Biological Properties of Arginine-rich Peptides and their Application in Cargo Delivery to Cancer

Title:Biological Properties of Arginine-rich Peptides and their Application in Cargo Delivery to Cancer

Volume: 20

Author(s): Minghai Ma, Ruizhao Zhao, Xing Li, Minxuan Jing, Rundong Song and Jinhai Fan*

Affiliation:

• First Affiliated Hospital of Xi'an Jiaotong University Department of Urology Xi'an China

Abstract: Cell-penetrating peptides (CPPs) comprise short peptides of fewer than 30 amino acids, which are rich in arginine (Arg) or lysine (Lys). CPPs have attracted interest in the delivery of various cargos, such as drugs, nucleic acids, and other macromolecules over the last 30 years. Among all types of CPPs, arginine-rich CPPs exhibit higher transmembrane efficiency due to bidentate bonding between their guanidinium groups and negatively charged cellular components. Besides, endosome escape can be induced by arginine-rich CPPs to protect cargo from lysosome-dependent degradation. Here we summarize the function, design principles, and penetrating mechanisms of arginine-rich CPPs, and outline their biomedical applications in drug delivery and biosensing in tumors.

Cite this article as:

Ma Minghai, Zhao Ruizhao, Li Xing, Jing Minxuan, Song Rundong and Fan Jinhai*, Biological Properties of Arginine-rich Peptides and their Application in Cargo Delivery to Cancer, Current Drug Delivery 2023; 20 () . https://dx.doi.org/10.2174/1567201820666230417083350