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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Review Article

The Role of Neuronal Pathways in Gastrointestinal Cancers: Targets for Prevention and Treatment

Author(s): Mohadeseh Poudineh, Samaneh Mollazadeh, Shima Mehrabadi, Majid Khazaei, Seyed Mahdi Hassanian and Amir Avan*

Volume 21, Issue 14, 2024

Published on: 18 October, 2023

Page: [2875 - 2890] Pages: 16

DOI: 10.2174/0115701808258045231010102318

Price: $65

Abstract

In recent decades, the mortality and morbidity of Gastrointestinal (GI) cancer have remarkably increased, especially in younger individuals. Recent studies revealed that neuronal connections play an active part in GI tumor initiation and progression. Also, studies showed neurotransmitters and neuropeptides drive the activation of various oncogenic pathways downstream of neural receptors within cancer cells, underscoring the importance of neural signaling pathways in GI tumor malignancy. These studies show that the humoral and nervous pathways can transfer signals of tumors to the brain. But, the exact mechanism of this regulation from the brain to the gut is still unknown. In this review, we summarized the mechanism of the neuronal pathway in the regulation of promotion or suppression of GI cancer and oncogene activation, and we summarize recent findings linking the nervous system to GI tumor progression and highlight the importance of targeting neural mechanisms in GI tumor therapy

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