Login Register Cart 0
Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

An Immune-Suppressive Triterpenoid from the Roots of Kadsura coccinea

Author(s): Jiaxin Tian, Kunyu Li, Guanghai Ma, Gang Chen and Feng Gao*

Volume 19, Issue 12, 2022

Published on: 11 August, 2022

Page: [1128 - 1131] Pages: 4

DOI: 10.2174/1570178619666220527161914

Price: $65

Abstract

Kadsura coccinea is a folk medicine from the family Schisandraceae. Clinically, it has been used to treat many diseases like chronic gastritis and rheumatoid arthritis (RA). Lignans and triterpenes are the main constituents of it. In this paper, phytochemical research on the root of K. coccinea was carried out, leading to the isolation of a previously undescribed 3,4-secolanostane (1). Its structure was established by means of comprehensive spectral analysis, including ECD calculation. Furthermore, bioactivity assay revealed that 1 could elicit a moderate immune-suppressive activity, showing an IC50 value of 8.32 ± 0.13 μM against ConA-induced T-cell proliferation and with IC50 value of 15.58 ± 0.25 μM against LPS-induced B-cell proliferation. The results indicate that 1 might be used in the treatment of rheumatic diseases.

Keywords: Triterpenes, immune suppression, Kadsura coccinea, secolanostane, rheumatoid arthritis, TCMs.

« Previous Next »
Graphical Abstract

[1]
Zhang, W.F.; Yang, Y.; Su, X.; Xu, D.Y.; Yan, Y.L.; Gao, Q.; Duan, M.H. Saudi J. Gastroenterol., 2016, 22(6), 448-455.
[http://dx.doi.org/10.4103/1319-3767.195552] [PMID: 27976641]
[2]
Ma, X.; Zhu, Z.; Guo, S. J. Biotechnol. Appl. Biochem., 2021, 68, 52-59.
[http://dx.doi.org/10.1002/bab.1893]
[3]
Lee, K.; Ahn, J.H.; Lee, K.T.; Jang, D.S.; Choi, J.H. Nutrients, 2018, 10(1), 91.
[http://dx.doi.org/10.3390/nu10010091]
[4]
Yang, P.Y.; Hussain, N.; Zhang, L.; Jia, Y.Z.; Jian, Y.Q.; Li, B.; Choudhary, M.I.; Rahman, A.U.; Wang, W. Chin. Herb. Med., 2020, 12(3), 214-223.
[http://dx.doi.org/10.1016/j.chmed.2020.03.006]
[5]
Yang, Y.; Liu, Y.; Daniyal, M.; Yu, H.; Xie, Q.; Li, B.; Jian, Y.; Man, R.; Wang, S.; Zhou, X.; Liu, B.; Wang, W. Fitoterapia, 2019, 139, 104368.
[http://dx.doi.org/10.1016/j.fitote.2019.104368] [PMID: 31629046]
[6]
Zhou, M.; Peng, X.; Zhou, J.; Liu, Y.; Meng, X.; Ruan, H. Phytochemistry, 2020, 177, 112448.
[http://dx.doi.org/10.1016/j.phytochem.2020.112448] [PMID: 32570050]
[7]
Yang, X.W.; Li, S.M.; Wu, L.; Li, Y.L.; Feng, L.; Shen, Y.H.; Tian, J.M.; Tang, J.; Wang, N.; Liu, Y.; Zhang, W.D. Org. Biomol. Chem., 2010, 8(11), 2609-2616.
[http://dx.doi.org/10.1039/c001885f] [PMID: 20372737]

Rights & Permissions Print Cite
Article Metrics
8
© 2024 Bentham Science Publishers | Privacy Policy