Applications of Lentiviral Vectors for shRNA Delivery and Transgenesis

Title: Applications of Lentiviral Vectors for shRNA Delivery and Transgenesis

Volume: 8 Issue: 6

Author(s): Oded Singer and Inder M. Verma

Affiliation:

Keywords: Lentiviral Vectors, Transgenesis, RNAs, Gene therapy, neurological disorders

Abstract: Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.

Cite this article as:

Singer Oded and Verma M. Inder, Applications of Lentiviral Vectors for shRNA Delivery and Transgenesis, Current Gene Therapy 2008; 8 (6) . https://dx.doi.org/10.2174/156652308786848067