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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Recent Advancements in Development of Radical Silylation Reactions

Author(s): Mahender Khatravath*, Rohit Kumar Maurya, Ashutosh Dey, Amarender Goud Burra, Rana Chatterjee and Rambabu Dandela*

Volume 26, Issue 10, 2022

Published on: 17 August, 2022

Page: [920 - 960] Pages: 41

DOI: 10.2174/1385272826666220616155337

Price: $65

Abstract

Transition metal-free radical hydrosilylation of alkynes and factionalized alkenes to vinylsilanes, organosilanes from alkenes, radical silylative cyclizations for sila heterocycles, aromatic dehydrogenative radical silylation, sila-amino acids, silyl hydroperoxides by using transition metal-free reaction conditions such as peroxides, photocatalyst, hydrogen atom transfer catalyst, radical initiators have become one of the most important and useful methodologies for the construction of C-Si bonds for their synthetic applications. In order to demonstrate the growth in this area, this review highlights the last twenty years of success in the fields of silylation of aromatics, silylative cyclizations of sila heterocycles, synthesis of vinylsilanes by hydrosilylation of alkynes, and functionalized alkenes, organosilanes from alkenes and dehydrogenative approaches for vinylsilanes involving radical mechanisms. We believe that summarizing these methods would be very useful for the chemists who are interested in the synthesis of organosilicon compounds for drug discovery or the development of silicon-based materials for industrial applications.

Keywords: Hydrosilylation, radical silylation, alkenylsilanes, sila-heterocycles, transition-metal, industrial applications.

Graphical Abstract

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