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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Mini-Review Article

Pharmacological Action and Research Progress of Taraxasterol

Author(s): Yu Zhang, Ramizu Bin Shaari*, Mohamad Arif Bin Awang Nawi, Akram Bin Hassan and Caiyun Cui

Volume 25, Issue 14, 2024

Published on: 04 January, 2024

Page: [1767 - 1777] Pages: 11

DOI: 10.2174/0113892010276692231220103636

Price: $65

Abstract

Primarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes. The primary aim of this study is to thoroughly explore the diseasemodulating mechanisms and effects of taraxasterol. We endeavor to provide an exhaustive review of the experimental subjects, intervention components, distinct action modalities, contributing factors, and protein pathway expressions associated with taraxasterol, systematically represented via diagrams and tables. Such a schematic representation encourages a continued academic dialogue concerning taraxasterol's pharmacological characteristics. This review is envisioned as a practical guide for the selection of experimental subjects and methodologies in prospective research. It is intended to further illuminate taraxasterol's pharmacodynamics, thereby offering theoretical and empirical justification for its clinical application.

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Graphical Abstract

[1]
Forchielli, M.L.; Bersani, G.; Tala, S.; Grossi, G.; Puggioli, C.; Masi, M. The spectrum of plant and animal sterols in different oil-derived intravenous emulsions. Lipids, 2010, 45(1), 63-71.
[http://dx.doi.org/10.1007/s11745-009-3371-x] [PMID: 20049583]
[2]
Sharma, N.; Tan, M.A.; An, S.S.A. Phytosterols: Potential metabolic modulators in neurodegenerative diseases. Int. J. Mol. Sci., 2021, 22(22), 12255.
[http://dx.doi.org/10.3390/ijms222212255]
[3]
Weete, J.D.; Abril, M.; Blackwell, M. Phylogenetic distribution of fungal sterols. PLoS One, 2010, 5(5), e10899.
[http://dx.doi.org/10.1371/journal.pone.0010899] [PMID: 20526375]
[4]
Maggi, F. Nonvitamin and Nonmineral Nutritional Supplements;; Academic Press, 2019.
[5]
González-Castejón, M.; Visioli, F.; Rodriguez-Casado, A. Diverse biological activities of dandelion. Nutr. Rev., 2012, 70(9), 534-547.
[http://dx.doi.org/10.1111/j.1753-4887.2012.00509.x] [PMID: 22946853]
[6]
Jiao, F.; Tan, Z.; Yu, Z.; Zhou, B.; Meng, L.; Shi, X. The phytochemical and pharmacological profile of taraxasterol. Front. Pharmacol., 2022, 13, 927365.
[7]
Zafar, R.; Sharma, K. Occurrence of taraxerol and taraxasterol in medicinal plants. Pharmacogn. Rev., 2015, 9(17), 19-23.
[http://dx.doi.org/10.4103/0973-7847.156317] [PMID: 26009688]
[8]
Choi, H.S.; Han, J.Y.; Cheong, E.J.; Choi, Y.E. Characterization of a pentacyclic triterpene acetyltransferase involved in the biosynthesis of taraxasterol and ψ-taraxasterol acetates in lettuce. Front. Plant Sci., 2022, 12, 788356.
[http://dx.doi.org/10.3389/fpls.2021.788356] [PMID: 35046976]
[9]
Paşayeva, L.; Fatullayev, H.; Kiliç, Ş.; Üstün, O.; Tugay, O. HPLC-PDA determination of pseudo taraxasterol (ψ-taraxasterol)in different cousinia species. Saglik Bilim. Derg., 2021, 30(1), 17-20.
[http://dx.doi.org/10.34108/eujhs.632581]
[10]
Zhang, X.; Xiong, H.; Li, H.; Cheng, Y. Protective effect of taraxasterol against LPS-induced endotoxic shock by modulating inflammatory responses in mice. Immunopharmacol. Immunotoxicol., 2014, 36(1), 11-16.
[http://dx.doi.org/10.3109/08923973.2013.861482] [PMID: 24286370]
[11]
Li, Z.; Lian, Y.; Wei, R.; Jin, L.; Cao, H.; Zhao, T.; Ma, X.; Zhong, M.; Gao, Y.; Zhang, K. Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways. Life Sci., 2020, 262, 118546.
[http://dx.doi.org/10.1016/j.lfs.2020.118546]
[12]
Ovesná, Z.; Vachálková, A.; Horváthová, K. Taraxasterol and beta-sitosterol: New naturally compounds with chemoprotective/chemopreventive effects. Neoplasma, 2004, 51(6), 407-414.
[PMID: 15640948]
[13]
Deng, P.; Tang, N.; Li, L.; Zou, G.; Xu, Y.; Liu, Z. Diagnostic value of combined detection of IL-1β, IL-6, and TNF-α for sepsis-induced cardiomyopathy. Med. Clin. , 2022, 158(9), 413-417.
[http://dx.doi.org/10.1016/j.medcli.2021.04.025] [PMID: 34147250]
[14]
Yeung, Y.T.; Aziz, F.; Guerrero-Castilla, A.; Arguelles, S. Signaling pathways in inflammation and anti-inflammatory therapies. Curr. Pharm. Des., 2018, 24(14), 1449-1484.
[http://dx.doi.org/10.2174/1381612824666180327165604] [PMID: 29589535]
[15]
Batty, M.; Bennett, M.R.; Yu, E. The role of oxidative stress in atherosclerosis. Cells, 2022, 11(23), 3843.
[http://dx.doi.org/10.3390/cells11233843] [PMID: 36497101]
[16]
Cui, Z.; He, F.; Li, X.; Li, Y.; Huo, C.; Wang, H.; Qi, Y.; Tian, G.; Zong, W.; Liu, R. Response pathways of superoxide dismutase and catalase under the regulation of triclocarban-triggered oxidative stress in Eisenia foetida: Comprehensive mechanism analysis based on cytotoxicity and binding model. Sci. Total Environ., 2023, 854, 158821.
[http://dx.doi.org/10.1016/j.scitotenv.2022.158821] [PMID: 36116645]
[17]
Sies, H.; Berndt, C. Jones, DP Oxidative stress. Annu. Rev. Biochem., 2017, 86, 715-748.
[http://dx.doi.org/10.1146/annurev-biochem-061516-045037]
[18]
Ghoran, S.H.; Babaei, E.; Seresht, H.R.; Karimzadeh, Z. Cytotoxic constituents and molecular docking study of the active triterpenoids from tripleurospermum disciforme (C. A. Mey.) Schultz-Bip. Jundishapur J. Nat. Pharm. Prod., 2019, 15(2)
[19]
Jozova, B.; Novotny, L. Chemopreventivne ucinky prirodnych sterolov a pentacyklickych triterpenov. Vol. 69. Farm. Obz., 2000.
[20]
Ovesná, Z.; Vachálková, A.; Horváthová, K. Taraxasterol and β-sitosterol: New naturally compounds with chemoprotective/chemopreventive effects. Vol. 51. Neoplasma, 2004.
[21]
Jang, D.; Lee, A.H.; Shin, H.Y.; Song, H.R.; Park, J.H.; Kang, T.B.; Lee, S-R.; Yang, S-H. The role of tumor necrosis factor alpha (Tnf-α) in autoimmune disease and current tnf-α inhibitors in therapeutics. Vol. 22. Int. J. Mol. Sci., 2021, 22(5), 2719.
[http://dx.doi.org/10.3390/ijms22052719]
[22]
Kaminsky, L.W.; Al-Sadi, R.; Ma, T.Y. IL-1β and the intestinal epithelial tight junction barrier. Front. Immunol., 2021, 12, 767456.
[http://dx.doi.org/10.3389/fimmu.2021.767456] [PMID: 34759934]
[23]
Pinzon, R.T.; Wijaya, V.O.; Buana, R.B. Interleukin-6 (IL-6) inhibitors as therapeutic agents for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. J. Infect. Public Health, 2021, 14(8), 1001-1009.
[http://dx.doi.org/10.1016/j.jiph.2021.06.004] [PMID: 34153723]
[24]
Ciebiera, M.; Włodarczyk, M.; Wrzosek, M.; Męczekalski, B.; Nowicka, G.; Łukaszuk, K.; Ciebiera, M.; Słabuszewska-Jóźwiak, A.; Jakiel, G. Role of transforming growth factor β in uterine fibroid biology. Int. J. Mol. Sci., 2017, 18(11), 2435.
[http://dx.doi.org/10.3390/ijms18112435]
[25]
Che, L.; Li, Y.; Song, R.; Qin, C.; Hao, W.; Wang, B.; Yang, L.; Peng, P.; Xu, F. Anti inflammatory and anti apoptosis activity of taraxasterol in ulcerative colitis in-vitro and in-vivo. Exp. Ther. Med., 2019, 18(3), 1745-1751.
[http://dx.doi.org/10.3892/etm.2019.7736] [PMID: 31410133]
[26]
Liu, B.; He, Z.; Wang, J.; Xin, Z.; Wang, J.; Li, F.; Fu, Y. Taraxasterol inhibits LPS-induced inflammatory response in BV2 microglia cells by activating LXRα. Front. Pharmacol., 2018, 9(APR), 278.
[http://dx.doi.org/10.3389/fphar.2018.00278]
[27]
Xiong, H.; Cheng, Y.; Zhang, X.; Zhang, X. Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages. J. Ethnopharmacol., 2014, 155(1), 753-757.
[http://dx.doi.org/10.1016/j.jep.2014.06.023] [PMID: 24945401]
[28]
Xu, L; Yu, Y; Sang, R; Li, J; Ge, B; Zhang, X. Protective effects of taraxasterol against ethanol-induced liver injury by regulating CYP2E1/Nrf2/HO-1 and NF-κB signaling pathways in mice. Oxid. Med. Cell Longev., 2018, 2018
[29]
Sang, R.; Yu, Y.; Ge, B.; Xu, L.; Wang, Z.; Zhang, X. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif. Cells Nanomed. Biotechnol., 2019, 47(1), 3929-3937.
[http://dx.doi.org/10.1080/21691401.2019.1671433]
[30]
Xie, Z.; Wang, B.; Zheng, C.; Qu, Y.; Xu, J.; Wang, B.; Gao, Y.; Shen, P. Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway. Acta Biochim. Pol., 2022, 69(4)
[http://dx.doi.org/10.18388/abp.2020_6147]
[31]
Yang, F.; Ye, X.; Chen, M.; Li, H.; Wang, Y.; Zhong, M.; Zhong, C.; Zeng, B.; Xu, L.; He, X.; Ouyang, D. Inhibition of NLRP3 inflammasome activation and pyroptosis in macrophages by taraxasterol is associated with its regulation on mTOR signaling. Front. Immunol., 2021, 12, 632606.
[http://dx.doi.org/10.3389/fimmu.2021.632606] [PMID: 33679781]
[32]
San, Z.; Fu, Y.; Li, W.; Zhou, E.; Li, Y.; Song, X.; Wang, T.; Tian, Y.; Wei, Z.; Yao, M.; Cao, Y.; Zhang, N. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. Int. Immunopharmacol., 2014, 19(2), 342-350.
[http://dx.doi.org/10.1016/j.intimp.2014.01.031] [PMID: 24548765]
[33]
Liu, J.; Xiong, H.; Cheng, Y.; Cui, C.; Zhang, X.; Xu, L.; Zhang, X. Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. J. Ethnopharmacol., 2013, 148(3), 787-793.
[http://dx.doi.org/10.1016/j.jep.2013.05.006] [PMID: 23727181]
[34]
Wang, S.; Wang, Y.; Liu, X.; Guan, L.; Yu, L.; Zhang, X. Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats. J. Ethnopharmacol., 2016, 187, 42-48.
[http://dx.doi.org/10.1016/j.jep.2016.04.031] [PMID: 27109342]
[35]
Chen, J.; Wu, W.; Zhang, M.; Chen, C. Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice. Int. Immunopharmacol., 2019, 70, 274-283.
[http://dx.doi.org/10.1016/j.intimp.2019.02.029]
[36]
Xueshibojie, L.; Duo, Y.; Tiejun, W. Taraxasterol inhibits cigarette smoke-induced lung inflammation by inhibiting reactive oxygen species-induced TLR4 trafficking to lipid rafts. Eur. J. Pharmacol., 2016, 789, 301-307.
[http://dx.doi.org/10.1016/j.ejphar.2016.07.047] [PMID: 27477353]
[37]
Guo, Y.J.; Pan, W.W.; Liu, S.B.; Shen, Z.F.; Xu, Y.; Hu, L.L. ERK/MAPK signalling pathway and tumorigenesis. Exp. Ther. Med., 2020, 19(3), 1997-2007.
[PMID: 32104259]
[38]
Albensi, B.C. What is nuclear factor kappa B (NF-κB) doing in and to the mitochondrion? Vol. 7. Front. Cell Dev. Biol., 2019, 7, 154.
[http://dx.doi.org/10.3389/fcell.2019.00154] [PMID: 31448275]
[39]
Zheng, F.; Dong, X.; Meng, X. Anti-inflammatory effects of taraxasterol on LPS-stimulated human umbilical vein endothelial cells. Inflammation, 2018, 41(5), 1755-1761.
[http://dx.doi.org/10.1007/s10753-018-0818-3] [PMID: 29951871]
[40]
Zhang, X.; Xiong, H.; Liu, L. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J. Ethnopharmacol., 2012, 141(1), 206-211.
[http://dx.doi.org/10.1016/j.jep.2012.02.020] [PMID: 22366673]
[41]
Zhao, L.; Lei, W.; Deng, C.; Wu, Z.; Sun, M.; Jin, Z.; Song, Y.; Yang, Z.; Jiang, S.; Shen, M.; Yang, Y. The roles of liver X receptor α in inflammation and inflammation‐associated diseases. J. Cell. Physiol., 2021, 236(7), 4807-4828.
[http://dx.doi.org/10.1002/jcp.30204]
[42]
Liu, S.Y. Taraxasterol mitigates Con A-induced hepatitis in mice by suppressing interleukin-2 expression and its signaling in T lymphocytes. Int. Immunopharmacol., 2022, 102
[43]
Shan, Z.; Li, Q.; Wang, S.; Qian, Y.; Li, H. Taraxasterol inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells through regulating the p38/STAT3 signaling pathway. Food Sci. Technol., 2022, 42
[44]
Piao, T.; Ma, Z.; Li, X.; Liu, J. Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes. Eur. J. Pharmacol., 2015, 756, 38-42.
[http://dx.doi.org/10.1016/j.ejphar.2015.03.012] [PMID: 25797286]
[45]
Wang, S.; Tang, X. Protective effect of taraxasterol against myocardial damage caused by sepsis through inhibition of toll-like receptor 4/nuclear factor-kappa B signaling pathway. Curr. Top. Nutraceutical Res., 2021, 19(3), 339-344.
[http://dx.doi.org/10.37290/ctnr2641-452X.19:339-344]
[46]
Kalous, K.S.; Wynia-Smith, S.L.; Smith, B.C. Sirtuin oxidative post-translational modifications. Front. Physiol., 2021, 12, 763417.
[http://dx.doi.org/10.3389/fphys.2021.763417] [PMID: 34899389]
[47]
Ahmad, S.; Mahmood, R. Mercury chloride toxicity in human erythrocytes: Enhanced generation of ROS and RNS, hemoglobin oxidation, impaired antioxidant power, and inhibition of plasma membrane redox system. Environ. Sci. Pollut. Res. Int., 2019, 26(6), 5645-5657.
[http://dx.doi.org/10.1007/s11356-018-04062-5] [PMID: 30612358]
[48]
Simanjuntak, EJ Zulham, Z Superoksida Dismutase (SOD) dan radikal bebas. JKF, 2020, 2(2)
[49]
Li, C.; Zheng, Z.; Xie, Y.; Zhu, N.; Bao, J.; Yu, Q.; Zhou, Z.; Liu, J. Protective effect of taraxasterol on ischemia/reperfusion-induced acute kidney injury via inhibition of oxidative stress, inflammation, and apoptosis. Int. Immunopharmacol., 2020, 89(Pt A), 107169.
[http://dx.doi.org/10.1016/j.intimp.2020.107169] [PMID: 33183976]
[50]
Li, H.; Sang, R.; Zhao, X.; Li, C.; Wang, W.; Wang, M.; Ge, B.; Zhang, X. Research Note: Taraxasterol alleviates aflatoxin B1-induced oxidative stress in chicken primary hepatocytes. Poult. Sci., 2023, 102(1), 102286.
[http://dx.doi.org/10.1016/j.psj.2022.102286] [PMID: 36436372]
[51]
He, Y.; Jiang, K.; Zhao, X. Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway. Artif. Cells Nanomed. Biotechnol., 2020, 48(1), 252-258.
[http://dx.doi.org/10.1080/21691401.2019.1699831] [PMID: 31851841]
[52]
Ge, B.; Sang, R.; Wang, W.; Yan, K.; Yu, Y.; Kong, L.; Yu, M.; Liu, X.; Zhang, X. Protection of taraxasterol against acetaminophen-induced liver injury elucidated through network pharmacology and in vitroand in vivo experiments. Phytomedicine, 2023, 116, 154872.
[http://dx.doi.org/10.1016/j.phymed.2023.154872] [PMID: 37209606]
[53]
Bu, C.; Wang, R.; Wang, Y.; Lu, B.; He, S.; Zhao, X. Taraxasterol inhibits hyperactivation of macrophages to alleviate the sepsis-induced inflammatory response of ARDS Rats. Cell Biochem. Biophys., 2022, 80(4), 763-770.
[http://dx.doi.org/10.1007/s12013-022-01092-2] [PMID: 36070121]
[54]
Li, M.; He, Y.; Zhang, W.; Yin, Y.; Jiang, Q.; Loor, J.J.; Wang, J.; Wen, J.; Yang, W.; Xu, C.; Zhang, B. Taraxasterol alleviates fatty acid-induced lipid deposition in calf hepatocytes by decreasing ROS production and endoplasmic reticulum stress. J. Anim. Sci., 2023, 101, skad015.
[http://dx.doi.org/10.1093/jas/skad015] [PMID: 36638067]
[55]
Dall’Acqua, S.; Catanzaro, D.; Cocetta, V.; Igl, N.; Ragazzi, E.; Giron, M.C.; Cecconello, L.; Montopoli, M. Protective effects of ψ taraxasterol 3-O-myristate and arnidiol 3-O-myristate isolated from Calendula officinalis on epithelial intestinal barrier. Fitoterapia, 2016, 109, 230-235.
[http://dx.doi.org/10.1016/j.fitote.2016.01.007] [PMID: 26791917]
[56]
Liu, W.; Yu, Q.; Wang, F.; Li, Y.; Zhang, G.; Tao, S. Taraxasterol attenuates melanoma progression via inactivation of reactive oxygen species-mediated PI3K/Akt signaling pathway. Hum. Exp. Toxicol., 2022, 41, 09603271211069034.
[http://dx.doi.org/10.1177/09603271211069034] [PMID: 35128947]
[57]
Qiu, P.; Xu, T.J.; Lu, X.D.; Yang, W.; Zhang, Y.B.; Xu, G.M. MicroRNA-378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma. Oncol. Lett., 2018, 15(1), 789-794.
[PMID: 29399147]
[58]
Tang, C.T.; Yang, J.; Liu, Z.D.; Chen, Y.; Zeng, C. Taraxasterol acetate targets RNF31 to inhibit RNF31/p53 axis-driven cell proliferation in colorectal cancer. Cell Death Discov., 2021, 7(1), 66.
[http://dx.doi.org/10.1038/s41420-021-00449-5] [PMID: 33824292]
[59]
Bao, T.; Ke, Y.; Wang, Y.; Wang, W.; Li, Y.; Wang, Y.; Kui, X.; Zhou, Q.; Zhou, H.; Zhang, C.; Zhou, D.; Wang, L.; Xiao, C. Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression. J. Mol. Med. , 2018, 96(7), 661-672.
[http://dx.doi.org/10.1007/s00109-018-1652-7] [PMID: 29806073]
[60]
Ren, F.; Zhang, Y.; Qin, Y.; Shang, J.; Wang, Y.; Wei, P.; Guo, J.; Jia, H.; Zhao, T. Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes. Cell Death Discov., 2022, 8(1), 264.
[http://dx.doi.org/10.1038/s41420-022-01059-5] [PMID: 35577774]
[61]
Zhu, J.; Li, X.; Zhang, S.; Liu, J.; Yao, X.; Zhao, Q.; Kou, B.; Han, P.; Wang, X.; Bai, Y.; Zheng, Z.; Xu, C. Taraxasterol inhibits TGF-β1-induced epithelial-to-mesenchymal transition in papillary thyroid cancer cells through regulating the Wnt/β-catenin signaling. Hum. Exp. Toxicol., 2021, 40(12)(Suppl.), S87-S95.
[http://dx.doi.org/10.1177/09603271211023792] [PMID: 34219514]
[62]
Lu, J.; Shuai, B.; Shou, Z.; Guo, W.; Zhou, C.; Ouyang, X.; Zhou, H.; Li, J.; Cui, J.; Jiang, F.; Jin, K.Y.; Sarapultsev, A.; Li, F.; Zhang, G.; Luo, S.; Hu, D. Taraxasterol inhibits tumor growth by inducing apoptosis and modulating the tumor microenvironment in non-small cell lung cancer. Cancers , 2022, 14(19), 4645.
[http://dx.doi.org/10.3390/cancers14194645] [PMID: 36230568]
[63]
Zhao, Y.; Zhang, L.; Guo, M.; Yang, H. Taraxasterol suppresses cell proliferation and boosts cell apoptosis via inhibiting GPD2-mediated glycolysis in gastric cancer. Cytotechnology, 2021, 73(6), 815-825.
[http://dx.doi.org/10.1007/s10616-021-00499-8] [PMID: 34776631]
[64]
Chen, W.; Li, J.; Li, C.; Fan, H.N.; Zhang, J.; Zhu, J.S. Network pharmacology-based identification of the antitumor effects of taraxasterol in gastric cancer. Int. J. Immunopathol. Pharmacol., 2020, 34, 2058738420933107.
[http://dx.doi.org/10.1177/2058738420933107]
[65]
Movahhed, M.; Pazhouhi, M.; Ghaleh, H.; Jalali Kondori, B. Anti-metastatic effect of taraxasterol on prostate cancer cell lines. Res. Pharm. Sci., 2023, 18(4), 439-448.
[http://dx.doi.org/10.4103/1735-5362.378090] [PMID: 37614618]
[66]
Yang, J.; Xin, C.; Yin, G.; Li, J. Taraxasterol suppresses the proliferation and tumor growth of prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway. Sci. Rep., 2023, 13(1), 13072.
[http://dx.doi.org/10.21203/rs.3.rs-2437423/v1]
[67]
Rezaei-Zarchi, S.; Rashidi, I.; Khosravi-Bayangani, S. The effect of dandelion hydro-alcoholic extract and its active constituent on radiosensitivity of glioblastoma cancer cells: An in vitrostudy; World Cancer Res. J., 2023, p. 10.
[68]
Yang, Y.; Ying, G.; Wu, S.; Wu, F.; Chen, Z. In vitro inhibition effects of hepatitis B virus by dandelion and taraxasterol. Infect. Agent. Cancer, 2020, 15(1), 44.
[http://dx.doi.org/10.1186/s13027-020-00309-4] [PMID: 32647534]
[69]
Li, G.; Zhang, D.; Wang, S.; Jie, N.; Qin, Y. Protective role of taraxasterol against cardiovascular aging and aging-induced desensitization of insulin signaling. Front. Biosci., 2022, 27(11), fbl2711311.
[http://dx.doi.org/10.31083/j.fbl2711311]
[70]
Yousefi Ghale-Salimi, M.; Eidi, M.; Ghaemi, N.; Khavari-Nejad, R.A. Antiurolithiatic effect of the taraxasterol on ethylene glycol induced kidney calculi in male rats. Urolithiasis, 2018, 46(5), 419-428.
[http://dx.doi.org/10.1007/s00240-017-1023-9] [PMID: 29189886]
[71]
Hu, R.Y.; Li, B.; Sun, L.; Xu, F.B.; Yang, X.T.; Luo, R. Taraxasterol as a proliferation-enhancing agent to enhance osteogenic differentiation of rat osteoblastic cells. Int. J. Clin. Exp. Med., 2018, 11
[72]
Zhang, Y.; Fu, H.; Zhang, Y.; Wang, D.; Zhao, D.; Zhang, J.; Li, M.; Wang, C. Taraxasterol repairs UVB-induced skin barrier injury through MAPK/NF-κB signaling pathways. Food Agric. Immunol., 2022, 33(1), 604-616.
[http://dx.doi.org/10.1080/09540105.2022.2107619]
[73]
Zhao, M.; Lu, M.; Zeng, Y.; He, S.; Feng, Y.; Yang, S.; Jang, W. Taraxasterol inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt signaling pathway. Nat. Prod. Commun., 2023, 18(3), 1934578X2311540.
[http://dx.doi.org/10.1177/1934578X231154068]
[74]
He, H.; Xu, B.; Ge, P.; Gao, Y.; Wei, M.; Li, T.; Zhang, R.; Li, B.; Cao, H.; Zhang, K. The effects of taraxasterol on liver fibrosis revealed by RNA sequencing. Int. Immunopharmacol., 2023, 114, 109481.
[http://dx.doi.org/10.1016/j.intimp.2022.109481] [PMID: 36470119]
[75]
Yang, K.; Zhang, Y. Reversal of heavy metal-induced antibiotic resistance by dandelion root extracts and taraxasterol. J. Med. Microbiol., 2020, 69(8), 1049-1061.
[http://dx.doi.org/10.1099/jmm.0.001226] [PMID: 32602832]

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