Hyaluronan Oligosaccharides as a Potential Anticancer Therapeutic

Title: Hyaluronan Oligosaccharides as a Potential Anticancer Therapeutic

Volume: 9 Issue: 4

Author(s): Bryan P. Toole, Shibnath Ghatak and Suniti Misra

Affiliation:

Keywords: Cancer, metastasis, CD44, signaling, apoptosis

Abstract: Hyaluronan (HA) polysaccharide has differential effects on cells depending on polymer size. One of the more exciting findings is that small chains or oligosaccharides of HA (6-18 sugar units), but not large polymers, will kill many types of cancer cells by triggering apoptosis while leaving normal cells unaffected. Even chemoresistant cells become drug-sensitive when co-treated with HA oligosaccharides. Overall, these observations form the basis for new anticancer therapeutics.

Cite this article as:

Toole P. Bryan, Ghatak Shibnath and Misra Suniti, Hyaluronan Oligosaccharides as a Potential Anticancer Therapeutic, Current Pharmaceutical Biotechnology 2008; 9 (4) . https://dx.doi.org/10.2174/138920108785161569