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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Research Article

Trends in the Pharmaceutical Design of New Psychoactive Substances Detected in Oral Fluid OF Drivers Around a Music Festival in South-West France: Comparison 2019/2017

Author(s): Alexandr Gish, Véronique Dumestre-Toulet, Camille Richeval, Jean-François Wiart, Florian Hakim, Delphine Allorge and Jean-michel Gaulier*

Volume 28, Issue 15, 2022

Published on: 09 June, 2022

Page: [1245 - 1249] Pages: 5

DOI: 10.2174/1381612828666220517160545

Price: $65

Abstract

Objective: New psychoactive substance use (NPS) is a reality in France, including among drivers. This work aims (i) to report the pharmaceutical design of NPS detected in oral fluid (OF) from drivers initially screened for drugs around a music festival in 2019 and (ii) to compare obtained results with those of a previous similar study carried out in 2017 in the same situation (and the same music festival) and according to the same methodology.

Methods: OF specimens were recovered from the user devices of the salivary immunochemical tests used by the police during the controls carried out at the entering and leaving the festival. These OF were analyzed using liquid chromatography coupled with tandem mass spectrometry and high-resolution mass spectrometry methods using mass spectra libraries of approximately 1700 substances, including (in 2020) more than 650 NPS and metabolites.

Results: NPS was detected in 14 out of the 265 collected OF specimens. Ten NPS were identified (number of identification): APINACA (1), AB-Chminaca (1), 5F-AMB (1), 5F-PB-22 (5), 2C-D (1), methoxetamine (2), ketamine (1), x-CMC (1), 4-MEC (2), ethylone (2). The prevalence of NPS detection in OF (5.2%) is in the same order as the observed one in 2017 (6.8%), but these results are marked by the majority and increasing proportion of synthetic cannabinoids (47% of identified NPS in 2019 vs. 25% in 2017), an increase also in the proportion of cathinone derivatives (29% in 2019 vs. 6% in 2017), and a decrease in cyclohexanones (17% in 2019 vs. 43% in 2017).

Conclusion: These pharmaceutical design trends (2019 vs. 2017) observed in a population of drivers around a music festival seem to reflect those that can be seen in more general populations in France, with probably a rise in the consumption of synthetic cannabinoids.

Keywords: New psychoactive substances, drivers, music festival, oral fluid, LC-HRMS, LC-MS/MS.

« Previous Next »
[1]
Malaca S, Carlier J, Busardò FP. Advances in forensic toxicology. Curr Pharm Des 2020; 26(31): 3779-80.
[http://dx.doi.org/10.2174/138161282631200810123637] [PMID: 32942971]
[2]
European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2020: Trends and Developments. Luxembourg: Publications Office of the European Union 2020.. emcdda.europa.eu/system/files/publications/13236/TDAT20001ENN_web.pdf
[3]
Peacock A, Bruno R, Gisev N, et al. New psychoactive substances: Challenges for drug surveillance, control, and public health responses. Lancet 2019; 394(10209): 1668-84.
[http://dx.doi.org/10.1016/S0140-6736(19)32231-7] [PMID: 31668410]
[4]
Fels H, Herzog J, Skopp G, et al. Retrospective analysis of new psychoactive substances in blood samples of German drivers suspected of driving under the influence of drugs. Drug Test Anal 2020; 12(10): 1470-6.
[http://dx.doi.org/10.1002/dta.2897] [PMID: 32652866]
[5]
Tuv SS, Krabseth H, Karinen R, Olsen KM, Øiestad EL, Vindenes V. Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period. Accid Anal Prev 2014; 62: 26-31.
[http://dx.doi.org/10.1016/j.aap.2013.09.009] [PMID: 24129318]
[6]
Maas A, Wippich C, Madea B, Hess C. Driving under the influence of synthetic phenethylamines: A case series. Int J Legal Med 2015; 129(5): 997-1003.
[http://dx.doi.org/10.1007/s00414-015-1150-1] [PMID: 25618172]
[7]
Rojek S, Kula K. Maciów-Głąb M, Kłys M. New psychoactive substance α-PVP in a traffic accident case. Forensic Toxicol 2016; 34(2): 403-10.
[http://dx.doi.org/10.1007/s11419-016-0309-x] [PMID: 27429656]
[8]
Vaillancourt L, Viel E, Dombrowski C, Desharnais B, Mireault P. Drugs and driving prior to cannabis legalization: A 5-year review from DECP (DRE) cases in the province of Quebec, Canada. Accid Anal Prev 2021., 149105832.
[http://dx.doi.org/10.1016/j.aap.2020.105832] [PMID: 33220606]
[9]
Krotulski AJ, Mohr ALA, Diamond FX, Logan BK. Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework. Drug Test Anal 2020; 12(1): 136-44.
[http://dx.doi.org/10.1002/dta.2698] [PMID: 31788963]
[10]
Wille SMR, Richeval C, Nachon-Phanithavong M, et al. Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population. Drug Test Anal 2018; 10(3): 539-47.
[http://dx.doi.org/10.1002/dta.2232] [PMID: 28640970]
[11]
Richeval C, Wille SMR, Nachon-Phanithavong M, Samyn N, Allorge D, Gaulier JM. New psychoactive substances in oral fluid of French and Belgian drivers in 2016. Int J Drug Policy 2018; 57: 1-3.
[http://dx.doi.org/10.1016/j.drugpo.2018.03.013] [PMID: 29631107]
[12]
Richeval C, Nachon-Phanithavong M, Di Fazio V, et al. Prevalence of new psychoactive substances in oral fluid specimens from french and Belgian drivers: Comparison 2016/2017. J Anal Toxicol 2019; 43(2): e9-e10.
[http://dx.doi.org/10.1093/jat/bky101] [PMID: 30590712]
[13]
Richeval C, Gish A, Hakim F, et al. Prevalence of new psychoactive substances in oral fluid samples from French drivers: A longitudinal survey (2016-2020). J Anal Toxicol 2021; 45(6): e20-1.
[http://dx.doi.org/10.1093/jat/bkab045] [PMID: 33978145]
[14]
Richeval C, Dumestre-Toulet V, Wiart JF, et al. New psychoactive substances in oral fluid of drivers around a music festival in south-west France in 2017. Forensic Sci Int 2019; 297: 265-9.
[http://dx.doi.org/10.1016/j.forsciint.2019.02.029] [PMID: 30851602]
[15]
Fort C, Jourdan T. Jesse Kemp, Curtis B. Stability of synthetic cannabinoids in biological specimens: Analysis through liquid chromatography tandem mass spectrometry. J Anal Toxicol 2017; 41(5): 360-6.
[http://dx.doi.org/10.1093/jat/bkx015] [PMID: 28334817]
[16]
Simonsen KW, Linnet K, Rasmussen BS. Driving under the influence of alcohol and drugs in the eastern part of Denmark in 2015 and 2016: Abuse patterns and trends. Traffic Inj Prev 2018; 19(5): 468-75.
[http://dx.doi.org/10.1080/15389588.2018.1428743] [PMID: 29370543]
[17]
Messina BG, Dutta NM, Silvestri MM, et al. Modeling motivations for non-medical use of prescription drugs. Addict Behav 2016; 52: 46-51.
[http://dx.doi.org/10.1016/j.addbeh.2015.07.024] [PMID: 26355398]
[18]
Calle P, Maudens K, Lemoyne S, et al. Lessons to be learned from toxicological analyses in intoxicated patients and seized materials at an electronic music dance festival. Forensic Sci Int 2019; 299: 174-9.
[http://dx.doi.org/10.1016/j.forsciint.2019.03.047] [PMID: 31039545]
[19]
di Giannantonio M, Negri A, Schiavone S, et al. Prescription drug misuse in “Clubbers” and disco goers in Ibiza. Front Psychiatry 2020., 11592594.
[http://dx.doi.org/10.3389/fpsyt.2020.592594] [PMID: 33384628]
[20]
Brandeburová P, Bodík I, Horáková I, et al. Wastewater-based epidemiology to assess the occurrence of new psychoactive substances and alcohol consumption in Slovakia. Ecotoxicol Environ Saf 2020; 200, 110762.
[http://dx.doi.org/10.1016/j.ecoenv.2020.110762] [PMID: 32450441]
[21]
Mohr ALA, Fogarty MF, Krotulski AJ, Logan BK. Evaluating trends in novel psychoactive substances using a sentinel population of electronic dance music festival attendees. J Anal Toxicol 2021; 45(5): 490-7.
[http://dx.doi.org/10.1093/jat/bkaa104] [PMID: 32860703]
[22]
Gjerde H, Gjersing L, Baz-Lomba JA, et al. Drug use by music festival attendees: A novel triangulation approach using self-reported data and test results of oral fluid and pooled urine samples. Subst Use Misuse 2019; 54(14): 2317-27.
[http://dx.doi.org/10.1080/10826084.2019.1646285] [PMID: 31398072]
[23]
Bijlsma L, Celma A, Castiglioni S, et al. Monitoring psychoactive substance use at six European festivals through wastewater and pooled urine analysis. Sci Total Environ 2020; 725, 138376.
[http://dx.doi.org/10.1016/j.scitotenv.2020.138376] [PMID: 32298891]
[24]
Le Nézet O, Martinez M, Gérome C, Gandilhon M. Drugs Workbook. France; : OFDT 2020. 2020. Available from: . ofdt.fr/BDD/publications/docs/France2020-03-UsagesFR.pdf

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