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Research Article

（-）-表没食子儿茶素没食子酸酯可减轻大鼠臂丛神经根撕脱引起的脊髓性动螨死亡

卷 29, 期 30, 2022

发表于: 15 June, 2022

页: [5139 - 5154] 页: 16

弟呕挨: 10.2174/0929867329666220509204151

价格: $65

摘要

背景：最近的研究表明，表没食子儿茶素没食子酸酯（EGCG）有益于各种神经损伤。本研究旨在研究SD大鼠臂丛神经根撕脱术后EGCG的神经保护作用。 方法：将120只SD大鼠随机分为以下3组：EGCG组、撕脱组和Sham组。每组有40只大鼠。EGCG（100mg / kg，i.p.）或生理盐水在损伤后立即给予大鼠。治疗从第1天持续到第7天，并在术后第3天、第7天、第14天和第28天处死动物，用于收获脊髓样本，用于Nissl染色、免疫组织化学（半胱天冬酶-3、p-JNK、p-c-Jun）和蛋白质印迹分析（p-JNK、JNK、p-c-Jun）。 结果：与对照动物相比，EGCG治疗导致第14天和第28天存活的运动神经元百分比显着增加（p<0.05）。在撕脱后第3天和第7天，EGCG处理的动物中半胱天冬酶-3阳性运动神经元的数量明显少于对照动物（p<0.05）。损伤后撕脱组和EGCG治疗组的p-JNK阳性运动神经元数量和p-JNK/JNK比例均无显著差异。EGCG治疗组的p-c-Jun阳性运动神经元数量和p-c-Jun/c-Jun的比例均显著低于损伤后3d和7d的撕脱组（p<0.05）。 结论：EGCG保护动神经元免受臂丛神经根撕裂诱导的细胞死亡，且该作用与抑制c-Jun磷酸化相关。

关键词: 根撕裂，臂丛神经，表没食子儿茶素没食子酸酯，c-Jun磷酸化，运动神经元死亡，EGCG。

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