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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

Bioinformatics-based Analysis of the Variability of MPOX Virus Proteins

Author(s): Carlos Polanco*, Alberto Huberman, Enrique Hernandez Lemus, Vladimir N. Uversky, Martha Rios Castro, Mireya Martinez Garcia, Gilberto Vargas-Alarcon, Thomas Buhse, Claudia Pimentel Hernández, Cecilia Zazueta, Francisco J. Roldan Gomez and Erika Jeannette López Oliva

Volume 21, Issue 15, 2024

Published on: 08 November, 2023

Page: [3169 - 3185] Pages: 17

DOI: 10.2174/0115701808260478231023080842

Price: $65

Abstract

Background: Previously restricted to remote areas of Central and Western Africa, the MPOX virus-based disease, also known as monkeypox, has now spread to more than 90 countries and has become endemic. As a consequence, the MPOX virus has become a global public health concern.

Objective: The objective of this study was to conduct a computational-multiparametric study (at the genomic and proteomic levels) of the biological sequences that express the MPOX virus envelopes in order to fathom the physicochemical regularities of these proteins.

Methods: Using computer programs, we determined the polarity index method (PIM) profile and protein intrinsic disorder predisposition (PIDP) for each studied protein.

Results: The UniProt database was able to identify sequences similar to those of the MPOX virus expressed thanks to the computational regularities found in the virus' envelope sequences.

Conclusion: The polarity index method and protein intrinsic disorder predisposition profiles could aid in elucidating the sequence-level structural regularities of the MPOX virus envelopes.

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