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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Wnt/β-catenin Signaling in Lung Cancer: Association with Proliferation, Metastasis, and Therapy Resistance

Author(s): Maliheh Entezari, Mahshid Deldar Abad Paskeh, Sima Orouei, Amirabbas Kakavand, Shamin Rezaei, Elahe Sadat Hejazi, Parya Pashootan, Naghmeh Nazdari, Alireza Tavakolpournegari, Mehrdad Hashemi, Shokooh Salimimoghadam, Sepideh Mirzaei*, Afshin Taheriazam* and Saeed Samarghandian*

Volume 24, Issue 1, 2024

Published on: 12 June, 2023

Page: [94 - 113] Pages: 20

DOI: 10.2174/1568009623666230413094317

Abstract

The capacity of cancer cells for abnormal growth and metastasis has made it difficult to find a cure for tumor. Both males and females suffer from lung tumors, and physicians still deem them incurable. The initiation and development of lung tumors can be forced by genomic mutations. Wnt is a critical pathway for regulating growth, differentiation and migration. However, its oncogenic function has been observed in lung cancer. Wnt is able to increase the proliferation of lung tumors. The metastasis potential of lung tumors can be accelerated by Wnt/EMT axis. Overexpression of Wnt/β-catenin prevents chemotherapy-mediated cell death in lung tumors. This pathway promotes cancer stem cell features in lung tumors which induce radioresistance. Anti-cancer agents, such as curcumin, are able to inhibit Wnt in lung tumor treatment. Wnt interaction with other factors in lung tumors is essential in controlling biological behavior, and non-coding RNA transcripts are the most well-known ones. It can be concluded from the current study that Wnt is an important regulator of lung tumorigenesis, and the translation of these findings into the clinic is vital.

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