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Current Pharmacogenomics and Personalized Medicine

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ISSN (Print): 1875-6921
ISSN (Online): 1875-6913

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Regulatory Role, Mechanism, and Metabolic Profile of BIOTIN in Gene Expression

Author(s): Ankita Wal, Abhijit Sasmal, Riya Singh, Princy Yadav, Yogesh Singh, Vipin Garg and Pranay Wal*

Volume 20, Issue 2, 2023

Published on: 24 July, 2023

Page: [73 - 86] Pages: 14

DOI: 10.2174/1875692120666230712160812

Price: $65

Abstract

Biotin, a vitamin that is water-soluble, is part of the vitamin B complex and is required by all living things, including humans. Biotin-dependent carboxylases are a prosthetic group of enzymes, and biotin catalyzes essential processes in the production of fatty acids, the breakdown of amino acids, and gluconeogenesis in eukaryotic cells. The role of biotin as the prosthetic group of the four biotin-dependent carboxylases is well understood in higher animals. Based on the roles of these carboxylases in metabolism, it was discovered that biotin is required for cell survival, proliferation, and differentiation. Biotin appears to play a role in cell function and has a spermatogenic impact. Biotin has been found to have a direct impact on the transcription of important enzymes in glucose metabolism. Glucokinase and phosphoenolpyruvate carboxykinase are glycolytic enzymes that biotin controls (PEPCK). Biotin appears to be involved in gene control, which may explain some of its functions regarding fetal development and cellular biology. According to investigations using microarrays as well as other types of gene expression, biotin appears to affect the transcription of genes encoding cytokines and their receptors, glucose metabolism genes, and genes involved in cellular biotin homeostasis. A biotin shortage has a considerable effect on gene expression in numerous tissues and cells, according to a microarray study. Biotin supplementation affects the expression of several genes depending on the tissue, demonstrating that gene expression differences reflect tissue function. Biotin affects energy, lipid, and glucose metabolism, according to metabolite research, which has improved our understanding of the biotin metabolic pathway. Using microarray and transcriptome analysis, this research investigates the effect of biotin on gene expression.

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