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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

On Water Synthesis of 3-Aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines using Iodobenzene Diacetate

Author(s): Rinku Soni, Deepak Kumar Aneja*, Monika Sihag, Neha Rani and Mayank Kinger

Volume 20, Issue 5, 2023

Published on: 07 December, 2022

Page: [401 - 406] Pages: 6

DOI: 10.2174/1570178620666221025160300

Price: $65

Abstract

A simple and green methodology has been developed for the synthesis of 3-aryl-5,7- dimethyl-1,2,4-triazolo[4,3-a]pyrimidines in water. Oxidative cyclization of 4,6-dimethyl-2- pyrimidinylhydrazones of different aldehydes was achieved in good to excellent yield using iodobenzene diacetate at room temperature. High efficiency, easy work-up, short reaction time, non-toxicity of solvent and ambient temperature are the advantages of this methodology.

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