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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Bacterial Polyhydroxyalkanoates-based Therapeutics-delivery Nano-systems

Author(s): Esteban F. Durán-Lara*, Diana Rafael, Fernanda Andrade, Olga Lobos G. and Sekar Vijayakumar

Volume 31, Issue 36, 2024

Published on: 11 October, 2023

Page: [5884 - 5897] Pages: 14

DOI: 10.2174/0109298673268775231003111540

Price: $65

Abstract

Microbial polyhydroxyalkanoates (PHAs) are bio-based aliphatic biopolyester produced by bacteria as an intracellular storage material of carbon and energy under stressed conditions. PHAs have been paid attention to due to their unique and impressive biological properties including high biodegradability, biocompatibility, low cytotoxicity, and different mechanical properties. Under this context, the development of drug-delivery nanosystems based on PHAs has been revealed to have numerous advantages compared with synthetic polymers that included biocompatibility, biodegradability, non-toxic, and low-cost production, among others. In this review article, we present the available state of the art of PHAs. Moreover, we discussed the potential benefits, weaknesses, and perspectives of PHAs to the develop drug delivery systems.

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