Title:Recent Advances in Drug Delivery Approaches for Rheumatoid Arthritis
Volume: 31
Author(s): Abhishek Verma, Preeti Patel, Waleed Hassan Almalki, Amirhossein Sahebkar*, Balak Das Kurmi*Prashant Kesharwani*
Affiliation:
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University
of Medical Sciences, Mashhad, Iran
- Applied Biomedical Research Center, Mashhad University of
Medical Sciences, Mashhad, Iran
- Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga,
142001, Punjab, India
- Department of Pharmaceutics, School of Pharmaceutical Education and Research,
Jamia Hamdard, New Delhi, 110062, India
- Center for Transdisciplinary Research, Department of
Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, India
- University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India
Abstract: Morbidity, disability, and healthcare expenses associated with rheumatoid
arthritis (RA) impose a considerable health and economical burden on both patients and
healthcare systems. This review aimed to examine the pathophysiological aspects of RA
that may help design different types of drugs and drug delivery systems. These include
monoclonal antibodies, immunoglobulins, tiny chemicals, and transgenes for gene therapy.
These novel nanocarrier-based therapies target the underlying biological processes involved
in RA while minimizing the systemic adverse effects of drugs.