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Cardiovascular & Hematological Agents in Medicinal Chemistry

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ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

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Review Article

Therapeutic Potential of Stable Organosulfur Compounds of Aged Garlic

Author(s): Kumkum Sharma and Vibha Rani*

Volume 21, Issue 2, 2023

Published on: 19 December, 2022

Page: [84 - 95] Pages: 12

DOI: 10.2174/1871525721666221020123056

Price: $65

Abstract

Aged garlic extract (AGE) is an odorless derivative of garlic prepared by extracting garlic cloves in an aqueous solution for twenty months. During the process of aging, reactive organosulfur compounds such as allicin present in garlic are converted to their stable isoforms such as S- Allyl cysteine. The unstable organo sulfurs in garlic (Allium sativum L.) have been reported to cause problems in the gastrointestinal (GI) tract with an extremely pungent odor to attain its therapeutic potential. But these pharmacologically safer sulfur compounds of AGE have been studied and reported to have exceptional therapeutic potential in human health and various diseases. SAllyl cysteine (SAC), Diallyl disulfide (DADS), Diallyl trisulfide (DATS), S-allyl-mercaptocysteine (SAMC), are the most studied organosulfur compounds in in-vitro as well as in-vivo research. Biomedical research suggests that these phytoconstituents exhibit antioxidant, cardioprotective, cancer preventive, neuroprotective, immunomodulatory, antilipidemic, antidiabetic, hepatoprotective, and antiobesity effects. The therapeutic potential of aged garlic extract has been found to be extensively beneficial in these conditions, and provide a vast future in biomedical chemistry, herbdrug synergy and drug designing. The purpose of this review is to provide a mechanistic understanding of various organosulfur compounds of AGE in human health and disease based on data provided in the literature.

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[1]
Zohary, D.; Hopf, M. Domestication of Plants in the Old World, 3rd ed; Oxford University Press: England, 2001, p. 197.
[2]
Lawson, L.; Wang, Z. Pre-hepatic fate of the organosulfur compounds derived from garlic (Allium sativum). Plant Medica, 1993, 59(S1), A688-A689.
[3]
Kodera, Y.; Ushijima, M.; Amano, H.; Suzuki, J.; Matsutomo, T. Chemical and biological properties of S-1-propenyl-ʟ-cysteine in aged garlic extract. Molecules, 2017, 22(4), 570.
[http://dx.doi.org/10.3390/molecules22040570] [PMID: 28362335]
[4]
Freeman, F.; Kodera, Y. Garlic chemistry: Stability of S-(2-Propenyl)-2-Propene-1-sulfinothioate (Allicin) in blood, solvents, and simulated physiological fluids. J. Agric. Food Chem., 1995, 43(9), 2332-2338.
[http://dx.doi.org/10.1021/jf00057a004]
[5]
Colín-González, A.L.; Santana, R.A.; Silva-Islas, C.A.; Chánez-Cárdenas, M.E.; Santamaría, A.; Maldonado, P.D. The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxid. Med. Cell. Longev., 2012, 2012, 1-16.
[http://dx.doi.org/10.1155/2012/907162] [PMID: 22685624]
[6]
Bayan, L.; Koulivand, P.H.; Gorji, A. Garlic: A review of potential therapeutic effects. Avicenna J. Phytomed., 2014, 4(1), 1-14.
[PMID: 25050296]
[7]
Cervantes, M.I.; de Oca Balderas, P.M.; de Jesús Gutiérrez-Baños, J.; Orozco-Ibarra, M.; Fernández-Rojas, B.; Medina-Campos, O.N.; Espinoza-Rojo, M.; Ruiz-Tachiquín, M.; Ortiz-Plata, A.; Salazar, M.I.; Rubio-Osornio, M.; Castañeda-Saucedo, E.; Pedraza-Chaverri, J.; Calzada, F.; Aguilera, P. Comparison of antioxidant activity of hydroethanolic fresh and aged garlic extracts and their effects on cerebral ischemia. Food Chem., 2013, 140(1-2), 343-352.
[http://dx.doi.org/10.1016/j.foodchem.2013.02.053] [PMID: 23578652]
[8]
Munir, K.M.; Chandrasekaran, S.; Gao, F.; Quon, M.J. Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: Therapeutic implications for diabetes and its cardiovascular complications. Am. J. Physiol. Endocrinol. Metab., 2013, 305(6), E679-E686.
[http://dx.doi.org/10.1152/ajpendo.00377.2013] [PMID: 23900418]
[9]
Blumenthal, M. The complete german commission E monographs-Therapeutic guide to herbal medicines. American Botanical Council: Austin, TX, 2015; 14, p. 454.
[10]
Bardaweel, S.K.; Gul, M.; Alzweiri, M.; Ishaqat, A.; ALSalamat, H.A.; Bashatwah, R.M. Reactive oxygen species: The dual role in physiological and pathological conditions of the human body. Eurasian J. Med., 2018, 50(3), 193-201.
[http://dx.doi.org/10.5152/eurasianjmed.2018.17397] [PMID: 30515042]
[11]
Magder, S. Reactive oxygen species: Toxic molecules or spark of life? Crit. Care, 2006, 10(1), 208.
[http://dx.doi.org/10.1186/cc3992] [PMID: 16469133]
[12]
Pham-Huy, L.A.; He, H.; Pham-Huy, C. Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci., 2008, 4(2), 89-96.
[PMID: 23675073]
[13]
Omar, SH.; Al-Wabel, NA Organosulfur compounds and possible mechanism of garlic in cancer. Saudi Pharm. J., 2010, 18(1), 51-58.
[14]
Battin, E.E.; Brumaghim, J.L. Antioxidant activity of sulfur and selenium: A review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms. Cell Biochem. Biophys., 2009, 55(1), 1-23.
[http://dx.doi.org/10.1007/s12013-009-9054-7] [PMID: 19548119]
[15]
Mann, GE.; Niehueser, SJ.; Watson, AG. Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: Implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao, 2007, 59(2), 117-127.
[16]
Hiramatsu, K.; Tsuneyoshi, T.; Ogawa, T.; Morihara, N. Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2–related factor 2–antioxidant response element signaling pathway in human endothelial cells. Nutr. Res., 2016, 36(2), 143-149.
[http://dx.doi.org/10.1016/j.nutres.2015.09.018] [PMID: 26507778]
[17]
Medina-Campos, O.N.; Barrera, D.; Segoviano-Murillo, S.; Rocha, D.; Maldonado, P.D.; Mendoza-Patiño, N.; Pedraza-Chaverri, J. Sallylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK1 cells of potassium dichromate-induced toxicity. Food Chem. Toxicol., 2007, 45(10), 2030-2039.
[http://dx.doi.org/10.1016/j.fct.2007.05.002]
[18]
Ahmed, T.; Wang, C.K. Black garlic and its bioactive compounds on human health diseases: A review. Molecules, 2021, 26(16), 5028.
[http://dx.doi.org/10.3390/molecules26165028] [PMID: 34443625]
[19]
Jang, H.J.; Lee, H.J.; Yoon, D.K.; Ji, D.S.; Kim, J.H.; Lee, C.H. Antioxidant and antimicrobial activities of fresh garlic and aged garlic by-products extracted with different solvents. Food Sci. Biotechnol., 2018, 27(1), 219-225.
[http://dx.doi.org/10.1007/s10068-017-0246-4] [PMID: 30263743]
[20]
Jeong, Y.; Ryu, J.; Shin, J.H.; Kang, M.; Kang, J.; Han, J.; Kang, D. Comparison of anti-oxidant and anti-inflammatory effects between fresh and aged black garlic extracts. Molecules, 2016, 21(4), 430.
[http://dx.doi.org/10.3390/molecules21040430] [PMID: 27043510]
[21]
Ushijima, M.; Kunimura, K.; Suzuki, J.I. S-1 Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway. Exp. Ther. Med., 2020, 20(3), 2815-2821.
[http://dx.doi.org/10.3892/etm.2020.8969] [PMID: 32765777]
[22]
Tsuneyoshi, T.; Kunimura, K.; Morihara, N. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide, 2019, 84, 22-29.
[http://dx.doi.org/10.1016/j.niox.2019.01.003] [PMID: 30630055]
[23]
Warnatz, H.J.; Schmidt, D.; Manke, T.; Piccini, I.; Sultan, M.; Borodina, T.; Balzereit, D.; Wruck, W.; Soldatov, A.; Vingron, M.; Lehrach, H.; Yaspo, M.L. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. J. Biol. Chem., 2011, 286(26), 23521-23532.
[http://dx.doi.org/10.1074/jbc.M111.220178] [PMID: 21555518]
[24]
White, E.J.; Gyulay, G.; Lhoták, Š.; Szewczyk, M.M.; Chong, T.; Fuller, M.T.; Dadoo, O.; Fox-Robichaud, A.E.; Austin, R.C.; Trigatti, B.L.; Igdoura, S.A. Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice. J. Biol. Chem., 2018, 293(38), 14689-14706.
[http://dx.doi.org/10.1074/jbc.RA118.004589] [PMID: 30097518]
[25]
Ried, K.; Travica, N.; Sali, A. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The AGE at Heart trial. Integr. Blood Press. Control, 2016, 9, 9-21.
[http://dx.doi.org/10.2147/IBPC.S93335] [PMID: 26869811]
[26]
Bonarjee, V.V.S. Arterial stiffness: A prognostic marker in coronary heart disease. Front. Cardiovasc. Med., 2018, 5, 64.
[http://dx.doi.org/10.3389/fcvm.2018.00064] [PMID: 29951487]
[27]
Gómez-Arbeláez, D.; Lahera, V.; Oubiña, P. Aged garlic extract improves adiponectin levels in subjects with metabolic syndrome: A double-blind, placebo-controlled, randomized, crossover study. Mediat. Inflam., 2013, 28, 57-95.
[http://dx.doi.org/10.1155/2013/285795]
[28]
Atkin, M.; Laight, D.; Cummings, M.H. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial. J. Diabetes Compl., 2016, 30(4), 723-727.
[http://dx.doi.org/10.1016/j.jdiacomp.2016.01.003] [PMID: 26954484]
[29]
Pérez-Torres, I.; Torres-Narváez, JC.; Pedraza-Chaverri, J.; Rubio-Ruiz, ME. Effect of the aged garlic extract on cardiovascular function in metabolic syndrome rats. Molecules, 2016, 21(11), 1425.
[http://dx.doi.org/10.3390/molecules21111425]
[30]
Borek, C. Antioxidant health effects of aged garlic extract. J. Nutr., 2001, 131(3), 1010S-1015S.
[http://dx.doi.org/10.1093/jn/131.3.1010S] [PMID: 11238807]
[31]
Suridjan, I.; Herrmann, N.; Adibfar, A.; Saleem, M.; Andreazza, A.; Oh, P.I.; Lanctôt, K.L. Lipid peroxidation markers in coronary artery disease patients with possible vascular mild cognitive impairment. J. Alzheimers Dis., 2017, 58(3), 885-896.
[http://dx.doi.org/10.3233/JAD-161248] [PMID: 28505971]
[32]
Hara, Y.; Noda, A.; Miyata, S.; Minoshima, M.; Sugiura, M.; Kojima, J.; Otake, M.; Furukawa, M.; Cheng, X.W.; Nagata, K.; Murohara, T. Effects of aged garlic extract on left ventricular diastolic function and fibrosis in a rat hypertension model. Exp. Anim., 2013, 62(4), 305-310.
[http://dx.doi.org/10.1538/expanim.62.305] [PMID: 24172194]
[33]
Efendy, JL.; Simmons, DL.; Campbell, GR.; Campbell, JH. The effect of the aged garlic extract, 'Kyolic', on the development of experimental atherosclerosis. Atherosclerosis, 1997, 132(1), 37-42.
[34]
Matsutomo, T.; Ushijima, M.; Kodera, Y.; Nakamoto, M.; Takashima, M.; Morihara, N.; Tamura, K. Metabolomic study on the antihypertensive effect of S -1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2017, 1046(1046), 147-155.
[http://dx.doi.org/10.1016/j.jchromb.2017.01.029] [PMID: 28183044]
[35]
Wang, H.; Wang, X.; Qi, D.; Sun, M.; Hou, Q.; Li, Y.; Jiang, H. Establishment of the circadian metabolic phenotype strategy in spontaneously hypertensive rats: A dynamic metabolomics study. J. Transl. Med., 2020, 18(1), 38.
[http://dx.doi.org/10.1186/s12967-020-02222-1] [PMID: 31992312]
[36]
Ushijima, M.; Takashima, M. Effects of S -1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. J. Pharm. Pharmacol., 2018, 70(4), 559-565.
[37]
Budoff, M.J.; Ahmadi, N.; Gul, K.M.; Liu, S.T.; Flores, F.R.; Tiano, J.; Takasu, J.; Miller, E.; Tsimikas, S. Aged garlic extract supplemented with B vitamins, folic acid and l-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial. Prev. Med., 2009, 49(2-3), 101-107.
[http://dx.doi.org/10.1016/j.ypmed.2009.06.018] [PMID: 19573556]
[38]
Ahmadi, N.; Nabavi, V.; Hajsadeghi, F.; Zeb, I. Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis. Inter. J. Cardiol., 2013, 168(3), 2310-2314.
[http://dx.doi.org/10.1016/j.ijcard.2013.01.182]
[39]
Kim, H.K.; Choi, Y.W.; Lee, E.N.; Park, J.K.; Kim, S.G.; Park, D.J.; Kim, B.S.; Lim, Y.T.; Yoon, S. 5-Hydroxymethylfurfural from black garlic extract prevents TNFα-induced monocytic cell adhesion to HUVECs by suppression of vascular cell adhesion molecule-1 expression, reactive oxygen species generation and NF-κB activation. Phytother. Res., 2011, 25(7), 965-974.
[http://dx.doi.org/10.1002/ptr.3351] [PMID: 21213354]
[40]
Kaplanski, G.; Marin, V.; Fabrigoule, M.; Boulay, V.; Benoliel, A.M.; Bongrand, P.; Kaplanski, S.; Farnarier, C. Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (ICAM-1; CD54) and vascular cell adhesion molecule-1 (VCAM-1; CD106). Blood, 1998, 92(4), 1259-1267.
[http://dx.doi.org/10.1182/blood.V92.4.1259] [PMID: 9694714]
[41]
Haft, J.I. Role of blood platelets in coronary artery disease. Am. J. Cardiol., 1979, 43(6), 1197-1206.
[http://dx.doi.org/10.1016/0002-9149(79)90154-1] [PMID: 35967]
[42]
Herken, K.; Glauner, M.; Robert, S.C.; Maas, M.; Zippel, S.; Nowak-Göttl, U.; Zieger, B.; Lahav, J.; Fender, A.C.; Jurk, K.; Kehrel, B.E. Age-dependent control of collagen-dependent platelet responses by thrombospondin-1 comparative analysis of platelets from neonates, children, adolescents, and adults. Int. J. Mol. Sci., 2021, 22(9), 4883.
[http://dx.doi.org/10.3390/ijms22094883] [PMID: 34063076]
[43]
Allison, G.L.; Lowe, G.M.; Rahman, K. Aged garlic extract inhibits platelet activation by increasing intracellular cAMP and reducing the interaction of GPIIb/IIIa receptor with fibrinogen. Life Sci., 2012, 91(25-26), 1275-1280.
[http://dx.doi.org/10.1016/j.lfs.2012.09.019] [PMID: 23069586]
[44]
Rahman, K.; Lowe, G.M.; Smith, S. Aged garlic extract inhibits human platelet aggregation by altering intracellular signaling and platelet shape change. J. Nutr., 2016, 146(2), 410S-415S.
[http://dx.doi.org/10.3945/jn.114.202408] [PMID: 26764324]
[45]
Morihara, N.; Hino, A. Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets. J. Nat. Med., 2017, 71(1), 249-256.
[http://dx.doi.org/10.1007/s11418-016-1055-4] [PMID: 27766480]
[46]
Nakashima, D.; Onuma, T.; Tanabe, K.; Kito, Y.; Uematsu, K.; Mizutani, D.; Enomoto, Y.; Tsujimoto, M.; Doi, T.; Matsushima-Nishiwaki, R.; Tokuda, H.; Ogura, S.; Iwama, T.; Kozawa, O.; Iida, H. Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation. PLoS One, 2020, 15(10), e0241139.
[http://dx.doi.org/10.1371/journal.pone.0241139] [PMID: 33119719]
[47]
Jaishankar, M.; Tseten, T.; Anbalagan, N.; Mathew, B.B.; Beeregowda, K.N. Toxicity, mechanism and health effects of some heavy metals. Interdiscip. Toxicol., 2014, 7(2), 60-72.
[http://dx.doi.org/10.2478/intox-2014-0009] [PMID: 26109881]
[48]
Kim, H.S.; Kim, Y.J.; Seo, Y.R. An overview of carcinogenic heavy metal: Molecular toxicity mechanism and prevention. J. Cancer Prev., 2015, 20(4), 232-240.
[http://dx.doi.org/10.15430/JCP.2015.20.4.232] [PMID: 26734585]
[49]
Xiao, P.; Jia, X.D.; Zhong, W.J.; Jin, X.P.; Nordberg, G. Restorative effects of zinc and selenium on cadmium-induced kidney oxidative damage in rats. Biomed. Environ. Sci., 2002, 15(1), 67-74.
[PMID: 12046550]
[50]
Reisman, S.A.; Aleksunes, L.M.; Klaassen, C.D. Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem. Pharmacol., 2009, 77(7), 1273-1282.
[http://dx.doi.org/10.1016/j.bcp.2008.12.028] [PMID: 19283895]
[51]
Jikihara, H.; Qi, G.; Nozoe, K.; Hirokawa, M.; Sato, H.; Sugihara, Y.; Shimamoto, F. Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. Oncol. Rep., 2015, 33(3), 1131-1140.
[http://dx.doi.org/10.3892/or.2014.3705] [PMID: 25573280]
[52]
Tabari, M.A.; Ebrahimpour, S. Effect of aged garlic extract on immune responses to experimental fibrosarcoma tumor in BALB/c mice. Indian J. Cancer, 2014, 51(4), 609-613.
[http://dx.doi.org/10.4103/0019-509X.175359] [PMID: 26842212]
[53]
Ji, Y.B.; Ji, C.F.; Yue, L. Human gastric cancer cell line SGC-7901 apoptosis induced by SFPS-B2 via a mitochondrial-mediated pathway. Biomed. Mater. Eng., 2014, 24(1), 1141-1147.
[http://dx.doi.org/10.3233/BME-130914] [PMID: 24212007]
[54]
Sun, H.J.; Meng, L.Y.; Shen, Y.; Zhu, Y.Z.; Liu, H.R. S-benzyl-cysteine-mediated cell cycle arrest and apoptosis involving activation of mitochondrial-dependent caspase cascade through the p53 pathway in human gastric cancer SGC-7901 cells. Asian Pac. J. Cancer Prev., 2013, 14(11), 6379-6384.
[http://dx.doi.org/10.7314/APJCP.2013.14.11.6379] [PMID: 24377536]
[55]
Azadbakht, L.; Miraghajani, M.; Rafie, N.; Hajianfar, H.; Larijani, B. Aged garlic and cancer: A systematic review. Int. J. Prev. Med., 2018, 9(1), 84.
[http://dx.doi.org/10.4103/ijpvm.IJPVM_437_17]
[56]
Dong, M.; Yang, G.; Liu, H.; Liu, X.; Lin, S.; Sun, D.; Wang, Y. Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway. Biomed. Rep., 2014, 2(2), 250-254.
[http://dx.doi.org/10.3892/br.2014.226] [PMID: 24649105]
[57]
Park, C.; Park, S.; Chung, Y.H.; Kim, G.Y.; Choi, Y.W.; Kim, B.W.; Choi, Y.H. Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells. Nutr. Res. Pract., 2014, 8(2), 132-137.
[http://dx.doi.org/10.4162/nrp.2014.8.2.132] [PMID: 24741395]
[58]
Wang, X.; Jiao, F.; Wang, Q.W.; Wang, J.; Yang, K.; Hu, R.R.; Liu, H.C.; Wang, H.Y.; Wang, Y.S. Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. Mol. Med. Rep., 2012, 5(1), 66-72.
[PMID: 21922142]
[59]
Miller, R.P.; Tadagavadi, R.K.; Ramesh, G.; Reeves, W.B. Mechanisms of Cisplatin nephrotoxicity. Toxins (Basel), 2010, 2(11), 2490-2518.
[http://dx.doi.org/10.3390/toxins2112490] [PMID: 22069563]
[60]
Mittal, M.; Siddiqui, M.R.; Tran, K.; Reddy, S.P.; Malik, A.B. Reactive oxygen species in inflammation and tissue injury. Antioxid. Redox Signal., 2014, 20(7), 1126-1167.
[http://dx.doi.org/10.1089/ars.2012.5149] [PMID: 23991888]
[61]
Jahn, H. Memory loss in Alzheimer’s disease. Dialogues Clin. Neurosci., 2013, 15(4), 445-454.
[http://dx.doi.org/10.31887/DCNS.2013.15.4/hjahn] [PMID: 24459411]
[62]
Rajmohan, R.; Reddy, P.H. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. J. Alzheimers Dis., 2017, 57(4), 975-999.
[http://dx.doi.org/10.3233/JAD-160612] [PMID: 27567878]
[63]
Nillert, N.; Pannangrong, W.; Welbat, J.; Chaijaroonkhanarak, W.; Sripanidkulchai, K.; Sripanidkulchai, B. Neuroprotective effects of aged garlic extract on cognitive dysfunction and neuroinflammation induced by β-amyloid in rats. Nutrients, 2017, 9(1), 24.
[http://dx.doi.org/10.3390/nu9010024] [PMID: 28054940]
[64]
Beckhauser, T.F.; Francis-Oliveira, J.; De Pasquale, R. Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity. J. Exp. Neurosci., 2016, 10s1(Suppl. 1), JEN.S39887.
[http://dx.doi.org/10.4137/JEN.S39887] [PMID: 27625575]
[65]
Bachiller, S.; Jiménez-Ferrer, I.; Paulus, A.; Yang, Y.; Swanberg, M.; Deierborg, T.; Boza-Serrano, A. Microglia in neurological diseases: A road map to brain-disease dependent-inflammatory response. Front. Cell. Neurosci., 2018, 12, 488.
[66]
Rojas, P.; Serrano-García, N.; Medina-Campos, O.N.; Pedraza-Chaverri, J.; Maldonado, P.D.; Ruiz-Sánchez, E. S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. J. Nutr. Biochem., 2011, 22(10), 937-944.
[http://dx.doi.org/10.1016/j.jnutbio.2010.08.005] [PMID: 21190833]
[67]
Jonathon, S. What is brain ischemia? WSU Emergency Med. Cerebr. Resuscit. Labor., 2009.
[68]
Ashafaq, M.; Khan, M.M.; Shadab Raza, S.; Ahmad, A.; Khuwaja, G.; Javed, H.; Khan, A.; Islam, F.; Siddiqui, M.S.; Safhi, M.M.; Islam, F. S-allyl cysteine mitigates oxidative damage and improves neurologic deficit in a rat model of focal cerebral ischemia. Nutr. Res., 2012, 32(2), 133-143.
[http://dx.doi.org/10.1016/j.nutres.2011.12.014] [PMID: 22348462]
[69]
Ma, Y.F.; Wu, Z.H.; Gao, M.; Loor, J.J. Nuclear factor erythroid 2-related factor 2 antioxidant response element pathways protect bovine mammary epithelial cells against H2O2-induced oxidative damage in vitro. J. Dairy Sci., 2018, 101(6), 5329-5344.
[http://dx.doi.org/10.3168/jds.2017-14128] [PMID: 29573798]
[70]
Cemil, B.; Gokce, E.C.; Kahveci, R.; Gokce, A.; Aksoy, N.; Sargon, M.F.; Erdogan, B.; Kosem, B. Aged garlic extract attenuates neuronal injury in a rat model of spinal cord ischemia/reperfusion injury. J. Med. Food, 2016, 19(6), 601-606.
[http://dx.doi.org/10.1089/jmf.2016.0018] [PMID: 27183321]
[71]
Colín-González, A.L.; Ortiz-Plata, A.; Villeda-Hernández, J.; Barrera, D.; Molina-Jijón, E.; Pedraza-Chaverrí, J.; Maldonado, P.D. Aged garlic extract attenuates cerebral damage and cyclooxygenase-2 induction after ischemia and reperfusion in rats. Plant Foods Hum. Nutr., 2011, 66(4), 348-354.
[http://dx.doi.org/10.1007/s11130-011-0251-3] [PMID: 21850441]
[72]
Zhou, H.; Qu, Z.; Mossine, VV.; Nknolise, DL. Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells. PLoS One, 2014, 9(11), e113531.
[http://dx.doi.org/10.1371/journal.pone.0113531]
[73]
Orozco-Ibarra, M.; Muñoz-Sánchez, J.; Zavala-Medina, M.E.; Pineda, B.; Magaña-Maldonado, R.; Vázquez-Contreras, E.; Maldonado, P.D.; Pedraza-Chaverri, J.; Chánez-Cárdenas, M.E. Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model. Biol. Res., 2016, 49(1), 7.
[http://dx.doi.org/10.1186/s40659-016-0067-6] [PMID: 26830333]
[74]
Kyo, E.; Uda, N.; Kasuga, S.; Itakura, Y. Immunomodulatory effects of aged garlic extract. J. Nutr., 2001, 131(3), 1075S-1079S.
[http://dx.doi.org/10.1093/jn/131.3.1075S] [PMID: 11238820]
[75]
Vijay, K. Toll-like receptors in immunity and inflammatory diseases: Past, present, and future. Int. Immunopharmacol., 2018, 59, 391-412.
[http://dx.doi.org/10.1016/j.intimp.2018.03.002] [PMID: 29730580]
[76]
Suzuki, J.; Kodera, Y.; Miki, S.; Ushijima, M.; Takashima, M.; Matsutomo, T.; Morihara, N. Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci. Rep., 2018, 8(1), 14148.
[http://dx.doi.org/10.1038/s41598-018-32431-0] [PMID: 30237533]
[77]
Ide, N.; Keller, C.; Weiss, N. Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J. Nutr., 2006, 136(3)(Suppl.), 755S-758S.
[http://dx.doi.org/10.1093/jn/136.3.755S] [PMID: 16484557]
[78]
Vaisman, B.L.; Lambert, G.; Amar, M.; Joyce, C.; Ito, T.; Shamburek, R.D.; Cain, W.J.; Fruchart-Najib, J.; Neufeld, E.D.; Remaley, A.T.; Brewer, H.B., Jr; Santamarina-Fojo, S. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J. Clin. Invest., 2001, 108(2), 303-309.
[http://dx.doi.org/10.1172/JCI200112517] [PMID: 11457883]
[79]
Xu, C.; Mathews, A.E.; Rodrigues, C.; Eudy, B.J.; Rowe, C.A.; O’Donoughue, A.; Percival, S.S. Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial. Clin. Nutr. ESPEN, 2018, 24, 148-155.
[http://dx.doi.org/10.1016/j.clnesp.2017.11.010] [PMID: 29576354]
[80]
Seo, D.Y.; Lee, S.; Figueroa, A.; Kwak, Y.S.; Kim, N.; Rhee, B.D.; Ko, K.S.; Bang, H.S.; Baek, Y.H.; Han, J. Aged garlic extract enhances exercise-mediated improvement of metabolic parameters in high fat diet-induced obese rats. Nutr. Res. Pract., 2012, 6(6), 513-519.
[http://dx.doi.org/10.4162/nrp.2012.6.6.513] [PMID: 23346301]
[81]
Park, H.J.; Jeon, B.T.; Kim, H.C.; Roh, G.S.; Shin, J.H.; Sung, N.J.; Han, J.; Kang, D. Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction. Acta Physiol. (Oxf.), 2012, 205(1), 61-70.
[http://dx.doi.org/10.1111/j.1748-1716.2012.02425.x] [PMID: 22353229]
[82]
Behzadi, M.Y.; Fallah-Rostami, F.; Tabari, M.A.; Esfandiari, B.; Aghajanzadeh, H. Immunomodulatory activity of aged garlic extract against implanted fibrosarcoma tumor in mice. N. Am. J. Med. Sci., 2013, 5(3), 207-212.
[http://dx.doi.org/10.4103/1947-2714.109191] [PMID: 23626957]
[83]
Yoo, J.M.; Sok, D.E.; Kim, M.R. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. J. Med. Food, 2014, 17(1), 92-102.
[http://dx.doi.org/10.1089/jmf.2013.2927] [PMID: 24456359]
[84]
Shunsuke, K.; Tung, Y.C.; Pan, M.H.; Ying, S. Black garlic: A critical review of its production, bioactivity, and application. Yao Wu Shi Pin Fen Xi, 2017, 25(1), 62-70.
[85]
Chandrashekar, P.M.; Venkatesh, Y.P. Fructans from aged garlic extract produce a delayed immunoadjuvant response to ovalbumin antigen in BALB/c mice. Immunopharmacol. Immunotoxicol., 2012, 34(1), 174-180.
[http://dx.doi.org/10.3109/08923973.2011.584066] [PMID: 21631395]
[86]
Bischoff, F.R.; Maier, G.; Tilz, G.; Ponstingl, H. A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation. Proc. Natl. Acad. Sci. USA, 1990, 87(21), 8617-8621.
[http://dx.doi.org/10.1073/pnas.87.21.8617] [PMID: 2236072]
[87]
Elosta, A.; Slevin, M.; Rahman, K.; Ahmed, N. Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro. Sci. Rep., 2017, 7(1), 39613.
[http://dx.doi.org/10.1038/srep39613] [PMID: 28051097]
[88]
Thomson, M.; Al-Qattan, K.K.; Js, D.; Ali, M. Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats. BMC Complement. Altern. Med., 2015, 16(1), 17.
[http://dx.doi.org/10.1186/s12906-016-0992-5] [PMID: 26786785]
[89]
Eidi, A.; Eidi, M.; Esmaeili, E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine, 2006, 13(9-10), 624-629.
[http://dx.doi.org/10.1016/j.phymed.2005.09.010] [PMID: 17085291]
[90]
Baluchnejadmojarad, T.; Kiasalari, Z.; Afshin-Majd, S.; Ghasemi, Z.; Roghani, M. S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. Eur. J. Pharmacol., 2017, 794(794), 69-76.
[http://dx.doi.org/10.1016/j.ejphar.2016.11.033] [PMID: 27887948]
[91]
Guo, J.; Li, J.; Wei, H.; Liang, Z. Maackiain protects the kidneys of type 2 diabetic rats via modulating the Nrf2/HO-1 and TLR4/NF-κB/caspase-3 pathways. Drug Des. Devel. Ther., 2021, 15, 4339-4358.
[http://dx.doi.org/10.2147/DDDT.S326975] [PMID: 34703210]
[92]
Zhai, B.; Zhang, C.; Sheng, Y.; Zhao, C.; He, X.; Xu, W.; Huang, K.; Luo, Y. Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice. Sci. Rep., 2018, 8(1), 3527.
[http://dx.doi.org/10.1038/s41598-018-21421-x] [PMID: 29476144]
[93]
Dabla, P.K. Renal function in diabetic nephropathy. World J. Diabetes, 2010, 1(2), 48-56.
[http://dx.doi.org/10.4239/wjd.v1.i2.48] [PMID: 21537427]
[94]
Miki, S.; Inokuma, K.; Takashima, M.; Nishida, M.; Sasaki, Y.; Ushijima, M.; Suzuki, J.; Morihara, N. Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP-activated protein kinase in adipose tissue in TSOD mice. Mol. Nutr. Food Res., 2017, 61(5), 1600797.
[http://dx.doi.org/10.1002/mnfr.201600797] [PMID: 28074608]
[95]
Arriazu, E.; Ruiz de Galarreta, M.; Cubero, F.J.; Varela-Rey, M.; Pérez de Obanos, M.P.; Leung, T.M.; Lopategi, A.; Benedicto, A.; Abraham-Enachescu, I.; Nieto, N. Extracellular matrix and liver disease. Antioxid. Redox Signal., 2014, 21(7), 1078-1097.
[http://dx.doi.org/10.1089/ars.2013.5697] [PMID: 24219114]
[96]
Gong, Z.; Ye, H.; Huo, Y.; Wang, L.; Huang, Y.; Huang, M.; Yuan, X. S-allyl-cysteine attenuates carbon tetrachloride-induced liver fibrosis in rats by targeting STAT3/SMAD3 pathway. Am. J. Transl. Res., 2018, 10(5), 1337-1346.
[PMID: 29887949]
[97]
Shin, J.H.; Lee, C.W.; Oh, S.J.; Yun, J.; Kang, M.R.; Han, S.B.; Park, H.; Jung, J.C.; Chung, Y.H.; Kang, J.S. Hepatoprotective effect of aged black garlic extract in rodents. Toxicol. Res., 2014, 30(1), 49-54.
[http://dx.doi.org/10.5487/TR.2014.30.1.049] [PMID: 24795800]
[98]
Battal, M.; Kartal, A.; Citgez, B.; Yilmaz, B.; Akcakaya, A.; Karatepe, O. Impact of allyl disulfide on oxidative damage and liver regeneration in an experimental hepatectomy model. Chirurgia (Bucur.), 2015, 110(2), 117-122.
[PMID: 26011832]
[99]
Ramadan, M.A.; Shawkey, A.E.; Rabeh, M.A.; Abdellatif, A.O. Expression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro. Cytotechnology, 2019, 71(1), 461-473.
[http://dx.doi.org/10.1007/s10616-018-0287-4] [PMID: 30599074]
[100]
Pathak, S.; Catanzaro, R.; Vasan, D.; Marotta, F.; Chabria, Y.; Jothimani, G.; Verma, R.S.; Ramachandran, M.; Khuda-Bukhsh, A.R.; Banerjee, A. Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in Rattus norvegicus. Drug Chem. Toxicol., 2020, 43(5), 454-467.
[http://dx.doi.org/10.1080/01480545.2018.1499773] [PMID: 30207178]
[101]
Shao, W.; Espenshade, P.J. Expanding roles for SREBP in metabolism. Cell Metab., 2012, 16(4), 414-419.
[http://dx.doi.org/10.1016/j.cmet.2012.09.002] [PMID: 23000402]
[102]
Shiju, T.M.; Rajesh, N.G.; Viswanathan, P. Renoprotective effect of aged garlic extract in streptozotocin- induced diabetic rats. Indian J. Pharmacol., 2013, 45(1), 18-23.
[http://dx.doi.org/10.4103/0253-7613.106429] [PMID: 23543654]
[103]
Amor, S.; González-Hedström, D.; Martín-Carro, B. Beneficial effects of an aged black garlic extract in the metabolic and vascular alterations induced by a high fat/sucrose diet in male rats. Nutrients, 2019, 11(1), 153.
[104]
Nasr, A.Y. Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats. Toxicol. Rep., 2014, 1, 682-691.
[http://dx.doi.org/10.1016/j.toxrep.2014.09.003] [PMID: 28962282]
[105]
Asdaq, S.M.B. Antioxidant and hypolipidemic potential of aged garlic extract and its constituent, s-allyl cysteine, in rats. Evid. Based Complement. Alternat. Med., 2015, 2015, 1-7.
[http://dx.doi.org/10.1155/2015/328545] [PMID: 25918544]
[106]
Ha, A.W.; Ying, T.; Kim, W.K. The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet. Nutr. Res. Pract., 2015, 9(1), 30-36.
[http://dx.doi.org/10.4162/nrp.2015.9.1.30] [PMID: 25671065]

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