Abstract
Long-term diabetes can lead to renal injury known as diabetic nephropathy (DN), which is a major cause of end-stage renal disease (ESRD). However, its pathogenesis has not been well explained. Adipose tissue is recognized as an important energy storage device for the body. Interestingly, many studies have shown that adipose tissue can also act as an endocrine organ by secreting a variety of adipokines to maintain homeostasis. Here, we summarize some of the adipokines that have been identified so far to, more specifically, emphasize their role in DN progression and propose that the “adipose-renal axis” may be a potential target for treating DN.
Keywords: Diabetic nephropathy (DN), Adipose tissues, Adipokines, Adiponectin, Kidney, Diabetes
[http://dx.doi.org/10.1016/S0140-6736(09)62124-3] [PMID: 20580421]
[http://dx.doi.org/10.1017/erm.2021.27] [PMID: 34955116]
[http://dx.doi.org/10.2174/0929867327666201006152656] [PMID: 33023427]
[http://dx.doi.org/10.1089/ars.2016.6664] [PMID: 26906673]
[http://dx.doi.org/10.1007/978-981-15-4272-5_36] [PMID: 32671771]
[http://dx.doi.org/10.3390/nu13124552] [PMID: 34960104]
[http://dx.doi.org/10.1016/j.lfs.2021.120262] [PMID: 34968464]
[http://dx.doi.org/10.1016/j.tice.2021.101713] [PMID: 34952398]
[http://dx.doi.org/10.1016/j.metabol.2021.154916] [PMID: 34666067]
[http://dx.doi.org/10.1111/1753-0407.12938] [PMID: 31020790]
[http://dx.doi.org/10.1038/nrneph.2017.157] [PMID: 29199276]
[http://dx.doi.org/10.24875/GMM.M20000356] [PMID: 32285854]
[http://dx.doi.org/10.1210/jc.2004-0395] [PMID: 15181022]
[http://dx.doi.org/10.1038/s42255-018-0021-8] [PMID: 31903450]
[http://dx.doi.org/10.1242/jeb.161570] [PMID: 29514893]
[http://dx.doi.org/10.1111/j.1467-789X.2009.00623.x] [PMID: 19656312]
[http://dx.doi.org/10.3390/ijms20092358] [PMID: 31085992]
[http://dx.doi.org/10.1111/obr.12958] [PMID: 31777187]
[http://dx.doi.org/10.3390/ijms21176039] [PMID: 32839413]
[http://dx.doi.org/10.3390/ijms21041219] [PMID: 32059381]
[http://dx.doi.org/10.1515/hmbci-2014-0022] [PMID: 25390014]
[http://dx.doi.org/10.1152/ajpendo.00691.2006] [PMID: 17473055]
[http://dx.doi.org/10.3389/fendo.2020.00498] [PMID: 32849287]
[http://dx.doi.org/10.1038/387090a0] [PMID: 9139827]
[http://dx.doi.org/10.3389/fendo.2019.00368] [PMID: 31281288]
[http://dx.doi.org/10.1074/jbc.M109.053942] [PMID: 20028987]
[http://dx.doi.org/10.1016/j.cell.2012.05.016] [PMID: 22796012]
[http://dx.doi.org/10.1002/cphy.c170001] [PMID: 28915325]
[http://dx.doi.org/10.1158/1541-7786.MCR-15-0151] [PMID: 26464213]
[http://dx.doi.org/10.1155/2017/5468023] [PMID: 28490838]
[http://dx.doi.org/10.1016/j.cyto.2020.155144] [PMID: 32559663]
[http://dx.doi.org/10.1016/j.bcp.2019.03.030] [PMID: 30910694]
[http://dx.doi.org/10.1038/nrrheum.2016.209] [PMID: 28053336]
[http://dx.doi.org/10.1152/ajprenal.00263.2013] [PMID: 24107418]
[http://dx.doi.org/10.1002/cphy.c170046] [PMID: 29978896]
[http://dx.doi.org/10.3390/ijms18061321] [PMID: 28635626]
[http://dx.doi.org/10.1007/s11154-013-9256-6] [PMID: 23990400]
[http://dx.doi.org/10.1093/jmcb/mjw011] [PMID: 26993047]
[http://dx.doi.org/10.1038/nature01705] [PMID: 12802337]
[http://dx.doi.org/10.1074/jbc.M117.780734] [PMID: 28325833]
[http://dx.doi.org/10.1016/0896-6273(91)90291-7] [PMID: 1654948]
[http://dx.doi.org/10.1172/JCI43464] [PMID: 21041950]
[http://dx.doi.org/10.1210/en.2014-1618] [PMID: 25514086]
[http://dx.doi.org/10.1210/en.2016-1765] [PMID: 28402446]
[http://dx.doi.org/10.1152/ajprenal.00373.2007] [PMID: 18256313]
[http://dx.doi.org/10.1210/jc.2002-021721] [PMID: 12788897]
[http://dx.doi.org/10.1006/bbrc.2001.5904] [PMID: 11700024]
[http://dx.doi.org/10.1074/jbc.M400238200] [PMID: 15037635]
[http://dx.doi.org/10.1038/ncb1404] [PMID: 16622416]
[http://dx.doi.org/10.1152/ajpendo.90731.2008] [PMID: 18854421]
[http://dx.doi.org/10.1021/acs.jafc.1c04481] [PMID: 34586803]
[http://dx.doi.org/10.1016/j.celrep.2014.04.006] [PMID: 24813896]
[http://dx.doi.org/10.1074/jbc.RA118.001801] [PMID: 29991592]
[http://dx.doi.org/10.1016/j.ajhg.2015.05.011] [PMID: 26073777]
[http://dx.doi.org/10.1016/j.metabol.2019.153955] [PMID: 31390528]
[http://dx.doi.org/10.1016/S0092-8674(04)00117-5] [PMID: 15016378]
[http://dx.doi.org/10.1038/sj.emboj.7601771] [PMID: 17581628]
[http://dx.doi.org/10.1074/jbc.M109.010355] [PMID: 19661063]
[http://dx.doi.org/10.1186/1471-2350-13-22] [PMID: 22462604]
[http://dx.doi.org/10.2337/db14-0337] [PMID: 24879834]
[http://dx.doi.org/10.1007/s11033-014-3082-0] [PMID: 24469713]
[http://dx.doi.org/10.1038/ki.2012.421] [PMID: 23283133]
[http://dx.doi.org/10.1681/ASN.V131134] [PMID: 11752030]
[http://dx.doi.org/10.1093/ndt/gfu249] [PMID: 25049200]
[http://dx.doi.org/10.3904/kjim.2016.114] [PMID: 27809453]
[http://dx.doi.org/10.1038/ki.2008.201] [PMID: 18496510]
[http://dx.doi.org/10.1172/JCI32691] [PMID: 18431508]
[http://dx.doi.org/10.1038/s41419-021-04326-y] [PMID: 34718329]
[http://dx.doi.org/10.1681/ASN.2017060627] [PMID: 29330340]
[http://dx.doi.org/10.1016/j.atherosclerosis.2006.08.023] [PMID: 17112529]
[http://dx.doi.org/10.1038/hr.2014.51] [PMID: 24599011]
[http://dx.doi.org/10.1038/sj.ki.5002516] [PMID: 17805239]
[http://dx.doi.org/10.1098/rspb.1953.0009] [PMID: 13027283]
[http://dx.doi.org/10.1007/BF01221857] [PMID: 4767369]
[http://dx.doi.org/10.1038/372425a0] [PMID: 7984236]
[http://dx.doi.org/10.1016/j.metabol.2014.09.010] [PMID: 25305050]
[PMID: 19436260]
[http://dx.doi.org/10.1038/29547] [PMID: 9723619]
[http://dx.doi.org/10.1136/thx.2007.085423] [PMID: 18835960]
[http://dx.doi.org/10.1073/pnas.94.20.11073] [PMID: 9380761]
[http://dx.doi.org/10.1210/jc.84.7.2270] [PMID: 10404789]
[http://dx.doi.org/10.1038/27376] [PMID: 9796811]
[http://dx.doi.org/10.1038/35007534] [PMID: 10766253]
[http://dx.doi.org/10.1038/382250a0] [PMID: 8717038]
[http://dx.doi.org/10.1002/cphy.c160041] [PMID: 29357132]
[http://dx.doi.org/10.1210/endrev/bnaa027] [PMID: 33150398]
[http://dx.doi.org/10.1016/j.cyto.2016.10.011] [PMID: 27916613]
[http://dx.doi.org/10.3389/fendo.2020.00354] [PMID: 32655492]
[http://dx.doi.org/10.3390/biom11071045] [PMID: 34356668]
[http://dx.doi.org/10.3389/fendo.2017.00030] [PMID: 28270795]
[http://dx.doi.org/10.1146/annurev.physiol.70.113006.100707] [PMID: 17937601]
[http://dx.doi.org/10.1016/j.dsx.2019.02.004] [PMID: 31336472]
[http://dx.doi.org/10.2147/DMSO.S305054] [PMID: 34079314]
[http://dx.doi.org/10.2337/diacare.28.7.1710] [PMID: 15983324]
[http://dx.doi.org/10.2337/dc11-1039] [PMID: 21994433]
[http://dx.doi.org/10.1152/ajprenal.00315.2002] [PMID: 12736165]
[http://dx.doi.org/10.1152/ajprenal.00607.2010] [PMID: 21147843]
[http://dx.doi.org/10.1096/fj.04-2183fje] [PMID: 15496495]
[http://dx.doi.org/10.1046/j.1523-1755.1999.00626.x] [PMID: 10469355]
[PMID: 8289818]
[http://dx.doi.org/10.1128/JB.183.4.1168-1174.2001] [PMID: 11157928]
[http://dx.doi.org/10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L] [PMID: 12555668]
[http://dx.doi.org/10.5603/GP.a2018.0088] [PMID: 30318580]
[http://dx.doi.org/10.1677/jme.0.0260107] [PMID: 11241162]
[http://dx.doi.org/10.1016/j.cmet.2007.09.003] [PMID: 17983582]
[http://dx.doi.org/10.1016/j.cmet.2015.04.002] [PMID: 25921090]
[http://dx.doi.org/10.1007/s12291-018-0749-7] [PMID: 31391726]
[PMID: 29891746]
[http://dx.doi.org/10.1111/j.1440-1797.2009.01173.x] [PMID: 20470283]
[http://dx.doi.org/10.3889/oamjms.2017.065] [PMID: 28698746]
[http://dx.doi.org/10.1152/ajprenal.90231.2008] [PMID: 18768589]
[http://dx.doi.org/10.1038/ki.2010.98] [PMID: 20375985]
[http://dx.doi.org/10.1016/j.celrep.2019.03.024] [PMID: 30943401]
[http://dx.doi.org/10.3109/00365513.2015.1137349] [PMID: 26922969]
[http://dx.doi.org/10.1073/pnas.98.2.502] [PMID: 11209052]
[http://dx.doi.org/10.1038/35053000] [PMID: 11201732]
[http://dx.doi.org/10.1055/s-2007-985897] [PMID: 17952831]
[http://dx.doi.org/10.1016/j.clim.2009.07.013] [PMID: 19740705]
[http://dx.doi.org/10.1371/journal.pmed.0010045] [PMID: 15578112]
[http://dx.doi.org/10.1016/j.mad.2019.01.004] [PMID: 30650338]
[http://dx.doi.org/10.1016/j.bbrc.2003.09.093] [PMID: 14550293]
[http://dx.doi.org/10.1016/j.cca.2014.07.043] [PMID: 25128719]
[http://dx.doi.org/10.1016/j.bbcan.2020.188419] [PMID: 32822824]
[http://dx.doi.org/10.2337/db12-0237] [PMID: 22961082]
[http://dx.doi.org/10.1038/onc.2017.357] [PMID: 28991224]
[http://dx.doi.org/10.1007/s11255-020-02434-w] [PMID: 32173772]
[http://dx.doi.org/10.1016/j.jdiacomp.2019.107422] [PMID: 31484628]
[http://dx.doi.org/10.1055/s-0043-121262] [PMID: 29421824]
[http://dx.doi.org/10.1016/j.jdiacomp.2011.06.001] [PMID: 21813294]
[http://dx.doi.org/10.1073/pnas.0504703102] [PMID: 16030142]
[http://dx.doi.org/10.1002/psc.2621] [PMID: 24596079]
[http://dx.doi.org/10.1007/s00018-013-1258-8] [PMID: 23370777]
[http://dx.doi.org/10.2337/db12-0232] [PMID: 22837305]
[http://dx.doi.org/10.1530/JOE-18-0528] [PMID: 30721136]
[http://dx.doi.org/10.1186/s12902-017-0216-0] [PMID: 29065866]
[http://dx.doi.org/10.1080/0886022X.2016.1183444] [PMID: 27216464]
[http://dx.doi.org/10.1038/s42003-021-01902-y] [PMID: 33742129]
[http://dx.doi.org/10.1038/ki.2009.518] [PMID: 20130530]
[http://dx.doi.org/10.1007/s12020-008-9058-x] [PMID: 18392690]
[http://dx.doi.org/10.1111/j.1463-1326.2010.01297.x] [PMID: 20977580]
[http://dx.doi.org/10.1507/endocrj.K06-172] [PMID: 17457016]
[http://dx.doi.org/10.1210/jc.2006-2092] [PMID: 17341566]
[PMID: 24878942]