Inhibitors and Activators of the p38 Mitogen-Activated MAP Kinase
(MAPK) Family as Drugs to Treat Cancer and Inflammation

William   A.   Denny
doi:10.2174/1568009622666220215142837
Abstract

The p38 MAP kinases are a sub-family of the broad group of mitogen-activated serinethreonine protein kinases. The best-characterised, most widely expressed, and most targeted by drugs is p38α MAP kinase. This review briefly summarises the place of p38α MAP kinase in cellular signalling and discusses the structures and activity profiles of representative examples of the major classes of inhibitors and activators (both synthetic compounds and natural products) of this enzyme. Primary screening was direct in vitro inhibition of isolated p38α enzyme.
Keywords: Kinase, p38MAPK, inhibitors, cancer, inflammation, review, activators.
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DOI https://dx.doi.org/10.2174/1568009622666220215142837	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
Current Cancer Drug Targets

Inhibitors and Activators of the p38 Mitogen-Activated MAP Kinase (MAPK) Family as Drugs to Treat Cancer and Inflammation

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