Oxytocin: An Old Hormone, a Novel Psychotropic Drug and its Possible Use in Treating Psychiatric Disorders

Feldman, R.; Monakhov, M.; Pratt, M.; Ebstein, R.P. Oxytocin pathway genes: Evolutionary ancient system impacting on human affiliation, sociality, and psychopathology. Biol. Psychiatry, 2016, 79(3), 174-184.
[http://dx.doi.org/10.1016/j.biopsych.2015.08.008] [PMID: 26392129]

Busnelli, M.; Chini, B. Molecular basis of oxytocin receptor signalling in the brain: What we know and what we need to know. Curr. Top. Behav. Neurosci., 2017, 35, 3-29.
[http://dx.doi.org/10.1007/7854_2017_6] [PMID: 28812263]

Maejima, Y.; Sakuma, K.; Santoso, P.; Gantulga, D.; Katsurada, K.; Ueta, Y.; Hiraoka, Y.; Nishimori, K.; Tanaka, S.; Shimomura, K.; Yada, T. Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett., 2014, 588(23), 4404-4412.
[http://dx.doi.org/10.1016/j.febslet.2014.10.010] [PMID: 25448678]

Gimpl, G.; Fahrenholz, F. The oxytocin receptor system: Structure, function, and regulation. Physiol. Rev., 2001, 81(2), 629-683.
[http://dx.doi.org/10.1152/physrev.2001.81.2.629] [PMID: 11274341]

Quintana, D.S.; Rokicki, J.; van der Meer, D.; Alnæs, D.; Kaufmann, T.; Córdova-Palomera, A.; Dieset, I.; Andreassen, O.A.; Westlye, L.T. Oxytocin pathway gene networks in the human brain. Nat. Commun., 2019, 10(1), 668.
[http://dx.doi.org/10.1038/s41467-019-08503-8] [PMID: 30737392]

Valtcheva, S.; Froemke, R.C. Neuromodulation of maternal circuits by oxytocin. Cell Tissue Res., 2019, 375(1), 57-68.
[http://dx.doi.org/10.1007/s00441-018-2883-1] [PMID: 30062614]

Uvnäs-Moberg, K.; Ekström-Bergström, A.; Berg, M.; Buckley, S.; Pajalic, Z.; Hadjigeorgiou, E.; Kotłowska, A.; Lengler, L.; Kielbratowska, B.; Leon-Larios, F.; Magistretti, C.M.; Downe, S.; Lindström, B.; Dencker, A. Maternal plasma levels of oxytocin during physiological childbirth – a systematic review with implications for uterine contractions and central actions of oxytocin. BMC Pregnancy Childbirth, 2019, 19(1), 285.
[http://dx.doi.org/10.1186/s12884-019-2365-9] [PMID: 31399062]

Kamikawa, A.; Seko, J. Physiological and pharmacological evaluation of oxytocin-induced milk ejection in mice. Exp. Anim., 2020, 69(3), 345-353.
[http://dx.doi.org/10.1538/expanim.19-0126] [PMID: 32213759]

Knobloch, H.S.; Charlet, A.; Hoffmann, L.C.; Eliava, M.; Khrulev, S.; Cetin, A.H.; Osten, P.; Schwarz, M.K.; Seeburg, P.H.; Stoop, R.; Grinevich, V. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron, 2012, 73(3), 553-566.
[http://dx.doi.org/10.1016/j.neuron.2011.11.030] [PMID: 22325206]

Zoicas, I.; Slattery, D.A.; Neumann, I.D. Brain oxytocin in social fear conditioning and its extinction: Involvement of the lateral septum. Neuropsychopharmacology, 2014, 39(13), 3027-3035.
[http://dx.doi.org/10.1038/npp.2014.156] [PMID: 24964815]

Eliava, M.; Melchior, M.; Knobloch-Bollmann, H.S.; Wahis, J.; da Silva Gouveia, M.; Tang, Y.; Ciobanu, A.C.; Triana del Rio, R.; Roth, L.C.; Althammer, F.; Chavant, V.; Goumon, Y.; Gruber, T.; Petit-Demoulière, N.; Busnelli, M.; Chini, B.; Tan, L.L.; Mitre, M.; Froemke, R.C.; Chao, M.V.; Giese, G.; Sprengel, R.; Kuner, R.; Poisbeau, P.; Seeburg, P.H.; Stoop, R.; Charlet, A.; Grinevich, V. a new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing. Neuron, 2016, 89(6), 1291-1304.
[http://dx.doi.org/10.1016/j.neuron.2016.01.041] [PMID: 26948889]

Althammer, F.; Grinevich, V. Diversity of oxytocin neurons: Beyond magno- and parvocellular cell types? J. Neuroendocrinol., 2017.
[PMID: 29024187]

Zheng, J.J.; Li, S.J.; Zhang, X.D.; Miao, W.Y.; Zhang, D.; Yao, H.; Yu, X. Oxytocin mediates early experience–dependent cross-modal plasticity in the sensory cortices. Nat. Neurosci., 2014, 17(3), 391-399.
[http://dx.doi.org/10.1038/nn.3634] [PMID: 24464043]

Veening, J.G.; Olivier, B. Intranasal administration of oxytocin: Behavioral and clinical effects, a review. Neurosci. Biobehav. Rev., 2013, 37(8), 1445-1465.
[http://dx.doi.org/10.1016/j.neubiorev.2013.04.012] [PMID: 23648680]

Yamamoto, Y.; Higashida, H. RAGE regulates oxytocin transport into the brain. Commun. Biol., 2020, 3(1), 70.
[http://dx.doi.org/10.1038/s42003-020-0799-2] [PMID: 32054984]

Chini, B.; Verhage, M.; Grinevich, V. The action radius of oxytocin release in the mammalian CNS: From single vesicles to behavior. Trends Pharmacol. Sci., 2017, 38(11), 982-991.
[http://dx.doi.org/10.1016/j.tips.2017.08.005] [PMID: 28899620]

Devost, D.; Wrzal, P.; Zingg, H. Oxytocin receptor signalling. Prog. Brain Res., 2008, 170, 167-176.
[http://dx.doi.org/10.1016/S0079-6123(08)00415-9] [PMID: 18655881]

Jurek, B.; Neumann, I.D. The oxytocin receptor: From intracellular signaling to behavior. Physiol. Rev., 2018, 98(3), 1805-1908.
[http://dx.doi.org/10.1152/physrev.00031.2017] [PMID: 29897293]

Staes, N.; Guevara, E.E.; Helsen, P.; Eens, M.; Stevens, J.M.G. The Pan social brain: An evolutionary history of neurochemical receptor genes and their potential impact on sociocognitive differences. J. Hum. Evol., 2021, 152, , 102949..
[http://dx.doi.org/10.1016/j.jhevol.2021.102949] [PMID: 33578304]

King, C.E.; Gano, A.; Becker, H.C. The role of oxytocin in alcohol and drug abuse. Brain Res., 2020, 1736, , 146761..
[http://dx.doi.org/10.1016/j.brainres.2020.146761] [PMID: 32142721]

Sundar, M.; Patel, D.; Young, Z.; Leong, K.C. Oxytocin and addiction: Potential Glutamatergic mechanisms. Int. J. Mol. Sci., 2021, 22(5), 2405.
[http://dx.doi.org/10.3390/ijms22052405] [PMID: 33673694]

Che, X.; Cai, J.; Liu, Y.; Xu, T.; Yang, J.; Wu, C. Oxytocin signaling in the treatment of drug addic-tion: Therapeutic opportunities and challenges. Pharmacol. Ther., 2021, 223, , 107820..
[http://dx.doi.org/10.1016/j.pharmthera.2021.107820] [PMID: 33600854]

Rivera, D.S.; Lindsay, C.B.; Oliva, C.A.; Bozinovic, F.; Inestrosa, N.C. “Live together, die alone”: The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress. Neurobiol. Stress, 2021, 14, , 100289..
[http://dx.doi.org/10.1016/j.ynstr.2020.100289] [PMID: 33426200]

Neumann, I.D.; Slattery, D.A. Oxytocin in general anxiety and social fear: A translational approach. Biol. Psychiatry, 2016, 79(3), 213-221.
[http://dx.doi.org/10.1016/j.biopsych.2015.06.004] [PMID: 26208744]

Hung, L.W.; Neuner, S.; Polepalli, J.S.; Beier, K.T.; Wright, M.; Walsh, J.J.; Lewis, E.M.; Luo, L.; Deisseroth, K.; Dölen, G.; Malenka, R.C. Gating of social reward by oxytocin in the ventral tegmental area. Science, 2017, 357(6358), 1406-1411.
[http://dx.doi.org/10.1126/science.aan4994] [PMID: 28963257]

Lawson, E.A. The effects of oxytocin on eating behaviour and metabolism in humans. Nat. Rev. Endocrinol., 2017, 13(12), 700-709.
[http://dx.doi.org/10.1038/nrendo.2017.115] [PMID: 28960210]

Meyer-Lindenberg, A.; Domes, G.; Kirsch, P.; Heinrichs, M. Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nat. Rev. Neurosci., 2011, 12(9), 524-538.
[http://dx.doi.org/10.1038/nrn3044] [PMID: 21852800]

Marlin, B.J.; Mitre, M.; D’amour, J.A.; Chao, M.V.; Froemke, R.C. Oxytocin enables maternal behaviour by balancing cortical inhibition. Nature, 2015, 520(7548), 499-504.
[http://dx.doi.org/10.1038/nature14402] [PMID: 25874674]

Iovino, M.; Messana, T.; Iovino, E.; De Pergola, G.; Guastamacchia, E.; Giagulli, V.A.; Triggiani, V. Neuroendocrine mechanisms involved in male sexual and emotional behavior. Endocr. Metab. Immune Disord. Drug Targets, 2019, 19(4), 472-480.
[http://dx.doi.org/10.2174/1871530319666190131155310] [PMID: 30706797]

Peled-Avron, L.; Abu-Akel, A.; Shamay-Tsoory, S. Exogenous effects of oxytocin in five psychiatric disorders: A systematic review, meta-analyses and a personalized approach through the lens of the social salience hypothesis. Neurosci. Biobehav. Rev., 2020, 114, 70-95.
[http://dx.doi.org/10.1016/j.neubiorev.2020.04.023] [PMID: 32348803]

Rae, M.; Duarte, M.L.; Gomes, I.; Camarini, R.; Devi, L.A. Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects. Br. J. Pharmacol., 2021.
[PMID: 33817785]

Bukovskaya, O.; Shmukler, A. Oxytocin and social cognitions in schizophrenia: A systematic review. Psychiatr. Q., 2016, 87(3), 521-543.
[http://dx.doi.org/10.1007/s11126-015-9407-x] [PMID: 26689706]

Servan, A.; Brunelin, J.; Poulet, E. The effects of oxytocin on social cognition in borderline personality disorder. Encephale, 2018, 44(1), 46-51.
[http://dx.doi.org/10.1016/j.encep.2017.11.001] [PMID: 29273344]

Tan, B.L.; Lee, S.A.; Lee, J. Social cognitive interventions for people with schizophrenia: A systematic review. Asian J. Psychiatr., 2018, 35, 115-131.
[http://dx.doi.org/10.1016/j.ajp.2016.06.013] [PMID: 27670776]

Donadon, M.F.; Martin-Santos, R.; Osório, F.L. The associations between oxytocin and trauma in humans: A systematic review. Front. Pharmacol., 2018, 9, 154.
[http://dx.doi.org/10.3389/fphar.2018.00154] [PMID: 29545749]

Yoshida, M.; Takayanagi, Y.; Inoue, K.; Kimura, T.; Young, L.J.; Onaka, T.; Nishimori, K. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J. Neurosci., 2009, 29(7), 2259-2271.
[http://dx.doi.org/10.1523/JNEUROSCI.5593-08.2009] [PMID: 19228979]

de Oliveira, D.C.G.; Zuardi, A.W.; Graeff, F.G.; Queiroz, R.H.C.; Crippa, J.A.S. Anxiolytic-like effect of oxytocin in the simulated public speaking test. J. Psychopharmacol., 2012, 26(4), 497-504.
[http://dx.doi.org/10.1177/0269881111400642] [PMID: 21555332]

Panaitescu, A.; Isac, S.; Pavel, B.; Ilie, A.S.; Ceanga, M.; Totan, A.; Zagrean, L.; Peltecu, G.; Zagrean, A.M. Oxytocin reduces seizure burden and hippocampal injury in a rat model of perinatal asphyxia. Acta Endocrinol. (Bucur.), 2018, 14(3), 315-319.
[http://dx.doi.org/10.4183/aeb.2018.315] [PMID: 31149277]

Giovanna, G.; Damiani, S.; Fusar-Poli, L.; Rocchetti, M.; Brondino, N.; de Cagna, F.; Mori, A.; Politi, P. Intranasal oxytocin as a potential therapeutic strategy in post-traumatic stress disorder: A systematic review. Psychoneuroendocrinology, 2020, 115, , 104605..
[http://dx.doi.org/10.1016/j.psyneuen.2020.104605] [PMID: 32088633]

Carter, C.S.; Kenkel, W.M.; MacLean, E.L.; Wilson, S.R.; Perkeybile, A.M.; Yee, J.R.; Ferris, C.F.; Nazarloo, H.P.; Porges, S.W.; Davis, J.M.; Connelly, J.J.; Kingsbury, M.A. Is Oxytocin “Nature’s Medicine”? Pharmacol. Rev., 2020, 72(4), 829-861.
[http://dx.doi.org/10.1124/pr.120.019398] [PMID: 32912963]

Dale, H.H. On some physiological actions of ergot. J. Physiol., 1906, 34(3), 163-206.
[http://dx.doi.org/10.1113/jphysiol.1906.sp001148] [PMID: 16992821]

Pierce, J.G.; Gordon, S.; du Vigneaud, V. Further distribution studies on the oxytocic hormone of the posterior lobe of the pituitary gland and the preparation of an active crystalline flavianate. J. Biol. Chem., 1952, 199(2), 929-940.
[http://dx.doi.org/10.1016/S0021-9258(18)38532-6] [PMID: 13022701]

du Vigneaud, V.; Ressler, C.; Trippett, S. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. J. Biol. Chem., 1953, 205(2), 949-957.
[http://dx.doi.org/10.1016/S0021-9258(18)49238-1] [PMID: 13129273]

du Vigneaud, V. Trail of sulfur research: From insulin to oxytocin. Science, 1956, 123(3205), 967-974.
[http://dx.doi.org/10.1126/science.123.3205.967] [PMID: 13324123]

Fabian, M.; Forsling, M.L.; Jones, J.J.; Pryor, J.S. The clearance and antidiuretic potency of neurohy-pophysial hormones in man, and their plasma binding and stability. J. Physiol., 1969, 204(3), 653-668.
[http://dx.doi.org/10.1113/jphysiol.1969.sp008937] [PMID: 5824107]

Summar, M.L.; Phillips, J.A., III; Battey, J.; Castiglione, C.M.; Kidd, K.K.; Maness, K.J.; Weiffenbach, B.; Gravius, T.C. Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20. Mol. Endocrinol., 1990, 4(6), 947-950.
[http://dx.doi.org/10.1210/mend-4-6-947] [PMID: 1978246]

Brownstein, M.J.; Russell, J.T.; Gainer, H. Synthesis, transport, and release of posterior pituitary hormones. Science, 1980, 207(4429), 373-378.
[http://dx.doi.org/10.1126/science.6153132] [PMID: 6153132]

Sheldrick, E.L.; Flint, A.P.F. Post-translational processing of oxytocin-neurophysin prohormone in the ovine corpus luteum: Activity of peptidyl glycine α-amidating mono-oxygenase and concentrations of its cofactor, ascorbic acid. J. Endocrinol., 1989, 122(1), 313-322.
[http://dx.doi.org/10.1677/joe.0.1220313] [PMID: 2769155]

Tsujimoto, M.; Hattori, A. The oxytocinase subfamily of M1 aminopeptidases. Biochim. Biophys. Acta. Proteins Proteom., 2005, 1751(1), 9-18.
[http://dx.doi.org/10.1016/j.bbapap.2004.09.011] [PMID: 16054015]

Burns, P.; Bowditch, J.; McFadyen, J.; Loiacono, R.; Albiston, A.L.; Pham, V.; Chai, S.Y. Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse. Behav. Brain Res., 2019, 376, , 112150..
[http://dx.doi.org/10.1016/j.bbr.2019.112150] [PMID: 31419522]

Petersson, M.; Uvnäsmoberg, K. Prolyl-leucyl-glycinamide shares some effects with oxytocin but decreases oxytocin levels. Physiol. Behav., 2004, 83(3), 475-481.
[http://dx.doi.org/10.1016/j.physbeh.2004.08.034] [PMID: 15581670]

Uvnäs-Moberg, K.; Gross, M.M.; Agius, A.; Downe, S.; Calleja-Agius, J. Are there epigenetic oxytocin-mediated effects on the mother and infant during physiological childbirth? Int. J. Mol. Sci., 2020, 21(24), 9503.
[http://dx.doi.org/10.3390/ijms21249503] [PMID: 33327490]

Khan, R.S.; Yu, C.; Kastin, A.J.; He, Y.; Ehrensing, R.H.; Hsuchou, H.; Stone, K.P.; Pan, W. Brain activation by peptide Pro-Leu-Gly-NH(2) (MIF-1). Int. J. Pept., 2010.

Baribeau, D.A.; Anagnostou, E. Oxytocin and vasopressin: Linking pituitary neuropeptides and their receptors to social neurocircuits. Front. Neurosci., 2015, 9, 335.
[http://dx.doi.org/10.3389/fnins.2015.00335] [PMID: 26441508]

MacLean, E.L.; Wilson, S.R.; Martin, W.L.; Davis, J.M.; Nazarloo, H.P.; Carter, C.S. Challenges for measuring oxytocin: The blind men and the elephant? Psychoneuroendocrinology, 2019, 107, 225-231.
[http://dx.doi.org/10.1016/j.psyneuen.2019.05.018] [PMID: 31163380]

Carter, C.S. The Oxytocin–Vasopressin pathway in the context of love and fear. Front. Endocrinol. (Lausanne), 2017, 8, 356.
[http://dx.doi.org/10.3389/fendo.2017.00356] [PMID: 29312146]

Stadler, B.; Whittaker, M.R.; Exintaris, B.; Middendorff, R. Oxytocin in the male reproductive tract; The therapeutic potential of oxytocin-agonists and-antagonists. Front. Endocrinol. (Lausanne), 2020, 11, , 565731..
[http://dx.doi.org/10.3389/fendo.2020.565731] [PMID: 33193084]

Lemel, L.; Nieścierowicz, K.; García-Fernández, M.D.; Darré, L.; Durroux, T.; Busnelli, M.; Pezet, M.; Rébeillé, F.; Jouhet, J.; Mouillac, B.; Domene, C.; Chini, B.; Cherezov, V.; Moreau, C.J. The lig-and-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules. J. Lipid Res., 2021, 62, , 100059..
[http://dx.doi.org/10.1016/j.jlr.2021.100059] [PMID: 33647276]

Zingg, H.H.; Laporte, S.A. The oxytocin receptor. Trends Endocrinol. Metab., 2003, 14(5), 222-227.
[http://dx.doi.org/10.1016/S1043-2760(03)00080-8] [PMID: 12826328]

Oakley, R.H.; Laporte, S.A.; Holt, J.A.; Barak, L.S.; Caron, M.G. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis. J. Biol. Chem., 2001, 276(22), 19452-19460.
[http://dx.doi.org/10.1074/jbc.M101450200] [PMID: 11279203]

Conti, F.; Sertic, S.; Reversi, A.; Chini, B. Intracellular trafficking of the human oxytocin receptor: Evidence of receptor recycling via a Rab4/Rab5 “short cycle”. Am. J. Physiol. Endocrinol. Metab., 2009, 296(3), E532-E542.
[http://dx.doi.org/10.1152/ajpendo.90590.2008] [PMID: 19126785]

Baskaran, C.; Plessow, F.; Silva, L.; Asanza, E.; Marengi, D.; Eddy, K.T.; Sluss, P.M.; Johnson, M.L.; Misra, M.; Lawson, E.A. Oxytocin secretion is pulsatile in men and is related to social-emotional functioning. Psychoneuroendocrinology, 2017, 85, 28-34.
[http://dx.doi.org/10.1016/j.psyneuen.2017.07.486] [PMID: 28800490]

Ueda, T.; Yokoyama, Y.; Irahara, M.; Aono, T. Influence of psychological stress on suckling-induced pulsatile oxytocin release. Obstet. Gynecol., 1994, 84(2), 259-262.
[PMID: 8041543]

Tribollet, E.; Barberis, C.; Jard, S.; Dubois-Dauphin, M.; Dreifuss, J.J. Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography. Brain Res., 1988, 442(1), 105-118.
[http://dx.doi.org/10.1016/0006-8993(88)91437-0] [PMID: 2834008]

Boccia, M.L.; Petrusz, P.; Suzuki, K.; Marson, L.; Pedersen, C.A. Immunohistochemical localization of oxytocin receptors in human brain. Neuroscience, 2013, 253, 155-164.
[http://dx.doi.org/10.1016/j.neuroscience.2013.08.048] [PMID: 24012742]

Freeman, S.M.; Inoue, K.; Smith, A.L.; Goodman, M.M.; Young, L.J. The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta). Psychoneuroendocrinology, 2014, 45, 128-141.
[http://dx.doi.org/10.1016/j.psyneuen.2014.03.023] [PMID: 24845184]

Boccia, M.L.; Panicker, A.K.; Pedersen, C.; Petrusz, P. Oxytocin receptors in non-human primate brain visualized with monoclonal antibody. Neuroreport, 2001, 12(8), 1723-1726.
[http://dx.doi.org/10.1097/00001756-200106130-00041] [PMID: 11409747]

Freeman, S.M.; Palumbo, M.C.; Lawrence, R.H.; Smith, A.L.; Goodman, M.M.; Bales, K.L. Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and mid-brain. Transl. Psychiatry, 2018, 8(1), 257.
[http://dx.doi.org/10.1038/s41398-018-0315-3] [PMID: 30514927]

Nair, H.P.; Gutman, A.R.; Davis, M.; Young, L.J. Central oxytocin, vasopressin, and corticotropin-releasing factor receptor densities in the basal forebrain predict isolation potentiated startle in rats. J. Neurosci., 2005, 25(49), 11479-11488.
[http://dx.doi.org/10.1523/JNEUROSCI.2524-05.2005] [PMID: 16339041]

Blake, M.G.; Boccia, M.M. Basal forebrain cholinergic system and memory. Curr. Top. Behav. Neurosci., 2016, 37, 253-273.
[http://dx.doi.org/10.1007/7854_2016_467] [PMID: 28213811]

Loup, F.; Tribollet, E.; Dubois-Dauphin, M.; Pizzolato, G.; Dreifuss, J.J. Localization of oxytocin binding sites in the human brainstem and upper spinal cord: An autoradiographic study. Brain Res., 1989, 500(1-2), 223-230.
[http://dx.doi.org/10.1016/0006-8993(89)90317-X] [PMID: 2557960]

Loup, F.; Tribollet, E.; Dubois-Dauphin, M.; Dreifuss, J.J. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res., 1991, 555(2), 220-232.
[http://dx.doi.org/10.1016/0006-8993(91)90345-V] [PMID: 1657300]

Toloczko, D.M.; Young, L.; Insel, T.R. Are there oxytocin receptors in the primate brain? Ann. N. Y. Acad. Sci., 1997, 807(1 Integrative N), 506-509.
[http://dx.doi.org/10.1111/j.1749-6632.1997.tb51953.x] [PMID: 9071384]

Grinevich, V.; Stoop, R. Interplay between oxytocin and sensory systems in the orchestration of socio-emotional behaviors. Neuron, 2018, 99(5), 887-904.
[http://dx.doi.org/10.1016/j.neuron.2018.07.016] [PMID: 30189208]

Warfvinge, K.; Krause, D.; Edvinsson, L. The distribution of oxytocin and the oxytocin receptor in rat brain: Relation to regions active in migraine. J. Headache Pain, 2020, 21(1), 10.
[http://dx.doi.org/10.1186/s10194-020-1079-8] [PMID: 32028899]

Curley, J.P.; Jordan, E.R.; Swaney, W.T.; Izraelit, A.; Kammel, S.; Champagne, F.A. The meaning of weaning: Influence of the weaning period on behavioral development in mice. Dev. Neurosci., 2009, 31(4), 318-331.
[http://dx.doi.org/10.1159/000216543] [PMID: 19546569]

Higashida, H.; Lopatina, O.; Yoshihara, T.; Pichugina, Y.A.; Soumarokov, A.A.; Munesue, T.; Minabe, Y.; Kikuchi, M.; Ono, Y.; Korshunova, N.; Salmina, A.B. Oxytocin signal and social behaviour: Comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice. J. Neuroendocrinol., 2010, 22(5), 373-379.
[http://dx.doi.org/10.1111/j.1365-2826.2010.01976.x] [PMID: 20141571]

Lopatina, O.; Liu, H.X.; Amina, S.; Hashii, M.; Higashida, H. Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-riboseor Ca2+ concentrations is involved in autoregulation of oxytocin secretionin the hypothalamus and posterior pituitary in male mice. Neuropharmacology, 2010, 58(1), 50-55.
[http://dx.doi.org/10.1016/j.neuropharm.2009.06.012] [PMID: 19540855]

Lopatina, O.; Inzhutova, A.; Pichugina, Y.A.; Okamoto, H.; Salmina, A.B.; Higashida, H. Reproductive experience affects parental retrieval behaviour associated with increased plasma oxytocin levels in wild-type and CD38-knockout mice. J. Neuroendocrinol., 2011, 23(11), 1125-1133.
[http://dx.doi.org/10.1111/j.1365-2826.2011.02136.x] [PMID: 21501260]

Lukas, M.; Bredewold, R.; Neumann, I.D.; Veenema, A.H. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology, 2010, 58(1), 78-87.
[http://dx.doi.org/10.1016/j.neuropharm.2009.06.020] [PMID: 19560475]

Bales, K.L.; Boone, E.; Epperson, P.; Hoffman, G.; Carter, C.S. Are behavioral effects of early experience mediated by oxytocin? Front. Psychiatry, 2011, 2, 24.
[http://dx.doi.org/10.3389/fpsyt.2011.00024] [PMID: 21629841]

Veenema, A.H.; Bredewold, R.; Neumann, I.D. Opposite effects of maternal separation on intermale and maternal aggression in C57BL/6 mice: Link to hypothalamic vasopressin and oxytocin immunore-activity. Psychoneuroendocrinology, 2007, 32(5), 437-450.
[http://dx.doi.org/10.1016/j.psyneuen.2007.02.008] [PMID: 17433558]

Veenema, A.H.; Blume, A.; Niederle, D.; Buwalda, B.; Neumann, I.D. Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin. Eur. J. Neurosci., 2006, 24(6), 1711-1720.
[http://dx.doi.org/10.1111/j.1460-9568.2006.05045.x] [PMID: 17004935]

Boccia, M.L.; Pedersen, C.A. Brief vs. long maternal separations in infancy: Contrasting relationships with adult maternal behavior and lactation levels of aggression and anxiety. Psychoneuroendocrinology, 2001, 26(7), 657-672.
[http://dx.doi.org/10.1016/S0306-4530(01)00019-1] [PMID: 11500248]

Ming, G.; Song, H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci., 2005, 28(1), 223-250.
[http://dx.doi.org/10.1146/annurev.neuro.28.051804.101459] [PMID: 16022595]

Voss, P.; Thomas, M.E.; Cisneros-Franco, J.M.; de Villers-Sidani, É. Dynamic brains and the changing rules of neuroplasticity: Implications for learning and recovery. Front. Psychol., 2017, 8, 1657.
[http://dx.doi.org/10.3389/fpsyg.2017.01657] [PMID: 29085312]

Duffau, H. Brain plasticity and reorganization before, during, and after glioma resection. In: Glioblastoma; Elsevier: Amsterdam, 2016; pp. 225-236.

Sagi, Y.; Tavor, I.; Hofstetter, S.; Tzur-Moryosef, S.; Blumenfeld-Katzir, T.; Assaf, Y. Learning in the fast lane: New insights into neuroplasticity. Neuron, 2012, 73(6), 1195-1203.
[http://dx.doi.org/10.1016/j.neuron.2012.01.025] [PMID: 22445346]

Leuner, B.; Caponiti, J.M.; Gould, E. Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids. Hippocampus, 2012, 22(4), 861-868.
[http://dx.doi.org/10.1002/hipo.20947] [PMID: 21692136]

Opendak, M.; Offit, L.; Monari, P.; Schoenfeld, T.J.; Sonti, A.N.; Cameron, H.A.; Gould, E. Lasting adaptations in social behavior produced by social disruption and inhibition of adult neurogenesis. J. Neurosci., 2016, 36(26), 7027-7038.
[http://dx.doi.org/10.1523/JNEUROSCI.4435-15.2016] [PMID: 27358459]

Ji, H.; Su, W.; Zhou, R.; Feng, J.; Lin, Y.; Zhang, Y.; Wang, X.; Chen, X.; Li, J. Intranasal oxytocin administration improves depression-like behaviors in adult rats that experienced neonatal maternal deprivation. Behav. Pharmacol., 2016, 27(8), 689-696.
[http://dx.doi.org/10.1097/FBP.0000000000000248] [PMID: 27644094]

Sánchez-Vidaña, D.I.; Chan, N.M.J.; Chan, A.H.L.; Hui, K.K.Y.; Lee, S.; Chan, H.Y.; Law, Y.S.; Sze, M.Y.; Tsui, W.C.S.; Fung, T.K.H.; Lau, B.W.M.; Lai, C.Y.Y. Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior. Neuroscience, 2016, 333, 65-77.
[http://dx.doi.org/10.1016/j.neuroscience.2016.07.005] [PMID: 27418343]

Raymond, A.D.; Kucherepa, N.N.A.; Fisher, K.R.S.; Halina, W.G.; Partlow, G.D. Neurogenesis of oxytocin-containing neurons in the paraventricular nucleus (PVN) of the female pig in 3 reproductive states: Puberty gilts, adult gilts and lactating sows. Brain Res., 2006, 1102(1), 44-51.
[http://dx.doi.org/10.1016/j.brainres.2006.04.113] [PMID: 16806117]

Lévy, F.; Batailler, M.; Meurisse, M.; Keller, M.; Cornilleau, F.; Moussu, C.; Poissenot, K.; Migaud, M. Differential effects of oxytocin on olfactory, hippocampal and hypothalamic neurogenesis in adult sheep. Neurosci. Lett., 2019, 713, , 134520..
[http://dx.doi.org/10.1016/j.neulet.2019.134520] [PMID: 31562884]

Nicoll, R.A. A brief history of long-term potentiation. Neuron, 2017, 93(2), 281-290.
[http://dx.doi.org/10.1016/j.neuron.2016.12.015] [PMID: 28103477]

Pinar, C.; Fontaine, C.J.; Triviño-Paredes, J.; Lottenberg, C.P.; Gil-Mohapel, J.; Christie, B.R. Revisiting the flip side: Long-term depression of synaptic efficacy in the hippocampus. Neurosci. Biobehav. Rev., 2017, 80, 394-413.
[http://dx.doi.org/10.1016/j.neubiorev.2017.06.001] [PMID: 28624435]

Tomizawa, K.; Iga, N.; Lu, Y.F.; Moriwaki, A.; Matsushita, M.; Li, S.T.; Miyamoto, O.; Itano, T.; Matsui, H. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Nat. Neurosci., 2003, 6(4), 384-390.
[http://dx.doi.org/10.1038/nn1023] [PMID: 12598900]

Pagani, J.H.; Zhao, M.; Cui, Z.; Williams Avram, S.K.; Caruana, D.A.; Dudek, S.M.; Young, W.S. Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Mol. Psychiatry, 2015, 20(4), 490-499.
[http://dx.doi.org/10.1038/mp.2014.47] [PMID: 24863146]

Lin, Y.T.; Huang, C.C.; Hsu, K.S. Oxytocin promotes long-term potentiation by enhancing epidermal growth factor receptor-mediated local translation of protein kinase Mζ. J. Neurosci., 2012, 32(44), 15476-15488.
[http://dx.doi.org/10.1523/JNEUROSCI.2429-12.2012] [PMID: 23115185]

Lin, Y.T.; Hsieh, T.Y.; Tsai, T.C.; Chen, C.C.; Huang, C.C.; Hsu, K.S. Conditional deletion of hippocampal CA2/CA3a oxytocin receptors impairs the persistence of long-term social recognition memory in mice. J. Neurosci., 2018, 38(5), 1218-1231.
[http://dx.doi.org/10.1523/JNEUROSCI.1896-17.2017] [PMID: 29279308]

Diamond, D.M.; Campbell, A.M.; Park, C.R.; Halonen, J.; Zoladz, P.R. The temporal dynamics model of emotional memory processing: A synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson law. Neural Plast., 2007, 2007, 1-33.
[http://dx.doi.org/10.1155/2007/60803] [PMID: 17641736]

Penn, A.C.; Zhang, C.L.; Georges, F.; Royer, L.; Breillat, C.; Hosy, E.; Petersen, J.D.; Humeau, Y.; Choquet, D. Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature, 2017, 549(7672), 384-388.
[http://dx.doi.org/10.1038/nature23658] [PMID: 28902836]

Park, S.H.; Kim, Y.J.; Park, J.C.; Han, J.S.; Choi, S.Y. Intranasal Oxytocin following uncontrollable stress blocks impairments in hippocampal plasticity and recognition memory in stressed rats. Int. J. Neuropsychopharmacol., 2017, 20(10), 861-866.
[http://dx.doi.org/10.1093/ijnp/pyx061] [PMID: 28977526]

Lee, S.Y.; Park, S.H.; Chung, C.; Kim, J.J.; Choi, S.Y.; Han, J.S. Oxytocin protects hippocampal memory and plasticity from uncontrollable stress. Sci. Rep., 2015, 5(1), 18540.
[http://dx.doi.org/10.1038/srep18540] [PMID: 26688325]

Kelly, A.M.; Hiura, L.C.; Saunders, A.G.; Ophir, A.G. Oxytocin neurons exhibit extensive functional plasticity due to offspring age in mothers and fathers. Integr. Comp. Biol., 2017, 57(3), 603-618.
[http://dx.doi.org/10.1093/icb/icx036] [PMID: 28957529]

Beranger, G.E.; Pisani, D.F.; Castel, J.; Djedaini, M.; Battaglia, S.; Amiaud, J.; Boukhechba, F.; Ailhaud, G.; Michiels, J.F.; Heymann, D.; Luquet, S.; Amri, E.Z. Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. Endocrinology, 2014, 155(4), 1340-1352.
[http://dx.doi.org/10.1210/en.2013-1688] [PMID: 24506069]

Elabd, S.; Sabry, I. Two birds with one stone: Possible dual-role of oxytocin in the treatment of diabetes and osteoporosis. Front. Endocrinol. (Lausanne), 2015, 6, 121.
[http://dx.doi.org/10.3389/fendo.2015.00121] [PMID: 26322016]

Elabd, C.; Cousin, W.; Upadhyayula, P.; Chen, R.Y.; Chooljian, M.S.; Li, J.; Kung, S.; Jiang, K.P.; Conboy, I.M. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat. Commun., 2014, 5(1), 4082.
[http://dx.doi.org/10.1038/ncomms5082] [PMID: 24915299]

Cho, S.Y.; Kim, A.Y.; Kim, J.; Choi, D.H.; Son, E.D.; Shin, D.W. Oxytocin alleviates cellular senescence through oxytocin receptor‐mediated extracellular signal‐regulated kinase/Nrf2 signalling. Br. J. Dermatol., 2019, 181(6), 1216-1225.
[http://dx.doi.org/10.1111/bjd.17824] [PMID: 30801661]

Faraji, J.; Karimi, M.; Soltanpour, N.; Moharrerie, A.; Rouhzadeh, Z. lotfi, H.; Hosseini, S.A.; Jafari, S.Y.; Roudaki, S.; Moeeini, R.; Metz, G.A.S. Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking. eLife, 2018, 7, , e40262..
[http://dx.doi.org/10.7554/eLife.40262] [PMID: 30422111]

Haston, S.; Pozzi, S.; Carreno, G.; Manshaei, S.; Panousopoulos, L.; Gonzalez-Meljem, J.M.; Apps, J.R.; Virasami, A.; Thavaraj, S.; Gutteridge, A.; Forshew, T.; Marais, R.; Brandner, S.; Jacques, T.S.; Andoniadou, C.L.; Martinez-Barbera, J.P. MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary cranio-pharyngioma. Development, 2017, 144(12), 2141-2152.
[PMID: 28506993]

Boeck, C.; Gumpp, A.M.; Calzia, E.; Radermacher, P.; Waller, C.; Karabatsiakis, A.; Kolassa, I.T. The association between cortisol, oxytocin, and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment. Psychoneuroendocrinology, 2018, 96, 69-77.
[http://dx.doi.org/10.1016/j.psyneuen.2018.05.040] [PMID: 29908404]

Bordt, E.A.; Smith, C.J.; Demarest, T.G.; Bilbo, S.D.; Kingsbury, M.A. Mitochondria, oxytocin, and vasopressin: Unfolding the inflammatory protein response. Neurotox. Res., 2019, 36(2), 239-256.
[http://dx.doi.org/10.1007/s12640-018-9962-7] [PMID: 30259418]

Rubinsztein, D.C.; Mariño, G.; Kroemer, G. Autophagy and aging. Cell, 2011, 146(5), 682-695.
[http://dx.doi.org/10.1016/j.cell.2011.07.030] [PMID: 21884931]

Luo, D.; Jin, B.; Zhai, X.; Li, J.; Liu, C.; Guo, W.; Li, J. Oxytocin promotes hepatic regeneration in elderly mice. iScience, 2021, 24(2), , 102125..
[http://dx.doi.org/10.1016/j.isci.2021.102125] [PMID: 33659883]

Buemann, B.; Uvnäs-Moberg, K. Oxytocin may have a therapeutical potential against cardiovascular disease. Possible pharmaceutical and behavioral approaches. Med. Hypotheses, 2020, 138, , 109597..
[http://dx.doi.org/10.1016/j.mehy.2020.109597] [PMID: 32032912]

Li, T.; Wang, P.; Wang, S.C.; Wang, Y.F. Approaches mediating oxytocin regulation of the immune system. Front. Immunol., 2017, 7, 693.
[http://dx.doi.org/10.3389/fimmu.2016.00693] [PMID: 28119696]

Kingsbury, M.A.; Bilbo, S.D. The inflammatory event of birth: How oxytocin signaling may guide the development of the brain and gastrointestinal system. Front. Neuroendocrinol., 2019, 55, , 100794..
[http://dx.doi.org/10.1016/j.yfrne.2019.100794] [PMID: 31560883]

Geenen, V. Thymus-dependent T cell tolerance of neuroendocrine functions: Principles, reflections, and implications for tolerogenic/negative self-vaccination. Ann. N. Y. Acad. Sci., 2006, 1088(1), 284-296.
[http://dx.doi.org/10.1196/annals.1366.009] [PMID: 17192574]

Murgatroyd, C.A.; Hicks-Nelson, A.; Fink, A.; Beamer, G.; Gurel, K.; Elnady, F.; Pittet, F.; Nephew, B.C. Effects of chronic social stress and maternal intranasal oxytocin and vasopressin on offspring Interferon-γ and behavior. Front. Endocrinol. (Lausanne), 2016, 7, 155.
[http://dx.doi.org/10.3389/fendo.2016.00155] [PMID: 28018290]

Rotondo, F.; Butz, H.; Syro, L.V.; Yousef, G.M.; Di Ieva, A.; Restrepo, L.M.; Quintanar-Stephano, A.; Berczi, I.; Kovacs, K. Arginine vasopressin (AVP): A review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system. Pituitary, 2016, 19(4), 345-355.
[http://dx.doi.org/10.1007/s11102-015-0703-0] [PMID: 26762848]

Karelina, K.; Stuller, K.A.; Jarrett, B.; Zhang, N.; Wells, J.; Norman, G.J.; DeVries, A.C. Oxytocin mediates social neuroprotection after cerebral ischemia. Stroke, 2011, 42(12), 3606-3611.
[http://dx.doi.org/10.1161/STROKEAHA.111.628008] [PMID: 21960564]

Yuan, L.; Liu, S.; Bai, X.; Gao, Y.; Liu, G.; Wang, X.; Liu, D.; Li, T.; Hao, A.; Wang, Z. Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice. J. Neuroinflammation, 2016, 13(1), 77.
[http://dx.doi.org/10.1186/s12974-016-0541-7] [PMID: 27075756]

Clodi, M.; Vila, G.; Geyeregger, R.; Riedl, M.; Stulnig, T.M.; Struck, J.; Luger, T.A.; Luger, A. Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. Am. J. Physiol. Endocrinol. Metab., 2008, 295(3), E686-E691.
[http://dx.doi.org/10.1152/ajpendo.90263.2008] [PMID: 18593851]

Mairesse, J.; Zinni, M.; Pansiot, J.; Hassan-Abdi, R.; Demene, C.; Colella, M.; Charriaut-Marlangue, C.; Rideau Batista Novais, A.; Tanter, M.; Maccari, S.; Gressens, P.; Vaiman, D.; Soussi-Yanicostas, N.; Baud, O. Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia. Glia, 2019, 67(2), 345-359.
[http://dx.doi.org/10.1002/glia.23546] [PMID: 30506969]

Szeto, A.; Sun-Suslow, N.; Mendez, A.J.; Hernandez, R.I.; Wagner, K.V.; McCabe, P.M. Regulation of the macrophage oxytocin receptor in response to inflammation. Am. J. Physiol. Endocrinol. Metab., 2017, 312(3), E183-E189.
[http://dx.doi.org/10.1152/ajpendo.00346.2016] [PMID: 28049625]

Wee, C.L.; Nikitchenko, M.; Wang, W.C.; Luks-Morgan, S.J.; Song, E.; Gagnon, J.A.; Randlett, O.; Bianco, I.H.; Lacoste, A.M.B.; Glushenkova, E.; Barrios, J.P.; Schier, A.F.; Kunes, S.; Engert, F.; Douglass, A.D. Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Nat. Neurosci., 2019, 22(9), 1477-1492.
[http://dx.doi.org/10.1038/s41593-019-0452-x] [PMID: 31358991]

Poisbeau, P.; Grinevich, V.; Charlet, A. Oxytocin signaling in Pain: Cellular, circuit, system, and behavioral levels. Curr. Trop. Behav. Neurosci., 2017, 35, 193-211.
[http://dx.doi.org/10.1007/7854_2017_14] [PMID: 28942595]

Tsuchiya, S.; Yamabe, M.; Yamaguchi, Y.; Kobayashi, Y.; Konno, T.; Tada, K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer, 1980, 26(2), 171-176.
[http://dx.doi.org/10.1002/ijc.2910260208] [PMID: 6970727]

Kaneko, Y.; Pappas, C.; Tajiri, N.; Borlongan, C.V. Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Sci. Rep., 2016, 6(1), 35659.
[http://dx.doi.org/10.1038/srep35659] [PMID: 27767042]

Lagercrantz, H.; Slotkin, T.A. The “stress” of being born. Sci. Am., 1986, 254(4), 100-107.
[http://dx.doi.org/10.1038/scientificamerican0486-100] [PMID: 3961465]

Maron, J.L.; Johnson, K.L.; Parkin, C.; Iyer, L.; Davis, J.M.; Bianchi, D.W. Cord blood genomic analysis highlights the role of redox balance. Free Radic. Biol. Med., 2010, 49(6), 992-996.
[http://dx.doi.org/10.1016/j.freeradbiomed.2010.05.026] [PMID: 20566327]

Tyzio, R.; Cossart, R.; Khalilov, I.; Minlebaev, M.; Hübner, C.A.; Represa, A.; Ben-Ari, Y.; Khazipov, R. Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science, 2006, 314(5806), 1788-1792.
[http://dx.doi.org/10.1126/science.1133212] [PMID: 17170309]

Castillo-Ruiz, A.; Mosley, M.; George, A.J.; Mussaji, L.F.; Fullerton, E.F.; Ruszkowski, E.M.; Jacobs, A.J.; Gewirtz, A.T.; Chassaing, B.; Forger, N.G. The microbiota influences cell death and microglial colonization in the perinatal mouse brain. Brain Behav. Immun., 2018, 67, 218-229.
[http://dx.doi.org/10.1016/j.bbi.2017.08.027] [PMID: 28890156]

Costello, E.K.; Stagaman, K.; Dethlefsen, L.; Bohannan, B.J.M.; Relman, D.A. The application of ecological theory toward an understanding of the human microbiome. Science, 2012, 336(6086), 1255-1262.
[http://dx.doi.org/10.1126/science.1224203] [PMID: 22674335]

Khazipov, R.; Tyzio, R.; Benari, Y. Effects of oxytocin on GABA signalling in the foetal brain during delivery. Prog. Brain Res., 2008, 170, 243-257.
[http://dx.doi.org/10.1016/S0079-6123(08)00421-4] [PMID: 18655887]

Dantzer, R. Neuroimmune interactions: From the brain to the immune system and vice versa. Physiol. Rev., 2018, 98(1), 477-504.
[http://dx.doi.org/10.1152/physrev.00039.2016] [PMID: 29351513]

Dantzer, R. Can Immunopsychiatry help in understanding the basis of sex differences in major depressive disorder? Biol. Psychiatry Cogn. Neurosci. Neuroimaging, 2019, 4(7), 606-607.
[http://dx.doi.org/10.1016/j.bpsc.2019.04.011] [PMID: 31279402]

McCarthy, M.M.; Nugent, B.M.; Lenz, K.M. Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain. Nat. Rev. Neurosci., 2017, 18(8), 471-484.
[http://dx.doi.org/10.1038/nrn.2017.61] [PMID: 28638119]

Bartz, J.A.; Zaki, J.; Ochsner, K.N.; Bolger, N.; Kolevzon, A.; Ludwig, N.; Lydon, J.E. Effects of oxytocin on recollections of maternal care and closeness. Proc. Natl. Acad. Sci. USA, 2010, 107(50), 21371-21375.
[http://dx.doi.org/10.1073/pnas.1012669107] [PMID: 21115834]

Carter, C.S. The Role of Oxytocin and vasopressin in attachment. Psychodyn. Psychiatry, 2017, 45(4), 499-517.
[http://dx.doi.org/10.1521/pdps.2017.45.4.499] [PMID: 29244625]

Forsling, M.L. Neurohypophysial hormones and circadian rhythm. Ann. N. Y. Acad. Sci., 1993, 689(1), 382-395.
[http://dx.doi.org/10.1111/j.1749-6632.1993.tb55562.x] [PMID: 8373022]

Windle, R.J.; Forsling, M.L. Variations in oxytocin secretion during the 4-day oestrous cycle of the rat. J. Endocrinol., 1993, 136(2), 305-311.
[http://dx.doi.org/10.1677/joe.0.1360305] [PMID: 8459196]

Forsling, M.L.; Peysner, K. Pituitary and plasma vasopressin concentrations and fluid balance throughout the oestrous cycle of the rat. J. Endocrinol., 1988, 117(3), 397-402.
[http://dx.doi.org/10.1677/joe.0.1170397] [PMID: 3392496]

Kostoglou-Athanassiou, I.; Forsling, M.L. Effect of 5-hydroxytryptamine and pineal metabolites on the secretion of neurohypophysial hormones. Brain Res. Bull., 1998, 46(5), 417-422.
[http://dx.doi.org/10.1016/S0361-9230(98)00027-6] [PMID: 9739003]

Fuchs, A.R.; Behrens, O.; Liu, H.C. Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy. Am. J. Obstet. Gynecol., 1992, 167(6), 1559-1563.
[http://dx.doi.org/10.1016/0002-9378(92)91739-W] [PMID: 1471665]

Windle, R.J.; Forsling, M.L.; Guzek, J.W. Daily rhythms in the hormone content of the neurohypo-physial system and release of oxytocin and vasopressin in the male rat: Effect of constant light. J. Endocrinol., 1992, 133(2), 283-290.
[http://dx.doi.org/10.1677/joe.0.1330283] [PMID: 1613430]

Forsling, M.L. Diurnal rhythms in neurohypophysial function. Exp. Physiol., 2000, 85(s1), 179s-186s.
[http://dx.doi.org/10.1111/j.1469-445X.2000.tb00022.x] [PMID: 10795921]

Blevins, J.E.; Baskin, D.G. Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans. Physiol Behav, 2015, 152(Pt B), 438-449.

Blevins, J.E.; Graham, J.L.; Morton, G.J.; Bales, K.L.; Schwartz, M.W.; Baskin, D.G.; Havel, P.J. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2015, 308(5), R431-R438.
[http://dx.doi.org/10.1152/ajpregu.00441.2014] [PMID: 25540103]

Deblon, N.; Veyrat-Durebex, C.; Bourgoin, L.; Caillon, A.; Bussier, A.L.; Petrosino, S.; Piscitelli, F.; Legros, J.J.; Geenen, V.; Foti, M.; Wahli, W.; Di Marzo, V.; Rohner-Jeanrenaud, F. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One, 2011, 6(9), , e25565..
[http://dx.doi.org/10.1371/journal.pone.0025565] [PMID: 21980491]

Kublaoui, B.M.; Gemelli, T.; Tolson, K.P.; Wang, Y.; Zinn, A.R. Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol. Endocrinol., 2008, 22(7), 1723-1734.
[http://dx.doi.org/10.1210/me.2008-0067] [PMID: 18451093]

Arletti, R.; Benelli, A.; Bertolini, A. Influence of oxytocin on feeding behavior in the rat. Peptides, 1989, 10(1), 89-93.
[http://dx.doi.org/10.1016/0196-9781(89)90082-X] [PMID: 2748428]

Lawson, E.A.; Marengi, D.A.; DeSanti, R.L.; Holmes, T.M.; Schoenfeld, D.A.; Tolley, C.J. oxytocin reduces caloric intake in men. Obesity (Silver Spring), 2015, 23(5), 950-956.
[http://dx.doi.org/10.1002/oby.21069] [PMID: 25865294]

Ott, V.; Finlayson, G.; Lehnert, H.; Heitmann, B.; Heinrichs, M.; Born, J.; Hallschmid, M. Oxytocin reduces reward-driven food intake in humans. Diabetes, 2013, 62(10), 3418-3425.
[http://dx.doi.org/10.2337/db13-0663] [PMID: 23835346]

Kasahara, Y.; Takayanagi, Y.; Kawada, T.; Itoi, K.; Nishimori, K. Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure. Biosci. Biotechnol. Biochem., 2007, 71(12), 3122-3126.
[http://dx.doi.org/10.1271/bbb.70498] [PMID: 18071238]

Kasahara, Y.; Sato, K.; Takayanagi, Y.; Mizukami, H.; Ozawa, K.; Hidema, S.; So, K.H.; Kawada, T.; Inoue, N.; Ikeda, I.; Roh, S.G.; Itoi, K.; Nishimori, K. Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Endocrinology, 2013, 154(11), 4305-4315.
[http://dx.doi.org/10.1210/en.2012-2206] [PMID: 24002032]

Amico, J.A.; Vollmer, R.R.; Cai, H.; Miedlar, J.A.; Rinaman, L. Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2005, 289(6), R1798-R1806.
[http://dx.doi.org/10.1152/ajpregu.00558.2005] [PMID: 16150836]

Sclafani, A.; Rinaman, L.; Vollmer, R.R.; Amico, J.A. Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 292(5), R1828-R1833.
[http://dx.doi.org/10.1152/ajpregu.00826.2006] [PMID: 17272659]

Miedlar, J.A.; Rinaman, L.; Vollmer, R.R.; Amico, J.A. Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 293(3), R1063-R1068.
[http://dx.doi.org/10.1152/ajpregu.00228.2007] [PMID: 17596329]

Mullis, K.; Kay, K.; Williams, D.L. Oxytocin action in the ventral tegmental area affects sucrose intake. Brain Res., 2013, 1513, 85-91.
[http://dx.doi.org/10.1016/j.brainres.2013.03.026] [PMID: 23548602]

Wu, C.L.; Hung, C.R.; Chang, F.Y.; Pau, F.; Wang, J.L.; Wang, P. Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats. Pflugers Arch., 2002, 445(2), 187-193.
[http://dx.doi.org/10.1007/s00424-002-0925-7] [PMID: 12457239]

Rinaman, L.; Rothe, E.E. GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2002, 283(1), R99-R106.
[http://dx.doi.org/10.1152/ajpregu.00008.2002] [PMID: 12069935]

Wu, C.L.; Doong, M.L.; Wang, P.S. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats. Eur. J. Pharmacol., 2008, 580(3), 407-415.
[http://dx.doi.org/10.1016/j.ejphar.2007.11.024] [PMID: 18078924]

Takayanagi, Y.; Kasahara, Y.; Onaka, T.; Takahashi, N.; Kawada, T.; Nishimori, K. Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport, 2008, 19(9), 951-955.
[http://dx.doi.org/10.1097/WNR.0b013e3283021ca9] [PMID: 18520999]

Camerino, C. Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity (Silver Spring), 2009, 17(5), 980-984.
[http://dx.doi.org/10.1038/oby.2009.12] [PMID: 19247273]

Zhang, H.; Wu, C.; Chen, Q.; Chen, X.; Xu, Z.; Wu, J.; Cai, D. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One, 2013, 8(5), , e61477..
[http://dx.doi.org/10.1371/journal.pone.0061477] [PMID: 23700406]

Maejima, Y.; Iwasaki, Y.; Yamahara, Y.; Kodaira, M.; Sedbazar, U.; Yada, T. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY), 2011, 3(12), 1169-1177.
[http://dx.doi.org/10.18632/aging.100408] [PMID: 22184277]

Morton, G.J.; Thatcher, B.S.; Reidelberger, R.D.; Ogimoto, K.; Wolden-Hanson, T.; Baskin, D.G.; Schwartz, M.W.; Blevins, J.E. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am. J. Physiol. Endocrinol. Metab., 2012, 302(1), E134-E144.
[http://dx.doi.org/10.1152/ajpendo.00296.2011] [PMID: 22008455]

Pischon, T.; Boeing, H.; Hoffmann, K.; Bergmann, M.; Schulze, M.B.; Overvad, K.; van der Schouw, Y.T.; Spencer, E.; Moons, K.G.M.; Tjønneland, A.; Halkjaer, J.; Jensen, M.K.; Stegger, J.; Clavel-Chapelon, F.; Boutron-Ruault, M.C.; Chajes, V.; Linseisen, J.; Kaaks, R.; Trichopoulou, A.; Trichopoulos, D.; Bamia, C.; Sieri, S.; Palli, D.; Tumino, R.; Vineis, P.; Panico, S.; Peeters, P.H.M.; May, A.M.; Bueno-de-Mesquita, H.B.; van Duijnhoven, F.J.B.; Hallmans, G.; Weinehall, L.; Manjer, J.; Hedblad, B.; Lund, E.; Agudo, A.; Arriola, L.; Barricarte, A.; Navarro, C.; Martinez, C.; Quirós, J.R.; Key, T.; Bingham, S.; Khaw, K.T.; Boffetta, P.; Jenab, M.; Ferrari, P.; Riboli, E. General and abdominal adiposity and risk of death in Europe. N. Engl. J. Med., 2008, 359(20), 2105-2120.
[http://dx.doi.org/10.1056/NEJMoa0801891] [PMID: 19005195]

Stock, S.; Granström, L.; Backman, L.; Matthiesen, A.S.; Uvnäs-Moberg, K. Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Int. J. Obes., 1989, 13(2), 213-222.
[PMID: 2744933]

Schorr, M.; Marengi, D.A.; Pulumo, R.L.; Yu, E.; Eddy, K.T.; Klibanski, A.; Miller, K.K.; Lawson, E.A. Oxytocin and its relationship to body composition, bone mineral density, and hip geometry across the weight spectrum. J. Clin. Endocrinol. Metab., 2017, 102(8), 2814-2824.
[http://dx.doi.org/10.1210/jc.2016-3963] [PMID: 28586943]

Szulc, P.; Amri, E.Z.; Varennes, A.; Panaia-Ferrari, P.; Fontas, E.; Goudable, J.; Chapurlat, R.; Breuil, V. High serum oxytocin is associated with metabolic syndrome in older men – The MINOS study. Diabetes Res. Clin. Pract., 2016, 122, 17-27.
[http://dx.doi.org/10.1016/j.diabres.2016.09.022] [PMID: 27764720]

Lawson, E.A.; Ackerman, K.E.; Slattery, M.; Marengi, D.A.; Clarke, H.; Misra, M. Oxytocin secretion is related to measures of energy homeostasis in young amenorrheic athletes. J. Clin. Endocrinol. Metab., 2014, 99(5), E881-E885.
[http://dx.doi.org/10.1210/jc.2013-4136] [PMID: 24606095]

Lawson, E.A.; Donoho, D.A.; Blum, J.I.; Meenaghan, E.M.; Misra, M.; Herzog, D.B.; Sluss, P.M.; Miller, K.K.; Klibanski, A. Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass. J. Clin. Psychiatry, 2011, 72(11), 1546-1551.
[http://dx.doi.org/10.4088/JCP.10m06617] [PMID: 21903023]

Lee, M.R.; Scheidweiler, K.B.; Diao, X.X.; Akhlaghi, F.; Cummins, A.; Huestis, M.A.; Leggio, L.; Averbeck, B.B. Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: Determination using a novel oxytocin assay. Mol. Psychiatry, 2018, 23(1), 115-122.
[http://dx.doi.org/10.1038/mp.2017.27] [PMID: 28289281]

Liberati, A.; Altman, D.G.; Tetzlaff, J.; Mulrow, C.; Gøtzsche, P.C.; Ioannidis, J.P.A.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. J. Clin. Epidemiol., 2009, 62(10), e1-e34.
[http://dx.doi.org/10.1016/j.jclinepi.2009.06.006] [PMID: 19631507]

Elsabbagh, M.; Divan, G.; Koh, Y.J.; Kim, Y.S.; Kauchali, S.; Marcín, C.; Montiel-Nava, C.; Patel, V.; Paula, C.S.; Wang, C.; Yasamy, M.T.; Fombonne, E. Global prevalence of autism and other pervasive developmental disorders. Autism Res., 2012, 5(3), 160-179.
[http://dx.doi.org/10.1002/aur.239] [PMID: 22495912]

Posar, A.; Resca, F.; Visconti, P. Autism according to diagnostic and statistical manual of mental disorders. The need for further improvements. J. Pediatr. Neurosci., 2015, 10(2), 146-148.
[http://dx.doi.org/10.4103/1817-1745.159195] [PMID: 26167220]

APA. Diagnostic and Statistical Manual of Mental Disorders, 5th ed; American Psychiatric Publishing: USA, 2013.

Dell’Osso, L.; Lorenzi, P.; Carpita, B. Camouflaging: Psychopathological meanings and clinical relevance in autism spectrum conditions. CNS Spectr., 2021, 26(5), 437-439.
[PMID: 32450944]

Famitafreshi, H.; Karimian, M. Overview of the recent advances in pathophysiology and treatment for autism. CNS Neurol. Disord. Drug Targets, 2018, 17(8), 590-594.
[http://dx.doi.org/10.2174/1871527317666180706141654] [PMID: 29984672]

Posar, A.; Visconti, P. Autism in 2016: The need for answers. J. Pediatr. (Rio J.), 2017, 93(2), 111-119.
[http://dx.doi.org/10.1016/j.jped.2016.09.002] [PMID: 27837654]

Muskens, J.B.; Velders, F.P.; Staal, W.G. Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: A systematic review. Eur. Child Adolesc. Psychiatry, 2017, 26(9), 1093-1103.
[http://dx.doi.org/10.1007/s00787-017-1020-0] [PMID: 28674760]

Shaltout, E.; Al-Dewik, N.; Samara, M.; Morsi, H.; Khattab, A. Psychological comorbidities in autism spectrum disorder. Adv. Neurobiol., 2020, 24, 163-191.
[http://dx.doi.org/10.1007/978-3-030-30402-7_6] [PMID: 32006360]

Wakerley, J.B.; Lincoln, D.W. The milk-ejection reflex of the rat: A 20- to 40-fold acceleration in the firing of paraventricular neurones during oxytocin release. J. Endocrinol., 1973, 57(3), 477-493.
[http://dx.doi.org/10.1677/joe.0.0570477] [PMID: 4577217]

Carmichael, M.S.; Humbert, R.; Dixen, J.; Palmisano, G.; Greenleaf, W.; Davidson, J.M. Plasma ox-ytocin increases in the human sexual response. J. Clin. Endocrinol. Metab., 1987, 64(1), 27-31.
[http://dx.doi.org/10.1210/jcem-64-1-27] [PMID: 3782434]

Carter, C.S. Oxytocin and sexual behavior. Neurosci. Biobehav. Rev., 1992, 16(2), 131-144.
[http://dx.doi.org/10.1016/S0149-7634(05)80176-9] [PMID: 1630727]

Insel, T.R. Toward a neuroanatomy of obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1992, 49(9), 739-744.
[http://dx.doi.org/10.1001/archpsyc.1992.01820090067011] [PMID: 1514879]

Panksepp, J. Oxytocin effects on emotional processes: Separation distress, social bonding, and relationships to psychiatric disorders. Ann. N. Y. Acad. Sci., 1992, 652(1), 243-252.
[http://dx.doi.org/10.1111/j.1749-6632.1992.tb34359.x] [PMID: 1626832]

Insel, T.R.; O’Brien, D.J.; Leckman, J.F. Oxytocin, vasopressin, and autism: Is there a connection? Biol. Psychiatry, 1999, 45(2), 145-157.
[http://dx.doi.org/10.1016/S0006-3223(98)00142-5] [PMID: 9951561]

Insel, T.R.; Young, L.J. The neurobiology of attachment. Nat. Rev. Neurosci., 2001, 2(2), 129-136.
[http://dx.doi.org/10.1038/35053579] [PMID: 11252992]

Porges, S.W. The polyvagal theory: Neurophysiological foundations of emotions, attachment, communication, self-regulation. J. Can. Acad. Child Adolesc. Psychiatry, 2011, 21(4), 313-314.

Green, L.; Fein, D.; Modahl, C.; Feinstein, C.; Waterhouse, L.; Morris, M. Oxytocin and autistic disorder: Alterations in peptide forms. Biol. Psychiatry, 2001, 50(8), 609-613.
[http://dx.doi.org/10.1016/S0006-3223(01)01139-8] [PMID: 11690596]

Modahl, C.; Green, L.A.; Fein, D.; Morris, M.; Waterhouse, L.; Feinstein, C.; Levin, H. Plasma oxytocin levels in autistic children. Biol. Psychiatry, 1998, 43(4), 270-277.
[http://dx.doi.org/10.1016/S0006-3223(97)00439-3] [PMID: 9513736]

Al-Ayadhi, L.Y. Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia. Neurosciences (Riyadh), 2005, 10(1), 47-50.
[PMID: 22473184]

Alabdali, A.; Al-Ayadhi, L.; El-Ansary, A. Association of social and cognitive impairment and biomarkers in autism spectrum disorders. J. Neuroinflammation, 2014, 11(1), 4.
[http://dx.doi.org/10.1186/1742-2094-11-4] [PMID: 24400970]

Feldman, R.; Golan, O.; Hirschler-Guttenberg, Y.; Ostfeld-Etzion, S.; Zagoory-Sharon, O. Parent–child interaction and oxytocin production in pre-schoolers with autism spectrum disorder. Br. J. Psychiatry, 2014, 205(2), 107-112.
[http://dx.doi.org/10.1192/bjp.bp.113.137513] [PMID: 24855128]

Husarova, V.M.; Lakatosova, S.; Pivovarciova, A.; Babinska, K.; Bakos, J.; Durdiakova, J.; Kubranska, A.; Ondrejka, I.; Ostatnikova, D. Plasma Oxytocin in children with autism and its correlations with behavioral parameters in children and parents. Psychiatry Investig., 2016, 13(2), 174-183.
[http://dx.doi.org/10.4306/pi.2016.13.2.174] [PMID: 27081377]

Zhang, H.F.; Dai, Y.C.; Wu, J.; Jia, M.X.; Zhang, J.S.; Shou, X.J.; Han, S.P.; Zhang, R.; Han, J.S. Plasma oxytocin and arginine-vasopressin levels in children with autism spectrum disorder in China: Associations with symptoms. Neurosci. Bull., 2016, 32(5), 423-432.
[http://dx.doi.org/10.1007/s12264-016-0046-5] [PMID: 27342432]

Husarova, V.; Lakatosova, S.; Pivovarciova, A.; Bakos, J.; Durdiakova, J.; Kubranska, A.; Ostatnikova, D. Brief report: Plasma oxytocin is lower in children with Asperger syndrome and associated with autistic trait attention to detail. Open J. Psychiatr., 2013, 3(4), 399-402.
[http://dx.doi.org/10.4236/ojpsych.2013.34043]

Taurines, R.; Schwenck, C.; Lyttwin, B.; Schecklmann, M.; Jans, T.; Reefschläger, L.; Geissler, J.; Gerlach, M.; Romanos, M. Oxytocin plasma concentrations in children and adolescents with autism spectrum disorder: Correlation with autistic symptomatology. Atten. Defic. Hyperact. Disord., 2014, 6(3), 231-239.
[http://dx.doi.org/10.1007/s12402-014-0145-y] [PMID: 24989441]

Parker, K.J.; Garner, J.P.; Libove, R.A.; Hyde, S.A.; Hornbeak, K.B.; Carson, D.S.; Liao, C.P.; Phillips, J.M.; Hallmayer, J.F.; Hardan, A.Y. Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proc. Natl. Acad. Sci. USA, 2014, 111(33), 12258-12263.
[http://dx.doi.org/10.1073/pnas.1402236111] [PMID: 25092315]

Xu, X.J.; Shou, X.J.; Li, J.; Jia, M.X.; Zhang, J.S.; Guo, Y.; Wei, Q.Y.; Zhang, X.T.; Han, S.P.; Zhang, R.; Han, J.S. Mothers of autistic children: Lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone. PLoS One, 2013, 8(9), , e74849..
[http://dx.doi.org/10.1371/journal.pone.0074849] [PMID: 24086383]

Miller, M.; Bales, K.L.; Taylor, S.L.; Yoon, J.; Hostetler, C.M.; Carter, C.S.; Solomon, M. Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: Sex differences and associations with symptoms. Autism Res., 2013, 6(2), 91-102.
[http://dx.doi.org/10.1002/aur.1270] [PMID: 23413037]

Althaus, M.; Groen, Y.; A Wijers, A.; Noltes, H.; Tucha, O.; Sweep, F.C.; Calcagnoli, F.; Hoekstra, P.J. Do blood plasma levels of oxytocin moderate the effect of nasally administered oxytocin on social orienting in high-functioning male adults with autism spectrum disorder? Psychopharmacology (Berl.), 2016, 233(14), 2737-2751.
[http://dx.doi.org/10.1007/s00213-016-4339-1] [PMID: 27256356]

Bakker-Huvenaars, M.J.; Greven, C.U.; Herpers, P.; Wiegers, E.; Jansen, A.; van der Steen, R.; van Herwaarden, A.E.; Baanders, A.N.; Nijhof, K.S.; Scheepers, F.; Rommelse, N.; Glennon, J.C.; Buitelaar, J.K. Saliva oxytocin, cortisol, and testosterone levels in adolescent boys with autism spectrum disorder, oppositional defiant disorder/conduct disorder and typically developing individuals. Eur. Neuropsychopharmacol., 2020, 30, 87-101.
[http://dx.doi.org/10.1016/j.euroneuro.2018.07.097] [PMID: 30201120]

Fujisawa, T.X.; Tanaka, S.; Saito, D.N.; Kosaka, H.; Tomoda, A. Visual attention for social information and salivary oxytocin levels in preschool children with autism spectrum disorders: An eye-tracking study. Front. Neurosci., 2014, 8, 295.
[http://dx.doi.org/10.3389/fnins.2014.00295] [PMID: 25278829]

Fujioka, T.; Fujisawa, T.X.; Inohara, K.; Okamoto, Y.; Matsumura, Y.; Tsuchiya, K.J.; Katayama, T.; Munesue, T.; Tomoda, A.; Wada, Y.; Kosaka, H. Attenuated relationship between salivary oxytocin levels and attention to social information in adolescents and adults with autism spectrum disorder: A comparative study. Ann. Gen. Psychiatry, 2020, 19(1), 38.
[http://dx.doi.org/10.1186/s12991-020-00287-2] [PMID: 32518579]

Tick, B.; Bolton, P.; Happé, F.; Rutter, M.; Rijsdijk, F. Heritability of autism spectrum disorders: A meta-analysis of twin studies. J. Child Psychol. Psychiatry, 2016, 57(5), 585-595.
[http://dx.doi.org/10.1111/jcpp.12499] [PMID: 26709141]

Gaugler, T.; Klei, L.; Sanders, S.J.; Bodea, C.A.; Goldberg, A.P.; Lee, A.B.; Mahajan, M.; Manaa, D.; Pawitan, Y.; Reichert, J.; Ripke, S.; Sandin, S.; Sklar, P.; Svantesson, O.; Reichenberg, A.; Hultman, C.M.; Devlin, B.; Roeder, K.; Buxbaum, J.D. Most genetic risk for autism resides with common variation. Nat. Genet., 2014, 46(8), 881-885.
[http://dx.doi.org/10.1038/ng.3039] [PMID: 25038753]

Abrahams, B.S.; Geschwind, D.H. Advances in autism genetics: On the threshold of a new neurobiology. Nat. Rev. Genet., 2008, 9(5), 341-355.
[http://dx.doi.org/10.1038/nrg2346] [PMID: 18414403]

Buxbaum, J.D. Multiple rare variants in the etiology of autism spectrum disorders. Dialogues Clin. Neurosci., 2009, 11(1), 35-43.
[http://dx.doi.org/10.31887/DCNS.2009.11.1/jdbuxbaum] [PMID: 19432386]

Kumar, R.A.; Christian, S.L. Genetics of autism spectrum disorders. Curr. Neurol. Neurosci. Rep., 2009, 9(3), 188-197.
[http://dx.doi.org/10.1007/s11910-009-0029-2] [PMID: 19348707]

Gupta, A.R.; State, M.W. Recent advances in the genetics of autism. Biol. Psychiatry, 2007, 61(4), 429-437.
[http://dx.doi.org/10.1016/j.biopsych.2006.06.020] [PMID: 16996486]

Freitag, C.M. The genetics of autistic disorders and its clinical relevance: A review of the literature. Mol. Psychiatry, 2007, 12(1), 2-22.
[http://dx.doi.org/10.1038/sj.mp.4001896] [PMID: 17033636]

Veenstra-VanderWeele, J.; Cook, E.H., Jr. Molecular genetics of autism spectrum disorder. Mol. Psychiatry, 2004, 9(9), 819-832.
[http://dx.doi.org/10.1038/sj.mp.4001505] [PMID: 15197396]

Wang, K.; Zhang, H.; Ma, D.; Bucan, M.; Glessner, J.T.; Abrahams, B.S.; Salyakina, D.; Imielinski, M.; Bradfield, J.P.; Sleiman, P.M.A.; Kim, C.E.; Hou, C.; Frackelton, E.; Chiavacci, R.; Takahashi, N.; Sakurai, T.; Rappaport, E.; Lajonchere, C.M.; Munson, J.; Estes, A.; Korvatska, O.; Piven, J.; Sonnenblick, L.I.; Alvarez Retuerto, A.I.; Herman, E.I.; Dong, H.; Hutman, T.; Sigman, M.; Ozonoff, S.; Klin, A.; Owley, T.; Sweeney, J.A.; Brune, C.W.; Cantor, R.M.; Bernier, R.; Gilbert, J.R.; Cuccaro, M.L.; McMahon, W.M.; Miller, J.; State, M.W.; Wassink, T.H.; Coon, H.; Levy, S.E.; Schultz, R.T.; Nurnberger, J.I.; Haines, J.L.; Sutcliffe, J.S.; Cook, E.H.; Minshew, N.J.; Buxbaum, J.D.; Dawson, G.; Grant, S.F.A.; Geschwind, D.H.; Pericak-Vance, M.A.; Schellenberg, G.D.; Hakonarson, H. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature, 2009, 459(7246), 528-533.
[http://dx.doi.org/10.1038/nature07999] [PMID: 19404256]

Allen-Brady, K.; Miller, J.; Matsunami, N.; Stevens, J.; Block, H.; Farley, M.; Krasny, L.; Pingree, C.; Lainhart, J.; Leppert, M.; McMahon, W.M.; Coon, H. A high-density SNP genome-wide linkage scan in a large autism extended pedigree. Mol. Psychiatry, 2009, 14(6), 590-600.
[http://dx.doi.org/10.1038/mp.2008.14] [PMID: 18283277]

Ebstein, R.P.; Israel, S.; Lerer, E.; Uzefovsky, F.; Shalev, I.; Gritsenko, I.; Riebold, M.; Salomon, S.; Yirmiya, N. Arginine vasopressin and oxytocin modulate human social behavior. Ann. N. Y. Acad. Sci., 2009, 1167(1), 87-102.
[http://dx.doi.org/10.1111/j.1749-6632.2009.04541.x] [PMID: 19580556]

Hovey, D.; Zettergren, A.; Jonsson, L.; Melke, J.; Anckarsäter, H.; Lichtenstein, P.; Westberg, L. Associations between oxytocin-related genes and autistic-like traits. Soc. Neurosci., 2014, 9(4), 378-386.
[http://dx.doi.org/10.1080/17470919.2014.897995] [PMID: 24635660]

Francis, S.M.; Kim, S.J.; Kistner-Griffin, E.; Guter, S.; Cook, E.H.; Jacob, S. ASD and genetic associations with receptors for oxytocin and vasopressin—AVPR1A, AVPR1B, and OXTR. Front. Neurosci., 2016, 10, 516.
[http://dx.doi.org/10.3389/fnins.2016.00516] [PMID: 27920663]

Yrigollen, C.M.; Han, S.S.; Kochetkova, A.; Babitz, T.; Chang, J.T.; Volkmar, F.R.; Leckman, J.F.; Grigorenko, E.L. Genes controlling affiliative behavior as candidate genes for autism. Biol. Psychiatry, 2008, 63(10), 911-916.
[http://dx.doi.org/10.1016/j.biopsych.2007.11.015] [PMID: 18207134]

Horvath, S.; Xu, X.; Laird, N.M. The family based association test method: Strategies for studying general genotype–phenotype associations. Eur. J. Hum. Genet., 2001, 9(4), 301-306.
[http://dx.doi.org/10.1038/sj.ejhg.5200625] [PMID: 11313775]

LoParo, D.; Waldman, I.D. The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: A meta-analysis. Mol. Psychiatry, 2015, 20(5), 640-646.
[http://dx.doi.org/10.1038/mp.2014.77] [PMID: 25092245]

Wu, S.; Jia, M.; Ruan, Y.; Liu, J.; Guo, Y.; Shuang, M.; Gong, X.; Zhang, Y.; Yang, X.; Zhang, D. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol. Psychiatry, 2005, 58(1), 74-77.
[http://dx.doi.org/10.1016/j.biopsych.2005.03.013] [PMID: 15992526]

Jacob, S.; Brune, C.W.; Carter, C.S.; Leventhal, B.L.; Lord, C.; Cook, E.H. Jr. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci. Lett., 2007, 417(1), 6-9.
[http://dx.doi.org/10.1016/j.neulet.2007.02.001] [PMID: 17383819]

Lerer, E.; Levi, S.; Salomon, S.; Darvasi, A.; Yirmiya, N.; Ebstein, R.P. Association between the ox-ytocin receptor (OXTR) gene and autism: Relationship to Vineland Adaptive Behavior Scales and cognition. Mol. Psychiatry, 2008, 13(10), 980-988.
[http://dx.doi.org/10.1038/sj.mp.4002087] [PMID: 17893705]

Liu, X.; Kawamura, Y.; Shimada, T.; Otowa, T.; Koishi, S.; Sugiyama, T.; Nishida, H.; Hashimoto, O.; Nakagami, R.; Tochigi, M.; Umekage, T.; Kano, Y.; Miyagawa, T.; Kato, N.; Tokunaga, K.; Sasaki, T. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disor-der (ASD) in the Japanese population. J. Hum. Genet., 2010, 55(3), 137-141.
[http://dx.doi.org/10.1038/jhg.2009.140] [PMID: 20094064]

Jack, A.; Connelly, J.J.; Morris, J.P. DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Front. Hum. Neurosci., 2012, 6, 280.
[http://dx.doi.org/10.3389/fnhum.2012.00280] [PMID: 23087634]

Tost, H.; Kolachana, B.; Hakimi, S.; Lemaitre, H.; Verchinski, B.A.; Mattay, V.S.; Weinberger, D.R.; Meyer-Lindenberg, A. A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc. Natl. Acad. Sci. USA, 2010, 107(31), 13936-13941.
[http://dx.doi.org/10.1073/pnas.1003296107] [PMID: 20647384]

Wang, J.; Qin, W.; Liu, B.; Wang, D.; Zhang, Y.; Jiang, T.; Yu, C. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects. Neuroimage, 2013, 81, 199-204.
[http://dx.doi.org/10.1016/j.neuroimage.2013.05.029] [PMID: 23684879]

Wermter, A.K.; Kamp-Becker, I.; Hesse, P.; Schulte-Körne, G.; Strauch, K.; Remschmidt, H. Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 2010, 153B(2), 629-639.
[http://dx.doi.org/10.1002/ajmg.b.31032] [PMID: 19777562]

McDonald, N.M.; Baker, J.K.; Messinger, D.S. Oxytocin and parent–child interaction in the development of empathy among children at risk for autism. Dev. Psychol., 2016, 52(5), 735-745.
[http://dx.doi.org/10.1037/dev0000104] [PMID: 26998571]

Gregory, S.G.; Connelly, J.J.; Towers, A.J.; Johnson, J.; Biscocho, D.; Markunas, C.A.; Lintas, C.; Abramson, R.K.; Wright, H.H.; Ellis, P.; Langford, C.F.; Worley, G.; Delong, G.R.; Murphy, S.K.; Cuccaro, M.L.; Persico, A.; Pericak-Vance, M.A. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med., 2009, 7(1), 62.
[http://dx.doi.org/10.1186/1741-7015-7-62] [PMID: 19845972]

Rijlaarsdam, J.; van IJzendoorn, M.H.; Verhulst, F.C.; Jaddoe, V.W.V.; Felix, J.F.; Tiemeier, H.; Bakermans-Kranenburg, M.J. Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype. Autism Res., 2017, 10(3), 430-438.
[http://dx.doi.org/10.1002/aur.1681] [PMID: 27520745]

Andari, E.; Nishitani, S.; Kaundinya, G.; Caceres, G.A.; Morrier, M.J.; Ousley, O.; Smith, A.K.; Cubells, J.F.; Young, L.J. Epigenetic modification of the oxytocin receptor gene: Implications for autism symptom severity and brain functional connectivity. Neuropsychopharmacology, 2020, 45(7), 1150-1158.
[http://dx.doi.org/10.1038/s41386-020-0610-6] [PMID: 31931508]

Elagoz Yuksel, M.; Yuceturk, B.; Karatas, O.F.; Ozen, M.; Dogangun, B. The altered promoter methylation of oxytocin receptor gene in autism. J. Neurogenet., 2016, 30(3-4), 280-284.
[http://dx.doi.org/10.1080/01677063.2016.1202951] [PMID: 27309964]

Mosconi, M.W.; Cody-Hazlett, H.; Poe, M.D.; Gerig, G.; Gimpel-Smith, R.; Piven, J. Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism. Arch. Gen. Psychiatry, 2009, 66(5), 509-516.
[http://dx.doi.org/10.1001/archgenpsychiatry.2009.19] [PMID: 19414710]

Nyffeler, J.; Walitza, S.; Bobrowski, E.; Gundelfinger, R.; Grünblatt, E. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. J. Mol. Psychiatry, 2014, 2(1), 1.
[http://dx.doi.org/10.1186/2049-9256-2-1] [PMID: 25408912]

Wu, N.; Li, Z.; Su, Y. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J. Affect. Disord., 2012, 138(3), 468-472.
[http://dx.doi.org/10.1016/j.jad.2012.01.009] [PMID: 22357335]

Thompson, R.J.; Parker, K.J.; Hallmayer, J.F.; Waugh, C.E.; Gotlib, I.H. Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology, 2011, 36(1), 144-147.
[http://dx.doi.org/10.1016/j.psyneuen.2010.07.003] [PMID: 20708845]

Watanabe, T.; Otowa, T.; Abe, O.; Kuwabara, H.; Aoki, Y.; Natsubori, T.; Takao, H.; Kakiuchi, C.; Kondo, K.; Ikeda, M.; Iwata, N.; Kasai, K.; Sasaki, T.; Yamasue, H. Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism. Soc. Cogn. Affect. Neurosci., 2017, 12(3), 496-506.
[http://dx.doi.org/10.1093/scan/nsw150] [PMID: 27798253]

Tansey, K.E.; Brookes, K.J.; Hill, M.J.; Cochrane, L.E.; Gill, M.; Skuse, D.; Correia, C.; Vicente, A.; Kent, L.; Gallagher, L.; Anney, R.J.L. Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: Genetic and molecular studies. Neurosci. Lett., 2010, 474(3), 163-167.
[http://dx.doi.org/10.1016/j.neulet.2010.03.035] [PMID: 20303388]

Montag, C.; Sindermann, C.; Melchers, M.; Jung, S.; Luo, R.; Becker, B.; Xie, J.; Xu, W.; Guastella, A.J.; Kendrick, K.M. A functional polymorphism of the OXTR gene is associated with autistic traits in Caucasian and Asian populations. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 2017, 174(8), 808-816.
[http://dx.doi.org/10.1002/ajmg.b.32596] [PMID: 29027364]

Campbell, D.B.; Datta, D.; Jones, S.T.; Batey Lee, E.; Sutcliffe, J.S.; Hammock, E.A.D.; Levitt, P. Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. J. Neurodev. Disord., 2011, 3(2), 101-112.
[http://dx.doi.org/10.1007/s11689-010-9071-2] [PMID: 21484202]

Di Napoli, A.; Warrier, V.; Baron-Cohen, S.; Chakrabarti, B. Genetic variation in the oxytocin receptor (OXTR) gene is associated with asperger syndrome. Mol. Autism, 2014, 5(1), 48.
[http://dx.doi.org/10.1186/2040-2392-5-48] [PMID: 25264479]

Ma, W.J.; Hashii, M.; Munesue, T.; Hayashi, K.; Yagi, K.; Yamagishi, M.; Higashida, H.; Yokoyama, S. Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: A case–control study in a Japanese population and functional analysis. Mol. Autism, 2013, 4(1), 22.
[http://dx.doi.org/10.1186/2040-2392-4-22] [PMID: 23815867]

Liu, X.; Kawashima, M.; Miyagawa, T.; Otowa, T.; Latt, K.Z.; Thiri, M.; Nishida, H.; Sugiyama, T.; Tsurusaki, Y.; Matsumoto, N.; Mabuchi, A.; Tokunaga, K.; Sasaki, T. Novel rare variations of the oxytocin receptor (OXTR) gene in autism spectrum disorder individuals. Hum. Genome Var., 2015, 2(1), 15024.
[http://dx.doi.org/10.1038/hgv.2015.24] [PMID: 27081536]

Ebstein, R.P.; Knafo, A.; Mankuta, D.; Chew, S.H.; Lai, P.S. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm. Behav., 2012, 61(3), 359-379.
[http://dx.doi.org/10.1016/j.yhbeh.2011.12.014] [PMID: 22245314]

Kranz, T.M.; Kopp, M.; Waltes, R.; Sachse, M.; Duketis, E.; Jarczok, T.A.; Degenhardt, F.; Görgen, K.; Meyer, J.; Freitag, C.M.; Chiocchetti, A.G. Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder. Autism Res., 2016, 9(10), 1036-1045.
[http://dx.doi.org/10.1002/aur.1597] [PMID: 26788924]

Hernandez, L.M.; Krasileva, K.; Green, S.A.; Sherman, L.E.; Ponting, C.; McCarron, R.; Lowe, J.K.; Geschwind, D.H.; Bookheimer, S.Y.; Dapretto, M. Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism. Mol. Psychiatry, 2017, 22(8), 1134-1139.
[http://dx.doi.org/10.1038/mp.2016.209] [PMID: 27843152]

Uzefovsky, F.; Bethlehem, R.A.I.; Shamay-Tsoory, S.; Ruigrok, A.; Holt, R.; Spencer, M.; Chura, L.; Warrier, V.; Chakrabarti, B.; Bullmore, E.; Suckling, J.; Floris, D.; Baron-Cohen, S. The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism. Mol. Autism, 2019, 10(1), 12.
[http://dx.doi.org/10.1186/s13229-019-0258-4] [PMID: 30918622]

Ocakoğlu, F.T.; Köse, S.; Özbaran, B.; Onay, H. The oxytocin receptor gene polymorphism -rs237902- is associated with the severity of autism spectrum disorder: A pilot study. Asian J. Psychiatr., 2018, 31, 142-149.
[http://dx.doi.org/10.1016/j.ajp.2018.01.002] [PMID: 29428512]

Mor, M.; Nardone, S.; Sams, D.S.; Elliott, E. Hypomethylation of miR-142 promoter and upregulation of microRNAs that target the oxytocin receptor gene in the autism prefrontal cortex. Mol. Autism, 2015, 6(1), 46.
[http://dx.doi.org/10.1186/s13229-015-0040-1] [PMID: 26273428]

Nakata, M.; Kimura, R.; Funabiki, Y.; Awaya, T.; Murai, T.; Hagiwara, M. MicroRNA profiling in adults with high-functioning autism spectrum disorder. Mol. Brain, 2019, 12(1), 82.
[http://dx.doi.org/10.1186/s13041-019-0508-6] [PMID: 31639010]

Kumsta, R.; Hummel, E.; Chen, F.S.; Heinrichs, M. Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience. Front. Neurosci., 2013, 7, 83.
[http://dx.doi.org/10.3389/fnins.2013.00083] [PMID: 23734094]

Perkeybile, A.M.; Carter, C.S.; Wroblewski, K.L.; Puglia, M.H.; Kenkel, W.M.; Lillard, T.S.; Karaoli, T.; Gregory, S.G.; Mohammadi, N.; Epstein, L.; Bales, K.L.; Connelly, J.J. Early nurture epigenetically tunes the oxytocin receptor. Psychoneuroendocrinology, 2019, 99, 128-136.
[http://dx.doi.org/10.1016/j.psyneuen.2018.08.037] [PMID: 30227351]

Hollander, E.; Novotny, S.; Hanratty, M.; Yaffe, R.; DeCaria, C.M.; Aronowitz, B.R.; Mosovich, S. Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger’s disorders. Neuropsychopharmacology, 2003, 28(1), 193-198.
[http://dx.doi.org/10.1038/sj.npp.1300021] [PMID: 12496956]

Hollander, E.; Bartz, J.; Chaplin, W.; Phillips, A.; Sumner, J.; Soorya, L.; Anagnostou, E.; Wasser-man, S. Oxytocin increases retention of social cognition in autism. Biol. Psychiatry, 2007, 61(4), 498-503.
[http://dx.doi.org/10.1016/j.biopsych.2006.05.030] [PMID: 16904652]

Guastella, A.J.; Einfeld, S.L.; Gray, K.M.; Rinehart, N.J.; Tonge, B.J.; Lambert, T.J.; Hickie, I.B. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol. Psychiatry, 2010, 67(7), 692-694.
[http://dx.doi.org/10.1016/j.biopsych.2009.09.020] [PMID: 19897177]

Kruppa, J.A.; Gossen, A.; Oberwelland Weiß, E.; Kohls, G.; Großheinrich, N.; Cholemkery, H.; Freitag, C.M.; Karges, W.; Wölfle, E.; Sinzig, J.; Fink, G.R.; Herpertz-Dahlmann, B.; Konrad, K.; Schulte-Rüther, M. Neural modulation of social reinforcement learning by intranasal oxytocin in male adults with high-functioning autism spectrum disorder: A randomized trial. Neuropsychopharmacology, 2019, 44(4), 749-756.
[http://dx.doi.org/10.1038/s41386-018-0258-7] [PMID: 30390065]

Andari, E.; Duhamel, J.R.; Zalla, T.; Herbrecht, E.; Leboyer, M.; Sirigu, A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc. Natl. Acad. Sci. USA, 2010, 107(9), 4389-4394.
[http://dx.doi.org/10.1073/pnas.0910249107] [PMID: 20160081]

Auyeung, B.; Lombardo, M.V.; Heinrichs, M.; Chakrabarti, B.; Sule, A.; Deakin, J.B.; Bethlehem, R A I.; Dickens, L.; Mooney, N.; Sipple, J A N.; Thiemann, P.; Baron-Cohen, S. Oxytocin increases eye contact during a real-time, naturalistic social interaction in males with and without autism. Transl. Psychiatry, 2015, 5(2), , e507..
[http://dx.doi.org/10.1038/tp.2014.146] [PMID: 25668435]

Kanat, M.; Spenthof, I.; Riedel, A.; van Elst, L.T.; Heinrichs, M.; Domes, G. Restoring effects of oxytocin on the attentional preference for faces in autism. Transl. Psychiatry, 2017, 7(4), , e1097..
[http://dx.doi.org/10.1038/tp.2017.67] [PMID: 28418399]

Domes, G.; Kumbier, E.; Heinrichs, M.; Herpertz, S.C. Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome. Neuropsychopharmacology, 2014, 39(3), 698-706.
[http://dx.doi.org/10.1038/npp.2013.254] [PMID: 24067301]

Aoki, Y.; Yahata, N.; Watanabe, T.; Takano, Y.; Kawakubo, Y.; Kuwabara, H.; Iwashiro, N.; Natsubori, T.; Inoue, H.; Suga, M.; Takao, H.; Sasaki, H.; Gonoi, W.; Kunimatsu, A.; Kasai, K.; Yamasue, H. Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism. Brain, 2014, 137(11), 3073-3086.
[http://dx.doi.org/10.1093/brain/awu231] [PMID: 25149412]

Greene, R.K.; Spanos, M.; Alderman, C.; Walsh, E.; Bizzell, J.; Mosner, M.G.; Kinard, J.L.; Stuber, G.D.; Chandrasekhar, T.; Politte, L.C.; Sikich, L.; Dichter, G.S. The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder. J. Neurodev. Disord., 2018, 10(1), 12.
[http://dx.doi.org/10.1186/s11689-018-9228-y] [PMID: 29587625]

Quintana, D.S.; Westlye, L.T.; Hope, S.; Nærland, T.; Elvsåshagen, T.; Dørum, E.; Rustan, Ø.; Valstad, M.; Rezvaya, L.; Lishaugen, H.; Stensønes, E.; Yaqub, S.; Smerud, K.T.; Mahmoud, R.A.; Djupesland, P.G.; Andreassen, O.A. Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: A randomized placebo-controlled double-blind crossover trial. Transl. Psychiatry, 2017, 7(5), , e1136..
[http://dx.doi.org/10.1038/tp.2017.103] [PMID: 28534875]

Lin, I.F.; Kashino, M.; Ohta, H.; Yamada, T.; Tani, M.; Watanabe, H.; Kanai, C.; Ohno, T.; Takayama, Y.; Iwanami, A.; Kato, N. The effect of intranasal oxytocin versus placebo treatment on the auto-nomic responses to human sounds in autism: A single-blind, randomized, placebo-controlled, crossover design study. Mol. Autism, 2014, 5(1), 20.
[http://dx.doi.org/10.1186/2040-2392-5-20] [PMID: 24576333]

Strathearn, L.; Kim, S.; Bastian, D.A.; Jung, J.; Iyengar, U.; Martinez, S.; Goin-Kochel, R.P.; Fonagy, P. Visual systemizing preference in children with autism: A randomized controlled trial of intranasal oxytocin. Dev. Psychopathol., 2018, 30(2), 511-521.
[http://dx.doi.org/10.1017/S0954579417001018] [PMID: 28712371]

Domes, G.; Heinrichs, M.; Kumbier, E.; Grossmann, A.; Hauenstein, K.; Herpertz, S.C. Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder. Biol. Psychiatry, 2013, 74(3), 164-171.
[http://dx.doi.org/10.1016/j.biopsych.2013.02.007] [PMID: 23510581]

Gordon, I.; Vander Wyk, B.C.; Bennett, R.H.; Cordeaux, C.; Lucas, M.V.; Eilbott, J.A.; Zagoory-Sharon, O.; Leckman, J.F.; Feldman, R.; Pelphrey, K.A. Oxytocin enhances brain function in children with autism. Proc. Natl. Acad. Sci. USA, 2013, 110(52), 20953-20958.
[http://dx.doi.org/10.1073/pnas.1312857110] [PMID: 24297883]

Watanabe, T.; Abe, O.; Kuwabara, H.; Yahata, N.; Takano, Y.; Iwashiro, N.; Natsubori, T.; Aoki, Y.; Takao, H.; Kawakubo, Y.; Kamio, Y.; Kato, N.; Miyashita, Y.; Kasai, K.; Yamasue, H. Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: A randomized trial. JAMA Psychiatry, 2014, 71(2), 166-175.
[http://dx.doi.org/10.1001/jamapsychiatry.2013.3181] [PMID: 24352377]

Aoki, Y.; Watanabe, T.; Abe, O.; Kuwabara, H.; Yahata, N.; Takano, Y.; Iwashiro, N.; Natsubori, T.; Takao, H.; Kawakubo, Y.; Kasai, K.; Yamasue, H. Oxytocin’s neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: A randomized controlled trial. Mol. Psychiatry, 2015, 20(4), 447-453.
[http://dx.doi.org/10.1038/mp.2014.74] [PMID: 25070538]

Andari, E.; Richard, N.; Leboyer, M.; Sirigu, A. Adaptive coding of the value of social cues with oxytocin, an fMRI study in autism spectrum disorder. Cortex, 2016, 76, 79-88.
[http://dx.doi.org/10.1016/j.cortex.2015.12.010] [PMID: 26872344]

Anagnostou, E.; Soorya, L.; Chaplin, W.; Bartz, J.; Halpern, D.; Wasserman, S.; Wang, A.T.; Pepa, L.; Tanel, N.; Kushki, A.; Hollander, E. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: A randomized controlled trial. Mol. Autism, 2012, 3(1), 16.
[http://dx.doi.org/10.1186/2040-2392-3-16] [PMID: 23216716]

Tachibana, M.; Kagitani-Shimono, K.; Mohri, I.; Yamamoto, T.; Sanefuji, W.; Nakamura, A.; Oishi, M.; Kimura, T.; Onaka, T.; Ozono, K.; Taniike, M. Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. J. Child Adolesc. Psychopharmacol., 2013, 23(2), 123-127.
[http://dx.doi.org/10.1089/cap.2012.0048] [PMID: 23480321]

Watanabe, T.; Kuroda, M.; Kuwabara, H.; Aoki, Y.; Iwashiro, N.; Tatsunobu, N.; Takao, H.; Nip-pashi, Y.; Kawakubo, Y.; Kunimatsu, A.; Kasai, K.; Yamasue, H. Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism. Brain, 2015, 138(11), 3400-3412.
[http://dx.doi.org/10.1093/brain/awv249] [PMID: 26336909]

Kosaka, H.; Okamoto, Y.; Munesue, T.; Yamasue, H.; Inohara, K.; Fujioka, T.; Anme, T.; Orisaka, M.; Ishitobi, M.; Jung, M.; Fujisawa, T.X.; Tanaka, S.; Arai, S.; Asano, M.; Saito, D.N.; Sadato, N.; Tomoda, A.; Omori, M.; Sato, M.; Okazawa, H.; Higashida, H.; Wada, Y. Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: A 24-week randomized clinical trial. Transl. Psychiatry, 2016, 6(8), , e872..
[http://dx.doi.org/10.1038/tp.2016.152] [PMID: 27552585]

Fukai, M.; Hirosawa, T.; Kikuchi, M.; Ouchi, Y.; Takahashi, T.; Yoshimura, Y.; Miyagishi, Y.; Kosaka, H.; Yokokura, M.; Yoshikawa, E.; Bunai, T.; Minabe, Y. Oxytocin effects on emotional response to others’ faces via serotonin system in autism: A pilot study. Psychiatry Res. Neuroimaging, 2017, 267, 45-50.
[http://dx.doi.org/10.1016/j.pscychresns.2017.06.015] [PMID: 28738293]

Parker, K.J.; Oztan, O.; Libove, R.A.; Sumiyoshi, R.D.; Jackson, L.P.; Karhson, D.S.; Summers, J.E.; Hinman, K.E.; Motonaga, K.S.; Phillips, J.M.; Carson, D.S.; Garner, J.P.; Hardan, A.Y. Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism. Proc. Natl. Acad. Sci. USA, 2017, 114(30), 8119-8124.
[http://dx.doi.org/10.1073/pnas.1705521114] [PMID: 28696286]

Yamasue, H.; Okada, T.; Munesue, T.; Kuroda, M.; Fujioka, T.; Uno, Y.; Matsumoto, K.; Kuwabara, H.; Mori, D.; Okamoto, Y.; Yoshimura, Y.; Kawakubo, Y.; Arioka, Y.; Kojima, M.; Yuhi, T.; Owada, K.; Yassin, W.; Kushima, I.; Benner, S.; Ogawa, N.; Eriguchi, Y.; Kawano, N.; Uemura, Y.; Yamamoto, M.; Kano, Y.; Kasai, K.; Higashida, H.; Ozaki, N.; Kosaka, H. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: A randomized clinical trial. Mol. Psychiatry, 2020, 25(8), 1849-1858.
[http://dx.doi.org/10.1038/s41380-018-0097-2] [PMID: 29955161]

Yoshimura, Y.; Kikuchi, M.; Hiraishi, H.; Hasegawa, C.; Hirosawa, T.; Takahashi, T.; Munesue, T.; Kosaka, H.; Hiagashida, H.; Minabe, Y. Longitudinal changes in the mismatch field evoked by an empathic voice reflect changes in the empathy quotient in autism spectrum disorder. Psychiatry Res. Neuroimaging, 2018, 281, 117-122.
[http://dx.doi.org/10.1016/j.pscychresns.2018.05.003] [PMID: 30292077]

Bernaerts, S.; Boets, B.; Bosmans, G.; Steyaert, J.; Alaerts, K. Behavioral effects of multiple-dose oxytocin treatment in autism: A randomized, placebo-controlled trial with long-term follow-up. Mol. Autism, 2020, 11(1), 6.
[http://dx.doi.org/10.1186/s13229-020-0313-1] [PMID: 31969977]

Dadds, M.R.; MacDonald, E.; Cauchi, A.; Williams, K.; Levy, F.; Brennan, J. Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial. J. Autism Dev. Disord., 2014, 44(3), 521-531.
[http://dx.doi.org/10.1007/s10803-013-1899-3] [PMID: 23888359]

Guastella, A.J.; Gray, K.M.; Rinehart, N.J.; Alvares, G.A.; Tonge, B.J.; Hickie, I.B.; Keating, C.M.; Cacciotti-Saija, C.; Einfeld, S.L. The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: A randomized controlled trial. J. Child Psychol. Psychiatry, 2015, 56(4), 444-452.
[http://dx.doi.org/10.1111/jcpp.12305] [PMID: 25087908]

Yatawara, C.J.; Einfeld, S.L.; Hickie, I.B.; Davenport, T.A.; Guastella, A.J. The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: A randomized clinical crossover trial. Mol. Psychiatry, 2016, 21(9), 1225-1231.
[http://dx.doi.org/10.1038/mp.2015.162] [PMID: 26503762]

Munesue, T.; Nakamura, H.; Kikuchi, M.; Miura, Y.; Takeuchi, N.; Anme, T.; Nanba, E.; Adachi, K.; Tsubouchi, K.; Sai, Y.; Miyamoto, K.; Horike, S.; Yokoyama, S.; Nakatani, H.; Niida, Y.; Kosaka, H.; Minabe, Y.; Higashida, H. Oxytocin for male subjects with autism spectrum disorder and comorbid intellectual disabilities: A randomized pilot study. Front. Psychiatry, 2016, 7, 2.
[http://dx.doi.org/10.3389/fpsyt.2016.00002] [PMID: 26834651]

Hirosawa, T.; Kikuchi, M.; Ouchi, Y.; Takahashi, T.; Yoshimura, Y.; Kosaka, H.; Furutani, N.; Hiraishi, H.; Fukai, M.; Yokokura, M.; Yoshikawa, E.; Bunai, T.; Minabe, Y. A pilot study of serotonergic modulation after long‐term administration of oxytocin in autism spectrum disorder. Autism Res., 2017, 10(5), 821-828.
[http://dx.doi.org/10.1002/aur.1761] [PMID: 28266806]

Treasure, J.; Duarte, T.A.; Schmidt, U. Eating disorders. Lancet, 2020, 395(10227), 899-911.
[http://dx.doi.org/10.1016/S0140-6736(20)30059-3] [PMID: 32171414]

Erzegovesi, S.; Bellodi, L. Eating disorders. CNS Spectr., 2016, 21(4), 304-309.
[http://dx.doi.org/10.1017/S1092852916000304] [PMID: 27319605]

Tozzi, F.; Thornton, L.M.; Klump, K.L.; Fichter, M.M.; Halmi, K.A.; Kaplan, A.S.; Strober, M.; Woodside, D.B.; Crow, S.; Mitchell, J.; Rotondo, A.; Mauri, M.; Cassano, G.; Keel, P.; Plotnicov, K.H.; Pollice, C.; Lilenfeld, L.R.; Berrettini, W.H.; Bulik, C.M.; Kaye, W.H. Symptom fluctuation in eating disorders: Correlates of diagnostic crossover. Am. J. Psychiatry, 2005, 162(4), 732-740.
[http://dx.doi.org/10.1176/appi.ajp.162.4.732] [PMID: 15800146]

Castellini, G.; Lo Sauro, C.; Mannucci, E.; Ravaldi, C.; Rotella, C.M.; Faravelli, C.; Ricca, V. Diagnostic crossover and outcome predictors in eating disorders according to DSM-IV and DSM-V proposed criteria: A 6-year follow-up study. Psychosom. Med., 2011, 73(3), 270-279.
[http://dx.doi.org/10.1097/PSY.0b013e31820a1838] [PMID: 21257978]

Castellini, G.T.F.; Ricca, V. Psychopathology of eating disorders. J. Psychopathol., 2014, 20, 461-470.

Galmiche, M.; Déchelotte, P.; Lambert, G.; Tavolacci, M.P. Prevalence of eating disorders over the 2000–2018 period: A systematic literature review. Am. J. Clin. Nutr., 2019, 109(5), 1402-1413.
[http://dx.doi.org/10.1093/ajcn/nqy342] [PMID: 31051507]

Baranowska, B.; Kochanowski, J. Neuroendocrine aspects of anorexia nervosa and bulimia nervosa. Neuroendocrinol. Lett., 2018, 39(3), 172-178.
[PMID: 30431742]

Hoffman, E.R.; Brownley, K.A.; Hamer, R.M.; Bulik, C.M. Plasma, salivary, and urinary oxytocin in anorexia nervosa: A pilot study. Eat. Behav., 2012, 13(3), 256-259.
[http://dx.doi.org/10.1016/j.eatbeh.2012.02.004] [PMID: 22664406]

Demitrack, M.A.; Lesem, M.D.; Listwak, S.J.; Brandt, H.A.; Jimerson, D.C.; Gold, P.W. CSF oxytocin in anorexia nervosa and bulimia nervosa: Clinical and pathophysiologic considerations. Am. J. Psychiatry, 1990, 147(7), 882-886.
[http://dx.doi.org/10.1176/ajp.147.7.882] [PMID: 2356873]

Frank, G.K.; Kaye, W.H.; Altemus, M.; Greeno, C.G. CSF oxytocin and vasopressin levels after recovery from bulimia nervosa and anorexia nervosa, bulimic subtype. Biol. Psychiatry, 2000, 48(4), 315-318.
[http://dx.doi.org/10.1016/S0006-3223(00)00243-2] [PMID: 10960163]

Monteleone, A.M.; Scognamiglio, P.; Volpe, U.; Di Maso, V.; Monteleone, P. Investigation of oxytocin secretion in anorexia nervosa and bulimia nervosa: Relationships to temperament personality dimensions. Eur. Eat. Disord. Rev., 2016, 24(1), 52-56.
[http://dx.doi.org/10.1002/erv.2391] [PMID: 26259495]

Schmelkin, C.; Plessow, F.; Thomas, J.J.; Gray, E.K.; Marengi, D.A.; Pulumo, R.; Silva, L.; Miller, K.K.; Hadjikhani, N.; Franko, D.L.; Eddy, K.T.; Lawson, E.A. Low oxytocin levels are related to alexithymia in anorexia nervosa. Int. J. Eat. Disord., 2017, 50(11), 1332-1338.
[http://dx.doi.org/10.1002/eat.22784] [PMID: 29044580]

Afinogenova, Y.; Schmelkin, C.; Plessow, F.; Thomas, J.J.; Pulumo, R.; Micali, N.; Miller, K.K.; Eddy, K.T.; Lawson, E.A. Low fasting oxytocin levels are associated with psychopathology in anorexia nervosa in partial recovery. J. Clin. Psychiatry, 2016, 77(11), e1483-e1490.
[http://dx.doi.org/10.4088/JCP.15m10217] [PMID: 28076675]

Lawson, E.A.; Holsen, L.M.; Santin, M.; DeSanti, R.; Meenaghan, E.; Eddy, K.T.; Herzog, D.B.; Goldstein, J.M.; Klibanski, A. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J. Clin. Psychiatry, 2013, 74(5), e451-e457.
[http://dx.doi.org/10.4088/JCP.12m08154] [PMID: 23759466]

Lawson, E.A.; Holsen, L.M.; Santin, M.; Meenaghan, E.; Eddy, K.T.; Becker, A.E.; Herzog, D.B.; Goldstein, J.M.; Klibanski, A. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J. Clin. Endocrinol. Metab., 2012, 97(10), E1898-E1908.
[http://dx.doi.org/10.1210/jc.2012-1702] [PMID: 22872688]

Aulinas, A.; Plessow, F.; Pulumo, R.L.; Asanza, E.; Mancuso, C.J.; Slattery, M.; Tolley, C.; Thomas, J.J.; Eddy, K.T.; Miller, K.K.; Klibanski, A.; Misra, M.; Lawson, E.A. Disrupted oxytocin-appetite signaling in females with anorexia nervosa. J. Clin. Endocrinol. Metab., 2019, 104(10), 4931-4940.
[http://dx.doi.org/10.1210/jc.2019-00926] [PMID: 31251345]

Chiodera, P.; Volpi, R.; Capretti, L.; Marchesi, C.; d’Amato, L.; De Ferri, A.; Bianconi, L.; Coiro, V. Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia nervosa. Metabolism, 1991, 40(11), 1226-1230.
[http://dx.doi.org/10.1016/0026-0495(91)90220-Q] [PMID: 1943752]

Acevedo, S.F.; Valencia, C.; Lutter, M.; McAdams, C.J. Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa. Psychiatry Res., 2015, 228(3), 641-648.
[http://dx.doi.org/10.1016/j.psychres.2015.05.040] [PMID: 26106053]

Micali, N.; Crous-Bou, M.; Treasure, J.; Lawson, E.A. Association between oxytocin receptor geno-type, maternal care, and eating disorder behaviours in a community sample of women. Eur. Eat. Disord. Rev., 2017, 25(1), 19-25.
[http://dx.doi.org/10.1002/erv.2486] [PMID: 27862641]

Kim, Y.R.; Kim, J.H.; Kim, C.H.; Shin, J.G.; Treasure, J. Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa. Eur. Eat. Disord. Rev., 2015, 23(3), 171-178.
[http://dx.doi.org/10.1002/erv.2354] [PMID: 25773927]

Connelly, J.J.; Golding, J.; Gregory, S.P.; Ring, S.M.; Davis, J.M.; Davey Smith, G.; Harris, J.C.; Carter, C.S.; Pembrey, M. Personality, behavior and environmental features associated with OXTR genetic variants in British mothers. PLoS One, 2014, 9(3), , e90465..
[http://dx.doi.org/10.1371/journal.pone.0090465] [PMID: 24621820]

Boraska, V.; Franklin, C.S.; Floyd, J A B.; Thornton, L.M.; Huckins, L.M.; Southam, L.; Rayner, N.W.; Tachmazidou, I.; Klump, K.L.; Treasure, J.; Lewis, C.M.; Schmidt, U.; Tozzi, F.; Kiezebrink, K.; Hebebrand, J.; Gorwood, P.; Adan, R A H.; Kas, M.J.H.; Favaro, A.; Santonastaso, P.; Fernández-Aranda, F.; Gratacos, M.; Rybakowski, F.; Dmitrzak-Weglarz, M.; Kaprio, J.; Keski-Rahkonen, A.; Raevuori, A.; Van Furth, E.F.; Slof-Op ’t Landt, M.C.T.; Hudson, J.I.; Reichborn-Kjennerud, T.; Knudsen, G.P.S.; Monteleone, P.; Kaplan, A.S.; Karwautz, A.; Hakonarson, H.; Berrettini, W.H.; Guo, Y.; Li, D.; Schork, N.J.; Komaki, G.; Ando, T.; Inoko, H.; Esko, T.; Fischer, K.; Männik, K.; Metspalu, A.; Baker, J.H.; Cone, R.D.; Dackor, J.; DeSocio, J.E.; Hilliard, C.E.; O’Toole, J.K.; Pantel, J.; Szatkiewicz, J.P.; Taico, C.; Zerwas, S.; Trace, S.E.; Davis, O.S.P.; Helder, S.; Bühren, K.; Burghardt, R.; de Zwaan, M.; Egberts, K.; Ehrlich, S.; Herpertz-Dahlmann, B.; Herzog, W.; Imgart, H.; Scherag, A.; Scherag, S.; Zipfel, S.; Boni, C.; Ramoz, N.; Versini, A.; Brandys, M.K.; Danner, U.N.; de Kovel, C.; Hendriks, J.; Koeleman, B.P.C.; Ophoff, R.A.; Strengman, E.; van Elburg, A.A.; Bruson, A.; Clementi, M.; Degortes, D.; Forzan, M.; Tenconi, E.; Docampo, E.; Escaramís, G.; Jiménez-Murcia, S.; Lissowska, J.; Rajewski, A.; Szeszenia-Dabrowska, N.; Slopien, A.; Hauser, J.; Karhunen, L.; Meulenbelt, I.; Slagboom, P.E.; Tortorella, A.; Maj, M.; Dedoussis, G.; Dikeos, D.; Gonidakis, F.; Tziouvas, K.; Tsitsika, A.; Papezova, H.; Slachtova, L.; Martaskova, D.; Kennedy, J.L.; Levitan, R.D.; Yilmaz, Z.; Huemer, J.; Koubek, D.; Merl, E.; Wagner, G.; Lichtenstein, P.; Breen, G.; Cohen-Woods, S.; Farmer, A.; McGuffin, P.; Cichon, S.; Giegling, I.; Herms, S.; Rujescu, D.; Schreiber, S.; Wichmann, H-E.; Dina, C.; Sladek, R.; Gambaro, G.; Soranzo, N.; Julia, A.; Marsal, S.; Rabionet, R.; Gaborieau, V.; Dick, D.M.; Palotie, A.; Ripatti, S.; Widén, E.; Andreassen, O.A.; Espeseth, T.; Lundervold, A.; Reinvang, I.; Steen, V.M.; Le Hellard, S.; Mattingsdal, M.; Ntalla, I.; Bencko, V.; Foretova, L.; Janout, V.; Navratilova, M.; Gallinger, S.; Pinto, D.; Scherer, S.W.; Aschauer, H.; Carlberg, L.; Schosser, A.; Alfredsson, L.; Ding, B.; Klareskog, L.; Padyukov, L.; Courtet, P.; Guillaume, S.; Jaussent, I.; Finan, C.; Kalsi, G.; Roberts, M.; Logan, D.W.; Peltonen, L.; Ritchie, G.R.S.; Barrett, J.C.; Anderson, C.A.; Barrett, J.C.; Floyd, J.A.B.; Franklin, C.S.; McGinnis, R.; Soranzo, N.; Zeggini, E.; Sambrook, J.; Stephens, J.; Ouwehand, W.H.; McArdle, W.L.; Ring, S.M.; Strachan, D.P.; Alexander, G.; Bulik, C.M.; Collier, D.A.; Conlon, P.J.; Dominiczak, A.; Duncanson, A.; Hill, A.; Langford, C.; Lord, G.; Maxwell, A.P.; Morgan, L.; Peltonen, L.; Sandford, R.N.; Sheerin, N.; Soranzo, N.; Vannberg, F.O.; Barrett, J.C.; Blackburn, H.; Chen, W-M.; Edkins, S.; Gillman, M.; Gray, E.; Hunt, S.E.; Langford, C.; Onengut-Gumuscu, S.; Potter, S.; Rich, S.S.; Simpkin, D.; Whittaker, P.; Estivill, X.; Hinney, A.; Sullivan, P.F.; Collier, D.A.; Zeggini, E.; Bulik, C.M. A genome-wide association study of anorexia nervosa. Mol. Psychiatry, 2014, 19(10), 1085-1094.
[http://dx.doi.org/10.1038/mp.2013.187] [PMID: 24514567]

Kucharska, K.; Kot, E.; Biernacka, K.; Zimowski, J.; Rogoza, R.; Rybakowski, F.; Kostecka, B.; Bednarska-Makaruk, M. Interaction between polymorphisms of the oxytocinergic system genes and emotion perception in inpatients with anorexia nervosa. Eur. Eat. Disord. Rev., 2019, 27(5), , erv.2698..
[http://dx.doi.org/10.1002/erv.2698] [PMID: 31385420]

Kim, Y.R.; Kim, J.H.; Kim, M.J.; Treasure, J. Differential methylation of the oxytocin receptor gene in patients with anorexia nervosa: A pilot study. PLoS One, 2014, 9(2), , e88673..
[http://dx.doi.org/10.1371/journal.pone.0088673] [PMID: 24523928]

Thaler, L.; Brassard, S.; Booij, L.; Kahan, E.; McGregor, K.; Labbe, A.; Israel, M.; Steiger, H. Methylation of the OXTR gene in women with anorexia nervosa: Relationship to social behavior. Eur. Eat. Disord. Rev., 2020, 28(1), 79-86.
[http://dx.doi.org/10.1002/erv.2703] [PMID: 31823473]

Kim, Y.R.; Eom, J.S.; Yang, J.W.; Kang, J.; Treasure, J. The impact of oxytocin on food intake and emotion recognition in patients with eating disorders: A double blind single dose within-subject cross-over design. PLoS One, 2015, 10(9), , e0137514..
[http://dx.doi.org/10.1371/journal.pone.0137514] [PMID: 26402337]

Kim, Y.R.; Kim, C.H.; Cardi, V.; Eom, J.S.; Seong, Y.; Treasure, J. Intranasal oxytocin attenuates attentional bias for eating and fat shape stimuli in patients with anorexia nervosa. Psychoneuroendocrinology, 2014, 44, 133-142.
[http://dx.doi.org/10.1016/j.psyneuen.2014.02.019] [PMID: 24703429]

Leppanen, J.; Cardi, V.; Ng, K.W.; Paloyelis, Y.; Stein, D.; Tchanturia, K.; Treasure, J. The effects of intranasal oxytocin on smoothie intake, cortisol and attentional bias in anorexia nervosa. Psychoneuroendocrinology, 2017, 79, 167-174.
[http://dx.doi.org/10.1016/j.psyneuen.2017.01.017] [PMID: 28288443]

Kim, Y.R.; Eom, J.S.; Leppanen, J.; Leslie, M.; Treasure, J. Effects of intranasal oxytocin on the attentional bias to emotional stimuli in patients with bulimia nervosa. Psychoneuroendocrinology, 2018, 91, 75-78.
[http://dx.doi.org/10.1016/j.psyneuen.2018.02.029] [PMID: 29529522]

Kim, Y.R.; Kim, C.H.; Park, J.H.; Pyo, J.; Treasure, J. The impact of intranasal oxytocin on attention to social emotional stimuli in patients with anorexia nervosa: A double blind within-subject cross-over experiment. PLoS One, 2014, 9(3), , e90721..
[http://dx.doi.org/10.1371/journal.pone.0090721] [PMID: 24603863]

Leslie, M.; Leppanen, J.; Paloyelis, Y.; Treasure, J. The influence of oxytocin on eating behaviours and stress in women with bulimia nervosa and binge eating disorder. Mol. Cell. Endocrinol., 2019, 497, , 110354..
[http://dx.doi.org/10.1016/j.mce.2018.12.014] [PMID: 30579958]

Leslie, M.; Leppanen, J.; Paloyelis, Y.; Nazar, B.P.; Treasure, J. The influence of oxytocin on risk‐taking in the balloon analogue risk task among women with bulimia nervosa and binge eating disorder. J. Neuroendocrinol., 2019, 31(8), , e12771..
[http://dx.doi.org/10.1111/jne.12771] [PMID: 31283053]

Leppanen, J.; Cardi, V.; Ng, K.W.; Paloyelis, Y.; Stein, D.; Tchanturia, K.; Treasure, J. Effects of intranasal oxytocin on the interpretation and expression of emotions in anorexia nervosa. J. Neuroendocrinol., 2017, 29(3), 12458.
[http://dx.doi.org/10.1111/jne.12458] [PMID: 28140486]

Russell, J.; Maguire, S.; Hunt, G.E.; Kesby, A.; Suraev, A.; Stuart, J.; Booth, J.; McGregor, I.S. Intranasal oxytocin in the treatment of anorexia nervosa: Randomized controlled trial during re-feeding. Psychoneuroendocrinology, 2018, 87, 83-92.
[http://dx.doi.org/10.1016/j.psyneuen.2017.10.014] [PMID: 29049935]

Febo, M.; Ferris, C.F. Oxytocin and vasopressin modulation of the neural correlates of motivation and emotion: Results from functional MRI studies in awake rats. Brain Res., 2014, 1580, 8-21.
[http://dx.doi.org/10.1016/j.brainres.2014.01.019] [PMID: 24486356]

Gordon, I.; Martin, C.; Feldman, R.; Leckman, J.F. Oxytocin and social motivation. Dev. Cogn. Neurosci., 2011, 1(4), 471-493.
[http://dx.doi.org/10.1016/j.dcn.2011.07.007] [PMID: 21984889]

Gamal-Eltrabily, M.; Manzano-García, A. Role of central oxytocin and dopamine systems in nociception and their possible interactions: Suggested hypotheses. Rev. Neurosci., 2018, 29(4), 377-386.
[http://dx.doi.org/10.1515/revneuro-2017-0068] [PMID: 29222936]

Leng, G.; Onaka, T.; Caquineau, C.; Sabatier, N.; Tobin, V.; Takayanagi, Y. Oxytocin and appetite. Prog. Brain Res., 2008, 170, 137-151.
[http://dx.doi.org/10.1016/S0079-6123(08)00413-5] [PMID: 18655879]

Shamay-Tsoory, S.G.; Abu-Akel, A. The social salience hypothesis of Oxytocin. Biol. Psychiatry, 2016, 79(3), 194-202.
[http://dx.doi.org/10.1016/j.biopsych.2015.07.020] [PMID: 26321019]

Romano, A.; Friuli, M.; Cifani, C.; Gaetani, S. Oxytocin in the neural control of eating: At the cross-road between homeostatic and non-homeostatic signals. Neuropharmacology, 2020, 171, , 108082..
[http://dx.doi.org/10.1016/j.neuropharm.2020.108082] [PMID: 32259527]

Grinevich, V.; Knobloch-Bollmann, H.S.; Eliava, M.; Busnelli, M.; Chini, B. Assembling the puzzle: Pathways of oxytocin signaling in the brain. Biol. Psychiatry, 2016, 79(3), 155-164.
[http://dx.doi.org/10.1016/j.biopsych.2015.04.013] [PMID: 26001309]

Ruscio, A.M.; Stein, D.J.; Chiu, W.T.; Kessler, R.C. The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication. Mol. Psychiatry, 2010, 15(1), 53-63.
[http://dx.doi.org/10.1038/mp.2008.94] [PMID: 18725912]

Pauls, D.L.; Abramovitch, A.; Rauch, S.L.; Geller, D.A. Obsessive–compulsive disorder: An integrative genetic and neurobiological perspective. Nat. Rev. Neurosci., 2014, 15(6), 410-424.
[http://dx.doi.org/10.1038/nrn3746] [PMID: 24840803]

Stewart, S.E.; Yu, D.; Scharf, J.M.; Neale, B.M.; Fagerness, J.A.; Mathews, C.A.; Arnold, P.D.; Evans, P.D.; Gamazon, E.R.; Osiecki, L.; McGrath, L.; Haddad, S.; Crane, J.; Hezel, D.; Illman, C.; Mayerfeld, C.; Konkashbaev, A.; Liu, C.; Pluzhnikov, A.; Tikhomirov, A.; Edlund, C.K.; Rauch, S.L.; Moessner, R.; Falkai, P.; Maier, W.; Ruhrmann, S.; Grabe, H-J.; Lennertz, L.; Wagner, M.; Bellodi, L.; Cavallini, M.C.; Richter, M.A.; Cook, E.H., Jr; Kennedy, J.L.; Rosenberg, D.; Stein, D.J.; Hemmings, S.M.J.; Lochner, C.; Azzam, A.; Chavira, D.A.; Fournier, E.; Garrido, H.; Sheppard, B.; Umaña, P.; Murphy, D.L.; Wendland, J.R.; Veenstra-VanderWeele, J.; Denys, D.; Blom, R.; Deforce, D.; Van Nieuwerburgh, F.; Westenberg, H.G.M.; Walitza, S.; Egberts, K.; Renner, T.; Miguel, E.C.; Cappi, C.; Hounie, A.G.; Conceição do Rosário, M.; Sampaio, A.S.; Vallada, H.; Nicolini, H.; Lanzagorta, N.; Camarena, B.; Delorme, R.; Leboyer, M.; Pato, C.N.; Pato, M.T.; Voyiaziakis, E.; Heutink, P.; Cath, D.C.; Posthuma, D.; Smit, J.H.; Samuels, J.; Bienvenu, O.J.; Cullen, B.; Fyer, A.J.; Grados, M.A.; Greenberg, B.D.; McCracken, J.T.; Riddle, M.A.; Wang, Y.; Coric, V.; Leckman, J.F.; Bloch, M.; Pit-tenger, C.; Eapen, V.; Black, D.W.; Ophoff, R.A.; Strengman, E.; Cusi, D.; Turiel, M.; Frau, F.; Macciardi, F.; Gibbs, J.R.; Cookson, M.R.; Singleton, A.; Arepalli, S.; Cookson, M.R.; Dillman, A.; Ferrucci, L.; Gibbs, J.R.; Hernandez, D.G.; Johnson, R.; Longo, D.L.; Nalls, M.A.; O’Brien, R.; Singleton, A.; Traynor, B.; Troncoso, J.; van der Brug, M.; Zielke, H.R.; Zonderman, A.; Hardy, J.; Hardy, J.A.; Ryten, M.; Smith, C.; Trabzuni, D.; Walker, R.; Weale, M.; Crenshaw, A.T.; Parkin, M.A.; Mirel, D.B.; Conti, D.V.; Purcell, S.; Nestadt, G.; Hanna, G.L.; Jenike, M.A.; Knowles, J.A.; Cox, N.; Pauls, D.L. Genome-wide association study of obsessive-compulsive disorder. Mol. Psychiatry, 2013, 18(7), 788-798.
[http://dx.doi.org/10.1038/mp.2012.85] [PMID: 22889921]

Scantamburlo, G.; Ansseau, M.; Geenen, V.; Legros, J.J. Oxytocin: From milk ejection to maladaptation in stress response and psychiatric disorders. A psychoneuroendocrine perspective. Ann. Endocrinol. (Paris), 2009, 70(6), 449-454.
[http://dx.doi.org/10.1016/j.ando.2009.09.002] [PMID: 19878924]

Marazziti, D.; Dell’Osso, M. The role of oxytocin in neuropsychiatric disorders. Curr. Med. Chem., 2008, 15(7), 698-704.
[http://dx.doi.org/10.2174/092986708783885291] [PMID: 18336283]

Amico, J.A.; Mantella, R.C.; Vollmer, R.R.; Li, X. Anxiety and stress responses in female oxytocin deficient mice. J. Neuroendocrinol., 2004, 16(4), 319-324.
[http://dx.doi.org/10.1111/j.0953-8194.2004.01161.x] [PMID: 15089969]

Marazziti, D.; Baroni, S.; Giannaccini, G.; Betti, L.; Massimetti, G.; Carmassi, C. Catena-Dell’Osso, M. A link between oxytocin and serotonin in humans: Supporting evidence from peripheral markers. Eur. Neuropsychopharmacol., 2012, 22(8), 578-583.
[http://dx.doi.org/10.1016/j.euroneuro.2011.12.010] [PMID: 22297159]

Kovács, G.L.; Sarnyai, Z.; Szabó, G. Oxytocin and addiction: A review. Psychoneuroendocrinology, 1998, 23(8), 945-962.
[http://dx.doi.org/10.1016/S0306-4530(98)00064-X] [PMID: 9924746]

Cochran, D.M.; Fallon, D.; Hill, M.; Frazier, J.A. The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings. Harv. Rev. Psychiatry, 2013, 21(5), 219-247.
[http://dx.doi.org/10.1097/HRP.0b013e3182a75b7d] [PMID: 24651556]

Leckman, J.F.; Goodman, W.K.; North, W.G.; Chappell, P.B.; Price, L.H.; Pauls, D.L.; Anderson, G.M.; Riddle, M.A.; McSwiggan-Hardin, M.; McDougle, C.J. Elevated cerebrospinal fluid levels of oxytocin in obsessive-compulsive disorder. Comparison with Tourette’s syndrome and healthy controls. Arch. Gen. Psychiatry, 1994, 51(10), 782-792.
[http://dx.doi.org/10.1001/archpsyc.1994.03950100030003] [PMID: 7524462]

Swedo, S.E.; Leonard, H.L.; Kruesi, M.J.; Rettew, D.C.; Listwak, S.J.; Berrettini, W.; Stipetic, M.; Hamburger, S.; Gold, P.W.; Potter, W.Z. Cerebrospinal fluid neurochemistry in children and adolescents with obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1992, 49(1), 29-36.
[http://dx.doi.org/10.1001/archpsyc.1992.01820010029004] [PMID: 1370197]

Marazziti, D.; Baroni, S.; Giannaccini, G. Catena-Dell’‘Osso, M.; Piccinni, A.; Massimetti, G.; Dell’'Osso, L. Plasma oxytocin levels in untreated adult obsessive-compulsive disorder patients. Neuropsychobiology, 2015, 72(2), 74-80.
[http://dx.doi.org/10.1159/000438756] [PMID: 26509891]

Altemus, M.; Jacobson, K.R.; Debellis, M.; Kling, M.; Pigott, T.; Murphy, D.L.; Gold, P.W. Normal CSF oxytocin and NPY levels in OCD. Biol. Psychiatry, 1999, 45(7), 931-933.
[http://dx.doi.org/10.1016/S0006-3223(98)00263-7] [PMID: 10202583]

Humble, M.B.; Uvnäs-Moberg, K.; Engström, I.; Bejerot, S. Plasma oxytocin changes and anti-obsessive response during serotonin reuptake inhibitor treatment: A placebo controlled study. BMC Psychiatry, 2013, 13(1), 344.
[http://dx.doi.org/10.1186/1471-244X-13-344] [PMID: 24359174]

Epperson, C.N.; McDougle, C.J.; Price, L.H. Intranasal oxytocin in obsessive-compulsive disorder. Biol. Psychiatry, 1996, 40(6), 547-549.
[http://dx.doi.org/10.1016/0006-3223(96)00120-5] [PMID: 8879477]

den Boer, J.A.; Westenberg, H.G.M. Oxytocin in obsessive compulsive disorder. Peptides, 1992, 13(6), 1083-1085.
[http://dx.doi.org/10.1016/0196-9781(92)90010-Z] [PMID: 1494489]

Cushing, B.; Kramer, K. Mechanisms underlying epigenetic effects of early social experience: The role of neuropeptides and steroids. Neurosci. Biobehav. Rev., 2005, 29(7), 1089-1105.
[http://dx.doi.org/10.1016/j.neubiorev.2005.04.001] [PMID: 16099507]

Kang, J.I.; Kim, H.W.; Kim, C.H.; Hwang, E.H.; Kim, S.J. Oxytocin receptor gene polymorphisms exert a modulating effect on the onset age in patients with obsessive-compulsive disorder. Psychoneuroendocrinology, 2017, 86, 45-52.
[http://dx.doi.org/10.1016/j.psyneuen.2017.09.011] [PMID: 28915380]

Grisham, J.R.; Anderson, T.M.; Sachdev, P.S. Genetic and environmental influences on obsessive-compulsive disorder. Eur. Arch. Psychiatry Clin. Neurosci., 2008, 258(2), 107-116.
[http://dx.doi.org/10.1007/s00406-007-0789-0] [PMID: 18297419]

Cappi, C.; Diniz, J.B.; Requena, G.L.; Lourenço, T.; Lisboa, B.C.G.; Batistuzzo, M.C.; Marques, A.H.; Hoexter, M.Q.; Pereira, C.A.; Miguel, E.C.; Brentani, H. Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder. BMC Neurosci., 2016, 17(1), 79.
[http://dx.doi.org/10.1186/s12868-016-0313-4] [PMID: 27903255]

Vos, T.; Flaxman, A.D.; Naghavi, M.; Lozano, R.; Michaud, C.; Ezzati, M.; Shibuya, K.; Salomon, J.A.; Abdalla, S.; Aboyans, V.; Abraham, J.; Ackerman, I.; Aggarwal, R.; Ahn, S.Y.; Ali, M.K.; AlMazroa, M.A.; Alvarado, M.; Anderson, H.R.; Anderson, L.M.; Andrews, K.G.; Atkinson, C.; Baddour, L.M.; Bahalim, A.N.; Barker-Collo, S.; Barrero, L.H.; Bartels, D.H.; Basáñez, M-G.; Baxter, A.; Bell, M.L.; Benjamin, E.J.; Bennett, D.; Bernabé, E.; Bhalla, K.; Bhandari, B.; Bikbov, B.; Abdulhak, A.B.; Birbeck, G.; Black, J.A.; Blencowe, H.; Blore, J.D.; Blyth, F.; Bolliger, I.; Bonaventure, A.; Boufous, S.; Bourne, R.; Boussinesq, M.; Braithwaite, T.; Brayne, C.; Bridgett, L.; Brooker, S.; Brooks, P.; Brugha, T.S.; Bryan-Hancock, C.; Bucello, C.; Buchbinder, R.; Buckle, G.; Budke, C.M.; Burch, M.; Burney, P.; Burstein, R.; Calabria, B.; Campbell, B.; Canter, C.E.; Carabin, H.; Carapetis, J.; Carmona, L.; Cella, C.; Charlson, F.; Chen, H.; Cheng, A.T-A.; Chou, D.; Chugh, S.S.; Coffeng, L.E.; Colan, S.D.; Colquhoun, S.; Colson, K.E.; Condon, J.; Connor, M.D.; Cooper, L.T.; Corriere, M.; Cortinovis, M.; de Vaccaro, K.C.; Couser, W.; Cowie, B.C.; Criqui, M.H.; Cross, M.; Dabhadkar, K.C.; Dahiya, M.; Dahodwala, N.; Damsere-Derry, J.; Danaei, G.; Davis, A.; De Leo, D.; Degenhardt, L.; Dellavalle, R.; Delossantos, A.; Denenberg, J.; Derrett, S.; Des Jarlais, D.C.; Dharmaratne, S.D.; Dherani, M.; Diaz-Torne, C.; Dolk, H.; Dorsey, E.R.; Driscoll, T.; Duber, H.; Ebel, B.; Edmond, K.; Elbaz, A.; Ali, S.E.; Erskine, H.; Erwin, P.J.; Espindola, P.; Ewoigbokhan, S.E.; Farzadfar, F.; Feigin, V.; Felson, D.T.; Ferrari, A.; Ferri, C.P.; Fèvre, E.M.; Finucane, M.M.; Flaxman, S.; Flood, L.; Foreman, K.; Forouzanfar, M.H.; Fowkes, F.G.R.; Franklin, R.; Fransen, M.; Freeman, M.K.; Gabbe, B.J.; Gabriel, S.E.; Gakidou, E.; Ganatra, H.A.; Garcia, B.; Gaspari, F.; Gillum, R.F.; Gmel, G.; Gosselin, R.; Grainger, R.; Groeger, J.; Guillemin, F.; Gunnell, D.; Gupta, R.; Haagsma, J.; Hagan, H.; Halasa, Y.A.; Hall, W.; Haring, D.; Haro, J.M.; Harrison, J.E.; Havmoeller, R.; Hay, R.J.; Higashi, H.; Hill, C.; Hoen, B.; Hoffman, H.; Hotez, P.J.; Hoy, D.; Huang, J.J.; Ibeanusi, S.E.; Jacobsen, K.H.; James, S.L.; Jarvis, D.; Jasrasaria, R.; Jayaraman, S.; Johns, N.; Jonas, J.B.; Karthikeyan, G.; Kassebaum, N.; Kawakami, N.; Keren, A.; Khoo, J-P.; King, C.H.; Knowlton, L.M.; Kobusingye, O.; Koranteng, A.; Krishnamurthi, R.; Lalloo, R.; Laslett, L.L.; Lathlean, T.; Leasher, J.L.; Lee, Y.Y.; Leigh, J.; Lim, S.S.; Limb, E.; Lin, J.K.; Lipnick, M.; Lipshultz, S.E.; Liu, W.; Loane, M.; Ohno, S.L.; Lyons, R.; Ma, J.; Mabweijano, J.; MacIntyre, M.F.; Malekzadeh, R.; Mallinger, L.; Manivannan, S.; Marcenes, W.; March, L.; Margolis, D.J.; Marks, G.B.; Marks, R.; Matsumori, A.; Matzopoulos, R.; Mayosi, B.M.; McAnulty, J.H.; McDermott, M.M.; McGill, N.; McGrath, J.; Medina-Mora, M.E.; Meltzer, M.; Memish, Z.A.; Mensah, G.A.; Merriman, T.R.; Meyer, A-C.; Miglioli, V.; Miller, M.; Miller, T.R.; Mitchell, P.B.; Mocumbi, A.O.; Moffitt, T.E.; Mokdad, A.A.; Monasta, L.; Montico, M.; Moradi-Lakeh, M.; Moran, A.; Morawska, L.; Mori, R.; Murdoch, M.E.; Mwaniki, M.K.; Naidoo, K.; Nair, M.N.; Naldi, L.; Narayan, K.M.V.; Nelson, P.K.; Nelson, R.G.; Nevitt, M.C.; Newton, C.R.; Nolte, S.; Norman, P.; Norman, R.; O’Donnell, M.; O’Hanlon, S.; Olives, C.; Omer, S.B.; Ortblad, K.; Osborne, R.; Ozgediz, D.; Page, A.; Pahari, B.; Pandian, J.D.; Rivero, A.P.; Patten, S.B.; Pearce, N.; Padilla, R.P.; Perez-Ruiz, F.; Perico, N.; Pesudovs, K.; Phillips, D.; Phillips, M.R.; Pierce, K.; Pion, S.; Polanczyk, G.V.; Polinder, S.; Pope, C.A., III; Popova, S.; Porrini, E.; Pourmalek, F.; Prince, M.; Pullan, R.L.; Ramaiah, K.D.; Ranganathan, D.; Razavi, H.; Regan, M.; Rehm, J.T.; Rein, D.B.; Remuzzi, G.; Richardson, K.; Rivara, F.P.; Roberts, T.; Robinson, C.; De Leòn, F.R.; Ronfani, L.; Room, R.; Rosenfeld, L.C.; Rushton, L.; Sacco, R.L.; Saha, S.; Sampson, U.; Sanchez-Riera, L.; Sanman, E.; Schwebel, D.C.; Scott, J.G.; Segui-Gomez, M.; Shahraz, S.; Shepard, D.S.; Shin, H.; Shivakoti, R.; Silberberg, D.; Singh, D.; Singh, G.M.; Singh, J.A.; Singleton, J.; Sleet, D.A.; Sliwa, K.; Smith, E.; Smith, J.L.; Stapelberg, N.J.C.; Steer, A.; Steiner, T.; Stolk, W.A.; Stovner, L.J.; Sudfeld, C.; Syed, S.; Tamburlini, G.; Tavakkoli, M.; Taylor, H.R.; Taylor, J.A.; Taylor, W.J.; Thomas, B.; Thomson, W.M.; Thurston, G.D.; Tleyjeh, I.M.; Tonelli, M.; Towbin, J.A.; Truelsen, T.; Tsilimbaris, M.K.; Ubeda, C.; Undurraga, E.A.; van der Werf, M.J.; van Os, J.; Vavilala, M.S.; Venketasubramanian, N.; Wang, M.; Wang, W.; Watt, K.; Weatherall, D.J.; Weinstock, M.A.; Weintraub, R.; Weisskopf, M.G.; Weissman, M.M.; White, R.A.; Whiteford, H.; Wiersma, S.T.; Wilkinson, J.D.; Williams, H.C.; Williams, S.R.M.; Witt, E.; Wolfe, F.; Woolf, A.D.; Wulf, S.; Yeh, P-H.; Zaidi, A.K.M.; Zheng, Z-J.; Zonies, D.; Lopez, A.D.; Murray, C.J.L. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: A systematic analysis for the global burden of disease study 2010. Lancet, 2012, 380(9859), 2163-2196.
[http://dx.doi.org/10.1016/S0140-6736(12)61729-2] [PMID: 23245607]

Olff, M.; Frijling, J.L.; Kubzansky, L.D.; Bradley, B.; Ellenbogen, M.A.; Cardoso, C.; Bartz, J.A.; Yee, J.R.; van Zuiden, M. The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology, 2013, 38(9), 1883-1894.
[http://dx.doi.org/10.1016/j.psyneuen.2013.06.019] [PMID: 23856187]

Neumann, I.D.; Landgraf, R. Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors. Trends Neurosci., 2012, 35(11), 649-659.
[http://dx.doi.org/10.1016/j.tins.2012.08.004] [PMID: 22974560]

Bartz, J.A.; Zaki, J.; Bolger, N.; Ochsner, K.N. Social effects of oxytocin in humans: Context and person matter. Trends Cogn. Sci., 2011, 15(7), 301-309.
[http://dx.doi.org/10.1016/j.tics.2011.05.002] [PMID: 21696997]

Skuse, D.H.; Gallagher, L. Genetic influences on social cognition. Pediatr. Res., 2011, 69(5 Part 2), 85R-91R.
[http://dx.doi.org/10.1203/PDR.0b013e318212f562] [PMID: 21289535]

Heinrichs, M.; Baumgartner, T.; Kirschbaum, C.; Ehlert, U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol. Psychiatry, 2003, 54(12), 1389-1398.
[http://dx.doi.org/10.1016/S0006-3223(03)00465-7] [PMID: 14675803]

Winter, J.; Jurek, B. The interplay between oxytocin and the CRF system: Regulation of the stress response. Cell Tissue Res., 2019, 375(1), 85-91.
[http://dx.doi.org/10.1007/s00441-018-2866-2] [PMID: 29911261]

Domes, G.; Heinrichs, M.; Gläscher, J.; Büchel, C.; Braus, D.F.; Herpertz, S.C. Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol. Psychiatry, 2007, 62(10), 1187-1190.
[http://dx.doi.org/10.1016/j.biopsych.2007.03.025] [PMID: 17617382]

Kirsch, P.; Esslinger, C.; Chen, Q.; Mier, D.; Lis, S.; Siddhanti, S.; Gruppe, H.; Mattay, V.S.; Gallhofer, B.; Meyer-Lindenberg, A. Oxytocin modulates neural circuitry for social cognition and fear in humans. J. Neurosci., 2005, 25(49), 11489-11493.
[http://dx.doi.org/10.1523/JNEUROSCI.3984-05.2005] [PMID: 16339042]

Sripada, C.S.; Phan, K.L.; Labuschagne, I.; Welsh, R.; Nathan, P.J.; Wood, A.G. Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. Int. J. Neuropsychopharmacol., 2013, 16(2), 255-260.
[http://dx.doi.org/10.1017/S1461145712000533] [PMID: 22647521]

Owen, S.F.; Tuncdemir, S.N.; Bader, P.L.; Tirko, N.N.; Fishell, G.; Tsien, R.W. Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature, 2013, 500(7463), 458-462.
[http://dx.doi.org/10.1038/nature12330] [PMID: 23913275]

Nagasawa, M.; Okabe, S.; Mogi, K.; Kikusui, T. Oxytocin and mutual communication in mother-infant bonding. Front. Hum. Neurosci., 2012, 6, 31.
[http://dx.doi.org/10.3389/fnhum.2012.00031] [PMID: 22375116]

Lieberwirth, C.; Wang, Z. Social bonding: Regulation by neuropeptides. Front. Neurosci., 2014, 8, 171.
[http://dx.doi.org/10.3389/fnins.2014.00171] [PMID: 25009457]

Costa, B.; Pini, S.; Martini, C.; Abelli, M.; Gabelloni, P.; Ciampi, O.; Muti, M.; Gesi, C.; Lari, L.; Cardini, A.; Mucci, A.; Bucci, P.; Lucacchini, A.; Cassano, G.B. Mutation analysis of oxytocin gene in individuals with adult separation anxiety. Psychiatry Res., 2009, 168(2), 87-93.
[http://dx.doi.org/10.1016/j.psychres.2008.04.009] [PMID: 19473710]

Costa, B.; Pini, S.; Gabelloni, P.; Abelli, M.; Lari, L.; Cardini, A.; Muti, M.; Gesi, C.; Landi, S.; Galderisi, S.; Mucci, A.; Lucacchini, A.; Cassano, G.B.; Martini, C. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 2009, 34(10), 1506-1514.
[http://dx.doi.org/10.1016/j.psyneuen.2009.05.006] [PMID: 19515497]

Costa, B.; Pini, S.; Baldwin, D.S.; Silove, D.; Manicavasagar, V.; Abelli, M.; Coppedè, F.; Martini, C. Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety. J. Affect. Disord., 2017, 218, 365-373.
[http://dx.doi.org/10.1016/j.jad.2017.03.056] [PMID: 28499211]

Kim, H.S.; Sherman, D.K.; Sasaki, J.Y.; Xu, J.; Chu, T.Q.; Ryu, C.; Suh, E.M.; Graham, K.; Taylor, S.E. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc. Natl. Acad. Sci. USA, 2010, 107(36), 15717-15721.
[http://dx.doi.org/10.1073/pnas.1010830107] [PMID: 20724662]

Love, T.M.; Enoch, M.A.; Hodgkinson, C.A.; Peciña, M.; Mickey, B.; Koeppe, R.A.; Stohler, C.S.; Goldman, D.; Zubieta, J.K. Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol. Psychiatry, 2012, 72(3), 198-206.
[http://dx.doi.org/10.1016/j.biopsych.2012.01.033] [PMID: 22418012]

Marazziti, D.; Dell’Osso, B.; Baroni, S.; Mungai, F.; Catena, M.; Rucci, P.; Albanese, F.; Giannaccini, G.; Betti, L.; Fabbrini, L.; Italiani, P.; Del Debbio, A.; Lucacchini, A.; Dell’Osso, L. A relationship between oxytocin and anxiety of romantic attachment. Clin. Pract. Epidemiol. Ment. Health, 2006, 2(1), 28.
[http://dx.doi.org/10.1186/1745-0179-2-28] [PMID: 17034623]

Weisman, O.; Zagoory-Sharon, O.; Schneiderman, I.; Gordon, I.; Feldman, R. Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety. Psychoneuroendocrinology, 2013, 38(5), 694-701.
[http://dx.doi.org/10.1016/j.psyneuen.2012.08.011] [PMID: 22999263]

Lebowitz, E.R.; Leckman, J.F.; Feldman, R.; Zagoory-Sharon, O.; McDonald, N.; Silverman, W.K. Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology, 2016, 65, 35-43.
[http://dx.doi.org/10.1016/j.psyneuen.2015.12.007] [PMID: 26716876]

Lebowitz, E.R.; Silverman, W.K.; Martino, A.M.; Zagoory-Sharon, O.; Feldman, R.; Leckman, J.F. Oxytocin response to youth-mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior. Depress. Anxiety, 2017, 34(2), 127-136.
[http://dx.doi.org/10.1002/da.22585] [PMID: 28052452]

Tops, M.; van Peer, J.M.; Korf, J.; Wijers, A.A.; Tucker, D.M. Anxiety, cortisol, and attachment predict plasma oxytocin. Psychophysiology, 2007, 44(3), 444-449.
[http://dx.doi.org/10.1111/j.1469-8986.2007.00510.x] [PMID: 17371496]

Pierrehumbert, B.; Torrisi, R.; Ansermet, F.; Borghini, A.; Halfon, O. Adult attachment representations predict cortisol and oxytocin responses to stress. Attach. Hum. Dev., 2012, 14(5), 453-476.
[http://dx.doi.org/10.1080/14616734.2012.706394] [PMID: 22856618]

Eapen, V.; Dadds, M.; Barnett, B.; Kohlhoff, J.; Khan, F.; Radom, N.; Silove, D.M. Separation anxiety, attachment and inter-personal representations: Disentangling the role of oxytocin in the perinatal period. PLoS One, 2014, 9(9), , e107745..
[http://dx.doi.org/10.1371/journal.pone.0107745] [PMID: 25229827]

Buchheim, A.; Heinrichs, M.; George, C.; Pokorny, D.; Koops, E.; Henningsen, P.; O’Connor, M.F.; Gündel, H. Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology, 2009, 34(9), 1417-1422.
[http://dx.doi.org/10.1016/j.psyneuen.2009.04.002] [PMID: 19457618]

Guastella, A.J.; Carson, D.S.; Dadds, M.R.; Mitchell, P.B.; Cox, R.E. Does oxytocin influence the early detection of angry and happy faces? Psychoneuroendocrinology, 2009, 34(2), 220-225.
[http://dx.doi.org/10.1016/j.psyneuen.2008.09.001] [PMID: 18848401]

Abelson, J.L.; Khan, S.; Liberzon, I.; Young, E.A. HPA axis activity in patients with panic disorder: Review and synthesis of four studies. Depress. Anxiety, 2007, 24(1), 66-76.
[http://dx.doi.org/10.1002/da.20220] [PMID: 16845643]

Le Mellédo, J.M.; Bradwejn, J.; Koszycki, D.; Bellavance, F.; Bichet, D. Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptide. Peptides, 2001, 22(8), 1349-1357.
[http://dx.doi.org/10.1016/S0196-9781(01)00462-4] [PMID: 11457531]

Norman, G.J.; Hawkley, L.; Luhmann, M.; Ball, A.B.; Cole, S.W.; Berntson, G.G.; Cacioppo, J.T. Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: A population based study. Horm. Behav., 2012, 61(1), 134-139.
[http://dx.doi.org/10.1016/j.yhbeh.2011.11.006] [PMID: 22146101]

Onodera, M.; Ishitobi, Y.; Tanaka, Y.; Aizawa, S.; Masuda, K.; Inoue, A.; Oshita, H.; Okamoto, K.; Kawashima, C.; Nakanishi, M.; Hirakawa, H.; Ninomiya, T.; Maruyama, Y.; Kanehisa, M.; Higuma, H.; Akiyoshi, J. Genetic association of the oxytocin receptor genes with panic, major depressive disorder, and social anxiety disorder. Psychiatr. Genet., 2015, 25(5), 212.
[http://dx.doi.org/10.1097/YPG.0000000000000096] [PMID: 26110343]

Garcia, R. Neurobiology of fear and specific phobias. Learn. Mem., 2017, 24(9), 462-471.
[http://dx.doi.org/10.1101/lm.044115.116] [PMID: 28814472]

Janeček, M.; Dabrowska, J. Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies—potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST). Cell Tissue Res., 2019, 375(1), 143-172.
[http://dx.doi.org/10.1007/s00441-018-2889-8] [PMID: 30054732]

Molosh, A.I.; Dustrude, E.T.; Lukkes, J.L.; Fitz, S.D.; Caliman, I.F.; Abreu, A.R.R.; Dietrich, A.D.; Truitt, W.A.; Ver Donck, L.; Ceusters, M.; Kent, J.M.; Johnson, P.L.; Shekhar, A. Panic results in unique molecular and network changes in the amygdala that facilitate fear responses. Mol. Psychiatry, 2020, 25(2), 442-460.
[http://dx.doi.org/10.1038/s41380-018-0119-0] [PMID: 30108314]

Quintana, D.S.; Westlye, L.T.; Alnæs, D.; Rustan, Ø.G.; Kaufmann, T.; Smerud, K.T.; Mahmoud, R.A.; Djupesland, P.G.; Andreassen, O.A. Low dose intranasal oxytocin delivered with breath powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial. Psychoneuroendocrinology, 2016, 69, 180-188.
[http://dx.doi.org/10.1016/j.psyneuen.2016.04.010] [PMID: 27107209]

Dunsmoor, J.E.; Paz, R. Fear generalization and anxiety: Behavioral and neural mechanisms. Biol. Psychiatry, 2015, 78(5), 336-343.
[http://dx.doi.org/10.1016/j.biopsych.2015.04.010] [PMID: 25981173]

Eckstein, M.; Becker, B.; Scheele, D.; Scholz, C.; Preckel, K.; Schlaepfer, T.E.; Grinevich, V.; Kendrick, K.M.; Maier, W.; Hurlemann, R. Oxytocin facilitates the extinction of conditioned fear in humans. Biol. Psychiatry, 2015, 78(3), 194-202.
[http://dx.doi.org/10.1016/j.biopsych.2014.10.015] [PMID: 25542304]

Hu, J.; Wang, Z.; Feng, X.; Long, C.; Schiller, D. Post-retrieval oxytocin facilitates next day extinction of threat memory in humans. Psychopharmacology (Berl.), 2019, 236(1), 293-301.
[http://dx.doi.org/10.1007/s00213-018-5074-6] [PMID: 30370450]

Acheson, D.; Feifel, D.; de Wilde, S.; Mckinney, R.; Lohr, J.; Risbrough, V. The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample. Psychopharmacology (Berl.), 2013, 229(1), 199-208.
[http://dx.doi.org/10.1007/s00213-013-3099-4] [PMID: 23644911]

Kanat, M.; Heinrichs, M.; Mader, I.; van Elst, L.T.; Domes, G. Oxytocin modulates amygdala reactivity to masked fearful eyes. Neuropsychopharmacology, 2015, 40(11), 2632-2638.
[http://dx.doi.org/10.1038/npp.2015.111] [PMID: 25881796]

Kanat, M.; Heinrichs, M.; Schwarzwald, R.; Domes, G. Oxytocin attenuates neural reactivity to masked threat cues from the eyes. Neuropsychopharmacology, 2015, 40(2), 287-295.
[http://dx.doi.org/10.1038/npp.2014.183] [PMID: 25047745]

Acheson, D.T.; Feifel, D.; Kamenski, M.; Mckinney, R.; Risbrough, V.B. Intranasal oxytocin administration prior to exposure therapy for arachnophobia impedes treatment response. Depress. Anxiety, 2015, 32(6), 400-407.
[http://dx.doi.org/10.1002/da.22362] [PMID: 25826649]

Akiskal, H.S. Toward a definition of generalized anxiety disorder as an anxious temperament type. Acta Psychiatr. Scand., 1998, 98(s393), 66-73.
[http://dx.doi.org/10.1111/j.1600-0447.1998.tb05969.x] [PMID: 9777050]

Oliveira, D.C.G.; Chagas, M.H.N.; Garcia, L.V.; Crippa, J.A.S.; Zuardi, A.W. Oxytocin interference in the effects induced by inhalation of 7.5% CO2 in healthy volunteers. Hum. Psychopharmacol., 2012, 27(4), 378-385.
[http://dx.doi.org/10.1002/hup.2237] [PMID: 22711428]

Labuschagne, I.; Phan, K.L.; Wood, A.; Angstadt, M.; Chua, P.; Heinrichs, M.; Stout, J.C.; Nathan, P.J. Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. Int. J. Neuropsychopharmacol., 2012, 15(7), 883-896.
[http://dx.doi.org/10.1017/S1461145711001489] [PMID: 21996304]

Carson, D.S.; Berquist, S.W.; Trujillo, T.H.; Garner, J.P.; Hannah, S.L.; Hyde, S.A.; Sumiyoshi, R.D.; Jackson, L.P.; Moss, J.K.; Strehlow, M.C.; Cheshier, S.H.; Partap, S.; Hardan, A.Y.; Parker, K.J. Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children. Mol. Psychiatry, 2015, 20(9), 1085-1090.
[http://dx.doi.org/10.1038/mp.2014.132] [PMID: 25349162]

Anderberg, U.M.; Uvnäs-Moberg, K. Plasma oxytocin levels in female fibromyalgia syndrome pa-tients. Z. Rheumatol., 2000, 59(6), 373-379.
[http://dx.doi.org/10.1007/s003930070045] [PMID: 11201002]

Scantamburlo, G.; Hansenne, M.; Fuchs, S.; Pitchot, W.; Maréchal, P.; Pequeux, C.; Ansseau, M.; Legros, J.J. Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology, 2007, 32(4), 407-410.
[http://dx.doi.org/10.1016/j.psyneuen.2007.01.009] [PMID: 17383107]

Opacka-Juffry, J.; Mohiyeddini, C. Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress, 2012, 15(1), 1-10.
[http://dx.doi.org/10.3109/10253890.2011.560309] [PMID: 21682649]

Alvares, G.A.; Chen, N.T.M.; Balleine, B.W.; Hickie, I.B.; Guastella, A.J. Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males. Psychoneuroendocrinology, 2012, 37(12), 2022-2031.
[http://dx.doi.org/10.1016/j.psyneuen.2012.04.018] [PMID: 22613033]

Nissen, E.; Gustavsson, P.; Widström, A-M.; Uvnäs-Moberg, K. Oxytocin, prolactin, milk produc-tion and their relationship with personality traits in women after vaginal delivery or Cesarean section. J. Psychosom. Obstet. Gynaecol., 1998, 19(1), 49-58.
[http://dx.doi.org/10.3109/01674829809044221] [PMID: 9575469]

Stuebe, A.M.; Grewen, K.; Meltzer-Brody, S. Association between maternal mood and oxytocin response to breastfeeding. J. Womens Health (Larchmt.), 2013, 22(4), 352-361.
[http://dx.doi.org/10.1089/jwh.2012.3768] [PMID: 23586800]

Goodin, B.R.; Anderson, A.J.B.; Freeman, E.L.; Bulls, H.W.; Robbins, M.T.; Ness, T.J. Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood states. Clin. J. Pain, 2015, 31(9), 757-767.
[http://dx.doi.org/10.1097/AJP.0000000000000166] [PMID: 25370147]

Wang, J.; Qin, W.; Liu, B.; Zhou, Y.; Wang, D.; Zhang, Y.; Jiang, T.; Yu, C. Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament. Brain Struct. Funct., 2014, 219(5), 1543-1554.
[http://dx.doi.org/10.1007/s00429-013-0584-9] [PMID: 23708061]

Stankova, T.; Eichhammer, P.; Langguth, B.; Sand, P.G. Sexually dimorphic effects of oxytocin receptor gene (OXTR) variants on harm avoidance. Biol. Sex Differ., 2012, 3(1), 17.
[http://dx.doi.org/10.1186/2042-6410-3-17] [PMID: 22846218]

Apter-Levy, Y.; Feldman, M.; Vakart, A.; Ebstein, R.P.; Feldman, R. Impact of maternal depression across the first 6 years of life on the child’s mental health, social engagement, and empathy: The moderating role of oxytocin. Am. J. Psychiatry, 2013, 170(10), 1161-1168.
[http://dx.doi.org/10.1176/appi.ajp.2013.12121597] [PMID: 23846912]

Rodrigues, S.M.; Saslow, L.R.; Garcia, N.; John, O.P.; Keltner, D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc. Natl. Acad. Sci. USA, 2009, 106(50), 21437-21441.
[http://dx.doi.org/10.1073/pnas.0909579106] [PMID: 19934046]

Saphire-Bernstein, S.; Way, B.M.; Kim, H.S.; Sherman, D.K.; Taylor, S.E. Oxytocin receptor gene (OXTR) is related to psychological resources. Proc. Natl. Acad. Sci. USA, 2011, 108(37), 15118-15122.
[http://dx.doi.org/10.1073/pnas.1113137108] [PMID: 21896752]

Kumsta, R.; Heinrichs, M. Oxytocin, stress and social behavior: Neurogenetics of the human oxytocin system. Curr. Opin. Neurobiol., 2013, 23(1), 11-16.
[http://dx.doi.org/10.1016/j.conb.2012.09.004] [PMID: 23040540]

Klahr, A.M.; Klump, K.; Burt, S.A. A constructive replication of the association between the oxytocin receptor genotype and parenting. J. Fam. Psychol., 2015, 29(1), 91-99.
[http://dx.doi.org/10.1037/fam0000034] [PMID: 25419912]

Bakermans-Kranenburg, M.J.; van IJzendoorn, M.H. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc. Cogn. Affect. Neurosci., 2008, 3(2), 128-134.
[http://dx.doi.org/10.1093/scan/nsn004] [PMID: 19015103]

Bradley, B.; Davis, T.A.; Wingo, A.P.; Mercer, K.B.; Ressler, K.J. Family environment and adult resilience: Contributions of positive parenting and the oxytocin receptor gene. Eur. J. Psychotraumatol., 2013, 4(1), 21659.
[http://dx.doi.org/10.3402/ejpt.v4i0.21659] [PMID: 24058725]

Dannlowski, U.; Kugel, H.; Grotegerd, D.; Redlich, R.; Opel, N.; Dohm, K.; Zaremba, D.; Grögler, A.; Schwieren, J.; Suslow, T.; Ohrmann, P.; Bauer, J.; Krug, A.; Kircher, T.; Jansen, A.; Domschke, K.; Hohoff, C.; Zwitserlood, P.; Heinrichs, M.; Arolt, V.; Heindel, W.; Baune, B.T. Disadvantage of social sensitivity: Interaction of oxytocin receptor genotype and child maltreatment on brain structure. Biol. Psychiatry, 2016, 80(5), 398-405.
[http://dx.doi.org/10.1016/j.biopsych.2015.12.010] [PMID: 26858213]

Hostinar, C.E.; Cicchetti, D.; Rogosch, F.A. Oxytocin receptor gene polymorphism, perceived social support, and psychological symptoms in maltreated adolescents. Dev. Psychopathol., 2014, 26(2), 465-477.
[http://dx.doi.org/10.1017/S0954579414000066] [PMID: 24621832]

McQuaid, R.J.; McInnis, O.A.; Stead, J.D.; Matheson, K.; Anisman, H. A paradoxical association of an oxytocin receptor gene polymorphism: Early-life adversity and vulnerability to depression. Front. Neurosci., 2013, 7, 128.
[http://dx.doi.org/10.3389/fnins.2013.00128] [PMID: 23898235]

Notzon, S.; Domschke, K.; Holitschke, K.; Ziegler, C.; Arolt, V.; Pauli, P.; Reif, A.; Deckert, J.; Zwanzger, P. Attachment style and oxytocin receptor gene variation interact in influencing social anxiety. World J. Biol. Psychiatry, 2016, 17(1), 76-83.
[http://dx.doi.org/10.3109/15622975.2015.1091502] [PMID: 26488131]

Moons, W.G.; Way, B.M.; Taylor, S.E. Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress. Emotion, 2014, 14(3), 562-572.
[http://dx.doi.org/10.1037/a0035503] [PMID: 24660771]

van Roekel, E.; Verhagen, M.; Scholte, R.H.J.; Kleinjan, M.; Goossens, L.; Engels, R.C.M.E. The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: Evidence for micro-level gene-environment interactions. PLoS One, 2013, 8(11), , e77689..
[http://dx.doi.org/10.1371/journal.pone.0077689] [PMID: 24223720]

Lucht, M.J.; Barnow, S.; Sonnenfeld, C.; Rosenberger, A.; Grabe, H.J.; Schroeder, W.; Völzke, H.; Freyberger, H.J.; Herrmann, F.H.; Kroemer, H.; Rosskopf, D. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2009, 33(5), 860-866.
[http://dx.doi.org/10.1016/j.pnpbp.2009.04.004] [PMID: 19376182]

Nelemans, S.A.; van Assche, E.; Bijttebier, P.; Colpin, H.; van Leeuwen, K.; Verschueren, K.; Claes, S.; van den Noortgate, W.; Goossens, L. Parenting interacts with oxytocin polymorphisms to predict adolescent social anxiety symptom development: A novel polygenic approach. J. Abnorm. Child Psychol., 2019, 47(7), 1107-1120.
[http://dx.doi.org/10.1007/s10802-018-0432-8] [PMID: 29696435]

Olofsdotter, S.; Åslund, C.; Furmark, T.; Comasco, E.; Nilsson, K.W. Differential susceptibility effects of oxytocin gene ( OXT ) polymorphisms and perceived parenting on social anxiety among adolescents. Dev. Psychopathol., 2018, 30(2), 449-459.
[http://dx.doi.org/10.1017/S0954579417000967] [PMID: 28606214]

Ziegler, C.; Dannlowski, U.; Bräuer, D.; Stevens, S.; Laeger, I.; Wittmann, H.; Kugel, H.; Dobel, C.; Hurlemann, R.; Reif, A.; Lesch, K.P.; Heindel, W.; Kirschbaum, C.; Arolt, V.; Gerlach, A.L.; Hoyer, J.; Deckert, J.; Zwanzger, P.; Domschke, K. Oxytocin receptor gene methylation: Converging multi-level evidence for a role in social anxiety. Neuropsychopharmacology, 2015, 40(6), 1528-1538.
[http://dx.doi.org/10.1038/npp.2015.2] [PMID: 25563749]

Hoge, E.A.; Pollack, M.H.; Kaufman, R.E.; Zak, P.J.; Simon, N.M. Oxytocin levels in social anxiety disorder. CNS Neurosci. Ther., 2008, 14(3), 165-170.
[http://dx.doi.org/10.1111/j.1755-5949.2008.00051.x] [PMID: 18801109]

Hoge, E.A.; Lawson, E.A.; Metcalf, C.A.; Keshaviah, A.; Zak, P.J.; Pollack, M.H.; Simon, N.M. Plasma oxytocin immunoreactive products and response to trust in patients with social anxiety disorder. Depress. Anxiety, 2012, 29(11), 924-930.
[http://dx.doi.org/10.1002/da.21973] [PMID: 22807189]

Oh, K.S.; Kim, E.J.; Ha, J.W.; Woo, H.Y.; Kwon, M.J.; Shin, D.W.; Shin, Y.C.; Lim, S.W. The rela-tionship between plasma oxytocin levels and social anxiety symptoms. Psychiatry Investig., 2018, 15(11), 1079-1086.
[http://dx.doi.org/10.30773/pi.2018.08.31] [PMID: 30301300]

Tabak, B.A.; McCullough, M.E.; Szeto, A.; Mendez, A.J.; McCabe, P.M. Oxytocin indexes relational distress following interpersonal harms in women. Psychoneuroendocrinology, 2011, 36(1), 115-122.
[http://dx.doi.org/10.1016/j.psyneuen.2010.07.004] [PMID: 20688437]

Labuschagne, I.; Phan, K.L.; Wood, A.; Angstadt, M.; Chua, P.; Heinrichs, M.; Stout, J.C.; Nathan, P.J. Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology, 2010, 35(12), 2403-2413.
[http://dx.doi.org/10.1038/npp.2010.123] [PMID: 20720535]

Ditzen, B.; Schaer, M.; Gabriel, B.; Bodenmann, G.; Ehlert, U.; Heinrichs, M. Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol. Psychiatry, 2009, 65(9), 728-731.
[http://dx.doi.org/10.1016/j.biopsych.2008.10.011] [PMID: 19027101]

Domes, G.; Heinrichs, M.; Michel, A.; Berger, C.; Herpertz, S.C. Oxytocin improves “mind-reading” in humans. Biol. Psychiatry, 2007, 61(6), 731-733.
[http://dx.doi.org/10.1016/j.biopsych.2006.07.015] [PMID: 17137561]

Kosfeld, M.; Heinrichs, M.; Zak, P.J.; Fischbacher, U.; Fehr, E. Oxytocin increases trust in humans. Nature, 2005, 435(7042), 673-676.
[http://dx.doi.org/10.1038/nature03701] [PMID: 15931222]

Linnen, A.M.; Ellenbogen, M.A.; Cardoso, C.; Joober, R. Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students. Stress, 2012, 15(4), 393-402.
[http://dx.doi.org/10.3109/10253890.2011.631154] [PMID: 22044077]

Mikolajczak, M.; Pinon, N.; Lane, A.; de Timary, P.; Luminet, O. Oxytocin not only increases trust when money is at stake, but also when confidential information is in the balance. Biol. Psychol., 2010, 85(1), 182-184.
[http://dx.doi.org/10.1016/j.biopsycho.2010.05.010] [PMID: 20678992]

Cardoso, C.; Ellenbogen, M.A.; Serravalle, L.; Linnen, A.M. Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress? Psychoneuroendocrinology, 2013, 38(11), 2800-2804.
[http://dx.doi.org/10.1016/j.psyneuen.2013.05.006] [PMID: 23768973]

Alvares, G.A.; Hickie, I.B.; Guastella, A.J. Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection. Exp. Clin. Psychopharmacol., 2010, 18(4), 316-321.
[http://dx.doi.org/10.1037/a0019719] [PMID: 20695687]

Guastella, A.J.; Howard, A.L.; Dadds, M.R.; Mitchell, P.; Carson, D.S. A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology, 2009, 34(6), 917-923.
[http://dx.doi.org/10.1016/j.psyneuen.2009.01.005] [PMID: 19246160]

Di Simplicio, M.; Harmer, C.J. Oxytocin and emotion processing. J. Psychopharmacol., 2016, 30(11), 1156-1159.
[http://dx.doi.org/10.1177/0269881116641872] [PMID: 27071915]

Geng, Y.; Zhao, W.; Zhou, F.; Ma, X.; Yao, S.; Hurlemann, R.; Becker, B.; Kendrick, K.M. Oxytocin enhancement of emotional empathy: Generalization across cultures and effects on amygdala activity. Front. Neurosci., 2018, 12, 512.
[http://dx.doi.org/10.3389/fnins.2018.00512] [PMID: 30108475]

Clark-Elford, R.; Nathan, P.J.; Auyeung, B.; Mogg, K.; Bradley, B.P.; Sule, A.; Müller, U.; Dudas, R.B.; Sahakian, B.J.; Baron-Cohen, S. Effects of oxytocin on attention to emotional faces in healthy volunteers and highly socially anxious males. Int. J. Neuropsychopharmacol., 2014, 18(2), , pyu012..
[PMID: 25552432]

Domes, G.; Sibold, M.; Schulze, L.; Lischke, A.; Herpertz, S.C.; Heinrichs, M. Intranasal oxytocin increases covert attention to positive social cues. Psychol. Med., 2013, 43(8), 1747-1753.
[http://dx.doi.org/10.1017/S0033291712002565] [PMID: 23146328]

Bartz, J.A.; Zaki, J.; Bolger, N.; Hollander, E.; Ludwig, N.N.; Kolevzon, A.; Ochsner, K.N. Oxytocin selectively improves empathic accuracy. Psychol. Sci., 2010, 21(10), 1426-1428.
[http://dx.doi.org/10.1177/0956797610383439] [PMID: 20855907]

Gamer, M.; Zurowski, B.; Büchel, C. Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Proc. Natl. Acad. Sci. USA, 2010, 107(20), 9400-9405.
[http://dx.doi.org/10.1073/pnas.1000985107] [PMID: 20421469]

Marsh, A.A.; Yu, H.H.; Pine, D.S.; Blair, R.J.R. Oxytocin improves specific recognition of positive facial expressions. Psychopharmacology (Berl.), 2010, 209(3), 225-232.
[http://dx.doi.org/10.1007/s00213-010-1780-4] [PMID: 20186397]

Evans, S.; Shergill, S.S.; Averbeck, B.B. Oxytocin decreases aversion to angry faces in an associative learning task. Neuropsychopharmacology, 2010, 35(13), 2502-2509.
[http://dx.doi.org/10.1038/npp.2010.110] [PMID: 20844475]

Shahrestani, S.; Kemp, A.H.; Guastella, A.J. The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: A meta-analysis. Neuropsychopharmacology, 2013, 38(10), 1929-1936.
[http://dx.doi.org/10.1038/npp.2013.86] [PMID: 23575742]

Schulze, L.; Lischke, A.; Greif, J.; Herpertz, S.C.; Heinrichs, M.; Domes, G. Oxytocin increases recognition of masked emotional faces. Psychoneuroendocrinology, 2011, 36(9), 1378-1382.
[http://dx.doi.org/10.1016/j.psyneuen.2011.03.011] [PMID: 21477929]

Rimmele, U.; Hediger, K.; Heinrichs, M.; Klaver, P. Oxytocin makes a face in memory familiar. J. Neurosci., 2009, 29(1), 38-42.
[http://dx.doi.org/10.1523/JNEUROSCI.4260-08.2009] [PMID: 19129382]

Tabak, B.A.; Meyer, M.L.; Dutcher, J.M.; Castle, E.; Irwin, M.R.; Lieberman, M.D.; Eisenberger, N.I. Oxytocin, but not vasopressin, impairs social cognitive ability among individuals with higher levels of social anxiety: A randomized controlled trial. Soc. Cogn. Affect. Neurosci., 2016, 11(8), 1272-1279.
[http://dx.doi.org/10.1093/scan/nsw041] [PMID: 27053769]

Petrovic, P.; Kalisch, R.; Singer, T.; Dolan, R.J. Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. J. Neurosci., 2008, 28(26), 6607-6615.
[http://dx.doi.org/10.1523/JNEUROSCI.4572-07.2008] [PMID: 18579733]

Lischke, A.; Gamer, M.; Berger, C.; Grossmann, A.; Hauenstein, K.; Heinrichs, M.; Herpertz, S.C.; Domes, G. Oxytocin increases amygdala reactivity to threatening scenes in females. Psychoneuroendocrinology, 2012, 37(9), 1431-1438.
[http://dx.doi.org/10.1016/j.psyneuen.2012.01.011] [PMID: 22365820]

Domes, G.; Lischke, A.; Berger, C.; Grossmann, A.; Hauenstein, K.; Heinrichs, M.; Herpertz, S.C. Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology, 2010, 35(1), 83-93.
[http://dx.doi.org/10.1016/j.psyneuen.2009.06.016] [PMID: 19632787]

Gorka, S.M.; Fitzgerald, D.A.; Labuschagne, I.; Hosanagar, A.; Wood, A.G.; Nathan, P.J.; Phan, K.L. Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology, 2015, 40(2), 278-286.
[http://dx.doi.org/10.1038/npp.2014.168] [PMID: 24998619]

Dodhia, S.; Hosanagar, A.; Fitzgerald, D.A.; Labuschagne, I.; Wood, A.G.; Nathan, P.J.; Phan, K.L. Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder. Neuropsychopharmacology, 2014, 39(9), 2061-2069.
[http://dx.doi.org/10.1038/npp.2014.53] [PMID: 24594871]

Hu, J.; Qi, S.; Becker, B.; Luo, L.; Gao, S.; Gong, Q.; Hurlemann, R.; Kendrick, K.M. Oxytocin selectively facilitates learning with social feedback and increases activity and functional connectivity in emotional memory and reward processing regions. Hum. Brain Mapp., 2015, 36(6), 2132-2146.
[http://dx.doi.org/10.1002/hbm.22760] [PMID: 25664702]

Fang, A.; Hoge, E.A.; Heinrichs, M.; Hofmann, S.G. Attachment style moderates the effects of oxytocin on social behaviors and cognitions during social rejection. Clin. Psychol. Sci., 2014, 2(6), 740-747.
[http://dx.doi.org/10.1177/2167702614527948] [PMID: 25419499]

Eckstein, M.; Scheele, D.; Patin, A.; Preckel, K.; Becker, B.; Walter, A.; Domschke, K.; Grinevich, V.; Maier, W.; Hurlemann, R. Oxytocin facilitates pavlovian fear learning in males. Neuropsychopharmacology, 2016, 41(4), 932-939.
[http://dx.doi.org/10.1038/npp.2015.245] [PMID: 26272050]

Baumgartner, T.; Heinrichs, M.; Vonlanthen, A.; Fischbacher, U.; Fehr, E. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron, 2008, 58(4), 639-650.
[http://dx.doi.org/10.1016/j.neuron.2008.04.009] [PMID: 18498743]

Rilling, J.K.; DeMarco, A.C.; Hackett, P.D.; Chen, X.; Gautam, P.; Stair, S.; Haroon, E.; Thompson, R.; Ditzen, B.; Patel, R.; Pagnoni, G. Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction. Psychoneuroendocrinology, 2014, 39, 237-248.
[http://dx.doi.org/10.1016/j.psyneuen.2013.09.022] [PMID: 24157401]

Feng, C.; Lori, A.; Waldman, I.D.; Binder, E.B.; Haroon, E.; Rilling, J.K. A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans. Genes Brain Behav., 2015, 14(7), 516-525.
[http://dx.doi.org/10.1111/gbb.12234] [PMID: 26178189]

Gradus, J. Prevalence and prognosis of stress disorders: A review of the epidemiologic literature. Clin. Epidemiol., 2017, 9, 251-260.
[http://dx.doi.org/10.2147/CLEP.S106250] [PMID: 28496365]

Olff, M.; Langeland, W.; Gersons, B.P.R. The psychobiology of PTSD: Coping with trauma. Psychoneuroendocrinology, 2005, 30(10), 974-982.
[http://dx.doi.org/10.1016/j.psyneuen.2005.04.009] [PMID: 15964146]

Broekman, B.F.P.; Olff, M.; Boer, F. The genetic background to PTSD. Neurosci. Biobehav. Rev., 2007, 31(3), 348-362.
[http://dx.doi.org/10.1016/j.neubiorev.2006.10.001] [PMID: 17126903]

Afifi, T.O.; Asmundson, G.J.G.; Taylor, S.; Jang, K.L. The role of genes and environment on trauma exposure and posttraumatic stress disorder symptoms: A review of twin studies. Clin. Psychol. Rev., 2010, 30(1), 101-112.
[http://dx.doi.org/10.1016/j.cpr.2009.10.002] [PMID: 19892451]

Schumacher, S.; Niemeyer, H.; Engel, S.; Cwik, J.C.; Laufer, S.; Klusmann, H.; Knaevelsrud, C. HPA axis regulation in posttraumatic stress disorder: A meta-analysis focusing on potential moderators. Neurosci. Biobehav. Rev., 2019, 100, 35-57.
[http://dx.doi.org/10.1016/j.neubiorev.2019.02.005] [PMID: 30790632]

Grinevich, V.; Neumann, I.D. Brain oxytocin: How puzzle stones from animal studies translate into psychiatry. Mol. Psychiatry, 2021, 26(1), 265-279.
[http://dx.doi.org/10.1038/s41380-020-0802-9] [PMID: 32514104]

Landgraf, R.; Neumann, I.D. Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication. Front. Neuroendocrinol., 2004, 25(3-4), 150-176.
[http://dx.doi.org/10.1016/j.yfrne.2004.05.001] [PMID: 15589267]

DeVries, A.C.; Glasper, E.R.; Detillion, C.E. Social modulation of stress responses. Physiol. Behav., 2003, 79(3), 399-407.
[http://dx.doi.org/10.1016/S0031-9384(03)00152-5] [PMID: 12954434]

Love, T.M. The impact of oxytocin on stress: The role of sex. Curr. Opin. Behav. Sci., 2018, 23, 136-142.
[http://dx.doi.org/10.1016/j.cobeha.2018.06.018] [PMID: 31745496]

Porges, S.W. Love: An emergent property of the mammalian autonomic nervous system. Psychoneuroendocrinology, 1998, 23(8), 837-861.
[http://dx.doi.org/10.1016/S0306-4530(98)00057-2] [PMID: 9924740]

Brewin, C.R.; Andrews, B.; Valentine, J.D. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J. Consult. Clin. Psychol., 2000, 68(5), 748-766.
[http://dx.doi.org/10.1037/0022-006X.68.5.748] [PMID: 11068961]

Amico, J.A.R. Oxytocin: Clinical and laboratory studies; Excerpta Medica: Netherlands, 1985.

Maroun, M.; Wagner, S. Oxytocin and memory of emotional stimuli: Some dance to remember, some dance to forget. Biol. Psychiatry, 2016, 79(3), 203-212.
[http://dx.doi.org/10.1016/j.biopsych.2015.07.016] [PMID: 26300273]

Mitre, M.; Minder, J.; Morina, E.X.; Chao, M.V.; Froemke, R.C. Oxytocin modulation of neural circuits. Curr. Top. Behav. Neurosci., 2017, 35, 31-53.
[http://dx.doi.org/10.1007/7854_2017_7] [PMID: 28864972]

Teicher, M.H.; Andersen, S.L.; Polcari, A.; Anderson, C.M.; Navalta, C.P. Developmental neurobiology of childhood stress and trauma. Psychiatr. Clin. North Am., 2002, 25(2), 397-426. , vii-viii.
[http://dx.doi.org/10.1016/S0193-953X(01)00003-X] [PMID: 12136507]

Yehuda, R.; LeDoux, J. Response variation following trauma: A translational neuroscience approach to understanding PTSD. Neuron, 2007, 56(1), 19-32.
[http://dx.doi.org/10.1016/j.neuron.2007.09.006] [PMID: 17920012]

Ellis, B.J.; Horn, A.J.; Carter, C.S.; van IJzendoorn, M.H.; Bakermans-Kranenburg, M.J. Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation. Clin. Psychol. Rev., 2021, 86, , 101985..
[http://dx.doi.org/10.1016/j.cpr.2021.101985] [PMID: 33770582]

Bertsch, K.; Schmidinger, I.; Neumann, I.D.; Herpertz, S.C. Reduced plasma oxytocin levels in female patients with borderline personality disorder. Horm. Behav., 2013, 63(3), 424-429.
[http://dx.doi.org/10.1016/j.yhbeh.2012.11.013] [PMID: 23201337]

Bomann, A.C.; Jørgensen, M.B.; Bo, S.; Nielsen, M.; Gede, L.B.; Elfving, B.; Simonsen, E. The neurobiology of social deficits in female patients with borderline personality disorder: The importance of oxytocin. Pers. Ment. Health, 2017, 11(2), 91-100.
[http://dx.doi.org/10.1002/pmh.1369] [PMID: 28397403]

Bizik, G.; Bob, P.; Pavlat, J.; Raboch, J.; Uhrova, J.; Benakova, H.; Zima, T. P-473 - Oxytocin reflects levels of trauma-related and dissociative symptoms in patients with severe depression. Eur. Psychiatry, 2012, 27(S1), 1-1.
[http://dx.doi.org/10.1016/S0924-9338(12)74640-0]

Crowley, S.K.; Pedersen, C.A.; Leserman, J.; Girdler, S.S. The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder. Biol. Psychol., 2015, 109, 1-9.
[http://dx.doi.org/10.1016/j.biopsycho.2015.04.003] [PMID: 25892085]

Cao, C.; Wang, L.; Wang, R.; Qing, Y.; Zhang, J. Oxytocin is associated with PTSD’s anxious arousal symptoms in Chinese male earthquake survivors. Eur. J. Psychotraumatol., 2014, 5(1), 26530.
[http://dx.doi.org/10.3402/ejpt.v5.26530] [PMID: 25511734]

Munro, M.L.; Brown, S.L.; Pournajafi-Nazarloo, H.; Carter, C.S.; Lopez, W.D.; Seng, J.S. In search of an adult attachment stress provocation to measure effect on the oxytocin system: A pilot validation study. J. Am. Psychiatr. Nurses Assoc., 2013, 19(4), 180-191.
[http://dx.doi.org/10.1177/1078390313492173] [PMID: 23950541]

Bradley, B. Peripheral oxytocin, social support and psychological functioning in a highly traumatized sample. Eur. J. Psychotraumatol., 2012, 3(0), 3.
[http://dx.doi.org/10.3402/ejpt.v3i0.19450]

Seng, J.; Miller, J.; Sperlich, M.; van de Ven, C.J.M.; Brown, S.; Carter, C.S.; Liberzon, I. Exploring dissociation and oxytocin as pathways between trauma exposure and trauma-related hyperemesis gravidarum: A test-of-concept pilot. J. Trauma Dissociation, 2013, 14(1), 40-55.
[http://dx.doi.org/10.1080/15299732.2012.694594] [PMID: 23282046]

Mielke, E.L.; Neukel, C.; Bertsch, K.; Reck, C.; Möhler, E.; Herpertz, S.C. Alterations of brain volumes in women with early life maltreatment and their associations with oxytocin. Horm. Behav., 2018, 97, 128-136.
[http://dx.doi.org/10.1016/j.yhbeh.2017.11.005] [PMID: 29129623]

Reijnen, A.; Geuze, E.; Vermetten, E. Individual variation in plasma oxytocin and vasopressin levels in relation to the development of combat-related PTSD in a large military cohort. J. Psychiatr. Res., 2017, 94, 88-95.
[http://dx.doi.org/10.1016/j.jpsychires.2017.06.010] [PMID: 28689067]

Sippel, L.M.; King, C.E.; Wahlquist, A.E.; Flanagan, J.C. A Preliminary examination of endogenous peripheral oxytocin in a pilot randomized clinical trial of oxytocin-enhanced psychotherapy for post-traumatic stress disorder. J. Clin. Psychopharmacol., 2020, 40(4), 401-404.
[http://dx.doi.org/10.1097/JCP.0000000000001226] [PMID: 32639293]

Nishi, D.; Hashimoto, K.; Noguchi, H.; Kim, Y.; Matsuoka, Y. Serum oxytocin, posttraumatic coping and C-reactive protein in motor vehicle accident survivors by gender. Neuropsychobiology, 2015, 71(4), 196-201.
[http://dx.doi.org/10.1159/000382021] [PMID: 26044751]

Mizushima, S.G.; Fujisawa, T.X.; Takiguchi, S.; Kumazaki, H.; Tanaka, S.; Tomoda, A. Effect of the nature of subsequent environment on oxytocin and cortisol secretion in maltreated children. Front. Psychiatry, 2015, 6, 173.
[http://dx.doi.org/10.3389/fpsyt.2015.00173] [PMID: 26696910]

Ulmer-Yaniv, A.; Djalovski, A.; Yirmiya, K.; Halevi, G.; Zagoory-Sharon, O.; Feldman, R. Maternal immune and affiliative biomarkers and sensitive parenting mediate the effects of chronic early trauma on child anxiety. Psychol. Med., 2018, 48(6), 1020-1033.
[http://dx.doi.org/10.1017/S0033291717002550] [PMID: 28889808]

Suzuki, S.; Fujisawa, T.X.; Sakakibara, N.; Fujioka, T.; Takiguchi, S.; Tomoda, A. Development of social attention and oxytocin levels in maltreated children. Sci. Rep., 2020, 10(1), 7407.
[http://dx.doi.org/10.1038/s41598-020-64297-6] [PMID: 32366913]

Frijling, J.L.; van Zuiden, M.; Nawijn, L.; Koch, S.B.J.; Neumann, I.D.; Veltman, D.J.; Olff, M. Salivary oxytocin and vasopressin levels in police officers with and without post-traumatic stress disorder. J. Neuroendocrinol., 2015, 27(10), 743-751.
[http://dx.doi.org/10.1111/jne.12300] [PMID: 26184739]

Valstad, M.; Alvares, G.A.; Egknud, M.; Matziorinis, A.M.; Andreassen, O.A.; Westlye, L.T.; Quintana, D.S. The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neurosci. Biobehav. Rev., 2017, 78, 117-124.
[http://dx.doi.org/10.1016/j.neubiorev.2017.04.017] [PMID: 28442403]

Dadds, M.R.; Moul, C.; Cauchi, A.; Dobson-Stone, C.; Hawes, D.J.; Brennan, J.; Ebstein, R.E. Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy. Dev. Psychopathol., 2014, 26(1), 33-40.
[http://dx.doi.org/10.1017/S0954579413000497] [PMID: 24059811]

Martin, J.; Kagerbauer, S.M.; Gempt, J.; Podtschaske, A.; Hapfelmeier, A.; Schneider, G. Oxytocin levels in saliva correlate better than plasma levels with concentrations in the cerebrospinal fluid of patients in neurocritical care. J. Neuroendocrinol., 2018, 30(5), , e12596..
[http://dx.doi.org/10.1111/jne.12596] [PMID: 29611254]

Lucas-Thompson, R.G.; Holman, E.A. Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress. Horm. Behav., 2013, 63(4), 615-624.
[http://dx.doi.org/10.1016/j.yhbeh.2013.02.015] [PMID: 23470776]

Sippel, L.M.; Han, S.; Watkins, L.E.; Harpaz-Rotem, I.; Southwick, S.M.; Krystal, J.H.; Olff, M.; Sherva, R.; Farrer, L.A.; Kranzler, H.R.; Gelernter, J.; Pietrzak, R.H. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans study. J. Psychiatr. Res., 2017, 94, 139-147.
[http://dx.doi.org/10.1016/j.jpsychires.2017.07.008] [PMID: 28715704]

Cao, C.; Wang, L.; Wu, J.; Li, G.; Fang, R.; Liu, P.; Luo, S.; Elhai, J.D. Association between the OXTR rs53576 genotype and latent profiles of post-traumatic stress disorder and depression symptoms in a representative sample of earthquake survivors. Anxiety Stress Coping, 2020, 33(2), 140-147.
[http://dx.doi.org/10.1080/10615806.2019.1695604] [PMID: 31771350]

Kučukalić, S.; Ferić Bojić, E.; Babić, R.; Avdibegović, E.; Babić, D.; Agani, F.; Jakovljević, M.; Kučukalić, A.; Bravo Mehmedbašić, A.; Šabić Džananović, E.; Marjanović, D.; Kravic, N.; Pavlović, M.; Aukst Margetic, B.; Jaksic, N.; Cima Franc, A.; Rudan, D.; Haxhibeqiri, S.; Goci Uka, A.; Hoxha, B.; Haxhibeqiri, V.; Muminović Umihanić, M.; Sinanović, O.; Božina, N.; Ziegler, C.; Wolf, C.; Warrings, B.; Domschke, K.; Deckert, J.; Džubur Kulenović, A. Genetic susceptibility to posttraumatic stress disorder: Analyses of the oxytocin receptor, retinoic acid receptor-related orphan receptor A and cannabinoid receptor 1 genes. Psychiatr. Danub., 2019, 31(2), 219-226.
[http://dx.doi.org/10.24869/psyd.2019.219] [PMID: 31291229]

Feldman, R.; Vengrober, A.; Ebstein, R.P. Affiliation buffers stress: Cumulative genetic risk in oxytocin–vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children. Transl. Psychiatry, 2014, 4(3), , e370..
[http://dx.doi.org/10.1038/tp.2014.6] [PMID: 24618689]

Zeev-Wolf, M.; Levy, J.; Ebstein, R.P.; Feldman, R. Cumulative risk on oxytocin-pathway genes impairs default mode network connectivity in trauma-exposed youth. Front. Endocrinol. (Lausanne), 2020, 11, 335.
[http://dx.doi.org/10.3389/fendo.2020.00335] [PMID: 32528417]

Palgi, S.; Klein, E.; Shamay-Tsoory, S. The role of oxytocin in empathy in PTSD. Psychol. Trauma, 2017, 9(1), 70-75.
[http://dx.doi.org/10.1037/tra0000142] [PMID: 27243570]

Zhang, K.; Li, G.; Wang, L.; Cao, C.; Fang, R.; Luo, S.; Liu, P.; Zhang, X. An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort. Sci. Rep., 2019, 9(1), 19252.
[http://dx.doi.org/10.1038/s41598-019-55936-8] [PMID: 31848444]

Dunn, E.C.; Solovieff, N.; Lowe, S.R.; Gallagher, P.J.; Chaponis, J.; Rosand, J.; Koenen, K.C.; Waters, M.C.; Rhodes, J.E.; Smoller, J.W. Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth: A prospective analysis of low income adults. J. Affect. Disord., 2014, 152-154, 243-249.
[http://dx.doi.org/10.1016/j.jad.2013.09.018] [PMID: 24161451]

Nawijn, L.; Krzyzewska, I.M.; van Zuiden, M.; Henneman, P.; Koch, S.B.J.; Mul, A.N.; Frijling, J.L.; Veltman, D.J.; Mannens, M.M.A.M.; Olff, M. Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls. Eur. Neuropsychopharmacol., 2019, 29(1), 147-155.
[http://dx.doi.org/10.1016/j.euroneuro.2018.10.006] [PMID: 30415783]

Pitman, R.K.; Orr, S.P.; Lasko, N.B. Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res., 1993, 48(2), 107-117.
[http://dx.doi.org/10.1016/0165-1781(93)90035-F] [PMID: 8416021]

Sack, M.; Spieler, D.; Wizelman, L.; Epple, G.; Stich, J.; Zaba, M.; Schmidt, U. Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial. BMC Med., 2017, 15(1), 40.
[http://dx.doi.org/10.1186/s12916-017-0801-0] [PMID: 28209155]

Flanagan, J.C.; Sippel, L.M.; Wahlquist, A.; Moran-Santa Maria, M.M.; Back, S.E. Augmenting prolonged exposure therapy for PTSD with intranasal oxytocin: A randomized, placebo-controlled pilot trial. J. Psychiatr. Res., 2018, 98, 64-69.
[http://dx.doi.org/10.1016/j.jpsychires.2017.12.014] [PMID: 29294429]

Frijling, J.L.; van Zuiden, M.; Koch, S.B.J.; Nawijn, L.; Veltman, D.J.; Olff, M. Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals. Soc. Cogn. Affect. Neurosci., 2016, 11(2), 327-336.
[http://dx.doi.org/10.1093/scan/nsv116] [PMID: 26382634]

Frijling, J.L.; van Zuiden, M.; Koch, S.B.J.; Nawijn, L.; Veltman, D.J.; Olff, M. Intranasal oxytocin affects amygdala functional connectivity after trauma script-driven imagery in distressed recently trauma-exposed individuals. Neuropsychopharmacology, 2016, 41(5), 1286-1296.
[http://dx.doi.org/10.1038/npp.2015.278] [PMID: 26346640]

Flanagan, J.C.; Sippel, L.M.; Santa Maria, M.M.M.; Hartwell, K.J.; Brady, K.T.; Joseph, J.E. Impact of Oxytocin on the neural correlates of fearful face processing in PTSD related to childhood trauma. Eur. J. Psychotraumatol., 2019, 10(1), , 1606626..
[http://dx.doi.org/10.1080/20008198.2019.1606626] [PMID: 31105906]

Flanagan, J.C.; Allan, N.P.; Calhoun, C.D.; Badour, C.L.; Moran-Santa Maria, M.; Brady, K.T.; Back, S.E. Effects of oxytocin on stress reactivity and craving in veterans with co-occurring PTSD and alcohol use disorder. Exp. Clin. Psychopharmacol., 2019, 27(1), 45-54.
[http://dx.doi.org/10.1037/pha0000232] [PMID: 30382728]

van Zuiden, M.; Frijling, J.L.; Nawijn, L.; Koch, S.B.J.; Goslings, J.C.; Luitse, J.S.; Biesheuvel, T.H.; Honig, A.; Veltman, D.J.; Olff, M. Intranasal oxytocin to prevent posttraumatic stress disorder symptoms: A randomized controlled trial in emergency department patients. Biol. Psychiatry, 2017, 81(12), 1030-1040.
[http://dx.doi.org/10.1016/j.biopsych.2016.11.012] [PMID: 28087128]

Eidelman-Rothman, M.; Goldstein, A.; Levy, J.; Weisman, O.; Schneiderman, I.; Mankuta, D.; Zagoory-Sharon, O.; Feldman, R. Oxytocin affects spontaneous neural oscillations in trauma-exposed war veterans. Front. Behav. Neurosci., 2015, 9, 165.
[http://dx.doi.org/10.3389/fnbeh.2015.00165] [PMID: 26175673]

Koch, S.B.J.; van Zuiden, M.; Nawijn, L.; Frijling, J.L.; Veltman, D.J.; Olff, M. Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD Patients. Neuropsychopharmacology, 2016, 41(6), 1495-1504.
[http://dx.doi.org/10.1038/npp.2015.299] [PMID: 26404844]

Koch, S.B.J.; van Zuiden, M.; Nawijn, L.; Frijling, J.L.; Veltman, D.J.; Olff, M. Intranasal oxytocin normalizes amygdala functional connectivity in posttraumatic stress disorder. Neuropsychopharmacology, 2016, 41(8), 2041-2051.
[http://dx.doi.org/10.1038/npp.2016.1] [PMID: 26741286]

Koch, S.B.J.; van Zuiden, M.; Nawijn, L.; Frijling, J.L.; Veltman, D.J.; Olff, M. Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder. Eur. Neuropsychopharmacol., 2019, 29(2), 266-277.
[http://dx.doi.org/10.1016/j.euroneuro.2018.12.002] [PMID: 30554861]

Nawijn, L.; van Zuiden, M.; Koch, S.B.J.; Frijling, J.L.; Veltman, D.J.; Olff, M. Intranasal oxytocin enhances neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls. Psychoneuroendocrinology, 2016, 66, 228-237.
[http://dx.doi.org/10.1016/j.psyneuen.2016.01.020] [PMID: 26851698]

Flanagan, J.C.; Hand, A.; Jarnecke, A.M.; Moran-Santa Maria, M.M.; Brady, K.T.; Joseph, J.E. Effects of oxytocin on working memory and executive control system connectivity in posttraumatic stress disorder. Exp. Clin. Psychopharmacol., 2018, 26(4), 391-402.
[http://dx.doi.org/10.1037/pha0000197] [PMID: 30070567]

Nawijn, L.; van Zuiden, M.; Koch, S.B.J.; Frijling, J.L.; Veltman, D.J.; Olff, M. Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder. Soc. Cogn. Affect. Neurosci., 2017, 12(2), 212-223.
[http://dx.doi.org/10.1093/scan/nsw123] [PMID: 27614769]

Palgi, S.; Klein, E.; Shamay-Tsoory, S.G. Oxytocin improves compassion toward women among patients with PTSD. Psychoneuroendocrinology, 2016, 64, 143-149.
[http://dx.doi.org/10.1016/j.psyneuen.2015.11.008] [PMID: 26671007]

Stauffer, C.S.; Meinzer, N.K.; Morrison, T.; Wen, J.H.; Radanovich, L.; Leung, D.; Niles, A.; O’Donovan, A.; Batki, S.L.; Woolley, J.D. Effects of oxytocin administration on Cue‐induced craving in Co‐occurring alcohol use disorder and PTSD: A within‐participant randomized clinical trial. Alcohol. Clin. Exp. Res., 2019, 43(12), 2627-2636.
[http://dx.doi.org/10.1111/acer.14217] [PMID: 31610033]

Malhi, G.S.; Mann, J.J. Depression. Lancet, 2018, 392(10161), 2299-2312.
[http://dx.doi.org/10.1016/S0140-6736(18)31948-2] [PMID: 30396512]

Chen, P.; Dols, A.; Rej, S.; Sajatovic, M. Update on the epidemiology, diagnosis, and treatment of mania in older-age bipolar disorder. Curr. Psychiatry Rep., 2017, 19(8), 46.
[http://dx.doi.org/10.1007/s11920-017-0804-8] [PMID: 28647815]

Ferrari, A.J.; Charlson, F.J.; Norman, R.E.; Patten, S.B.; Freedman, G.; Murray, C.J.L.; Vos, T.; Whiteford, H.A. Burden of depressive disorders by country, sex, age, and year: Findings from the global burden of disease study 2010. PLoS Med., 2013, 10(11), , e1001547..
[http://dx.doi.org/10.1371/journal.pmed.1001547] [PMID: 24223526]

Neumann, I.D. Stimuli and consequences of dendritic release of oxytocin within the brain. Biochem. Soc. Trans., 2007, 35(5), 1252-1257.
[http://dx.doi.org/10.1042/BST0351252] [PMID: 17956324]

Neumann, I.D.; Wigger, A.; Torner, L.; Holsboer, F.; Landgraf, R. Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: Partial action within the paraventricular nucleus. J. Neuroendocrinol., 2000, 12(3), 235-243.
[http://dx.doi.org/10.1046/j.1365-2826.2000.00442.x] [PMID: 10718919]

Rotzinger, S.; Lovejoy, D.A.; Tan, L.A. Behavioral effects of neuropeptides in rodent models of depression and anxiety. Peptides, 2010, 31(4), 736-756.
[http://dx.doi.org/10.1016/j.peptides.2009.12.015] [PMID: 20026211]

Legros, J.J.; Louis, F. Identification of a vasopressin-neurophysin and of an oxytocin-neurophysin in man. Neuroendocrinology, 1973, 13(6), 371-375.
[http://dx.doi.org/10.1159/000122223] [PMID: 4366879]

Jones, P.M.; Robinson, I.C.A.F. Differential clearance of neurophysin and neurohypophysial peptides from the cerebrospinal fluid in conscious guinea pigs. Neuroendocrinology, 1982, 34(4), 297-302.
[http://dx.doi.org/10.1159/000123316] [PMID: 7070597]

Linkowski, P.; Geenen, V.; Kerkhofs, M.; Mendlewicz, J.; Legros, J.J. Cerebrospinal fluid neurophysins in affective illness and in schizophrenia. Eur. Arch. Psychiatry Neurol. Sci., 1984, 234(3), 162-165.
[http://dx.doi.org/10.1007/BF00461555] [PMID: 6489403]

Legros, J.J.G.V.; Linkowski, P.; Mendlewicz, J. Increased neurophysin I and II cerbrospinal fluid concentration from bipolar versus unipolar depressed patients. Neuroendocrinol. Lett., 1983, 5(4), 201-205.

Pitts, A.F.; Samuelson, S.D.; Meller, W.H.; Bissette, G.; Nemeroff, C.B.; Kathol, R.G. Cerebrospinal fluid corticotropin-releasing hormone, vasopressin, and oxytocin concentrations in treated patients with major depression and controls. Biol. Psychiatry, 1995, 38(5), 330-335.
[http://dx.doi.org/10.1016/0006-3223(95)00229-A] [PMID: 7495928]

Scantamburlo, G.; Hansenne, M.; Fuchs, S.; Pitchot, W.; Pinto, E.; Reggers, J.; Ansseau, M.; Legros, J.J. AVP- and OT-neurophysins response to apomorphine and clonidine in major depression. Psychoneuroendocrinology, 2005, 30(9), 839-845.
[http://dx.doi.org/10.1016/j.psyneuen.2005.04.015] [PMID: 15964147]

Sasayama, D.; Hattori, K.; Teraishi, T.; Hori, H.; Ota, M.; Yoshida, S.; Arima, K.; Higuchi, T.; Amano, N.; Kunugi, H. Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia. Schizophr. Res., 2012, 139(1-3), 201-206.
[http://dx.doi.org/10.1016/j.schres.2012.06.016] [PMID: 22742979]

van Londen, L.; Goekoop, J.G.; van Kempen, G.M.; Frankhuijzen-Sierevogel, A.C.; Wiegant, V.M.; van der Velde, E.A.; De Wied, D. Plasma levels of arginine vasopressin elevated in patients with major depression. Neuropsychopharmacology, 1997, 17(4), 284-292.
[http://dx.doi.org/10.1016/S0893-133X(97)00054-7] [PMID: 9326754]

Jobst, A.; Sabass, L.; Palagyi, A.; Bauriedl-Schmidt, C.; Mauer, M.C.; Sarubin, N.; Buchheim, A.; Renneberg, B.; Falkai, P.; Zill, P.; Padberg, F. Effects of social exclusion on emotions and oxytocin and cortisol levels in patients with chronic depression. J. Psychiatr. Res., 2015, 60, 170-177.
[http://dx.doi.org/10.1016/j.jpsychires.2014.11.001] [PMID: 25466833]

Tang, A.L.; Thomas, S.J.; Larkin, T. Cortisol, oxytocin, and quality of life in major depressive disorder. Qual. Life Res., 2019, 28(11), 2919-2928.
[http://dx.doi.org/10.1007/s11136-019-02236-3] [PMID: 31227958]

Thomas, S.J.; Larkin, T. Cognitive distortions in relation to plasma cortisol and oxytocin levels in major depressive disorder. Front. Psychiatry, 2020, 10, 971.
[http://dx.doi.org/10.3389/fpsyt.2019.00971] [PMID: 32038321]

van Londen, L.; Kerkhof, G.A.; van den Berg, F.; Goekoop, J.G.; Zwinderman, K.H.; Frankhuijzen-Sierevogel, A.C.; Wiegant, V.M.; de Wied, D. Plasma arginine vasopressin and motor activity in major depression. Biol. Psychiatry, 1998, 43(3), 196-204.
[http://dx.doi.org/10.1016/S0006-3223(97)80433-7] [PMID: 9494701]

Van Londen, L.; Goekoop, J.G.; Zwinderman, A.H.; Lanser, J.B.K.; Wiegant, V.M.; De Wied, D. Neuropsychological performance and plasma cortisol, arginine vasopressin and oxytocin in patients with major depression. Psychol. Med., 1998, 28(2), 275-284.
[http://dx.doi.org/10.1017/S0033291797006284] [PMID: 9572085]

Rubin, L.H.; Carter, C.S.; Bishop, J.R.; Pournajafi-Nazarloo, H.; Drogos, L.L.; Hill, S.K.; Ruocco, A.C.; Keedy, S.K.; Reilly, J.L.; Keshavan, M.S.; Pearlson, G.D.; Tamminga, C.A.; Gershon, E.S.; Sweeney, J.A. Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophr. Bull., 2014, 40(6), 1374-1384.
[http://dx.doi.org/10.1093/schbul/sbu027] [PMID: 24619535]

Frasch, A.; Zetzsche, T.; Steiger, A.; Jirikowski, G.F. Reduction of plasma oxytocin levels in patients suffering from major depression. Adv. Exp. Med. Biol., 1995, 395, 257-258.
[PMID: 8713975]

Zetzsche, T.; Frasch, A.; Jirikowski, G.; Murck, H.; Steiger, A. Nocturnal oxytocin secretion is reduced in major depression. Biol. Psychiatry, 1996, 290, 39.

Ozsoy, S.; Esel, E.; Kula, M. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res., 2009, 169(3), 249-252.
[http://dx.doi.org/10.1016/j.psychres.2008.06.034] [PMID: 19732960]

Yuen, K.W.; Garner, J.P.; Carson, D.S.; Keller, J.; Lembke, A.; Hyde, S.A.; Kenna, H.A.; Tennakoon, L.; Schatzberg, A.F.; Parker, K.J. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol. J. Psychiatr. Res., 2014, 51, 30-36.
[http://dx.doi.org/10.1016/j.jpsychires.2013.12.012] [PMID: 24405552]

Bergant, A.M.; Nguyen, T.; Heim, K.; Ulmer, H.; Dapunt, O. German language version and validation of the Edinburgh postnatal depression scale. Dtsch. Med. Wochenschr., 1998, 123(3), 35-40.
[http://dx.doi.org/10.1055/s-2007-1023895] [PMID: 9472218]

Cox, J.L.; Holden, J.M.; Sagovsky, R. Detection of postnatal depression. development of the 10-item edinburgh postnatal depression scale. Br. J. Psychiatry, 1987, 150(6), 782-786.
[http://dx.doi.org/10.1192/bjp.150.6.782] [PMID: 3651732]

Austin, M.P.; Hadzi-Pavlovic, D.; Saint, K.; Parker, G. Antenatal screening for the prediction of postnatal depression: Validation of a psychosocial pregnancy risk questionnaire. Acta Psychiatr. Scand., 2005, 112(4), 310-317.
[http://dx.doi.org/10.1111/j.1600-0447.2005.00594.x] [PMID: 16156839]

Cyranowski, J.M.; Hofkens, T.L.; Frank, E.; Seltman, H.; Cai, H.M.; Amico, J.A. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom. Med., 2008, 70(9), 967-975.
[http://dx.doi.org/10.1097/PSY.0b013e318188ade4] [PMID: 19005082]

Seay, J.S.; Lattie, E.; Schneiderman, N.; Antoni, M.H.; Fekete, E.M.; Mendez, A.J.; Szeto, A.; Fletcher, M.A. Linear and quadratic associations of plasma oxytocin with depressive symptoms in ethnic minority women living with HIV. J. Appl. Biobehav. Res., 2014, 19(1), 70-78.
[http://dx.doi.org/10.1111/jabr.12016]

Parker, K.J.; Kenna, H.A.; Zeitzer, J.M.; Keller, J.; Blasey, C.M.; Amico, J.A.; Schatzberg, A.F. Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Res., 2010, 178(2), 359-362.
[http://dx.doi.org/10.1016/j.psychres.2009.09.017] [PMID: 20494448]

Turan, T.; Uysal, C.; Asdemir, A.; Kılıç, E. May oxytocin be a trait marker for bipolar disorder? Psychoneuroendocrinology, 2013, 38(12), 2890-2896.
[http://dx.doi.org/10.1016/j.psyneuen.2013.07.017] [PMID: 24080188]

Lien, Y-J.; Chang, H.H.; Yang, Y.K.; Lu, R-B.; Chen, P.S. PS50. The serum oxytocin levels among major depressive and bipolar II disorder. Int. J. Neuropsychopharmacol., 2016, 19(Suppl. 1), 17-17.
[http://dx.doi.org/10.1093/ijnp/pyw043.050]

Lien, Y.J.; Chang, H.H.; Tsai, H.C.; Kuang Yang, Y.; Lu, R.B. See Chen, P. Plasma oxytocin levels in major depressive and bipolar II disorders. Psychiatry Res., 2017, 258, 402-406.
[http://dx.doi.org/10.1016/j.psychres.2017.08.080] [PMID: 28865715]

Parris, M.S.; Grunebaum, M.F.; Galfalvy, H.C.; Andronikashvili, A.; Burke, A.K.; Yin, H.; Min, E.; Huang, Y.; Mann, J.J. Attempted suicide and oxytocin-related gene polymorphisms. J. Affect. Disord., 2018, 238, 62-68.
[http://dx.doi.org/10.1016/j.jad.2018.05.022] [PMID: 29860184]

Na, K.S.; Won, E.; Kang, J.; Kim, A.; Choi, S.; Kim, Y.K.; Lee, M.S.; Ham, B.J. Interaction effects of oxytocin receptor gene polymorphism and depression on hippocampal volume. Psychiatry Res. Neuroimaging, 2018, 282, 18-23.
[http://dx.doi.org/10.1016/j.pscychresns.2018.10.004] [PMID: 30384146]

Choi, D.; Tsuchiya, K.J.; Takei, N. Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems. Sci. Rep., 2019, 9(1), 7685.
[http://dx.doi.org/10.1038/s41598-019-44175-6] [PMID: 31118457]

Purba, J.S.; Hoogendijk, W.J.; Hofman, M.A.; Swaab, D.F. Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch. Gen. Psychiatry, 1996, 53(2), 137-143.
[http://dx.doi.org/10.1001/archpsyc.1996.01830020055007] [PMID: 8629889]

Meynen, G.; Unmehopa, U.A.; Hofman, M.A.; Swaab, D.F.; Hoogendijk, W.J.G. Hypothalamic oxytocin mRNA expression and melancholic depression. Mol. Psychiatry, 2007, 12(2), 118-119.
[http://dx.doi.org/10.1038/sj.mp.4001911] [PMID: 17252002]

Mah, B.L.; Van IJzendoorn, M.H.; Smith, R.; Bakermans-Kranenburg, M.J. Oxytocin in postnatally depressed mothers: Its influence on mood and expressed emotion. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2013, 40, 267-272.
[http://dx.doi.org/10.1016/j.pnpbp.2012.10.005] [PMID: 23085508]

Pincus, D.; Kose, S.; Arana, A.; Johnson, K.; Morgan, P.S.; Borckardt, J.; Herbsman, T.; Hardaway, F.; George, M.S.; Panksepp, J.; Nahas, Z. Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: A double-blind placebo controlled fMRI study. Front. Psychiatry, 2010, 1, 134.
[http://dx.doi.org/10.3389/fpsyt.2010.00134] [PMID: 21423444]

Mah, B.L.; Bakermans-Kranenburg, M.J.; Van IJzendoorn, M.H.; Smith, R. Oxytocin promotes protective behavior in depressed mothers: A pilot study with the enthusiastic stranger paradigm. Depress. Anxiety, 2015, 32(2), 76-81.
[http://dx.doi.org/10.1002/da.22245] [PMID: 24523054]

MacDonald, K.; MacDonald, T.M.; Brüne, M.; Lamb, K.; Wilson, M.P.; Golshan, S.; Feifel, D. Oxytocin and psychotherapy: A pilot study of its physiological, behavioral and subjective effects in males with depression. Psychoneuroendocrinology, 2013, 38(12), 2831-2843.
[http://dx.doi.org/10.1016/j.psyneuen.2013.05.014] [PMID: 23810433]

Domes, G.; Normann, C.; Heinrichs, M. The effect of oxytocin on attention to angry and happy faces in chronic depression. BMC Psychiatry, 2016, 16(1), 92.
[http://dx.doi.org/10.1186/s12888-016-0794-9] [PMID: 27048333]

Scantamburlo, G.; Hansenne, M.; Geenen, V.; Legros, J.J.; Ansseau, M. Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial. Eur. Psychiatry, 2015, 30(1), 65-68.
[http://dx.doi.org/10.1016/j.eurpsy.2014.08.007] [PMID: 25282363]

Donadon, M.F.; Martin-Santos, R.; L. Osório, F. Oxytocin effects on the cognition of women with postpartum depression: A randomized, placebo-controlled clinical trial. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2021, 111, , 110098..
[http://dx.doi.org/10.1016/j.pnpbp.2020.110098] [PMID: 32937192]

Newlin, E.; Weinstein, B. Personality disorders. Continuum (Minneap. Minn.), 2015, 21(3), 806-817.
[http://dx.doi.org/10.1212/01.CON.0000466668.02477.0c] [PMID: 26039856]

Ekselius, L. Personality disorder: A disease in disguise. Ups. J. Med. Sci., 2018, 123(4), 194-204.
[http://dx.doi.org/10.1080/03009734.2018.1526235] [PMID: 30539674]

Gunderson, J.G. Clinical practice. Borderline personality disorder. N. Engl. J. Med., 2011, 364(21), 2037-2042.
[http://dx.doi.org/10.1056/NEJMcp1007358] [PMID: 21612472]

Stanley, B.; Siever, L.J. The interpersonal dimension of borderline personality disorder: Toward a neuropeptide model. Am. J. Psychiatry, 2010, 167(1), 24-39.
[http://dx.doi.org/10.1176/appi.ajp.2009.09050744] [PMID: 19952075]

Jobst, A.; Albert, A.; Bauriedl-Schmidt, C.; Mauer, M.C.; Renneberg, B.; Buchheim, A.; Sabass, L.; Falkai, P.; Zill, P.; Padberg, F. Social exclusion leads to divergent changes of oxytocin levels in borderline patients and healthy subjects. Psychother. Psychosom., 2014, 83(4), 252-254.
[http://dx.doi.org/10.1159/000358526] [PMID: 24969030]

Jobst, A.; Padberg, F.; Mauer, M.C.; Daltrozzo, T.; Bauriedl-Schmidt, C.; Sabass, L.; Sarubin, N.; Falkai, P.; Renneberg, B.; Zill, P.; Gander, M.; Buchheim, A. Lower oxytocin plasma levels in borderline patients with unresolved attachment representations. Front. Hum. Neurosci., 2016, 10, 125.
[http://dx.doi.org/10.3389/fnhum.2016.00125] [PMID: 27064696]

Hammen, C.; Bower, J.E.; Cole, S.W. Oxytocin receptor gene variation and differential susceptibility to family environment in predicting youth borderline symptoms. J. Pers. Disord., 2015, 29(2), 177-192.
[http://dx.doi.org/10.1521/pedi_2014_28_152] [PMID: 25102084]

Cicchetti, D.; Rogosch, F.A.; Hecht, K.F.; Crick, N.R.; Hetzel, S. Moderation of maltreatment effects on childhood borderline personality symptoms by gender and oxytocin receptor and FK506 binding protein 5 genes. Dev. Psychopathol., 2014, 26(3), 831-849.
[http://dx.doi.org/10.1017/S095457941400042X] [PMID: 25047302]

Simeon, D.; Bartz, J.; Hamilton, H.; Crystal, S.; Braun, A.; Ketay, S.; Hollander, E. Oxytocin administration attenuates stress reactivity in borderline personality disorder: A pilot study. Psychoneuroendocrinology, 2011, 36(9), 1418-1421.
[http://dx.doi.org/10.1016/j.psyneuen.2011.03.013] [PMID: 21546164]

Bartz, J.; Simeon, D.; Hamilton, H.; Kim, S.; Crystal, S.; Braun, A.; Vicens, V.; Hollander, E. Oxytocin can hinder trust and cooperation in borderline personality disorder. Soc. Cogn. Affect. Neurosci., 2011, 6(5), 556-563.
[http://dx.doi.org/10.1093/scan/nsq085] [PMID: 21115541]

Ebert, A.; Kolb, M.; Heller, J.; Edel, M.A.; Roser, P.; Brüne, M. Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma. Soc. Neurosci., 2013, 8(4), 305-313.
[http://dx.doi.org/10.1080/17470919.2013.807301] [PMID: 23802121]

Bertsch, K.; Gamer, M.; Schmidt, B.; Schmidinger, I.; Walther, S.; Kästel, T.; Schnell, K.; Büchel, C.; Domes, G.; Herpertz, S.C. Oxytocin and reduction of social threat hypersensitivity in women with borderline personality disorder. Am. J. Psychiatry, 2013, 170(10), 1169-1177.
[http://dx.doi.org/10.1176/appi.ajp.2013.13020263] [PMID: 23982273]

Lischke, A.; Herpertz, S.C.; Berger, C.; Domes, G.; Gamer, M. Divergent effects of oxytocin on (para-)limbic reactivity to emotional and neutral scenes in females with and without borderline personality disorder. Soc. Cogn. Affect. Neurosci., 2017, 12(11), 1783-1792.
[http://dx.doi.org/10.1093/scan/nsx107] [PMID: 29036358]

Brüne, M.; Kolb, M.; Ebert, A.; Roser, P.; Edel, M.A. Nonverbal communication of patients with borderline personality disorder during clinical interviews: A double-blind placebo-controlled study using intranasal oxytocin. J. Nerv. Ment. Dis., 2015, 203(2), 107-111.
[http://dx.doi.org/10.1097/NMD.0000000000000240] [PMID: 25594788]

Brüne, M.; Ebert, A.; Kolb, M.; Tas, C.; Edel, M.A.; Roser, P. Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder. Hum. Psychopharmacol., 2013, 28(6), 552-561.
[http://dx.doi.org/10.1002/hup.2343] [PMID: 23950057]

Timmermann, M.; Jeung, H.; Schmitt, R.; Boll, S.; Freitag, C.M.; Bertsch, K.; Herpertz, S.C. Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder. Psychoneuroendocrinology, 2017, 85, 158-164.
[http://dx.doi.org/10.1016/j.psyneuen.2017.07.483] [PMID: 28865940]

Alcorn, J.L., III; Rathnayaka, N.; Swann, A.C.; Moeller, F.G.; Lane, S.D. Effects of intranasal oxytocin on aggressive responding in antisocial personality disorder. Psychol. Rec., 2015, 65(4), 691-703.
[http://dx.doi.org/10.1007/s40732-015-0139-y] [PMID: 27022201]

Blanchard, J.J.; Savage, C.L.G.; Orth, R.D.; Jacome, A.M.; Bennett, M.E. Sleep problems and social impairment in psychosis: A transdiagnostic study examining multiple social domains. Front. Psychiatry, 2020, 11, 486.
[http://dx.doi.org/10.3389/fpsyt.2020.00486] [PMID: 32547433]

Díaz-Caneja, C.M.; Pina-Camacho, L.; Rodríguez-Quiroga, A.; Fraguas, D.; Parellada, M.; Arango, C. Predictors of outcome in early-onset psychosis: A systematic review. NPJ Schizophr., 2015, 1(1), 14005.
[http://dx.doi.org/10.1038/npjschz.2014.5] [PMID: 27336027]

Charlson, F.J.; Ferrari, A.J.; Santomauro, D.F.; Diminic, S.; Stockings, E.; Scott, J.G.; McGrath, J.J.; Whiteford, H.A. Global epidemiology and burden of schizophrenia: Findings from the global burden of disease study 2016. Schizophr. Bull., 2018, 44(6), 1195-1203.
[http://dx.doi.org/10.1093/schbul/sby058] [PMID: 29762765]

Yang, A.; Tsai, S.J. New targets for schizophrenia treatment beyond the dopamine hypothesis. Int. J. Mol. Sci., 2017, 18(8), 1689.
[http://dx.doi.org/10.3390/ijms18081689] [PMID: 28771182]

Lieberman, J.A.; Girgis, R.R.; Brucato, G.; Moore, H.; Provenzano, F.; Kegeles, L.; Javitt, D.; Kantrowitz, J.; Wall, M.M.; Corcoran, C.M.; Schobel, S.A.; Small, S.A. Hippocampal dysfunction in the pathophysiology of schizophrenia: A selective review and hypothesis for early detection and intervention. Mol. Psychiatry, 2018, 23(8), 1764-1772.
[http://dx.doi.org/10.1038/mp.2017.249] [PMID: 29311665]

Grace, A.A. Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression. Nat. Rev. Neurosci., 2016, 17(8), 524-532.
[http://dx.doi.org/10.1038/nrn.2016.57] [PMID: 27256556]

Balu, D.T. The NMDA receptor and schizophrenia. Adv. Pharmacol., 2016, 76, 351-382.
[http://dx.doi.org/10.1016/bs.apha.2016.01.006] [PMID: 27288082]

Mai, J.K.; Berger, K.; Sofroniew, M.V. Morphometric evaluation of neurophysin-immunoreactivity in the human brain: Pronounced inter-individual variability and evidence for altered staining patterns in schizophrenia. J. Hirnforsch., 1993, 34(2), 133-154.
[PMID: 8228177]

Rosenfeld, A.J.; Lieberman, J.A.; Jarskog, L.F. Oxytocin, dopamine, and the amygdala: A neurofunctional model of social cognitive deficits in schizophrenia. Schizophr. Bull., 2011, 37(5), 1077-1087.
[http://dx.doi.org/10.1093/schbul/sbq015] [PMID: 20308198]

Dumais, K.M.; Veenema, A.H. Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior. Front. Neuroendocrinol., 2016, 40, 1-23.
[http://dx.doi.org/10.1016/j.yfrne.2015.04.003] [PMID: 25951955]

Strauss, G.P.; Keller, W.R.; Koenig, J.I.; Gold, J.M.; Ossenfort, K.L.; Buchanan, R.W. Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia. Schizophr. Res., 2015, 162(1-3), 57-61.
[http://dx.doi.org/10.1016/j.schres.2014.12.023] [PMID: 25583247]

Strauss, G.P.; Keller, W.R.; Koenig, J.I.; Gold, J.M.; Frost, K.H.; Buchanan, R.W. Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia. Schizophr. Res., 2015, 162(1-3), 47-51.
[http://dx.doi.org/10.1016/j.schres.2015.01.034] [PMID: 25673435]

Brown, E.C.; Tas, C.; Kuzu, D.; Esen-Danaci, A.; Roelofs, K.; Brüne, M. Social approach and avoidance behaviour for negative emotions is modulated by endogenous oxytocin and paranoia in schizophrenia. Psychiatry Res., 2014, 219(3), 436-442.
[http://dx.doi.org/10.1016/j.psychres.2014.06.038] [PMID: 25048758]

Speck, L.G.; Schöner, J.; Bermpohl, F.; Heinz, A.; Gallinat, J.; Majić, T.; Montag, C. Endogenous oxytocin response to film scenes of attachment and loss is pronounced in schizophrenia. Soc. Cogn. Affect. Neurosci., 2019, 14(1), 109-117.
[http://dx.doi.org/10.1093/scan/nsy110] [PMID: 30481342]

Jobst, A.; Dehning, S.; Ruf, S.; Notz, T.; Buchheim, A.; Henning-Fast, K.; Meißner, D.; Meyer, S.; Bondy, B.; Müller, N.; Zill, P. Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients. Acta Neuropsychiatr., 2014, 26(6), 347-355.
[http://dx.doi.org/10.1017/neu.2014.20] [PMID: 25288094]

Aydın, O.; Lysaker, P.H.; Balıkçı, K.; Ünal-Aydın, P.; Esen-Danacı, A. Associations of oxytocin and vasopressin plasma levels with neurocognitive, social cognitive and meta cognitive function in schizophrenia. Psychiatry Res., 2018, 270, 1010-1016.
[http://dx.doi.org/10.1016/j.psychres.2018.03.048] [PMID: 29609987]

Aydın, O.; Balıkçı, K.; Taş, C.; Ünal-Aydın, P.; Taneli, F.; Esen-Danacı, A. Assessing the relationship between attachment, parental attitude and plasma oxytocin in schizophrenia patients and their unaffected siblings. Nord. J. Psychiatry, 2019, 73(1), 51-57.
[http://dx.doi.org/10.1080/08039488.2018.1554698] [PMID: 30636461]

Strauss, G.P.; Chapman, H.C.; Keller, W.R.; Koenig, J.I.; Gold, J.M.; Carpenter, W.T.; Buchanan, R.W. Endogenous oxytocin levels are associated with impaired social cognition and neurocognition in schizophrenia. J. Psychiatr. Res., 2019, 112, 38-43.
[http://dx.doi.org/10.1016/j.jpsychires.2019.02.017] [PMID: 30849617]

Rubin, L.H.; Carter, C.S.; Drogos, L.; Pournajafi-Nazarloo, H.; Sweeney, J.A.; Maki, P.M. Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophr. Res., 2010, 124(1-3), 13-21.
[http://dx.doi.org/10.1016/j.schres.2010.09.014] [PMID: 20947304]

Rubin, L.H.; Carter, C.S.; Drogos, L.; Jamadar, R.; Pournajafi-Nazarloo, H.; Sweeney, J.A.; Maki, P.M. Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia. Schizophr. Res., 2011, 130(1-3), 266-270.
[http://dx.doi.org/10.1016/j.schres.2011.06.002] [PMID: 21684122]

Walss-Bass, C.; Fernandes, J.M.; Roberts, D.L.; Service, H.; Velligan, D. Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia. Schizophr. Res., 2013, 147(2-3), 387-392.
[http://dx.doi.org/10.1016/j.schres.2013.04.003] [PMID: 23628601]

Goldman, M.; Marlow-O’Connor, M.; Torres, I.; Carter, C.S. Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits. Schizophr. Res., 2008, 98(1-3), 247-255.
[http://dx.doi.org/10.1016/j.schres.2007.09.019] [PMID: 17961988]

Kéri, S.; Kiss, I.; Kelemen, O. Sharing secrets: Oxytocin and trust in schizophrenia. Soc. Neurosci., 2009, 4(4), 287-293.
[http://dx.doi.org/10.1080/17470910802319710] [PMID: 18671168]

Beckmann, H.; Lang, R.E.; Gattaz, W.F. Vasopressin-oxytocin in cerebrospinal fluid of schizophrenic patients and normal controls. Psychoneuroendocrinology, 1985, 10(2), 187-191.
[http://dx.doi.org/10.1016/0306-4530(85)90056-3] [PMID: 4034849]

Glovinsky, D.; Kalogeras, K.; Kirch, D.; Suddath, R.; Wyatt, R. Cerebrospinal fluid oxytocin concentration in schizophrenic patients does not differ from control subjects and is not changed by neuroleptic medication. Schizophr. Res., 1994, 11(3), 273-276.
[http://dx.doi.org/10.1016/0920-9964(94)90021-3] [PMID: 7910756]

Montag, C.; Schöner, J.; Speck, L.G.; Just, S.; Stuke, F.; Rentzsch, J.; Gallinat, J.; Majić, T. Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia. PLoS One, 2020, 15(4), e0231257.
[http://dx.doi.org/10.1371/journal.pone.0231257] [PMID: 32255800]

Rubin, L.H.; Li, S.; Yao, L.; Keedy, S.K.; Reilly, J.L.; Hill, S.K.; Bishop, J.R.; Sue Carter, C.; Pour-najafi-Nazarloo, H.; Drogos, L.L.; Gershon, E.; Pearlson, G.D.; Tamminga, C.A.; Clementz, B.A.; Keshavan, M.S.; Lui, S.; Sweeney, J.A. Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia. Schizophr. Res., 2018, 202, 173-179.
[http://dx.doi.org/10.1016/j.schres.2018.07.003] [PMID: 30539769]

Wehring, H.J.; Buchanan, R.W.; Feldman, S.; Carpenter, W.T.; McMahon, R.P.; Weiner, E.; Gold, J.M.; Adams, H.A.; Strauss, G.P.; Rubin, L.H.; Kelly, D.L. Oxytocin and sexual function in males and females with schizophrenia. Schizophr. Res., 2018, 199, 431-432.
[http://dx.doi.org/10.1016/j.schres.2018.03.013] [PMID: 29551232]

Bakharev, V.D.; Tikhomirov, S.M.; Lozhkina, T.K. Psychotropic properties of oxytocin. Neurosci. Behav. Physiol., 1986, 16(2), 160-164.
[http://dx.doi.org/10.1007/BF01186517] [PMID: 3748373]

Pedersen, C.A.; Gibson, C.M.; Rau, S.W.; Salimi, K.; Smedley, K.L.; Casey, R.L.; Leserman, J.; Jarskog, L.F.; Penn, D.L. Intranasal oxytocin reduces psychotic symptoms and improves theory of mind and social perception in schizophrenia. Schizophr. Res., 2011, 132(1), 50-53.
[http://dx.doi.org/10.1016/j.schres.2011.07.027] [PMID: 21840177]

Gibson, C.M.; Penn, D.L.; Smedley, K.L.; Leserman, J.; Elliott, T.; Pedersen, C.A. A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia. Schizophr. Res., 2014, 156(2-3), 261-265.
[http://dx.doi.org/10.1016/j.schres.2014.04.009] [PMID: 24799299]

Averbeck, B.B.; Bobin, T.; Evans, S.; Shergill, S.S. Emotion recognition and oxytocin in patients with schizophrenia. Psychol. Med., 2012, 42(2), 259-266.
[http://dx.doi.org/10.1017/S0033291711001413] [PMID: 21835090]

Goldman, M.B.; Gomes, A.M.; Carter, C.S.; Lee, R. Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia. Psychopharmacology (Berl.), 2011, 216(1), 101-110.
[http://dx.doi.org/10.1007/s00213-011-2193-8] [PMID: 21301811]

De Coster, L.; Lin, L.; Mathalon, D.H.; Woolley, J.D. Neural and behavioral effects of oxytocin administration during theory of mind in schizophrenia and controls: A randomized control trial. Neuropsychopharmacology, 2019, 44(11), 1925-1931.
[http://dx.doi.org/10.1038/s41386-019-0417-5] [PMID: 31103018]

Caravaggio, F.; Gerretsen, P.; Mar, W.; Chung, J.K.; Plitman, E.; Nakajima, S.; Kim, J.; Iwata, Y.; Patel, R.; Chakravarty, M.M.; Remington, G.; Graff-Guerrero, A.; Menon, M. Intranasal oxytocin does not modulate jumping to conclusions in schizophrenia: Potential interactions with caudate volume and baseline social functioning. Psychoneuroendocrinology, 2017, 81, 80-87.
[http://dx.doi.org/10.1016/j.psyneuen.2017.03.020] [PMID: 28431278]

Woolley, J.D.; Chuang, B.; Lam, O.; Lai, W.; O’Donovan, A.; Rankin, K.P.; Mathalon, D.H.; Vinogradov, S. Oxytocin administration enhances controlled social cognition in patients with schizophrenia. Psychoneuroendocrinology, 2014, 47, 116-125.
[http://dx.doi.org/10.1016/j.psyneuen.2014.04.024] [PMID: 25001961]

Fischer-Shofty, M.; Shamay-Tsoory, S.G.; Levkovitz, Y. Characterization of the effects of oxytocin on fear recognition in patients with schizophrenia and in healthy controls. Front. Neurosci., 2013, 7, 127.
[http://dx.doi.org/10.3389/fnins.2013.00127] [PMID: 23882178]

Davis, M.C.; Green, M.F.; Lee, J.; Horan, W.P.; Senturk, D.; Clarke, A.D.; Marder, S.R. Oxytocin-augmented social cognitive skills training in schizophrenia. Neuropsychopharmacology, 2014, 39(9), 2070-2077.
[http://dx.doi.org/10.1038/npp.2014.68] [PMID: 24637803]

Davis, M.C.; Lee, J.; Horan, W.P.; Clarke, A.D.; McGee, M.R.; Green, M.F.; Marder, S.R. Effects of single dose intranasal oxytocin on social cognition in schizophrenia. Schizophr. Res., 2013, 147(2-3), 393-397.
[http://dx.doi.org/10.1016/j.schres.2013.04.023] [PMID: 23676253]

Bradley, E.R.; Seitz, A.; Niles, A.N.; Rankin, K.P.; Mathalon, D.H.; O’Donovan, A.; Woolley, J.D. Oxytocin increases eye gaze in schizophrenia. Schizophr. Res., 2019, 212, 177-185.
[http://dx.doi.org/10.1016/j.schres.2019.07.039] [PMID: 31416746]

Woolley, J.D.; Chuang, B.; Fussell, C.; Scherer, S.; Biagianti, B.; Fulford, D.; Mathalon, D.H.; Vinogradov, S. Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls. Psychol. Med., 2017, 47(7), 1311-1322.
[http://dx.doi.org/10.1017/S0033291716003433] [PMID: 28091349]

Bradley, E.R.; Brustkern, J.; De Coster, L.; van den Bos, W.; McClure, S.M.; Seitz, A.; Woolley, J.D. Victory is its own reward: Oxytocin increases costly competitive behavior in schizophrenia. Psychol. Med., 2020, 50(4), 674-682.
[http://dx.doi.org/10.1017/S0033291719000552] [PMID: 30944045]

Ota, M.; Yoshida, S.; Nakata, M.; Yada, T.; Kunugi, H. The effects of adjunctive intranasal oxytocin in patients with schizophrenia. Postgrad. Med., 2018, 130(1), 122-128.
[http://dx.doi.org/10.1080/00325481.2018.1398592] [PMID: 29105546]

Feifel, D.; Macdonald, K.; Nguyen, A.; Cobb, P.; Warlan, H.; Galangue, B.; Minassian, A.; Becker, O.; Cooper, J.; Perry, W.; Lefebvre, M.; Gonzales, J.; Hadley, A. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol. Psychiatry, 2010, 68(7), 678-680.
[http://dx.doi.org/10.1016/j.biopsych.2010.04.039] [PMID: 20615494]

Feifel, D.; MacDonald, K.; Cobb, P.; Minassian, A. Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia. Schizophr. Res., 2012, 139(1-3), 207-210.
[http://dx.doi.org/10.1016/j.schres.2012.05.018] [PMID: 22682705]

Zheng, W.; Zhu, X.M.; Zhang, Q.E.; Yang, X.H.; Cai, D.B.; Li, L.; Li, X.B.; Ng, C.H.; Ungvari, G.S.; Ning, Y.P.; Xiang, Y.T. Adjunctive intranasal oxytocin for schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials. Schizophr. Res., 2019, 206, 13-20.
[http://dx.doi.org/10.1016/j.schres.2018.12.007] [PMID: 30573406]

Modabbernia, A.; Rezaei, F.; Salehi, B.; Jafarinia, M.; Ashrafi, M.; Tabrizi, M.; Hosseini, S.M.R.; Tajdini, M.; Ghaleiha, A.; Akhondzadeh, S. Intranasal oxytocin as an adjunct to risperidone in patients with schizophrenia: An 8-week, randomized, double-blind, placebo-controlled study. CNS Drugs, 2013, 27(1), 57-65.
[http://dx.doi.org/10.1007/s40263-012-0022-1] [PMID: 23233269]

Buchanan, R.W.; Kelly, D.L.; Weiner, E.; Gold, J.M.; Strauss, G.P.; Koola, M.M.; McMahon, R.P.; Carpenter, W.T. A randomized clinical trial of oxytocin or galantamine for the treatment of negative symptoms and cognitive impairments in people with schizophrenia. J. Clin. Psychopharmacol., 2017, 37(4), 394-400.
[http://dx.doi.org/10.1097/JCP.0000000000000720] [PMID: 28590362]

Cacciotti-Saija, C.; Langdon, R.; Ward, P.B.; Hickie, I.B.; Scott, E.M.; Naismith, S.L.; Moore, L.; Alvares, G.A.; Redoblado Hodge, M.A.; Guastella, A.J. A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis. Schizophr. Bull., 2015, 41(2), 483-493.
[http://dx.doi.org/10.1093/schbul/sbu094] [PMID: 24962607]

Strauss, G.P.; Granholm, E.; Holden, J.L.; Ruiz, I.; Gold, J.M.; Kelly, D.L.; Buchanan, R.W. The effects of combined oxytocin and cognitive behavioral social skills training on social cognition in schizophrenia. Psychol. Med., 2019, 49(10), 1731-1739.
[http://dx.doi.org/10.1017/S0033291718002465] [PMID: 30180918]

Halverson, T.; Jarskog, L.F.; Pedersen, C.; Penn, D. Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial. Schizophr. Res., 2019, 204, 178-182.
[http://dx.doi.org/10.1016/j.schres.2018.09.013] [PMID: 30243853]

Busnelli, M.; Dagani, J.; de Girolamo, G.; Balestrieri, M.; Pini, S.; Saviotti, F.M.; Scocco, P.; Sisti, D.; Rocchi, M.; Chini, B. Unaltered oxytocin and vasopressin plasma levels in patients with schizophrenia after 4 months of daily treatment with intranasal oxytocin. J. Neuroendocrinol., 2016, 28(4)
[http://dx.doi.org/10.1111/jne.12359] [PMID: 26715485]

Abu-Akel, A.; Fischer-Shofty, M.; Levkovitz, Y.; Decety, J.; Shamay-Tsoory, S. The role of oxytocin in empathy to the pain of conflictual out-group members among patients with schizophrenia. Psychol. Med., 2014, 44(16), 3523-3532.
[http://dx.doi.org/10.1017/S003329171400097X] [PMID: 25065955]

Fulford, D.; Treadway, M.; Woolley, J. Social motivation in schizophrenia: The impact of oxytocin on vigor in the context of social and nonsocial reinforcement. J. Abnorm. Psychol., 2018, 127(1), 116-128.
[http://dx.doi.org/10.1037/abn0000320] [PMID: 29369669]

Bradley, E.R.; van Nieuwenhuizen, A.; Abram, S.; Niles, A.N.; Woolley, J.D. Oxytocin does not improve working memory in schizophrenia. Schizophr. Res., 2019, 208, 486-487.
[http://dx.doi.org/10.1016/j.schres.2019.01.020] [PMID: 30712813]

Tas, C.; Brown, E.C.; Eskikurt, G.; Irmak, S.; Aydın, O.; Esen-Danaci, A.; Brüne, M. Cortisol response to stress in schizophrenia: Associations with oxytocin, social support and social functioning. Psychiatry Res., 2018, 270, 1047-1052.
[http://dx.doi.org/10.1016/j.psychres.2018.05.011] [PMID: 29960725]

Warren, K.R.; Wehring, H.J.; Liu, F.; McMahon, R.P.; Chen, S.; Chester, C.; Kelly, D.L. Effects of intranasal oxytocin on satiety signaling in people with schizophrenia. Physiol. Behav., 2018, 189, 86-91.
[http://dx.doi.org/10.1016/j.physbeh.2018.03.008] [PMID: 29524451]

Watanabe, Y.; Kaneko, N.; Nunokawa, A.; Shibuya, M.; Egawa, J.; Someya, T. Oxytocin receptor (OXTR) gene and risk of schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population. Psychiatry Clin. Neurosci., 2012, 66(7), 622.
[http://dx.doi.org/10.1111/j.1440-1819.2012.02396.x] [PMID: 23252931]

Montag, C.; Brockmann, E.M.; Bayerl, M.; Rujescu, D.; Müller, D.J.; Gallinat, J. Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study. World J. Biol. Psychiatry, 2013, 14(7), 500-508.
[http://dx.doi.org/10.3109/15622975.2012.677547] [PMID: 22651577]

Montag, C.; Brockmann, E.M.; Lehmann, A.; Müller, D.J.; Rujescu, D.; Gallinat, J. Association between oxytocin receptor gene polymorphisms and self-rated ‘empathic concern’ in schizophrenia. PLoS One, 2012, 7(12), , e51882..
[http://dx.doi.org/10.1371/journal.pone.0051882] [PMID: 23284802]

Souza, R.P.; de Luca, V.; Meltzer, H.Y.; Lieberman, J.A.; Kennedy, J.L. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int. J. Neuropsychopharmacol., 2010, 13(6), 793-798.
[http://dx.doi.org/10.1017/S1461145710000167] [PMID: 20196918]

Souza, R.P.; Ismail, P.; Meltzer, H.Y.; Kennedy, J.L. Variants in the oxytocin gene and risk for schizophrenia. Schizophr. Res., 2010, 121(1-3), 279-280.
[http://dx.doi.org/10.1016/j.schres.2010.04.019] [PMID: 20547038]

Teltsh, O.; Kanyas-Sarner, K.; Rigbi, A.; Greenbaum, L.; Lerer, B.; Kohn, Y. Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree. Int. J. Neuropsychopharmacol., 2012, 15(3), 309-319.
[http://dx.doi.org/10.1017/S1461145711001374] [PMID: 21899794]

Veras, A.B.; Getz, M.; Froemke, R.C.; Nardi, A.E.; Alves, G.S.; Walsh-Messinger, J.; Chao, M.V.; Kranz, T.M.; Malaspina, D. Rare missense coding variants in oxytocin receptor (OXTR) in schizophrenia cases are associated with early trauma exposure, cognition and emotional processing. J. Psychiatr. Res., 2018, 97, 58-64.
[http://dx.doi.org/10.1016/j.jpsychires.2017.11.011] [PMID: 29190530]

Bang, M.; Kang, J.I.; Kim, S.J.; Park, J.Y.; Kim, K.R.; Lee, S.Y.; Park, K.; Lee, E.; Lee, S.K.; An, S.K.; Reduced, DNA Methylation of the oxytocin receptor gene is associated with anhedonia-asociality in women with recent-onset schizophrenia and ultra-high risk for psychosis. Schizophr. Bull., 2019, 45(6), 1279-1290.
[http://dx.doi.org/10.1093/schbul/sbz016] [PMID: 31220321]

Uhrig, S.; Hirth, N.; Broccoli, L.; von Wilmsdorff, M.; Bauer, M.; Sommer, C.; Zink, M.; Steiner, J.; Frodl, T.; Malchow, B.; Falkai, P.; Spanagel, R.; Hansson, A.C.; Schmitt, A. Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study. Schizophr. Res., 2016, 177(1-3), 59-66.
[http://dx.doi.org/10.1016/j.schres.2016.04.019] [PMID: 27132494]

Zhang, J.; Zhou, L.; Yang, Y.; Peng, W.; Wang, W.; Chen, X. Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics. Lancet Respir. Med., 2020, 8(3), e11-e12.
[http://dx.doi.org/10.1016/S2213-2600(20)30071-0] [PMID: 32061335]

Hodgson, S.H.; Mansatta, K.; Mallett, G.; Harris, V.; Emary, K.R.W.; Pollard, A.J. What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. Lancet Infect. Dis., 2021, 21(2), e26-e35.
[http://dx.doi.org/10.1016/S1473-3099(20)30773-8] [PMID: 33125914]

Chakraborty, S.; Mallajosyula, V.; Tato, C.M.; Tan, G.S.; Wang, T.T. SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand? Adv. Drug Deliv. Rev., 2021, 172, 314-338.
[http://dx.doi.org/10.1016/j.addr.2021.01.014] [PMID: 33482248]

Libby, P.; Lüscher, T. COVID-19 is, in the end, an endothelial disease. Eur. Heart J., 2020, 41(32), 3038-3044.
[http://dx.doi.org/10.1093/eurheartj/ehaa623] [PMID: 32882706]

Alharthy, A.; Faqihi, F.; Memish, Z.A.; Karakitsos, D. Fragile endothelium and brain dysregulated neurochemical activity in COVID-19. ACS Chem. Neurosci., 2020, 11(15), 2159-2162.
[http://dx.doi.org/10.1021/acschemneuro.0c00437] [PMID: 32786343]

Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X.; Cheng, Z.; Yu, T.; Xia, J.; Wei, Y.; Wu, W.; Xie, X.; Yin, W.; Li, H.; Liu, M.; Xiao, Y.; Gao, H.; Guo, L.; Xie, J.; Wang, G.; Jiang, R.; Gao, Z.; Jin, Q.; Wang, J.; Cao, B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, 395(10223), 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]

Chen, N.; Zhou, M.; Dong, X.; Qu, J.; Gong, F.; Han, Y.; Qiu, Y.; Wang, J.; Liu, Y.; Wei, Y.; Xia, J.; Yu, T.; Zhang, X.; Zhang, L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet, 2020, 395(10223), 507-513.
[http://dx.doi.org/10.1016/S0140-6736(20)30211-7] [PMID: 32007143]

Buemann, B.; Marazziti, D.; Uvnäs-Moberg, K. Can intravenous oxytocin infusion counteract hyper-inflammation in COVID-19 infected patients? World J. Biol. Psychiatry, 2021, 22(5), 387-398.
[http://dx.doi.org/10.1080/15622975.2020.1814408] [PMID: 32914674]

Soumier, A.; Sirigu, A. Oxytocin as a potential defence against COVID-19? Med. Hypotheses, 2020, 140, , 109785..
[http://dx.doi.org/10.1016/j.mehy.2020.109785] [PMID: 32344303]

Korkmaz, H.; Önal, D.; Alışık, M.; Erel, Ö.; Pehlivanoğlu, B. The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats. Biol. Chem., 2020, 401(11), 1283-1292.
[http://dx.doi.org/10.1515/hsz-2020-0190] [PMID: 32554831]

Panaro, M.A.; Benameur, T.; Porro, C. Hypothalamic neuropeptide brain protection: Focus on oxytocin. J. Clin. Med., 2020, 9(5), 1534.
[http://dx.doi.org/10.3390/jcm9051534] [PMID: 32438751]

Jankowski, M.; Broderick, T.L.; Gutkowska, J. The role of oxytocin in cardiovascular protection. Front. Psychol., 2020, 11, 2139.
[http://dx.doi.org/10.3389/fpsyg.2020.02139] [PMID: 32982875]

Zahran, A.M.; Zahran, Z.A.M.; Mady, Y.H.; Mahran, E.E.M.O.; Rashad, A.; Makboul, A.; Nasif, K.A.; Abdelmaksoud, A.A.; El-Badawy, O. Differential alterations in peripheral lymphocyte subsets in COVID-19 patients: Upregulation of double-positive and double-negative T cells. Multidiscip. Respir. Med., 2021, 16(2), 758.
[http://dx.doi.org/10.4081/mrm.2021.758] [PMID: 34221400]

Kratzer, B.; Trapin, D.; Ettel, P.; Körmöczi, U.; Rottal, A.; Tuppy, F.; Feichter, M.; Gattinger, P.; Borochova, K.; Dorofeeva, Y.; Tulaeva, I.; Weber, M.; Grabmeier-Pfistershammer, K.; Tauber, P.A.; Gerdov, M.; Mühl, B.; Perkmann, T.; Fae, I.; Wenda, S.; Führer, H.; Henning, R.; Valenta, R.; Pickl, W.F. Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations. Allergy, 2021, 76(3), 751-765.
[http://dx.doi.org/10.1111/all.14647] [PMID: 33128792]

Gan, J.; Li, J.; Li, S.; Yang, C. Leucocyte subsets effectively predict the clinical outcome of patients with COVID-19 pneumonia: A retrospective case-control study. Front. Public Health, 2020, 8, 299.
[http://dx.doi.org/10.3389/fpubh.2020.00299] [PMID: 32626680]

Rezaei, M.; Marjani, M.; Mahmoudi, S.; Mortaz, E.; Mansouri, D. Dynamic changes of lymphocyte subsets in the course of COVID-19. Int. Arch. Allergy Immunol., 2021, 182(3), 254-262.
[http://dx.doi.org/10.1159/000514202] [PMID: 33498051]

Schultze-Florey, C.R.; Chukhno, E.; Goudeva, L.; Blasczyk, R.; Ganser, A.; Prinz, I.; Förster, R.; Koenecke, C.; Odak, I. Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry. Leukemia, 2021, 35(10), 3021-3025.
[http://dx.doi.org/10.1038/s41375-021-01348-5] [PMID: 34290358]

Lagunas-Rangel, F.A. Neutrophil‐to‐lymphocyte ratio and lymphocyte‐to‐C‐reactive protein ratio in patients with severe coronavirus disease 2019 (COVID‐19): A meta‐analysis. J. Med. Virol., 2020, 92(10), 1733-1734.
[http://dx.doi.org/10.1002/jmv.25819] [PMID: 32242950]

Wang, F.; Nie, J.; Wang, H.; Zhao, Q.; Xiong, Y.; Deng, L.; Song, S.; Ma, Z.; Mo, P.; Zhang, Y. Characteristics of peripheral lymphocyte subset alteration in COVID-19 Pneumonia. J. Infect. Dis., 2020, 221(11), 1762-1769.
[http://dx.doi.org/10.1093/infdis/jiaa150] [PMID: 32227123]

Middleton, E.A.; He, X.Y.; Denorme, F.; Campbell, R.A.; Ng, D.; Salvatore, S.P.; Mostyka, M.; Baxter-Stoltzfus, A.; Borczuk, A.C.; Loda, M.; Cody, M.J.; Manne, B.K.; Portier, I.; Harris, E.S.; Petrey, A.C.; Beswick, E.J.; Caulin, A.F.; Iovino, A.; Abegglen, L.M.; Weyrich, A.S.; Rondina, M.T.; Egeblad, M.; Schiffman, J.D.; Yost, C.C. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 2020, 136(10), 1169-1179.
[http://dx.doi.org/10.1182/blood.2020007008] [PMID: 32597954]

Parackova, Z.; Bloomfield, M.; Klocperk, A.; Sediva, A. Neutrophils mediate Th17 promotion in COVID‐19 patients. J. Leukoc. Biol., 2021, 109(1), 73-76.
[http://dx.doi.org/10.1002/JLB.4COVCRA0820-481RRR] [PMID: 33289169]

Barnes, B.J.; Adrover, J.M.; Baxter-Stoltzfus, A.; Borczuk, A.; Cools-Lartigue, J.; Crawford, J.M.; Daßler-Plenker, J.; Guerci, P.; Huynh, C.; Knight, J.S.; Loda, M.; Looney, M.R.; McAllister, F.; Rayes, R.; Renaud, S.; Rousseau, S.; Salvatore, S.; Schwartz, R.E.; Spicer, J.D.; Yost, C.C.; Weber, A.; Zuo, Y.; Egeblad, M. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J. Exp. Med., 2020, 217(6), , e20200652..
[http://dx.doi.org/10.1084/jem.20200652] [PMID: 32302401]

Wang, J.; Li, Q.; Yin, Y.; Zhang, Y.; Cao, Y.; Lin, X.; Huang, L.; Hoffmann, D.; Lu, M.; Qiu, Y. Excessive neutrophils and neutrophil extracellular traps in COVID-19. Front. Immunol., 2020, 11, 2063.
[http://dx.doi.org/10.3389/fimmu.2020.02063] [PMID: 33013872]

Carsana, L.; Sonzogni, A.; Nasr, A.; Rossi, R.S.; Pellegrinelli, A.; Zerbi, P.; Rech, R.; Colombo, R.; Antinori, S.; Corbellino, M.; Galli, M.; Catena, E.; Tosoni, A.; Gianatti, A.; Nebuloni, M. Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: A two-centre descriptive study. Lancet Infect. Dis., 2020, 20(10), 1135-1140.
[http://dx.doi.org/10.1016/S1473-3099(20)30434-5] [PMID: 32526193]

Paidi, R.K.; Jana, M.; Mishra, R.K.; Dutta, D.; Raha, S.; Pahan, K. ACE-2-interacting domain of SARS-CoV-2 (AIDS) peptide suppresses inflammation to reduce fever and protect lungs and heart in mice: Implications for COVID-19 therapy. J. Neuroimmune Pharmacol., 2021, 16(1), 59-70.
[http://dx.doi.org/10.1007/s11481-020-09979-8] [PMID: 33426604]

Kelesoglu, S.; Yilmaz, Y.; Ozkan, E.; Calapkorur, B.; Gok, M.; Dursun, Z.B.; Kilic, A.U.; Demirelli, S.; Simsek, Z.; Elcık, D. New onset atrial fibrilation and risk faktors in COVID-19. J. Electrocardiol., 2021, 65, 76-81.
[http://dx.doi.org/10.1016/j.jelectrocard.2020.12.005] [PMID: 33556739]

Wang, S.C.; Wang, Y.F. Cardiovascular protective properties of oxytocin against COVID-19. Life Sci., 2021, 270, , 119130..
[http://dx.doi.org/10.1016/j.lfs.2021.119130] [PMID: 33513400]

Gustine, J.N.; Jones, D. Immunopathology of hyperinflammation in COVID-19. Am. J. Pathol., 2021, 191(1), 4-17.
[http://dx.doi.org/10.1016/j.ajpath.2020.08.009] [PMID: 32919977]

McGonagle, D.; Sharif, K.; O’Regan, A.; Bridgewood, C. The role of cytokines including Interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun. Rev., 2020, 19(6), , 102537..
[http://dx.doi.org/10.1016/j.autrev.2020.102537] [PMID: 32251717]

Merad, M.; Martin, J.C. Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages. Nat. Rev. Immunol., 2020, 20(6), 355-362.
[http://dx.doi.org/10.1038/s41577-020-0331-4] [PMID: 32376901]

Soy, M.; Keser, G.; Atagündüz, P.; Tabak, F.; Atagündüz, I.; Kayhan, S. Cytokine storm in COVID-19: Pathogenesis and overview of anti-inflammatory agents used in treatment. Clin. Rheumatol., 2020, 39(7), 2085-2094.
[http://dx.doi.org/10.1007/s10067-020-05190-5] [PMID: 32474885]

İşeri, S.Ö.; Şener, G.; Sağlam, B.; Gedik, N.; Ercan, F.; Yeğen, B.Ç. Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism. Peptides, 2005, 26(3), 483-491.
[http://dx.doi.org/10.1016/j.peptides.2004.10.005] [PMID: 15652655]

İşeri, S.Ö.; Şener, G.; Saǧlam, B.; Gedik, N.; Ercan, F.; Yeǧen, B.Ç. Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils. J. Surg. Res., 2005, 126(1), 73-81.
[http://dx.doi.org/10.1016/j.jss.2005.01.021] [PMID: 15916978]

Bıyıklı, N.K.; Tuğtepe, H.; Şener, G.; Velioğlu-Öğünç, A.; Çetinel, Ş.; Midillioğlu, Ş.; Gedik, N.; Yeğen, B.Ç. Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism. Peptides, 2006, 27(9), 2249-2257.
[http://dx.doi.org/10.1016/j.peptides.2006.03.029] [PMID: 16707192]

Düşünceli, F.; İşeri, S.Ö.; Ercan, F.; Gedik, N.; Yeğen, C.; Yeğen, B.Ç. Oxytocin alleviates hepatic ischemia–reperfusion injury in rats. Peptides, 2008, 29(7), 1216-1222.
[http://dx.doi.org/10.1016/j.peptides.2008.02.010] [PMID: 18403049]

Mou, X.; Fang, J.; Yang, A.; Du, G. Oxytocin ameliorates bone cancer pain by suppressing toll-like receptor 4 and proinflammatory cytokines in rat spinal cord. J. Neurogenet., 2020, 34(2), 216-222.
[http://dx.doi.org/10.1080/01677063.2019.1711077] [PMID: 32116108]

Hu, G.; Malik, A.B.; Minshall, R.D. Toll-like receptor 4 mediates neutrophil sequestration and lung injury induced by endotoxin and hyperinflation. Crit. Care Med., 2010, 38(1), 194-201.
[http://dx.doi.org/10.1097/CCM.0b013e3181bc7c17] [PMID: 19789446]

Tuğtepe, H.; Şener, G.; Bıyıklı, N.K.; Yüksel, M.; Çetinel, Ş.; Gedik, N.; Yeğen, B.Ç. The protective effect of oxytocin on renal ischemia/reperfusion injury in rats. Regul. Pept., 2007, 140(3), 101-108.
[http://dx.doi.org/10.1016/j.regpep.2006.11.026] [PMID: 17261335]

Deing, V.; Roggenkamp, D.; Kühnl, J.; Gruschka, A.; Stäb, F.; Wenck, H.; Bürkle, A.; Neufang, G. Oxytocin modulates proliferation and stress responses of human skin cells: Implications for atopic dermatitis. Exp. Dermatol., 2013, 22(6), 399-405.
[http://dx.doi.org/10.1111/exd.12155] [PMID: 23711064]

Jankowski, M.; Bissonauth, V.; Gao, L.; Gangal, M.; Wang, D.; Danalache, B.; Wang, Y.; Stoyanova, E.; Cloutier, G.; Blaise, G.; Gutkowska, J. Anti-inflammatory effect of oxytocin in rat myocardial infarction. Basic Res. Cardiol., 2010, 105(2), 205-218.
[http://dx.doi.org/10.1007/s00395-009-0076-5] [PMID: 20012748]

Dou, D.; Liang, J.; Zhai, X.; Li, G.; Wang, H.; Han, L.; Lin, L.; Ren, Y.; Liu, S.; Liu, C.; Guo, W.; Li, J. Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis. Clin. Sci. (Lond.), 2021, 135(4), 597-611.
[http://dx.doi.org/10.1042/CS20201438] [PMID: 33564880]

Fekete, E.M.; Antoni, M.H.; Lopez, C.; Mendez, A.J.; Szeto, A.; Fletcher, M.A.; Klimas, N.; Kumar, M.; Schneiderman, N. Stress buffering effects of oxytocin on HIV status in low-income ethnic minority women. Psychoneuroendocrinology, 2011, 36(6), 881-890.
[http://dx.doi.org/10.1016/j.psyneuen.2010.12.003] [PMID: 21215526]

Singh, B.; Schwartz, J.A.; Sandrock, C.; Bellemore, S.M.; Nikoopour, E. Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. Indian J. Med. Res., 2013, 138(5), 591-594.
[PMID: 24434314]

Hansenne, I.; Rasier, G.; Péqueux, C.; Brilot, F.; Renard, C.; Breton, C.; Greimers, R.; Legros, J.J.; Geenen, V.; Martens, H.J. Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network. J. Neuroimmunol., 2005, 158(1-2), 67-75.
[http://dx.doi.org/10.1016/j.jneuroim.2004.08.007] [PMID: 15589039]

Macciò, A.; Madeddu, C.; Chessa, P.; Panzone, F.; Lissoni, P.; Mantovani, G. Oxytocin both increases proliferative response of peripheral blood lymphomonocytes to phytohemagglutinin and reverses immunosuppressive estrogen activity. In Vivo, 2010, 24(2), 157-163.
[PMID: 20363988]

Stanić, D.; Plećaš-Solarović, B.; Petrović, J.; Bogavac-Stanojević, N.; Sopić, M.; Kotur-Stevuljević, J.; Ignjatović, S.; Pešić, V. Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment. Chem. Biol. Interact., 2016, 256, 134-141.
[http://dx.doi.org/10.1016/j.cbi.2016.07.006] [PMID: 27402529]

Tang, Y.; Shi, Y.; Gao, Y.; Xu, X.; Han, T.; Li, J.; Liu, C. Oxytocin system alleviates intestinal inflammation by regulating macrophages polarization in experimental colitis. Clin. Sci. (Lond.), 2019, 133(18), 1977-1992.
[http://dx.doi.org/10.1042/CS20190756] [PMID: 31519790]

Garrido-Urbani, S.; Deblon, N.; Poher, A.L.; Caillon, A.; Ropraz, P.; Rohner-Jeanrenaud, F.; Altirriba, J. Inhibitory role of oxytocin on TNFα expression assessed in vitro and in vivo. Diabetes Metab., 2018, 44(3), 292-295.
[http://dx.doi.org/10.1016/j.diabet.2017.10.004] [PMID: 29129540]

Szeto, A.; Nation, D.A.; Mendez, A.J.; Dominguez-Bendala, J.; Brooks, L.G.; Schneiderman, N.; McCabe, P.M. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am. J. Physiol. Endocrinol. Metab., 2008, 295(6), E1495-E1501.
[http://dx.doi.org/10.1152/ajpendo.90718.2008] [PMID: 18940936]

Huang, S.; Zhu, B.; Cheon, I.S.; Goplen, N.P.; Jiang, L.; Zhang, R.; Peebles, R.S.; Mack, M.; Kaplan, M.H.; Limper, A.H.; Sun, J. PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection. J. Virol., 2019, 93(9), e00030-19.
[http://dx.doi.org/10.1128/JVI.00030-19] [PMID: 30787149]

Eckertova, M.; Ondrejcakova, M.; Krskova, K.; Zorad, S.; Jezova, D. Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis. Br. J. Pharmacol., 2011, 162(2), 452-463.
[http://dx.doi.org/10.1111/j.1476-5381.2010.01037.x] [PMID: 20846187]

Rashed, L.A.; Hashem, R.M.; Soliman, H.M. Oxytocin inhibits NADPH oxidase and P38 MAPK in cisplatin-induced nephrotoxicity. Biomed. Pharmacother., 2011, 65(7), 474-480.
[http://dx.doi.org/10.1016/j.biopha.2011.07.001] [PMID: 21993003]

Thibonnier, M.; Conarty, D.M.; Preston, J.A.; Plesnicher, C.L.; Dweik, R.A.; Erzurum, S.C. Human vascular endothelial cells express oxytocin receptors. Endocrinology, 1999, 140(3), 1301-1309.
[http://dx.doi.org/10.1210/endo.140.3.6546] [PMID: 10067857]

Gonzalez-Reyes, A.; Menaouar, A.; Yip, D.; Danalache, B.; Plante, E.; Noiseux, N.; Gutkowska, J.; Jankowski, M. Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion. Mol. Cell. Endocrinol., 2015, 412, 170-181.
[http://dx.doi.org/10.1016/j.mce.2015.04.028] [PMID: 25963797]

Khan, R.; Kirschenbaum, L.A.; LaRow, C.; Berna, G.; Griffin, K.; Astiz, M.E. Augmentation of platelet and endothelial cell eNOS activity decreases sepsis-related neutrophilendothelial cell interactions. Shock, 2010, 33(3), 242-246.
[http://dx.doi.org/10.1097/SHK.0b013e3181b0f96f] [PMID: 19536045]

Furube, E.; Mannari, T.; Morita, S.; Nishikawa, K.; Yoshida, A.; Itoh, M.; Miyata, S. VEGF-dependent and PDGF-dependent dynamic neurovascular reconstruction in the neurohypophysis of adult mice. J. Endocrinol., 2014, 222(1), 161-179.
[http://dx.doi.org/10.1530/JOE-14-0075] [PMID: 24860149]

Mei, S.H.J.; Haitsma, J.J.; Dos Santos, C.C.; Deng, Y.; Lai, P.F.H.; Slutsky, A.S.; Liles, W.C.; Stewart, D.J. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am. J. Respir. Crit. Care Med., 2010, 182(8), 1047-1057.
[http://dx.doi.org/10.1164/rccm.201001-0010OC] [PMID: 20558630]

Kim, Y.S.; Ahn, Y.; Kwon, J.S.; Cho, Y.K.; Jeong, M.H.; Cho, J.G.; Park, J.C.; Kang, J.C. Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury. Cells Tissues Organs, 2012, 195(5), 428-442.
[http://dx.doi.org/10.1159/000329234] [PMID: 21893931]

Plante, E.; Menaouar, A.; Danalache, B.A.; Yip, D.; Broderick, T.L.; Chiasson, J.L.; Jankowski, M.; Gutkowska, J. Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice. Endocrinology, 2015, 156(4), 1416-1428.
[http://dx.doi.org/10.1210/en.2014-1718] [PMID: 25562615]

Noiseux, N.; Borie, M.; Desnoyers, A.; Menaouar, A.; Stevens, L.M.; Mansour, S.; Danalache, B.A.; Roy, D.C.; Jankowski, M.; Gutkowska, J. Preconditioning of stem cells by oxytocin to improve their therapeutic potential. Endocrinology, 2012, 153(11), 5361-5372.
[http://dx.doi.org/10.1210/en.2012-1402] [PMID: 23024264]

Everett, N.A.; Turner, A.J.; Costa, P.A.; Baracz, S.J.; Cornish, J.L. The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats. Neuropsychopharmacology, 2021, 46(2), 297-304.
[http://dx.doi.org/10.1038/s41386-020-0719-7] [PMID: 32450570]

Chen, X.; Zhao, C.; Zhang, C.; Li, Q.; Chen, J.; Cheng, L.; Zhou, J.; Su, X.; Song, Y. Vagal-α7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair. Stem Cell Res. Ther., 2020, 11(1), 230.
[http://dx.doi.org/10.1186/s13287-020-01757-w] [PMID: 32522255]

Iwasaki, Y.; Maejima, Y.; Suyama, S.; Yoshida, M.; Arai, T.; Katsurada, K.; Kumari, P.; Nakabayashi, H.; Kakei, M.; Yada, T. Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: A route for ameliorating hyperphagia and obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2015, 308(5), R360-R369.
[http://dx.doi.org/10.1152/ajpregu.00344.2014] [PMID: 25540101]

Uvnäs-Moberg, K.; Handlin, L.; Petersson, M. Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Front. Psychol., 2015, 5, 1529.
[http://dx.doi.org/10.3389/fpsyg.2014.01529] [PMID: 25628581]

Borovikova, L.V.; Ivanova, S.; Nardi, D.; Zhang, M.; Yang, H.; Ombrellino, M.; Tracey, K.J. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton. Neurosci., 2000, 85(1-3), 141-147.
[http://dx.doi.org/10.1016/S1566-0702(00)00233-2] [PMID: 11189021]

Aa, S. Exogenous oxytocin (OT) ameliorates pulmonary damage caused by Escherichia coli (E. coli) infection in chronically stressed rats. FASEB, 2011, 25(1), 999.4.
[http://dx.doi.org/10.1096/fasebj.25.1_supplement.999.4]

Wang, P.; Wang, S.C.; Yang, H.; Lv, C.; Jia, S.; Liu, X.; Wang, X.; Meng, D.; Qin, D.; Zhu, H.; Wang, Y.F. Therapeutic potential of oxytocin in atherosclerotic cardiovascular disease: Mechanisms and signaling pathways. Front. Neurosci., 2019, 13, 454.
[http://dx.doi.org/10.3389/fnins.2019.00454] [PMID: 31178679]

Mukaddam-Daher, S.; Yin, Y.L.; Roy, J.; Gutkowska, J.; Cardinal, R. Negative inotropic and chronotropic effects of oxytocin. Hypertension, 2001, 38(2), 292-296.
[http://dx.doi.org/10.1161/01.HYP.38.2.292] [PMID: 11509492]

Michelini, L.C.; Marcelo, M.C.; Amico, J.; Morris, M. Oxytocinergic regulation of cardiovascular function: Studies in oxytocin-deficient mice. Am. J. Physiol. Heart Circ. Physiol., 2003, 284(6), H2269-H2276.
[http://dx.doi.org/10.1152/ajpheart.00774.2002] [PMID: 12531722]

De Melo, V.U.; Saldanha, R.R.M.; Dos Santos, C.R.; De Campos Cruz, J.; Lira, V.A.; Santana-Filho, V.J.; Michelini, L.C. Ovarian hormone deprivation reduces oxytocin expression in paraventricular nucleus preautonomic neurons and correlates with baroreflex impairment in rats. Front. Physiol., 2016, 7, 461.
[http://dx.doi.org/10.3389/fphys.2016.00461] [PMID: 27790154]

Garrott, K.; Dyavanapalli, J.; Cauley, E.; Dwyer, M.K.; Kuzmiak-Glancy, S.; Wang, X.; Mendelowitz, D.; Kay, M.W. Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure. Cardiovasc. Res., 2017, 113(11), 1318-1328.
[http://dx.doi.org/10.1093/cvr/cvx084] [PMID: 28472396]

Gutkowska, J.; Jankowski, M.; Lambert, C.; Mukaddam-Daher, S.; Zingg, H.H.; McCann, S.M. Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart. Proc. Natl. Acad. Sci. USA, 1997, 94(21), 11704-11709.
[http://dx.doi.org/10.1073/pnas.94.21.11704] [PMID: 9326674]

Ishii, H.; Amano, T.; Matsubara, T.; Murohara, T. Pharmacological intervention for prevention of left ventricular remodeling and improving prognosis in myocardial infarction. Circulation, 2008, 118(25), 2710-2718.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.107.748772] [PMID: 19106394]

Breidenbach, J.; Dube, P.; Ghosh, S.; Abdullah, B.; Modyanov, N.; Malhotra, D.; Dworkin, L.; Haller, S.; Kennedy, D. Impact of comorbidities on SARS-CoV-2 viral entry-related genes. J. Pers. Med., 2020, 10(4), 146.
[http://dx.doi.org/10.3390/jpm10040146] [PMID: 32992731]

Kobayashi, H.; Yasuda, S.; Bao, N.; Iwasa, M.; Kawamura, I.; Yamada, Y.; Yamaki, T.; Sumi, S.; Ushikoshi, H.; Nishigaki, K.; Takemura, G.; Fujiwara, T.; Fujiwara, H.; Minatoguchi, S. Postinfarct treatment with oxytocin improves cardiac function and remodeling via activating cell-survival signals and angiogenesis. J. Cardiovasc. Pharmacol., 2009, 54(6), 510-519.
[http://dx.doi.org/10.1097/FJC.0b013e3181bfac02] [PMID: 19755919]

Polshekan, M.; Khori, V.; Alizadeh, A.M.; Ghayour-Mobarhan, M.; Saeidi, M.; Jand, Y.; Rajaei, M.; Farnoosh, G.; Jamialahmadi, K. The SAFE pathway is involved in the postconditioning mechanism of oxytocin in isolated rat heart. Peptides, 2019, 111, 142-151.
[http://dx.doi.org/10.1016/j.peptides.2018.04.002] [PMID: 29635063]

Xiong, W.; Yao, M.; Zhou, R.; Qu, Y.; Yang, Y.; Wang, Z.; Song, N.; Chen, H.; Qian, J. Oxytocin ameliorates ischemia/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart. Biomed. Pharmacother., 2020, 128, , 110358..
[http://dx.doi.org/10.1016/j.biopha.2020.110358] [PMID: 32526456]

Houshmand, F.; Faghihi, M.; Zahediasl, S. Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats. Peptides, 2009, 30(12), 2301-2308.
[http://dx.doi.org/10.1016/j.peptides.2009.09.010] [PMID: 19761809]