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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

Coriandrum sativum and Aloysia triphylla can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay

Author(s): Omar F. Khabour, Sawsan Abuhammad, Karem H. Alzoubi* and Ahmad S. Alkofahi

Volume 24, Issue 4, 2024

Published on: 21 September, 2023

Page: [455 - 462] Pages: 8

DOI: 10.2174/1568009623666230817101757

Abstract

Aim: The aim of this study is to examine the protective properties of Coriandrum sativum and Aloysia triphylla against the development of skin cancer.

Methods: The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).

Results: The study found that A. triphylla extract reduced both tumor incidence (P<0.01) and papilloma frequency (P<0.001) and delayed the onset of tumor development (P<0.001). The A. triphylla extract did not affect tumor size in animals. C. sativum leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (P<0.05). In addition, it delayed (P<0.01) the onset of tumors. Treatment of animals with C. sativum seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (P<0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (P>0.05).

Conclusion: The findings of this study revealed that C. sativum and A. triphylla could protect against cancer development as indicated using the animal model of skin painting assay.

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[1]
Afifi, R.; Khabour, O.F. Antibacterial activity of the Saudi Red Sea sponges against gram-positive pathogens. J. King Saud Univ. Sci., 2019, 31(4), 753-757.
[http://dx.doi.org/10.1016/j.jksus.2017.08.009]
[2]
Banihani, S.A.; Makahleh, S.M.; El-Akawi, Z.; Al-Fashtaki, R.A.; Khabour, O.F.; Gharibeh, M.Y.; Saadah, N.A.; Al-Hashimi, F.H.; Al-Khasieb, N.J. Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutr. Res., 2014, 34(10), 862-867.
[http://dx.doi.org/10.1016/j.nutres.2014.08.003] [PMID: 25223711]
[3]
Murali, C.; Mudgil, P.; Gan, C.Y.; Tarazi, H.; El-Awady, R.; Abdalla, Y.; Amin, A.; Maqsood, S. Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma. Sci. Rep., 2021, 11(1), 7062.
[http://dx.doi.org/10.1038/s41598-021-86391-z] [PMID: 33782460]
[4]
Mattiuzzi, C.; Lippi, G. Cancer statistics: A comparison between World Health Organization (WHO) and Global Burden of Disease (GBD). Eur. J. Public Health, 2020, 30(5), 1026-1027.
[http://dx.doi.org/10.1093/eurpub/ckz216] [PMID: 31764976]
[5]
Cortes, J.; Perez-García, J.M.; Llombart-Cussac, A.; Curigliano, G.; El Saghir, N.S.; Cardoso, F.; Barrios, C.H.; Wagle, S.; Roman, J.; Harbeck, N.; Eniu, A.; Kaufman, P.A.; Tabernero, J.; García-Estévez, L.; Schmid, P.; Arribas, J. Enhancing global access to cancer medicines. CA Cancer J. Clin., 2020, 70(2), 105-124.
[http://dx.doi.org/10.3322/caac.21597] [PMID: 32068901]
[6]
Hull, M.A. Nutritional prevention of colorectal cancer. Proc. Nutr. Soc., 2021, 80(1), 59-64.
[http://dx.doi.org/10.1017/S0029665120000051] [PMID: 32019626]
[7]
Nasir, A.; Bullo, M.M.H.; Ahmed, Z.; Imtiaz, A.; Yaqoob, E.; Safdar, M.; Ahmed, H.; Afreen, A.; Yaqoob, S. Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review. Crit. Rev. Food Sci. Nutr., 2020, 60(8), 1375-1387.
[http://dx.doi.org/10.1080/10408398.2019.1571480] [PMID: 30729798]
[8]
Abdalla, A.; Murali, C.; Amin, A. Safranal inhibits angiogenesis via targeting HIF-1α/VEGF Machinery: In vitro and ex vivo insights. Front. Oncol., 2022, 11, 789172.
[http://dx.doi.org/10.3389/fonc.2021.789172] [PMID: 35211395]
[9]
Lichota, A.; Gwozdzinski, K. Anticancer activity of natural compounds from plant and marine environment. Int. J. Mol. Sci., 2018, 19(11), 3533.
[http://dx.doi.org/10.3390/ijms19113533] [PMID: 30423952]
[10]
Juaid, N.; Amin, A.; Abdalla, A.; Reese, K.; Alamri, Z.; Moulay, M.; Abdu, S.; Miled, N. Anti-hepatocellular carcinoma biomolecules: Molecular targets insights. Int. J. Mol. Sci., 2021, 22(19), 10774.
[http://dx.doi.org/10.3390/ijms221910774] [PMID: 34639131]
[11]
Bechoux, L.; De Vleeschouwer, O.; Vanheuverzwijn, C.; Verhegghen, F.; Detiffe, A.; Colle, F.; Fallon, C.; Thoreau, F. Conflict of interest policies at Belgian medical faculties: Cross-sectional study indicates little oversight. PLoS One, 2021, 16(2), e0245736.
[http://dx.doi.org/10.1371/journal.pone.0245736] [PMID: 33566836]
[12]
Oukerrou, M. A.; Tilaoui, M. Chemical composition and cytotoxic and antibacterial activities of the essential oil of Aloysia citriodora palau grown in morocco. Adv. Pharmacol. Pharmaceut. Sci., 2017, 2017, 10.
[http://dx.doi.org/10.1155/2017/7801924]
[13]
Rojas, J.; Palacios, O.; Ronceros, S. [The effect of the essential oil from Aloysia triphylla britton (lemon verbena) on Trypanosoma cruzi in mice]. Rev. Peru. Med. Exp. Salud Publica, 2012, 29(1), 61-68.
[http://dx.doi.org/10.1590/S1726-46342012000100009] [PMID: 22510908]
[14]
Lenoir, L.; Joubert-Zakeyh, J.; Texier, O.; Lamaison, J.L.; Vasson, M.P.; Felgines, C. Aloysia triphylla infusion protects rats against dextran sulfate sodium-induced colonic damage. J. Sci. Food Agric., 2012, 92(7), 1570-1572.
[http://dx.doi.org/10.1002/jsfa.5544] [PMID: 22190244]
[15]
Ponce-Monter, H.; Fernández-Martínez, E.; Ortiz, M. I.; Ramírez-Montiel, M. L.; Cruz-Elizalde, D.; Pérez-Hernández, N.; Cariño-Cortés, R. Spasmolytic and anti-inflammatory effects of Aloysia triphylla and citral, in vitro and in vivo studies. J Smooth Muscle Res., 2010, 46(6), 309-19.
[16]
Laribi, B.; Kouki, K.; M’Hamdi, M.; Bettaieb, T. Coriander (Coriandrum sativum L.) and its bioactive constituents. Fitoterapia, 2015, 103, 9-26.
[http://dx.doi.org/10.1016/j.fitote.2015.03.012] [PMID: 25776008]
[17]
Prachayasittikul, V.; Prachayasittikul, S.; Ruchirawat, S.; Prachayasittikul, V. Coriander (Coriandrum sativum): A promising functional food toward the well-being. Food Res. Int., 2018, 105, 305-323.
[http://dx.doi.org/10.1016/j.foodres.2017.11.019] [PMID: 29433220]
[18]
Asgarpanah, J.; Kazemivash, N. Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L. Chin. J. Integr. Med., 2013, 19(2), 153-159.
[http://dx.doi.org/10.1007/s11655-013-1354-5] [PMID: 23371463]
[19]
Padmaa, M. Coriandrum sativum linn: A review. Pharmacol. online Newsl., 2009, 3, 561-573.
[20]
Sreelatha, S.; Padma, P. R.; Umadevi, M. Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. Food Chem. Toxicol., 2009, 47(4), 702-8.
[21]
Zamorano-Ponce, E.; Morales, C.; Ramos, D.; Sepúlveda, C.; Cares, S.; Rivera, P.; Fernández, J.; Carballo, M.A. Anti-genotoxic effect of Aloysia triphylla infusion against acrylamide-induced DNA damage as shown by the comet assay technique. Mutat. Res. Genet. Toxicol. Environ. Mutagen., 2006, 603(2), 145-150.
[http://dx.doi.org/10.1016/j.mrgentox.2005.11.009] [PMID: 16413820]
[22]
Talapatra, S.N.; Dasgupta, S.; Guha, G.; Auddy, M.; Mukhopadhyay, A. Therapeutic efficacies of Coriandrum sativum aqueous extract against metronidazole-induced genotoxicity in Channa punctatus peripheral erythrocytes. Food Chem. Toxicol., 2010, 48(12), 3458-3461.
[http://dx.doi.org/10.1016/j.fct.2010.09.021] [PMID: 20858524]
[23]
Zamorano-Ponce, E.; Fernández, J.; Vargas, G.; Rivera, P.; Carballo, M.A. Protective activity of cedron (Aloysia triphylla) infusion over genetic damage induced by cisplatin evaluated by the comet assay technique. Toxicol. Lett., 2004, 152(1), 85-90.
[http://dx.doi.org/10.1016/j.toxlet.2004.04.002] [PMID: 15294350]
[24]
Park, G.; Kim, H.G.; Kim, Y.O.; Park, S.H.; Kim, S.Y.; Oh, M.S. Coriandrum sativum L. protects human keratinocytes from oxidative stress by regulating oxidative defense systems. Skin Pharmacol. Physiol., 2012, 25(2), 93-99.
[http://dx.doi.org/10.1159/000335257] [PMID: 22301773]
[25]
Sreelatha, S.; Inbavalli, R. Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats. J. Food Sci., 2012, 77(7), T119-T123.
[http://dx.doi.org/10.1111/j.1750-3841.2012.02755.x] [PMID: 22671941]
[26]
Gopalakrishnan, T.; Ganapathy, S.; Veeran, V.; Namasivayam, N. Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events. Biomed. Pharmacother., 2019, 111, 178-187.
[27]
H Alzoubi, K.; F Khabour, O.; S Alkofahi, A.; M Mhaidat, N.; A Abu-Siniyeh, A. Anticancer and antimutagenic activity of Silybum marianum L. and Eucalyptus camaldulensis Dehnh. against skin cancer induced by DMBA: In vitro and in vivo models. Pak. J. Pharm. Sci., 2021, 34(3), 987-993.
[PMID: 34602423]
[28]
Alkofahi, A.S.; Abdul-Razzak, K.K.; Alzoubi, K.H.; Khabour, O.F. Report - Screening of the Anti-hyperglycemic activity of some medicinal plants of Jordan. Pak. J. Pharm. Sci., 2017, 30(3), 907-912.
[PMID: 28653938]
[29]
Roemer, E.; Ottmueller, T.H.; Urban, H.J.; Baillet-Mignard, C. SKH-1 mouse skin painting: A short-term assay to evaluate the tumorigenic activity of cigarette smoke condensate. Toxicol. Lett., 2010, 192(2), 155-161.
[http://dx.doi.org/10.1016/j.toxlet.2009.10.019] [PMID: 19854249]
[30]
Sancheti, G.; Goyal, P. Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis. Asian Pac. J. Cancer Prev., 2006, 7(2), 331-335.
[PMID: 16839234]
[31]
Gaworski, C.L.; Heck, J.D.; Bennett, M.B.; Wenk, M.L. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: Skin painting bioassay of cigarette smoke condensate in SENCAR mice. Toxicology, 1999, 139(1-2), 1-17.
[http://dx.doi.org/10.1016/S0300-483X(99)00094-3] [PMID: 10614684]
[32]
Roemer, F.W.; Kassim Javaid, M.; Guermazi, A.; Thomas, M.; Kiran, A.; Keen, R.; King, L.; Arden, N.K. Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI. Osteoarthritis Cartilage, 2010, 18(10), 1269-1274.
[http://dx.doi.org/10.1016/j.joca.2010.07.008] [PMID: 20691796]
[33]
Sancheti, G.; Goyal, P.K. Effect of rosmarinus officinalis in modulating 7,12-dimethylbenz(a)anthracene induced skin tumorigenesis in mice. Phytother. Res., 2006, 20(11), 981-986.
[http://dx.doi.org/10.1002/ptr.1989] [PMID: 16927448]
[34]
Singleton, V.L.; Rossi, J.A., Jr Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic., 1965, 16(3), 144-158.
[http://dx.doi.org/10.5344/ajev.1965.16.3.144]
[35]
Tsao, A.S.; Kim, E.S.; Hong, W.K. Chemoprevention of cancer. CA Cancer J. Clin., 2004, 54(3), 150-180.
[http://dx.doi.org/10.3322/canjclin.54.3.150] [PMID: 15195789]
[36]
Ahmad, R.; Khan, M.A.; Srivastava, A.N.; Gupta, A.; Srivastava, A.; Jafri, T.R.; Siddiqui, Z.; Chaubey, S.; Khan, T.; Srivastava, A.K. Anticancer potential of dietary natural products: A comprehensive review. Anticancer. Agents Med. Chem., 2020, 20(2), 122-236.
[http://dx.doi.org/10.2174/1871520619666191015103712] [PMID: 31749433]
[37]
Ding, X.; Chen, H. Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion. J BUON., 2018, 23(3), 747-751.
[PMID: 30003746]
[38]
Vinothkumar, R.; Sudha, M.; Viswanathan, P.; Kabalimoorthy, J.; Balasubramanian, T.; Nalini, N. Modulating effect of D -carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis. Cell Prolif., 2013, 46(6), 705-720.
[http://dx.doi.org/10.1111/cpr.12062] [PMID: 24118219]
[39]
Tang, E.L.H.; Rajarajeswaran, J.; Fung, S.Y.; Kanthimathi, M.S. Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration. BMC Complement. Altern. Med., 2013, 13(1), 347.
[http://dx.doi.org/10.1186/1472-6882-13-347] [PMID: 24517259]
[40]
Crabas, N.; Marongiu, B.; Piras, A.; Pivetta, T.; Porcedda, S. Extraction, separation and isolation of volatiles and dyes from Calendula officinalis L. and Aloysia triphylla (L’Her.) Britton by supercritical CO2. J. Essent. Oil Res., 2003, 15(4), 272-277.
[http://dx.doi.org/10.1080/10412905.2003.9712141]
[41]
Gautam, N.; Mantha, A. K.; Mittal, S. Essential oils and their constituents as anticancer agents: A mechanistic view. Biomed. Res. Int., 2014, 2014, 154106.
[http://dx.doi.org/10.1155/2014/154106]
[42]
Gil, A.; Van Baren, C.M.; Di Leo Lira, P.M.; Bandoni, A.L. Identification of the genotype from the content and composition of the essential oil of lemon verbena (Aloysia citriodora Palau). J. Agric. Food Chem., 2007, 55(21), 8664-8669.
[http://dx.doi.org/10.1021/jf0708387] [PMID: 17880159]
[43]
Freires, I.A.; Murata, R.M.; Furletti, V.F.; Sartoratto, A.; Alencar, S.M.; Figueira, G.M.; de Oliveira Rodrigues, J.A.; Duarte, M.C.T.; Rosalen, P.L. Coriandrum sativum L. (Coriander) essential oil: Antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression. PLoS One, 2014, 9(6), e99086.
[http://dx.doi.org/10.1371/journal.pone.0099086] [PMID: 24901768]
[44]
Khazdair, M.R.; Anaeigoudari, A.; Hashemzehi, M.; Mohebbati, R. Neuroprotective potency of some spice herbs, a literature review. J. Tradit. Complement. Med., 2019, 9(2), 98-105.
[http://dx.doi.org/10.1016/j.jtcme.2018.01.002] [PMID: 30963044]
[45]
Donaldson, J.R.; Cates, R.G. Screening for anticancer agents from Sonoran desert plants: A chemical ecology approach. Pharm. Biol., 2004, 42(7), 478-487.
[http://dx.doi.org/10.3109/13880200490891287]
[46]
Abderrahim, F.; Estrella, S.; Susín, C.; Arribas, S.M.; González, M.C.; Condezo-Hoyos, L. The antioxidant activity and thermal stability of lemon verbena (Aloysia triphylla) infusion. J. Med. Food, 2011, 14(5), 517-527.
[http://dx.doi.org/10.1089/jmf.2010.0102] [PMID: 21434775]
[47]
Rashid, H.M.; Mahmod, A.I.; Afifi, F.U.; Talib, W.H. Antioxidant and antiproliferation activities of lemon verbena (Aloysia citrodora): An in vitro and in vivo Study. Plants, 2022, 11(6), 785.
[http://dx.doi.org/10.3390/plants11060785] [PMID: 35336667]

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