Selection of Targets for Drug Development Against Protozoan Parasites

Title: Selection of Targets for Drug Development Against Protozoan Parasites

Volume: 10 Issue: 3

Author(s): Walter Filgueira de Azevedo Junior and Milena Botelho Pereira Soares

Affiliation:

Keywords: Virtual screening, parasites, molecular targets, drug design

Abstract: Sequencing of parasite genomes opened the possibity to identify potential protein targets for drug development. Several protein targets have been found in the genome of Plasmodium falciparum, Trypanosoma cruzi, Trypanosoma brucei and Leishmania major. Bioinformatics analysis is an important tool for the identification of protein targets for drug development against parasitic diseases. In this review we comment about three protein targets, identified in parasite genomes, and discuss the main features that may guide future efforts for virtual screening initiatives.

Cite this article as:

de Azevedo Junior Filgueira Walter and Pereira Soares Botelho Milena, Selection of Targets for Drug Development Against Protozoan Parasites, Current Drug Targets 2009; 10 (3) . https://dx.doi.org/10.2174/138945009787581186