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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

From Plants to Therapies: Exploring the Pharmacology of Coumestrol for Neurological Conditions

In Press, (this is not the final "Version of Record"). Available online 26 October, 2023
Author(s): Madhav Singla, Smriti Verma, Kiran Thakur, Ahsas Goyal, Vishal Sharma, Diksha Sharma, Omji Porwal, Vetriselvan Subramaniyan, Tapan Behl, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta* and Saurabh Gupta*
Published on: 26 October, 2023

DOI: 10.2174/0109298673250784231011094322

Price: $95

Abstract

Neurological disorders are possibly the most prevalent and have been identified to occur among individuals with autism beyond chance. These disorders encompass a diverse range of consequences with neurological causes and have been regarded as a major threat to public mental health. There is no tried-and-true approach for completely protecting the nervous system. Therefore, plant-derived compounds have developed significantly nowadays. Coumestrol (CML) is a potent isoflavone phytoestrogen with a protective effect against neurological dysfunction and has been discovered to be structurally and functionally similar to estrogen. In recent years, more research has been undertaken on phytoestrogens. This research demonstrates the biological complexity of phytoestrogens, which consist of multiple chemical families and function in various ways. This review aimed to explore recent findings on the most significant pharmacological advantages of CML by emphasising neurological benefits. Numerous CML extraction strategies and their pharmacological effects on various neurological disorders, including PD, AD, HD, anxiety, and cognitive impairments, were also documented.

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