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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Review Article

Delivery of Genetic Materials for the Management of Biological Disorders: Advancement and Roles of Polysaccharides and their Derivatives

Author(s): Nandan Gupta and Rishabha Malviya*

Volume 20, Issue 5, 2023

Published on: 11 August, 2022

Page: [545 - 565] Pages: 21

DOI: 10.2174/1567201819666220422154504

Price: $65

Abstract

Advancement in nanotechnology leads to the development of polysaccharides which are very efficient carriers in delivering therapeutic substances like drugs, proteins, and genes. This review describes the role of polysaccharides and their derivatives in the cellular targeting of genetic materials for the treatment of various biological disorders. Applications, challenges, advantages, and disadvantages of polysaccharides used in gene delivery are discussed in the manuscript. Cationic and natural polysaccharides are generally used for RNA and DNA delivery and exhibit better performance in gene transfection. After a substantial literature survey, it can be concluded that different polysaccharides and their derivatives are effectively used in the delivery of genetic material. Natural polysaccharides are widely used due to their advantageous properties like biocompatibility, biodegradability, and low toxicity in the biological environment.

Keywords: Polysaccharide, gene delivery, targeted drug delivery, nanoparticles, genetic material, drugs.

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Graphical Abstract

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