Endophthalmitis: Gram Positive Ethiological Agents and Susceptibility to Glycopeptides

Title: Endophthalmitis: Gram Positive Ethiological Agents and Susceptibility to Glycopeptides

Volume: 3 Issue: 3

Author(s): Giuseppe Chisari

Affiliation:

Keywords: Endophthalmitis, Gram-positive bacteria, teicoplanin, vancomycin

Abstract: Endophthalmitis is a serious sight-threatening condition, with a postoperative incidence of 0.13 -0.7%. This study aimed to investigate the spectrum of Gram-positive bacteria causing culture-proven endophthalmitis and their susceptibility to teicoplanin and vancomycin. At this purpose, minimum inhibitory concentrations of teicoplanin and vancomycin of Gram-positive bacteria isolated in the period 2001-2007 from vitreous cultures were determined. Staphylococcus epidermidis was the most common organisms identified (31,8 %), followed by Staphylococcus aureus, Peptococcus spp. e Bacillus spp. All bacteria were susceptible to teicoplanin and vancomycin. The two drugs showed a comparable activity against staphylococci and bacilli, while teicoplanin was more potent against streptococci and anaerobes. In conclusion, teicoplanin showed a spectrum of activity similar or even better that of vancomycin against the most common ethiological agents of postoperative endophthalmitis.

Cite this article as:

Chisari Giuseppe, Endophthalmitis: Gram Positive Ethiological Agents and Susceptibility to Glycopeptides, Current Clinical Pharmacology 2008; 3 (3) . https://dx.doi.org/10.2174/157488408785747692