The Chiptip: A Novel Tool for Automated Patch Clamp

Title: The Chiptip: A Novel Tool for Automated Patch Clamp

Volume: 12 Issue: 1

Author(s): Andjelko Golubovic, Martina Knirsch, Uwe Czubayko, Alexander Hummer, Albrecht Lepple-Wienhues and Dirck Lassen

Affiliation:

Keywords: ligand gated channel, voltage gated channel, membrane protein, glass micropipettes, automated patch clamp, Ion channel

Abstract: To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 μL. This apparatus is suitable for the study small cells, subcellular organelles and bacteria.

Cite this article as:

Golubovic Andjelko, Knirsch Martina, Czubayko Uwe, Hummer Alexander, Lepple-Wienhues Albrecht and Lassen Dirck, The Chiptip: A Novel Tool for Automated Patch Clamp, Combinatorial Chemistry & High Throughput Screening 2009; 12 (1) . https://dx.doi.org/10.2174/138620709787047984