-1626-1-282] [PMID: 18959791]

[23]
Meraz ÁD, Benardete HDN, Hernández AI, et al. Hidradenoma papilliferum of the vulva. An Med Asoc Med Hosp ABC  2015; 60(2): 125-8.

[24]
Wang DQ, Wang L, Xia XS, et al. Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: A retrospective cross-sectional study in a tertiary hospital. Quant Imaging Med Surg  2022; 12(4): 2385-96.
 [http://dx.doi.org/10.21037/qims-21-786] [PMID: 35371929]

[25]
Ngo N, Susa M, Nakagawa T, et al. Malignant transformation of nodular hidradenoma in the lower leg. Case Rep Oncol  2018; 11(2): 298-304.
 [http://dx.doi.org/10.1159/000489255] [PMID: 29928207]

[26]
De Giorgi V, Zuccaro B, Silvestri F, Venturi F. Hidradenoma papilliferum of the vulva: A dermoscopic challenging diagnosis. An Bras Dermatol  2023; 98(4): 546-8.
 [http://dx.doi.org/10.1016/j.abd.2021.11.014] [PMID: 36967274]

Rights & Permissions Print Cite

Journal Information

For Authors

For Editors

For Reviewers

Explore Articles

Open Access

Open Access Articles

For Visitors

DOI https://dx.doi.org/10.2174/0115733947268827231122034503	Print ISSN 1573-3947
Publisher Name Bentham Science Publisher	Online ISSN 1875-6301

Current Cancer Therapy Reviews

Hidradenoma Papilliferum of Vulva Simulating Vulval Carcinoma: A Case Report

Abstract Play Pause

Related Journals

Related Books

Abstract