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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins

Author(s): Renfeng An, Wenjin Zhang and Xuefeng Huang*

Volume 22, Issue 17, 2022

Published on: 18 April, 2022

Page: [2188 - 2212] Pages: 25

DOI: 10.2174/1389557522666220217113719

Price: $65

Abstract

Steroidal saponins, a class of natural products formed by the combination of spirosteranes with sugars, are widely distributed in plants and have various biological activities, such as antitumor, anti-inflammatory, anti-bacterial, anti-Alzheimer's, anti-oxidation, etc. Particularly, extensive research on the antitumor property of steroidal saponins has been conducted. Steroidal sapogenins, the aglycones of steroidal saponins, also have attracted much attention due to a vast range of pharmacological activities similar to steroidal saponins. In the past few years, structural modifications on the aglycones and sugar chains of steroidal saponins have been carried out and some achievements have been made. In this mini-review, the antitumor activity, action mechanisms, and structural modifications, along with the structure-activity relationships of steroidal saponins and their derivatives, are summarized.

Keywords: Steroidal saponin, steroidal sapogenin, antitumor activity, mechanisms of action, structural modification, structureactivity relationships.

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Graphical Abstract

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