Platelet-Monocyte Interactions - A Dangerous Liaison Linking Thrombosis, Inflammation and Atherosclerosis

Title: Platelet-Monocyte Interactions - A Dangerous Liaison Linking Thrombosis, Inflammation and Atherosclerosis

Volume: 15 Issue: 20

Author(s): Peter Seizer, Meinrad Gawaz and Andreas E. May

Affiliation:

Keywords: Atherosclerosis, Thrombosis, inflammatory disease, Monocyte-platelet interactions, Receptor, Cytokine

Abstract: Atherosclerosis is an inflammatory disease. Monocyte-platelet interactions may play a key role in this process by various pathways. They “inflame” each other as well as adjacent cell types at the vascular wall by direct physical interactions, autocrine and paracrine activation processes. These processes promote monocyte recruitment (in)to the vascular wall – a key mechanism in atherogenesis. This article highlights the molecular basis and the inflammatory pathways initiated by platelet – monocyte interactions.

Cite this article as:

Seizer Peter, Gawaz Meinrad and May E. Andreas, Platelet-Monocyte Interactions - A Dangerous Liaison Linking Thrombosis, Inflammation and Atherosclerosis, Current Medicinal Chemistry 2008; 15 (20) . https://dx.doi.org/10.2174/092986708785132852