Abstract
Recent developments of biocatalytic reduction of carbonyl groups are reviewed. Methods to find, prepare and modify the biocatalysts and to improve productivity and enantioselectivity of the reactions are explained. Then, practical applications for the asymmetric reduction of carbonyl compounds with various functionalities are given, including the synthesis of pharmaceutically important compounds.
Keywords: glutathione S-transferase (GST), Redox Reaction, overexpression, Cofactor-Regenerating Enzymes, Molecular hydrogen, Geotrichum candidum
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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