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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Review Article

Review on Determination of Berberine in Biological and Pharmaceutical Matrices: An Analytical and Therapeutic Perspective

Author(s): Umang Shah*, Meghana Patel, Alkesh Patel, Krishna Patel, Mehul Patel, Ashok Akabari, Samir Patel, Veena Patel, Rajesh Maheshwari, Ashim Sen and Neeraj Kumar Sethiya

Volume 19, Issue 5, 2023

Published on: 26 May, 2023

Page: [379 - 398] Pages: 20

DOI: 10.2174/1573412919666230505095457

Price: $65

Abstract

Berberine (BRB) is a natural alkaloid of the isoquinoline class, mostly isolated from the Berberis genus, which exhibits antibiotic, immunostimulant, antitumor, cardiovascular protection, endocrine regulator, antidepressant, neuroprotective, antioxidant, anti-inflammatory, and other pharmacological properties. The poor aqueous solubility of BRB is one roadblock in scaling up activities for the clinical drug. However, this can be overcome by its chemical modification into salt form. Extraction of this biologically beneficial component becomes one of the important aspects, and for that, several extraction techniques are available using a variety of solvents. Numerous analytical methods are reported for the quantification of extracted BRB as well as simultaneous estimation of BRB in the presence of other components. Among them, RP-HPLC, LC/MS, and UPLC/MS are the most frequently used methods. The effectiveness and preciseness of these advanced methods could be the reason for analysts’ preferred choice for analysis.

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[1]
Li, T.; Wang, P.; Guo, W.; Huang, X.; Tian, X.; Wu, G.; Xu, B.; Li, F.; Yan, C.; Liang, X.J.; Lei, H. Natural berberine-based chinese herb medicine assembled nanostructures with modified antibacterial application. ACS Nano, 2019, 13(6), 6770-6781.
[http://dx.doi.org/10.1021/acsnano.9b01346] [PMID: 31135129]
[2]
Chueh, W.H.; Lin, J.Y. Berberine, an isoquinoline alkaloid in herbal plants, protects pancreatic islets and serum lipids in nonobese diabetic mice. J. Agric. Food Chem., 2011, 59(14), 8021-8027.
[http://dx.doi.org/10.1021/jf201627w] [PMID: 21696141]
[3]
Mohan, M.C.; Abhimannue, A.P.; Kumar, B.P. Identification and characterization of berberine in tinospora cordifolia by liquid chromatography quadrupole time of flight mass spectrometry (LC MS/MS Q-tof) and evaluation of its anti inflammatory potential. Pharmacogn. J., 2017, 9(3), 350-355.
[http://dx.doi.org/10.5530/pj.2017.3.59]
[4]
Mohammadzadeh, N.; Mehri, S.; Hosseinzadeh, H. Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities. Iran. J. Basic Med. Sci., 2017, 20(5), 538-551.
[PMID: 28656089]
[5]
Burkhart, E.P.; Zuiderveen, G.H. Wild Goldenseal (Hydrastis canadensis) rhizome/root alkaloid content in relation to colony and harvest stage. J. Herbs Spices Med. Plants, 2019, 25(2), 128-140.
[http://dx.doi.org/10.1080/10496475.2019.1577322]
[6]
Neag, M.A.; Mocan, A.; Echeverría, J.; Pop, R.M.; Bocsan, C.I.; Crişan, G.; Buzoianu, A.D.; Berberine Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders. Front. Pharmacol., 2018, 9, 557.
[http://dx.doi.org/10.3389/fphar.2018.00557] [PMID: 30186157]
[7]
Xu, K.; He, G.; Qin, J.; Cheng, X.; He, H.; Zhang, D.; Peng, W. High-efficient extraction of principal medicinal components from fresh Phellodendron bark (cortex phellodendri). Saudi J. Biol. Sci., 2018, 25(4), 811-815.
[http://dx.doi.org/10.1016/j.sjbs.2017.10.008] [PMID: 29740248]
[8]
Meng, F.C.; Wu, Z.F.; Yin, Z.Q.; Lin, L.G.; Wang, R.; Zhang, Q.W. Coptidis rhizoma and its main bioactive components: Recent advances in chemical investigation, quality evaluation and pharmacological activity. Chin. Med., 2018, 13(1), 13.
[http://dx.doi.org/10.1186/s13020-018-0171-3] [PMID: 29541156]
[9]
Yashiki, K.; Kiso, A.; Zhou, Y.Y.; Iwasaki, D.; Kambara, T.; Mizutani, K. The Effects of Coptis Japonica root extract and its key component, berberine, on human subcutaneous adipocytes. J. Soc. Cosmet. Chem. Japan, 2009, 43(4), 274-280.
[http://dx.doi.org/10.5107/sccj.43.274]
[10]
Kobayashi, Y.; Hara, M.; Fukui, H.; Tabata, M. The role of ethylene in berberine production byThalictrum minus cell suspension cultures. Phytochemistry, 1991, 30(11), 3605-3609.
[http://dx.doi.org/10.1016/0031-9422(91)80075-C]
[11]
Malhotra, B.; Kulkarni, G.T.; Dhiman, N.; Joshi, D.D.; Chander, S.; Kharkwal, A.; Sharma, A.K.; Kharkwal, H. Recent advances on Berberis aristata emphasizing berberine alkaloid including phytochemistry, pharmacology and drug delivery system. J. Herb. Med., 2021, 27, 100433.
[http://dx.doi.org/10.1016/j.hermed.2021.100433]
[12]
Roy, N.S.; Choi, I.Y.; Um, T.; Jeon, M.J.; Kim, B.Y.; Kim, Y.D.; Yu, J.K.; Kim, S.; Kim, N.S. Gene expression and isoform identification of pacbio full-length cdna sequences for berberine biosynthesis in Berberis koreana. Plants, 2021, 10(7), 1314.
[http://dx.doi.org/10.3390/plants10071314] [PMID: 34203474]
[13]
Hayashi, K.; Minoda, K.; Nagaoka, Y.; Hayashi, T.; Uesato, S. Antiviral activity of berberine and related compounds against human cytomegalovirus. Bioorg. Med. Chem. Lett., 2007, 17(6), 1562-1564.
[http://dx.doi.org/10.1016/j.bmcl.2006.12.085] [PMID: 17239594]
[14]
Birdsall, T.C.; Kelly, G.S. Berberine: Therapeutic potential of an alkaloid found in several medicinal plants. Altern. Med. Rev., 1997, 2, 94-103.
[15]
Taylor, C.T.; Winter, D.C.; Skelly, M.M.; O’Donoghue, D.P.; O’Sullivan, G.C.; Harvey, B.J.; Baird, A.W. Berberine inhibits ion transport in human colonic epithelia. Eur. J. Pharmacol., 1999, 368(1), 111-118.
[http://dx.doi.org/10.1016/S0014-2999(99)00023-0] [PMID: 10096776]
[16]
Bessi, I.; Bazzicalupi, C.; Richter, C.; Jonker, H.R.A.; Saxena, K.; Sissi, C.; Chioccioli, M.; Bianco, S.; Bilia, A.R.; Schwalbe, H.; Gratteri, P. Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA. ACS Chem. Biol., 2012, 7(6), 1109-1119.
[http://dx.doi.org/10.1021/cb300096g] [PMID: 22486369]
[17]
Li, Y.; Huang, J.; Liu, J.; Deng, S.; Lu, X. Adsorption of Berberine hydrochloride, ligustrazine hydrochloride, colchicine, and matrine alkaloids on macroporous resins. J. Chem. Eng. Data, 2013, 58(5), 1271-1279.
[http://dx.doi.org/10.1021/je400057w]
[18]
Fan, J.; Zhang, K.; Jin, Y.; Li, B.; Gao, S.; Zhu, J.; Cui, R. Pharmacological effects of berberine on mood disorders. J. Cell. Mol. Med., 2019, 23(1), 21-28.
[http://dx.doi.org/10.1111/jcmm.13930] [PMID: 30450823]
[19]
Cui, H-M.; Zhang, Q-Y.; Wang, J-L.; Chen, J-L.; Zhang, Y-L.; Tong, X.-L. In Vitro Studies of Berberine Metabolism and Its Effect of Enzyme Induction on HepG2 Cells. J. Ethnopharmacol., 2014, 158(Pt A), 388-396.
[20]
Guo, Y.; Pope, C.; Cheng, X.; Zhou, H.; Klaassen, C.D. Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. J. Ethnopharmacol., 2011, 138(1), 111-118.
[http://dx.doi.org/10.1016/j.jep.2011.08.058] [PMID: 21920422]
[21]
Marek, R.; Sečkářová, P.; Hulová, D.; Marek, J.; Dostál, J.; Sklenář, V. Palmatine and berberine isolation artifacts. J. Nat. Prod., 2003, 66(4), 481-486.
[http://dx.doi.org/10.1021/np0204996] [PMID: 12713397]
[22]
Grycová, L.; Dostál, J.; Marek, R. Quaternary protoberberine alkaloids. Phytochemistry, 2007, 68(2), 150-175.
[http://dx.doi.org/10.1016/j.phytochem.2006.10.004] [PMID: 17109902]
[23]
Babu, H.N.; Thriveni, H.N.; Vasudeva, R. Influence of drying methods and extraction procedures on the recovery of berberine content in Coscinium fenestratum. J. Nat. Prod. Plan. Resour., 2012, 2(4), 540-544.
[24]
Teng, H.; Choi, Y. Optimum extraction of bioactive alkaloid compounds from Rhizome Coptidis (Coptis Chinensi Franch.) using response surface methodology. Solvent Extr. Res. Dev. Jpn., 2013, 20(0), 91-104.
[http://dx.doi.org/10.15261/serdj.20.91]
[25]
Mokgadi, J.; Turner, C.; Torto, N. Pressurized hot water extraction of alkaloids in Goldenseal. Am. J. Anal. Chem., 2013, 4(8), 398-403.
[http://dx.doi.org/10.4236/ajac.2013.48050]
[26]
Rojsanga, P.; Gritsanapan, W. Variation of berberine content in coscinium fenestratum stem in Thailand market. Mahidol Univ. J. Pharm. Sci., 2005, 32(662), 66-70.
[27]
Shigwan, H.; Saklani, A.; Hamrapurkar, P.D.; Mane, T.; Bhatt, P. HPLC method development and validation for quantification of Berberine from Berberis Aristata and Berberis Tinctoria. Int. J. Appl. Sci. Eng., 2013, 11(2), 203-211.
[28]
Alupului, A.; Calinescu, I.; Lavric, V. Ultrasonic vs. microwave extraction intensification of active principles from medicinal plants. Chem. Eng. Trans., 2009, 17, 1023-1028.
[29]
Liao, G. Optimization for ultrahigh pressure extraction of berberine from cortex phellodendri by central composite design-response surface methodology. J. Med. Plants Res., 2012, 6(23), 3963-3970.
[30]
Schieffer, G.W.; Pfeiffer, K. Pressurized liquid extraction and multiple, ultrasonically-assisted extractions of hydrastine and berberine from goldenseal (hydrastis canadensis) with subsequent HPLC assay. J. Liq. Chromatogr. Relat. Technol., 2001, 24(16), 2415-2427.
[http://dx.doi.org/10.1081/JLC-100105948]
[31]
Karthikeyan, R. Quantitative analysis of berberine in homeopathic formulation containing Berberis Vulgaris L. BY UV. Electronic J. Biosci., 2015, 2(1), 91-98.
[32]
Díaz, M.S.; Freile, M.L.; Gutiérrez, M.I. Solvent effect on the UV/Vis absorption and fluorescence spectroscopic properties of berberine. Photochem. Photobiol. Sci., 2009, 8(7), 970-974.
[http://dx.doi.org/10.1039/b822363g] [PMID: 19582272]
[33]
Joshi, H.R.; Kanaki, N. Quantitative analysis of berberine in an ayurvedic formulation-rasayana churna by UV Spectrophotometry. J. Pharm. Sci. Biosci. Res., 2013, 3(1), 32-34.
[34]
Pundarikakshudu, K.; Dave, H.N. Simultaneous determination of curcumin and berberine in their pure form and from the combined extracts of curcuma longa and berberis aristata. Int. J. Appl. Sci. Eng., 2010, 8(8), 19-26.
[35]
Wen, A.; Peng, X.; Zhang, P.; Long, Y.; Gong, H.; Xie, Q.; Yue, M.; Chen, S. Spectrofluorometric determination of berberine using a novel Au nanocluster with large Stokes shift. Anal. Bioanal. Chem., 2018, 410(25), 6489-6495.
[http://dx.doi.org/10.1007/s00216-018-1246-9] [PMID: 30022234]
[36]
Cao, M.; Liu, M.; Cao, C.; Xia, Y.; Bao, L.; Jin, Y.; Yang, S.; Zhu, C. A simple fluorescence quenching method for berberine determination using water-soluble CdTe quantum dots as probes. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2010, 75(3), 1043-1046.
[http://dx.doi.org/10.1016/j.saa.2009.12.050] [PMID: 20093069]
[37]
Kovár, J. Direct fluorometric determination of liver alcohol dehydrogenase with berberine. Eur. J. Biochem., 1974, 49(1), 179-183.
[http://dx.doi.org/10.1111/j.1432-1033.1974.tb03823.x] [PMID: 4477529]
[38]
Liang, S.; Kuang, Y.; Ma, F.; Chen, S.; Long, Y. A sensitive spectrofluorometric method for detection of berberine hydrochloride using Ag nanoclusters directed by natural fish sperm DNA. Biosens. Bioelectron., 2016, 85, 758-763.
[http://dx.doi.org/10.1016/j.bios.2016.05.070] [PMID: 27266661]
[39]
Liu, F.; Liang, H.; Xu, K.; Tong, L.; Tang, B. Supramolecular interaction of ethylenediamine linked β-cyclodextrin dimer and berberine hydrochloride by spectrofluorimetry and its analytical application. Talanta, 2007, 74(1), 140-145.
[http://dx.doi.org/10.1016/j.talanta.2007.05.048] [PMID: 18371623]
[40]
Liu, Q.; Xie, Z.; Liu, T.; Fan, J. Determination of berberine hydrochloride using a fluorimetric method with silica nanoparticles as a probe. RSC Advances, 2018, 8(11), 6075-6082.
[http://dx.doi.org/10.1039/C7RA13048A] [PMID: 35539602]
[41]
Wang, H.; Zhang, M.; Lv, Q.; Yue, N.; Gong, B. Determination of berberine and the study of fluorescence quenching mechanism between berberine and enzyme-catalyzed product. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2009, 73(4), 682-686.
[http://dx.doi.org/10.1016/j.saa.2009.03.017] [PMID: 19380247]
[42]
Goswami, A.K.; Gogoi, N.; Shakya, A.; Sharma, H.K. Development and validation of high-performance thin-layer chromatographic method for quantification of berberine in Rhizomes of Coptis teeta wall, an endangered species collected from Arunachal Pradesh, India. J. Chromatogr. Sci., 2019, 57(5), 411-417.
[http://dx.doi.org/10.1093/chromsci/bmz009] [PMID: 30753457]
[43]
Rajendran, J.; Jyothi, A.; Jacob, L.; Vinod, S.; Kochupappy, R.T. Simultaneous determination of berberine and β- sitosterol in the leaf extracts of Naravelia zeylanica by analytical methods and their in vitro Anti diabetic activity. J. Adv. Pharm. Educ. & Res., 2014, 4(3), 365-371.
[44]
Satija, S.; Tambuwala, M.M.; Pabreja, K.; Bakshi, H.A.; Chellappan, D.K.; Aljabali, A.A.; Nammi, S.; Singh, T.G.; Dureja, H.; Gupta, G.; Dua, K.; Mehta, M.; Garg, M. Development of a novel HPTLC fingerprint method for simultaneous estimation of berberine and rutin in medicinal plants and their pharmaceutical preparations followed by its application in antioxidant assay. J. Planar Chromatogr. Mod. TLC, 2020, 33(3), 313-319.
[http://dx.doi.org/10.1007/s00764-020-00035-y]
[45]
Tarte, P.S.; Shedharkar, G.R. Force degradation study of berberine chloride by using stability indicating Hplc method. Int. J. Pharm. Tech. Res., 2014, 6(5), 1490-1500.
[46]
Karthikeyan, R.; Devadasu, C.; Srinivasa, P.; Sukumar, C.b. Isolation, characterisation and RP-HPLC estimation of berberine in homeopathic formulation. Central European Journal of Experimental Biology., 2014, 3(4), 31-37.
[47]
Singh, R.; Katiyar, C.K.; Pasrija, A. Validated HPLC-UV method for the determination of berberine in raw herb Daruharidra (Berberis aristata DC), its extract, and in commercially marketed ayurvedic dosage forms. Int. J. Ayurveda Res., 2010, 1(4), 243-246.
[http://dx.doi.org/10.4103/0974-7788.76789] [PMID: 21455453]
[48]
Sakinala, P.; Sree, S.; Velivela, R. Rp-Hplc Method Development and Validation for Estimation of Berberine in Bulk and Pharmaceutical Dosage Forms. IJRAR19J1705 Int. J. Res. Anal. Rev., 2019, 357(1), 357-368.
[49]
Kim, E.K.; Jeong, E.K.; Han, S.B.; Jung, J.H.; Hong, J.K. HPLC separation of isoquinoline alkaloids for quality control of corydalis species. Bull. Korean Chem. Soc., 2011, 32(10), 3597-3602.
[http://dx.doi.org/10.5012/bkcs.2011.32.10.3597]
[50]
Kamal, Y.T.; Singh, M.; Tamboli, E.T.; Parveen, R.; Ahmad, S. Quantitative analysis of berberine in Berberis aristata fruits and in a traditional anti-inflammatory unani formulation by use of a validated HPLC method. Acta Chromatogr., 2011, 23(1), 157-168.
[http://dx.doi.org/10.1556/AChrom.21.2013.1.11]
[51]
Devaliya, R.; Shirsat, M. Development and Validation of RP-HPLC method for quantification of berberine in ethanol fraction of methanol extract and developed formulation of Tinospora cordifolia. Orient. J. Chem., 2017, 33(2), 989-994.
[http://dx.doi.org/10.13005/ojc/330253]
[52]
Das, P.; Prabhu, P.P.; Reddy, J. Chromatographic analysis and validation of berberine in Amrutharistam-A polyherbal formulation. Saudi J. of Med. and Pharm. Sci., 2018, 4(7), 775-779.
[http://dx.doi.org/10.36348/sjmps.2018.v04i07.009]
[53]
Xool-Tamayo, J.; Graniel-Sabido, M.; Mirón-López, G.; Mena-Rejón, G.; Monforte-González, M.; Vazquez-Flota, F. HPLC-DAD determination of berberine, chelerythrine and sanguinarine in the mexican prickly poppy (Argemone mexicana L. Papaveraceae), a medicinal plant. Quim. Nova, 2017, 40(10), 1238-1243.
[http://dx.doi.org/10.21577/0100-4042.20170111]
[54]
Abourashed, E.A.; Khan, I.A. High‐performance liquid chromatography determination of hydrastine and berberine in dietary supplements containing goldenseal. J. Pharm. Sci., 2001, 90(7), 817-822.
[http://dx.doi.org/10.1002/jps.1035] [PMID: 11458331]
[55]
Liu, F.; Li, Z.; Shi, X.; Zhong, M. Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography-electrospray ionization-mass spectrometry. J. Pharm. Biomed. Anal., 2011, 56(5), 1006-1015.
[http://dx.doi.org/10.1016/j.jpba.2011.08.001] [PMID: 21890297]
[56]
Zhou, N.; Liu, D.; Bao, X. A validated liquid chromatographic method for berberine analysis in tissue and application. Int. J. Anal. Chem., 2020, 2020, 1-7.
[http://dx.doi.org/10.1155/2020/8892696] [PMID: 33061977]
[57]
Wang, J.C.; Zhang, Q.; Cai, D.F. Stability-indicating validated HPLC method for analysis of berberine hydrochloride and trimethoprim in pharmaceutical dosage form. J. Chem., 2013, 2013, 1-9.
[http://dx.doi.org/10.1155/2013/360812]
[58]
Gao, Y.; Jin, F.Y.; Wang, X.P.; Zhao, Y.; Liang, G.Y. Simultaneous determination of seven bioactive compounds in wuji pill by HPLC. J. Chromat. Separation Techniq, 2012, 3(4), 1-5.
[http://dx.doi.org/10.4172/2157-7064.1000132]
[59]
Jo, B.; Kang, K.; Yang, M.H. Development and Validation of a HPLC-PDA Method for the Simultaneous Determination of Berberine, Palmatine, Geniposide, and Paeoniflorin in Haedoksamultang. Appl. Sci., 2020, 10(16), 5482.
[60]
Lee, H.S.; Eom, Y.E.; Eom, D.O. Narrowbore high performance liquid chromatography of berberine and palmatine in crude drugs and pharmaceuticals with ion-pair extraction using cobalt thiocyanate reagent. J. Pharm. Biomed. Anal., 1999, 21(1), 59-63.
[http://dx.doi.org/10.1016/S0731-7085(99)00113-2] [PMID: 10701913]
[61]
Patil, S.; Dash, R.P.; Anandjiwala, S.; Nivsarkar, M. Simultaneous quantification of berberine and lysergol by HPLC-UV: Evidence that lysergol enhances the oral bioavailability of berberine in rats. Biomed. Chromatogr., 2012, 26(10), 1170-1175.
[http://dx.doi.org/10.1002/bmc.2674] [PMID: 22213237]
[62]
Gondaliya, A.V.; Vikani, K.; Kapupara, P.P. Development and validation of analytical method for simultaneous estimation of berberine hydrochloride and embelin in polyherbal formulation. Inter. Bul of Drug Res., 2014, 4(6), 35-44.
[63]
Hua, W.; Ding, L.; Chen, Y.; Gong, B.; He, J.; Xu, G. Determination of berberine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry. J. Pharm. Biomed. Anal., 2007, 44(4), 931-937.
[http://dx.doi.org/10.1016/j.jpba.2007.03.022] [PMID: 17531424]
[64]
Naaz, I.; A Ali, S. Identification and characterization of bioactive compound berberine in the Berberis vulgaris root extract using HR-LC-MS analysis. J. Anal. Pharm. Res., 2018, 7(4), 467-470.
[http://dx.doi.org/10.15406/japlr.2018.07.00268]
[65]
Rashmi; Rajasekaran, A.; Pokhriyal, R.; Rashmi; Singh, Y.P. Quantitative estimation of berberine in roots of different provenances of Berberis aristata DC by HPLC and study of their antifungal properties. Pharmacogn. Mag., 2009, 5(20), 355-358.
[http://dx.doi.org/10.4103/0973-1296.58566]
[66]
Dar, O.; Lawrence, R.; Dar, S. HPLC, antioxidant and antibacterial activities of methanolic extract of Berberis aristata stem. Int J Sci Res., 2014, 3(11), 1137-1141.
[67]
Tsai, P-L.; Tsai, T.H. HPLC determination of berberine in medicinal herbs and a related traditional chinese medicine. Anal. Lett., 2002, 35(15), 2459-2470.
[http://dx.doi.org/10.1081/AL-120016537]
[68]
Zeng, X. HPLC determination of berberine in plasma of patients with ischemic heart failure. Chromatographia, 1998, 48(7-8), 589-590.
[http://dx.doi.org/10.1007/BF02466655]
[69]
Pradhan, D.; Biswasroy, P.; Suri, K.A. Isolation of berberine from berberis Vulgaris Linn. and standardization of aqueous extract by RP-HPLC. Int. J. Herb. Med., 2013, 1(2), 2-7.
[70]
Feng, J.; Xu, W.; Tao, X.; Wei, H.; Cai, F.; Jiang, B.; Chen, W. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. J. Pharm. Biomed. Anal., 2010, 53(3), 591-598.
[http://dx.doi.org/10.1016/j.jpba.2010.04.002] [PMID: 20430560]
[71]
Liu, G.; He, W.; Cai, H.; Sun, X.; Hou, W.; Lin, M.; Xie, Z.; Liao, Q. The simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine in rat plasma by LC-MS/MS and a pharmacokinetic comparison after the oral administration of Rhizoma coptidis and Jiao-Tai-Wan extract. Anal. Methods, 2014, 6(9), 2998-3008.
[http://dx.doi.org/10.1039/c3ay42000k]
[72]
Mittal, J.; Sharma, M. M. Enhanced production of berberine in in vitro regenerated cell of tinospora cordifolia and its analysis through LCMS QToF. 3 Biotech., 2017, 7(1), 1-12.
[73]
Yi, Z.B.; Yan, Yu.; Liang, Y.Z.; Bao, Z. Evaluation of the antimicrobial mode of berberine by LC/ESI-MS combined with principal component analysis. J. Pharm. Biomed. Anal., 2007, 44(1), 301-304.
[http://dx.doi.org/10.1016/j.jpba.2007.02.018] [PMID: 17383137]
[74]
Yu, S.; Pang, X.; Deng, Y.; Liu, L.; Liang, Y.; Liu, X.; Xie, L.; Wang, G.; Wang, X. A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma. Int. J. Mass Spectrom., 2007, 268(1), 30-37.
[http://dx.doi.org/10.1016/j.ijms.2007.08.003]
[75]
Li, G.; Yang, F.; Liu, M.; Su, X.; Zhao, M.; Zhao, L. Development and application of a UPLC-MS/MS method for simultaneous determination of fenofibric acid and berberine in rat plasma: Application to the drug-drug pharmacokinetic interaction study of fenofibrate combined with berberine after oral administrati. Biomed. Chromatogr., 2016, 30(7), 1075-1082.
[http://dx.doi.org/10.1002/bmc.3652] [PMID: 26577601]
[76]
Yang, L.; Meng, X.; Yu, X.; Kuang, H. Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats. J. Pharm. Biomed. Anal., 2017, 134, 43-52.
[http://dx.doi.org/10.1016/j.jpba.2016.11.021] [PMID: 27875787]
[77]
Huang, P.; Gao, J.; Shi, Z.; Zou, J.; Lu, Y.; Yuan, Y.; Yao, M. A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study. Bioanalysis, 2012, 4(10), 1205-1213.
[http://dx.doi.org/10.4155/bio.12.81] [PMID: 22651564]
[78]
Yuan, Z.W.; Leung, E.L.H.; Fan, X.X.; Zhou, H.; Ma, W.Z.; Liu, L.; Xie, Y. Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS. Talanta, 2015, 144, 20-28.
[http://dx.doi.org/10.1016/j.talanta.2015.05.017] [PMID: 26452787]
[79]
Xu, P.; Xu, C.; Li, X.; Li, D.; Li, Y.; Jiang, J.; Yang, P.; Duan, G. Rapid identification of berberine metabolites in rat plasma by UHPLC-Q-TOF-MS. Molecules, 2019, 24(10), 1994.
[http://dx.doi.org/10.3390/molecules24101994] [PMID: 31137649]
[80]
Gao, W.H.; Lin, S.Y.; Jia, L.; Guo, X.K.; Chen, X.G.; Hu, Z.D. Analysis of protoberberine alkaloids in several herbal drugs and related medicinal preparations by non-aqueous capillary electrophoresis. J. Sep. Sci., 2005, 28(1), 92-97.
[http://dx.doi.org/10.1002/jssc.200401863] [PMID: 15688637]
[81]
Huitao, L.; Ketai, W.; Xingguo, C.; Zhide, H. Determination of rhein, baicalin and berberine in traditional Chinese medicinal preparations by capillary electrophoresis with two-marker technique. Biomed. Chromatogr., 2004, 18(5), 288-292.
[http://dx.doi.org/10.1002/bmc.317] [PMID: 15236436]
[82]
Liu, Q.; Liu, Y.; Li, Y.; Yao, S. Nonaqueous capillary electrophoresis coupled with laser-induced native fluorescence detection for the analysis of berberine, palmatine, and jatrorrhizine in Chinese herbal medicines. J. Sep. Sci., 2006, 29(9), 1268-1274.
[http://dx.doi.org/10.1002/jssc.200600032] [PMID: 16833085]
[83]
Song, T.; Zhang, K.Y.; Lao, L.; Lee, K.F.; Wai Tang, S.C.; Ng, T.B.; Wing Sze, S.C Simultaneous determination of berberine and palmatine in human plasma and in urine by capillary electrophoresis combined with polypropylene hollow fiber liquid-liquid-liquid microextraction. Anal. Methods, 2014, 6(19), 7928-7934.
[http://dx.doi.org/10.1039/C4AY01442A]
[84]
Ying-Mei, L.; Shuenn-Jyi, S. Determination of coptisine, berberine and palmatine in traditional Chinese medicinal preparations by capillary electrophoresis. J. Chromatogr. A, 1993, 639(2), 323-328.
[http://dx.doi.org/10.1016/0021-9673(93)80269-E]
[85]
Zhang, S.; Ma, R.; Yang, X.; Wang, C.; Wang, Z. On-line sample concentration and determination of cationic alkaloids in human plasma by micelle to solvent stacking in capillary zone electrophoresis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2012, 906, 41-47.
[http://dx.doi.org/10.1016/j.jchromb.2012.08.017] [PMID: 22944006]
[86]
Hu, Z.; Xie, M.; Yang, D.; Chen, D.; Jian, J.; Li, H.; Yuan, K.; Jiang, Z.; Zhou, H. A simple, fast, and sensitive colorimetric assay for visual detection of berberine in human plasma by NaHSO 4 -optimized gold nanoparticles. RSC Advances, 2017, 7(55), 34746-34754.
[http://dx.doi.org/10.1039/C7RA05291J]
[87]
Ling, J.; Sang, Y.; Huang, C.Z. Visual colorimetric detection of berberine hydrochloride with silver nanoparticles. J. Pharm. Biomed. Anal., 2008, 47(4-5), 860-864.
[http://dx.doi.org/10.1016/j.jpba.2008.04.016] [PMID: 18513909]
[88]
Song, Z.; Wang, L.; Zhao, T. Chemiluminescence flow sensor for hydrazine with immobilized reagents. Anal. Lett., 2001, 34(3), 399-413.
[http://dx.doi.org/10.1081/AL-100102582]
[89]
Biparva, P.; Abedirad, S.M.; Kazemi, S.Y.; Shanehsaz, M. Chemiluminescence recognition of berberine triggered by biomimetically synthesized silver nanoparticles. Sens. Actuators B Chem., 2016, 234, 278-285.
[http://dx.doi.org/10.1016/j.snb.2016.04.133]
[90]
ZHANG, Y.; XIE, Y.F; SONG, F.R; LIU, Z.Q; CONG, Q; ZHAO, B. Quantitative analysis of berberine in processed coptis by near-infrared diffuse reflectance spectroscopy. Chem. Res. Chin. Univ., 2008, 24(6), 717-721.
[91]
Liang, L.; Sun, J.; He, Q.; Chen, Z.; Zhu, S.; Lin, L. Semi-quantitative analysis on the content of berberine hydrochloride in compound berberine tablets with the fluorescence spectral imaging method. J. Innov. Opt. Health Sci., 2016, 9(2), 1650018.
[http://dx.doi.org/10.1142/S1793545816500188]
[92]
Kostjukova, L.O.; Kostjukov, V.V. The electronic states and vibronic absorption spectrum of berberine in aqueous solution. Int. J. Quantum Chem., 2021, 121(6), e26537.
[http://dx.doi.org/10.1002/qua.26537]
[93]
Kosalec, I.; Jembrek, M.J.; Vlainić, J. The Spectrum of Berberine Antibacterial and Antifungal Activities. In: Promising Antimicrobials from Natural Products; Rai, M.; Kosalec, I., Eds.; Springer: Cham, 2022; pp. 119-132.
[http://dx.doi.org/10.1007/978-3-030-83504-0_7]
[94]
Feng, R.; Qu, J.; Zhou, W.; Wei, Q.; Yin, Z.; Du, Y.; Yan, K.; Wu, Z. Antibacterial activity and mechanism of berberine on avian pasteurella multocida., 2016, 9(11), 22886-22892.
[95]
Yu, H.H.; Kim, K.J.; Cha, J.D.; Kim, H.K.; Lee, Y.E.; Choi, N.Y.; You, Y.O. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J. Med. Food, 2005, 8(4), 454-461.
[http://dx.doi.org/10.1089/jmf.2005.8.454] [PMID: 16379555]
[96]
Amin, A.H.; Subbaiah, T.V.; Abbasi, K.M. Berberine sulfate: Antimicrobial activity, bioassay, and mode of action. Can. J. Microbiol., 1969, 15(9), 1067-1076.
[http://dx.doi.org/10.1139/m69-190] [PMID: 4906191]
[97]
Pierpaoli, E.; Cirioni, O.; Simonetti, O.; Orlando, F.; Giacometti, A.; Lombardi, P.; Provinciali, M. Potential application of berberine in the treatment of Escherichia coli sepsis, Nat. Prod. Res., 2021, 35(22), 4779-4784.
[http://dx.doi.org/10.1080/14786419.2020.1721729] [PMID: 32011175]
[98]
Warowicka, A.; Nawrot, R. Goździcka-Józefiak, A. Antiviral activity of berberine. Arch. Virol., 2020, 165(9), 1935-1945.
[http://dx.doi.org/10.1007/s00705-020-04706-3] [PMID: 32594322]
[99]
Jantan, I.; Ahmad, W.; Bukhari, S.N.A. Plant-derived immunomodulators: An insight on their preclinical evaluation and clinical trials. Front. Plant Sci., 2015, 6, 655.
[http://dx.doi.org/10.3389/fpls.2015.00655] [PMID: 26379683]
[100]
Ranade, A.; Shende, M. B. Neuro - pharmacological review on four medhya dravyas described by charaka. Int. ayurvedic Med. J., 2013, 1, 1-4.
[101]
Yates, C.R.; Bruno, E.J.; Yates, M.E.D. Tinospora Cordifolia: A review of its immunomodulatory properties. J. Diet. Suppl., 2021, 1-15.
[PMID: 33480818]
[102]
Mahmoudi, M.; Zamani Taghizadeh Rabe, S.; Balali-Mood, M.; Karimi, G.; Memar, B.; Rahnama, M.; Tabasi, N.; Khazaee, M.; Riahi-Zanjani, B. Immunotoxicity induced in mice by subacute exposure to berberine. J. Immunotoxicol., 2016, 13(2), 255-262.
[http://dx.doi.org/10.3109/1547691X.2015.1058306] [PMID: 26100397]
[103]
Sun, Y.; Xun, K.; Wang, Y.; Chen, X. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs, 2009, 20(9), 757-769.
[http://dx.doi.org/10.1097/CAD.0b013e328330d95b] [PMID: 19704371]
[104]
Ma, C.; Tang, K.; Liu, Q.; Zhu, R.; Cao, Z. Calmodulin as a potential target by which berberine induces cell cycle arrest in human hepatoma Bel7402 cells. Chem. Biol. Drug Des., 2013, 81(6), 775-783.
[http://dx.doi.org/10.1111/cbdd.12124] [PMID: 23421648]
[105]
Song, J.; Gao, X.; Tang, Z.; Li, H.; Ruan, Y.; Liu, Z.; Wang, T.; Wang, S.; Liu, J.; Jiang, H. Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats viainhibition of ROS/JAK2/NFκB pathway. Andrology, 2020, 8(3), 793-806.
[http://dx.doi.org/10.1111/andr.12764] [PMID: 32012485]
[106]
Kim, S.; You, D.; Jeong, Y.; Yu, J.; Kim, S.W.; Nam, S.J.; Lee, J.E. Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells. Phytomedicine, 2018, 50, 43-49.
[http://dx.doi.org/10.1016/j.phymed.2018.08.004] [PMID: 30466991]
[107]
Cicero, A.F.; Tartagni, E.; Borghi, C. Nutraceuticals with lipid-lowering activity: Do they have any effect beyond cholesterol reduction? Clin. Lipidol., 2012, 7(5), 549-559.
[http://dx.doi.org/10.2217/clp.12.55]
[108]
Hahn, F.E.; Ciak, J. Berberine BT - mechanism of action of Antimicrobial and Antitumor Agents; Corcoran, J.W.; Hahn, F.E.; Snell, J.F; Arora, K.L., Ed.; Springer: Heidelberg, Berlin, 1975, pp. 577-584.
[http://dx.doi.org/10.1007/978-3-642-46304-4_38]
[109]
Mollov, N.M.; Dutschewska, H.B.; Siljanovska, K.; Stojcev, S. Cytotoxic effect of alkaloids from Thalictrum minus ssp. elatum and their derivatives. Dokl. Bolg. Akad. Nauk, 1968, 21(6), 605-608.
[PMID: 5698998]
[110]
Yip, N.K.; Ho, W.S. Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells. Oncol. Rep., 2013, 30(3), 1107-1112.
[http://dx.doi.org/10.3892/or.2013.2543] [PMID: 23784371]
[111]
Fukuda, K.; Hibiya, Y.; Mutoh, M.; Koshiji, M.; Akao, S.; Fujiwara, H. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J. Ethnopharmacol., 1999, 66(2), 227-233.
[http://dx.doi.org/10.1016/S0378-8741(98)00162-7] [PMID: 10433483]
[112]
Nishino, H.; Kitagawa, K.; Fujiki, H.; Iwashima, A. Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. Oncology, 1986, 43(2), 131-134.
[http://dx.doi.org/10.1159/000226349] [PMID: 3081844]
[113]
Zhang, M.; Feng, L.; Li, J.; Chen, L. Therapeutic potential and mechanisms of berberine in cardiovascular disease. Curr. Pharmacol. Rep., 2016, 2(6), 281-292.
[http://dx.doi.org/10.1007/s40495-016-0070-1]
[114]
Zhu, M.L.; Yin, Y.L.; Ping, S.; Yu, H.Y.; Wan, G.R.; Jian, X.; Li, P. Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b. Clin. Exp. Hypertens., 2017, 39(7), 672-679.
[http://dx.doi.org/10.1080/10641963.2017.1313853] [PMID: 28722488]
[115]
Yao, J.; Kong, W.; Jiang, J. Learning from berberine: Treating chronic diseases through multiple targets. Sci. China Life Sci., 2015, 58(9), 854-859.
[http://dx.doi.org/10.1007/s11427-013-4568-z] [PMID: 24174332]
[116]
Lau, C.W.; Yao, X.Q.; Chen, Z.Y.; Ko, W.H.; Huang, Y. Cardiovascular actions of berberine. Cardiovasc. Drug Rev., 2001, 19(3), 234-244.
[http://dx.doi.org/10.1111/j.1527-3466.2001.tb00068.x] [PMID: 11607041]
[117]
Kong, W.J.; Zhang, H.; Song, D.Q.; Xue, R.; Zhao, W.; Wei, J.; Wang, Y.M.; Shan, N.; Zhou, Z.X.; Yang, P.; You, X.F.; Li, Z.R.; Si, S.Y.; Zhao, L.X.; Pan, H.N.; Jiang, J.D. Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism, 2009, 58(1), 109-119.
[http://dx.doi.org/10.1016/j.metabol.2008.08.013] [PMID: 19059538]
[118]
Vuddanda, P.R.; Chakraborty, S.; Singh, S. Berberine: A potential phytochemical with multispectrum therapeutic activities. Expert Opin. Investig. Drugs, 2010, 19(10), 1297-1307.
[http://dx.doi.org/10.1517/13543784.2010.517745] [PMID: 20836620]
[119]
Shen, H.R.; Xu, X.; Li, X.L. Berberine exerts a protective effect on rats with polycystic ovary syndrome by inhibiting the inflammatory response and cell apoptosis. Reprod. Biol. Endocrinol., 2021, 19(1), 3.
[http://dx.doi.org/10.1186/s12958-020-00684-y] [PMID: 33407557]
[120]
Kulkarni, S.K.; Dhir, A. Berberine: A plant alkaloid with therapeutic potential for central nervous system disorders. Phytother. Res., 2010, 24(3), 317-324.
[http://dx.doi.org/10.1002/ptr.2968] [PMID: 19998323]
[121]
Kumar, A.; Ekavali; Chopra, K.; Mukherjee, M.; Pottabathini, R.; Dhull, D.K. Current knowledge and pharmacological profile of berberine: An update. Eur. J. Pharmacol., 2015, 761, 288-297.
[http://dx.doi.org/10.1016/j.ejphar.2015.05.068] [PMID: 26092760]
[122]
Lee, B.; Sur, B.; Yeom, M.; Shim, I.; Lee, H.; Hahm, D.H. Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats. Korean J. Physiol. Pharmacol., 2012, 16(6), 379-386.
[http://dx.doi.org/10.4196/kjpp.2012.16.6.379] [PMID: 23269899]
[123]
Wang, K.; Feng, X.; Chai, L.; Cao, S.; Qiu, F. The metabolism of berberine and its contribution to the pharmacological effects. Drug Metab. Rev., 2017, 49(2), 139-157.
[http://dx.doi.org/10.1080/03602532.2017.1306544] [PMID: 28290706]
[124]
Chu, H.; Jin, G.; Friedman, E.; Zhen, X. Recent development in studies of tetrahydroprotoberberines: Mechanism in antinociception and drug addiction. Cell. Mol. Neurobiol., 2008, 28(4), 491-499.
[http://dx.doi.org/10.1007/s10571-007-9179-4] [PMID: 17710533]
[125]
Kulkarni, S.K.; Dhir, A. On the mechanism of antidepressant-like action of berberine chloride. Eur. J. Pharmacol., 2008, 589(1-3), 163-172.
[http://dx.doi.org/10.1016/j.ejphar.2008.05.043] [PMID: 18585703]
[126]
Peng, W.H.; Wu, C.R.; Chen, C.S.; Chen, C.F.; Leu, Z.C.; Hsieh, M.T. Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: Interaction with drugs acting at 5-HT receptors. Life Sci., 2004, 75(20), 2451-2462.
[http://dx.doi.org/10.1016/j.lfs.2004.04.032] [PMID: 15350820]
[127]
Ye, M.; Fu, S.; Pi, R.; He, F. Neuropharmacological and pharmacokinetic properties of berberine: A review of recent research. J. Pharm. Pharmacol., 2010, 61(7), 831-837.
[http://dx.doi.org/10.1211/jpp.61.07.0001] [PMID: 19589224]
[128]
Vaziri, Z.; Abbassian, H.; Sheibani, V.; Haghani, M.; Nazeri, M.; Aghaei, I.; Shabani, M. The therapeutic potential of Berberine chloride hydrate against harmaline-induced motor impairments in a rat model of tremor. Neurosci. Lett., 2015, 590, 84-90.
[http://dx.doi.org/10.1016/j.neulet.2015.01.078] [PMID: 25643620]
[129]
Nourbakhsh, F.; Read, M.I.; Barreto, G.E.; Sahebkar, A. Boosting the autophagy‐lysosomal pathway by phytochemicals: A potential therapeutic strategy against Alzheimer’s disease. IUBMB Life, 2020, 72(11), 2360-2281.
[http://dx.doi.org/10.1002/iub.2369] [PMID: 32894821]
[130]
Lin, W.C.; Lin, J.Y. Berberine down-regulates the Th1/Th2 cytokine gene expression ratio in mouse primary splenocytes in the absence or presence of lipopolysaccharide in a preventive manner. Int. Immunopharmacol., 2011, 11(12), 1984-1990.
[http://dx.doi.org/10.1016/j.intimp.2011.08.008] [PMID: 21867779]
[131]
Kuo, C.L.; Chi, C.W.; Liu, T.Y. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett., 2004, 203(2), 127-137.
[http://dx.doi.org/10.1016/j.canlet.2003.09.002] [PMID: 14732220]
[132]
Tew, X.N.; Xin Lau, N.J.; Chellappan, D.K.; Madheswaran, T.; Zeeshan, F.; Tambuwala, M.M.; Aljabali, A.A.A.; Balusamy, S.R.; Perumalsamy, H.; Gupta, G.; Oliver, B.G.; Hsu, A.; Wark, P.; Reddy, K.; Wadhwa, R.; Hansbro, P.M.; Dua, K. Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases. Chem. Biol. Interact., 2020, 317, 108947.
[http://dx.doi.org/10.1016/j.cbi.2020.108947] [PMID: 31968208]
[133]
Pirillo, A.; Catapano, A.L. Berberine, a plant alkaloid with lipid and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis, 2015, 243(2), 449-461.
[http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.032] [PMID: 26520899]
[134]
Cicero, A.F.G.; Ferroni, A.; Ertek, S. Tolerability and safety of commonly used dietary supplements and nutraceuticals with lipid-lowering effects. Expert Opin. Drug Saf., 2012, 11(5), 753-766.
[http://dx.doi.org/10.1517/14740338.2012.705827] [PMID: 22788832]
[135]
Hashemzaei, M.; Rezaee, R. A review on pain‐relieving activity of berberine. Phytother. Res., 2021, 35(6), 2846-2853.
[http://dx.doi.org/10.1002/ptr.6984] [PMID: 33340158]
[136]
Yamamoto, K.; Takase, H.; Abe, K.; Saito, Y.; Suzuki, A. Pharmacological studies on antidiarrheal effects of a preparation containing Berberine and Geranii Herba. Nippon Yakurigaku Zasshi, 1993, 101(3), 169-175.
[http://dx.doi.org/10.1254/fpj.101.3_169] [PMID: 8486321]
[137]
Swabb, E.A.; Tai, Y.H.; Jordan, L. Reversal of cholera toxin-induced secretion in rat ileum by luminal berberine. Am. J. Physiol., 1981, 241(3), G248-G252.
[PMID: 7282933]
[138]
Chan, E. Displacement of bilirubin from albumin by berberine. Neonatology, 1993, 63(4), 201-208.
[http://dx.doi.org/10.1159/000243932] [PMID: 8513024]
[139]
Tan, Y.Z.; Wu, A.C.; Tan, B.Y.; Wu, J.H.; Tang, L.F.; Li, J.H.; Li, Y.X.; Zhang, D.J. Study on the interactions of berberine displace other drug from their plasma proteins binding sites. Chi. Pharma. Bul., 2002, 18(5), 576-578.

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