Chemistry and Biology of Thyrotropin-Releasing Hormone (TRH) and its Analogs

Title: Chemistry and Biology of Thyrotropin-Releasing Hormone (TRH) and its Analogs

Volume: 15 Issue: 26

Author(s): Vikramdeep Monga, Chhuttan L. Meena, Navneet Kaur and Rahul Jain

Affiliation:

Keywords: Peptide, hormone, CNS, pituitary, receptors

Abstract: Thyrotropin-releasing hormone (TRH), a hypothalamic orally active neuropeptide, has been manifested in a wide range of biological responses. Besides its central role in regulating the pituitary-thyroid axis by simulating the release of thyrotropin, TRH has considerable influence on the activity of a number of neurobiological systems. Due to the therapeutic potential of TRH to treat several CNS maladies, the development of CNS-selective and metabolically stable TRH analogs is an area of interest. TRH is known to elicit its biological response through two G-protein coupled receptors for TRH (namely, TRH-R1 and TRH-R2). The distinct distribution of TRH receptors in tissues has provided opportunity to discover receptor subtype-specific analogs, which would demonstrate high CNS activities, and are completely free of hormonal activities. In this review, an in-depth analysis of the chemistry and biology of TRH and its analogs is provided. Recent discoveries of TRH-R2 selective analogs, TRH super agonists, metabolically stable TRH analogs, and targeted delivery of TRH analogs have been also discussed.

Cite this article as:

Monga Vikramdeep, Meena L. Chhuttan, Kaur Navneet and Jain Rahul, Chemistry and Biology of Thyrotropin-Releasing Hormone (TRH) and its Analogs, Current Medicinal Chemistry 2008; 15 (26) . https://dx.doi.org/10.2174/092986708786242912