HCV and Autoimmunity

Title: HCV and Autoimmunity

Volume: 14 Issue: 17

Author(s): S. Ferri, L. Muratori, M. Lenzi, A. Granito, F. B. Bianchi and D. Vergani

Affiliation:

Keywords: Hepatitis C virus, immune system dysregulation, molecular mimicry, antiviral therapy

Abstract: Hepatitis C virus (HCV) infection is characterized by a number of autoreactive manifestations, such as autoantibody production, cryoglobulinemia and thyroid disorders. We will analyse critically the mechanisms invoked, and partially documented, to explain such manifestations arising in genetically predisposed individuals exposed to HCV. In particular we will examine the available evidence implicating the virus in lowering the B cell activation threshold, in directly infecting lymphocytes and in inducing self-reactivity through a mechanism of molecular mimicry. We will then move to the HCV related clinical immunopathological manifestations, with a specific attention to the effects of antiviral treatment.

Cite this article as:

Ferri S., Muratori L., Lenzi M., Granito A., Bianchi B. F. and Vergani D., HCV and Autoimmunity, Current Pharmaceutical Design 2008; 14 (17) . https://dx.doi.org/10.2174/138161208784746824